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  1. Article: Infiltrative Type I Collagen in the Treatment of Morton's Neuroma: A Mini-Series.

    Giarda, Federico / Agostini, Adele / Colonna, Stefano / Sciumè, Luciana / Meroni, Alberto / Beretta, Giovanna / Dalla Costa, Davide

    Journal of clinical medicine

    2023  Volume 12, Issue 14

    Abstract: Morton's neuroma (MN) is a compressive neuropathy of the common plantar digital nerve, most commonly affecting the third inter-digital space. The conservative approach is the first recommended treatment option. However, other different approaches have ... ...

    Abstract Morton's neuroma (MN) is a compressive neuropathy of the common plantar digital nerve, most commonly affecting the third inter-digital space. The conservative approach is the first recommended treatment option. However, other different approaches have been proposed, offering several options of treatments, where, several degrees of efficacy and safety have been reported. We treated five consecutive patients affected by MN through three indirect ultrasound-guided injections of type I porcine collagen at weekly intervals. All patients were assessed before the treatment, after the treatment and up to 6 months after the last injection via AOFAS and VNS scores for pain, in which the function and pain were evaluated, respectively. