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Article ; Online: The positive impact of lifestyle intervention on selected mio- and chemokines levels in prepubertal children with obesity.

Kozioł-Kozakowska, Agnieszka / Wójcik, Małgorzata / Januś, Dominika / Starzyk, Jerzy

Pediatric endocrinology, diabetes, and metabolism

2023 Volume 29, Issue 2, Page(s) 83–90

Abstract: Introduction: It is proven that life style modification (diet and physical exercises) have positive effect on the metabolic functions in pa-tients with obesity, even without significant weight reduction.: Aim of the study: The objective of the ... ...

Title translation	Pozytywny wpływ modyfikacji stylu życia na poziom wybranych mio- i chemokin u dzieci z otyłością w okresie przedpokwitaniowym.
Abstract	Introduction: It is proven that life style modification (diet and physical exercises) have positive effect on the metabolic functions in pa-tients with obesity, even without significant weight reduction. Aim of the study: The objective of the present study was to check whether the intensive controlled lifestyle intervention (personalized diet modification and monitored, regular physical activity) may have positive impact on the concentration of irisin and chemerin in children with obesity. Material and methods: Twenty children (mean age 8.9) were included in the prospective, cross-over study. They were randomly assigned to group A (with three months intensive intervention), and B (standard intervention). After three months, the groups were switched. Results: Mean irisin level increased significantly after the phase of intensive intervention (4.8 to 5.1 µg/ml; p = 0.03), regardless of whether the intervention was applied from the beginning (Group A) or after 3 months from the advice of healthy-lifestyle (Group B). A period without intensive monitoring was associated with a significant reduction of irisin level. For chemerin in the group A (starting from intensive intervention) mean level decreased after the phase of intensive intervention (65.8 to 57.0 ng/ml), and then increased to 67 ng/ml during the standard intervention. In the group B after the standard intervention period chemerin level increased 67.5 to 68.8 ng/ml (p = 0.03), and then after introduction the intensive intervention de-creased to 63.7 ng/ml. Conclusions: Personalized diet modification and regular, daily exercises may positively influence on the levels of irisin and chemerin.
MeSH term(s)	Humans ; Child ; Cross-Over Studies ; Fibronectins ; Prospective Studies ; Life Style ; Obesity ; Chemokines
Chemical Substances	Fibronectins ; Chemokines
Language	English
Publishing date	2023-09-20
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2617120-X
ISSN	2083-8441 ; 2083-8441
ISSN (online)	2083-8441
ISSN	2083-8441
DOI	10.5114/pedm.2023.127273
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Article: Beyond the Metabolic Syndrome: Non-Obvious Complications of Obesity in Children.

Kozioł-Kozakowska, Agnieszka / Januś, Dominika / Stępniewska, Anna / Szczudlik, Ewa / Stochel-Gaudyn, Anna / Wójcik, Małgorzata

Children (Basel, Switzerland)

2023 Volume 10, Issue 12

Abstract: Obesity is currently one of the most significant public health challenges worldwide due to the continuous increase in obesity rates among children, especially younger children. Complications related to obesity, including serious ones, are increasingly ... ...

Abstract	Obesity is currently one of the most significant public health challenges worldwide due to the continuous increase in obesity rates among children, especially younger children. Complications related to obesity, including serious ones, are increasingly being diagnosed in younger children. A search was performed from January 2023 to September 2023 using the PubMed, Cochrane Library, Science Direct, MEDLINE, and EBSCO databases. The focus was on English-language meta-analyses, systematic reviews, randomized clinical trials, and observational studies worldwide. Four main topics were defined as follows: disorders of glucose metabolism; liver disease associated with childhood obesity; the relationship between respiratory disorders and obesity in children; and the effects of obesity on the hypothalamic-pituitary-gonadal axis and puberty. Understanding potential complications and their underlying mechanisms can expedite the diagnostic process and enhance the effectiveness of treatment. We aspire that this study will bring insight into the often-overlooked complications associated with obesity.
Language	English
Publishing date	2023-12-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10121905
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Article ; Online: Exploring the connection between ego-resiliency and health behaviors: a cross-sectional study of Polish health sciences students.

Dębska-Janus, Małgorzata / Dębski, Paweł / Nawrocka, Agnieszka / Polechoński, Jacek / Madejczyk, Wojciech / Badura-Brzoza, Karina

BMC psychiatry

2024 Volume 24, Issue 1, Page(s) 168

Abstract: Background: The aim of this study was to examine the relationship between ego-resiliency and the intensity of health behaviors among Polish health sciences students.: Methods: The study involved 483 students from health-related faculties in southern ... ...

Abstract	Background: The aim of this study was to examine the relationship between ego-resiliency and the intensity of health behaviors among Polish health sciences students. Methods: The study involved 483 students from health-related faculties in southern Poland, consisting of 314 women (63.7%) and 179 men (36.3%). The average age of the participants was 21.7 ± 2.5 years. To assess resiliency (ER), the Ego-Resiliency Scale (ER89-R12) by Block and Kremen was used in its Polish adaptation. The intensity of health behaviors was examined using the Health Behavior Inventory (HBI) developed by Z. Juczyński. Results: The results revealed a positive correlation between the intensity of health behaviors and ER (r = 0.43, p < 0.001), both for the general factor and its categories (positive mental attitude, proper eating habits, preventive actions, and prohealth activities). Students with a high level of health behaviors exhibited significantly higher ER (M = 38.95, SD = 5.15) compared to those with average (M = 35.93, SD = 5.03) and low (M = 32.97, SD = 5.12) HBI levels. Among the HBI categories, Positive Mental Attitude showed the strongest correlation with both general ER and its factors: optimal regulation (OR) and openness to life experiences (OL). Furthermore, the correlation was found to be stronger with the OR and weaker with OL. Conclusion: Higher ER in students is correlated with a greater frequency of health behaviors. Nurturing the development of ER may contribute to the maintenance of prohealth practices despite life difficulties and temporary loss of motivation. This, in turn, promotes the regularity of health behaviors, which is crucial for their positive impact on overall health.
MeSH term(s)	Male ; Humans ; Female ; Young Adult ; Adult ; Resilience, Psychological ; Cross-Sectional Studies ; Poland ; Ego ; Health Behavior ; Students
Language	English
Publishing date	2024-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-024-05617-2
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Article: Influence of Obesity on Histological Tissue Structure of the Cardiovascular System in Horses.

Siwinska, Natalia / Janus, Izabela / Zak-Bochenek, Agnieszka / Noszczyk-Nowak, Agnieszka

Animals : an open access journal from MDPI

2022 Volume 12, Issue 6

Abstract: It has been well established that obesity in horses can have a negative impact on their health, including endocrine disturbances. In humans, it is well known that obesity leads to structural and functional changes of the cardiovascular system. The aim of ...

Abstract	It has been well established that obesity in horses can have a negative impact on their health, including endocrine disturbances. In humans, it is well known that obesity leads to structural and functional changes of the cardiovascular system. The aim of the study was to assess the impact of obesity on the histological structure of the myocardial tissue, as well as great and peripheral arteries in horses. The heart, arteries (aorta, pulmonary artery and palmar arteries) specimens from 7 horses with normal BCS (4-5/9) and 12 extremely obese (BCS 9/9) draft slaughter horses were obtained for histopathological evaluation. The heart tissue and great arteries showed more intense disturbances in the architecture and vacuolization in the aorta in obese horses as compared to the healthy group. The intima in the pulmonary artery, coronary arteries and palmar arteries was thicker in the obese, rather than healthy horses. The palmar arteries in obese horses had a larger lumen diameter and the lumen-to-total diameter ratio as compared to the control group. The presented study showed a significant effect of obesity on the heart as well as the central and peripheral vessels in horses. This forms the basis for a deeper reflection on the impact of obesity on the equine body.
Language	English
Publishing date	2022-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani12060732
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Article ; Online: Influence of Obesity on Histological Tissue Structure of the Cardiovascular System in Horses

Natalia Siwinska / Izabela Janus / Agnieszka Zak-Bochenek / Agnieszka Noszczyk-Nowak

Animals, Vol 12, Iss 732, p

2022 Volume 732

Abstract	It has been well established that obesity in horses can have a negative impact on their health, including endocrine disturbances. In humans, it is well known that obesity leads to structural and functional changes of the cardiovascular system. The aim of the study was to assess the impact of obesity on the histological structure of the myocardial tissue, as well as great and peripheral arteries in horses. The heart, arteries (aorta, pulmonary artery and palmar arteries) specimens from 7 horses with normal BCS (4–5/9) and 12 extremely obese (BCS 9/9) draft slaughter horses were obtained for histopathological evaluation. The heart tissue and great arteries showed more intense disturbances in the architecture and vacuolization in the aorta in obese horses as compared to the healthy group. The intima in the pulmonary artery, coronary arteries and palmar arteries was thicker in the obese, rather than healthy horses. The palmar arteries in obese horses had a larger lumen diameter and the lumen-to-total diameter ratio as compared to the control group. The presented study showed a significant effect of obesity on the heart as well as the central and peripheral vessels in horses. This forms the basis for a deeper reflection on the impact of obesity on the equine body.
Keywords	equine ; overweight ; heart ; vessels ; leptin ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
Subject code	630
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Perceived functions of allotment gardens and their importance during the COVID-19 pandemic in Poland

Janus, Edyta / Szewczyk-Taranek, Bożena / Smrokowska-Reichmann, Agnieszka

Folia horticulturae. 2022 May 13, v. 34, no. 1

2022

Abstract: This article describes the changes taking place in the functions of allotment gardens, their perceived value, reasons for purchasing allotments and subjective (self-reported) assessments of their importance during the pandemic. A questionnaire survey was ...

Abstract	This article describes the changes taking place in the functions of allotment gardens, their perceived value, reasons for purchasing allotments and subjective (self-reported) assessments of their importance during the pandemic. A questionnaire survey was conducted among 203 owners of allotment gardens located in three highly urbanised cities in the Silesian Voivodeship (Southern Poland). Semi-structured questionnaires and non-standardised questionnaires were used to collect the data. The results demonstrate that the respondents aged above 61 years (38.5%) have observed a generational change in the function of allotments, from cultivating fruits and vegetables to recreational purposes. Regardless of age, the owners of allotment gardens did not notice any technological progress or new crops. The young respondents (21–30 years) treated allotment gardens as an investment (36.7%), while the respondents aged below 20 years and over 61 years declared that the greatest benefits of allotment gardening are improved health and growing one’s own fruits and vegetables. The respondents aged over 41 years (25.9%) also pointed out the importance of growing their own produce. Allotments were especially important during the pandemic as a private space free from COVID-related restrictions. Extended interviews with the respondents revealed that allotment gardening was perceived as a coping strategy for the stress generated during the lockdown. This study showed that allotment gardens are important sites not only for food production but also for maintaining mental health, social capital and environmental engagement.
Keywords	COVID-19 infection ; food production ; mental health ; pandemic ; questionnaires ; social capital ; surveys ; urbanization ; Poland
Language	English
Dates of publication	2022-0513
Size	p. 51-63.
Publishing place	Sciendo
Document type	Article
ZDB-ID	2569108-9
ISSN	2083-5965 ; 0867-1761
ISSN (online)	2083-5965
ISSN	0867-1761
DOI	10.2478/fhort-2022-0006
Database	NAL-Catalogue (AGRICOLA)

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Article: Biomechanical-Structural Correlation of

Gach, Justyn / Janus, Izabela / Mackiewicz, Agnieszka / Klekiel, Tomasz / Noszczyk-Nowak, Agnieszka

Animals : an open access journal from MDPI

2021 Volume 11, Issue 6

Abstract: The mitral valve apparatus is a complex structure consisting of the mitral ring, valve leaflets, papillary muscles ... ...

Abstract	The mitral valve apparatus is a complex structure consisting of the mitral ring, valve leaflets, papillary muscles and
Language	English
Publishing date	2021-06-04
Publishing country	Switzerland
Document type	Journal Article
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani11061678
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Article ; Online: Hemorrhagic stroke caused by xylometazoline poisoning.

Banaś, Barbara Potocka / Brzeźniakiewicz-Janus, Katarzyna / Majdanik, Sławomir / Parafiniuk, Mirosław / Łużny, Sylwester / Stachowicz, Agnieszka / Janus, Tomasz

Journal of forensic sciences

2023 Volume 69, Issue 1, Page(s) 359–364

Abstract: An increase in the use of over-the-counter medications has been observed in recent years. This also concerns xylometazoline, approved for the treatment of allergic rhinitis or upper respiratory tract infections. We present the fatal case of a 40 year-old- ...

Abstract	An increase in the use of over-the-counter medications has been observed in recent years. This also concerns xylometazoline, approved for the treatment of allergic rhinitis or upper respiratory tract infections. We present the fatal case of a 40 year-old-woman with a massive hemorrhagic stroke. Initial toxicology tests of biological material collected during autopsy revealed the presence of xylometazoline. No other significant toxicology findings were noted. LC-MS/MS method has been developed to determine xylometazoline concentration, which was 18.6 ng/mL in blood and 498.9 ng/mL in urine. The macroscopically detected hemorrhagic focus was confirmed by histopathological which confirmed hemorrhagic infarcts in the brain tissue, especially in the subarachnoid area. No other pathological changes were found. Based on findings from autopsy and toxicological analyses, the direct cause of death was concluded to be hemorrhagic stroke resulting from xylometazoline intoxication. Although xylometazoline products are regarded as relatively safe and are available over the counter, the risk of adverse effects, in particular stroke leading to death, should be considered. If adverse effects are observed, it is reasonable to measure the concentration of the drug in blood and urine. With such data, it will be possible to assess the actual exposure to this xenobiotic and draw firmer conclusions.
MeSH term(s)	Female ; Humans ; Adult ; Hemorrhagic Stroke/chemically induced ; Hemorrhagic Stroke/drug therapy ; Chromatography, Liquid ; Nasal Decongestants/adverse effects ; Tandem Mass Spectrometry
Chemical Substances	xylometazoline (WPY40FTH8K) ; Nasal Decongestants
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Case Reports
ZDB-ID	219216-0
ISSN	1556-4029 ; 0022-1198
ISSN (online)	1556-4029
ISSN	0022-1198
DOI	10.1111/1556-4029.15416
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Article ; Online: Histamine and Serotonin Levels in Bone Marrow Stem Cells Niche as Potential Biomarkers of Systemic Mastocytosis and Myeloproliferative Disorders.

Janus, Tomasz / Korbal, Urszula / Żukowski, Maciej / Lewosiuk, Agnieszka / Koper, Katarzyna / Żukowska, Agnieszka / Brzeźniakiewicz-Janus, Katarzyna

Stem cell reviews and reports

2022 Volume 19, Issue 3, Page(s) 807–816

Abstract: Bone marrow studies currently provide a lot of valuable information in the diagnostics of hematological diseases including hematopoietic stem cells disorders. Our studies on low-molecular weight organic compounds in bone marrow stem cell niche in various ...

Abstract	Bone marrow studies currently provide a lot of valuable information in the diagnostics of hematological diseases including hematopoietic stem cells disorders. Our studies on low-molecular weight organic compounds in bone marrow stem cell niche in various pathogenic conditions, revealed relatively high variability of histamine levels in different groups of hematological diseases. It was also found that serotonin levels were significantly lower than those typically measured in peripheral blood as well as many have the influence on stem cells proliferative potential. This paper presents findings from quantitative and statistical analyses of histamine and serotonin levels. Bone marrow collected from patients undergoing routine diagnostic procedures for hematological diseases and receiving inpatient treatment were analyzed. Histamine and serotonin levels were measured using hydrophilic interaction liquid chromatography (HILIC) coupled with tandem mass spectrometry. Obtained data were analyzed statistically and correlated with the diagnosed groups of hematological diseases and the parameters of complete blood counts. Histamine was found in all tested samples, including those from patients without malignancy, and the reported levels were comparable to the reference values in blood. This observation allows us to assume that bone marrow cells can produce and accumulate histamine. Moreover, the statistical analysis revealed a significant relationship between histamine levels and diagnosed mastocytosis, and between histamine levels and myeloproliferative neoplasms. Different results were obtained for serotonin, and its concentrations in most cases were below the limit of quantification of the method used (< 0.2 ng/mL), which can only be compared to peripheral blood plasma. In a few cases, significantly higher serotonin levels were observed and it concerned diseases associated with an increased number of megakaryocytes in the bone marrow.
MeSH term(s)	Humans ; Bone Marrow/pathology ; Mastocytosis, Systemic/diagnosis ; Mastocytosis, Systemic/pathology ; Histamine ; Serotonin ; Myeloproliferative Disorders/diagnosis ; Myeloproliferative Disorders/pathology ; Hematologic Diseases/pathology ; Bone Marrow Cells ; Biomarkers
Chemical Substances	Histamine (820484N8I3) ; Serotonin (333DO1RDJY) ; Biomarkers
Language	English
Publishing date	2022-12-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2495577-2
ISSN	2629-3277 ; 1558-6804 ; 1550-8943
ISSN (online)	2629-3277 ; 1558-6804
ISSN	1550-8943
DOI	10.1007/s12015-022-10502-0
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Article ; Online: Moxetumomab pasudotox for the treatment of hairy cell leukemia.

Janus, Agnieszka / Robak, Tadeusz

Expert opinion on biological therapy

2019 Volume 19, Issue 6, Page(s) 501–508

Abstract: ... ...

Abstract	Introduction
MeSH term(s)	Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; B-Lymphocytes/cytology ; B-Lymphocytes/drug effects ; B-Lymphocytes/metabolism ; Bacterial Toxins/pharmacokinetics ; Bacterial Toxins/pharmacology ; Bacterial Toxins/therapeutic use ; Blood Cell Count ; Clinical Trials as Topic ; Exotoxins/pharmacokinetics ; Exotoxins/pharmacology ; Exotoxins/therapeutic use ; Half-Life ; Humans ; Leukemia, Hairy Cell/drug therapy
Chemical Substances	Antineoplastic Agents ; Bacterial Toxins ; Exotoxins ; immunotoxin HA22 (2NDX4B6N8F)
Language	English
Publishing date	2019-05-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2052501-1
ISSN	1744-7682 ; 1471-2598
ISSN (online)	1744-7682
ISSN	1471-2598
DOI	10.1080/14712598.2019.1614558
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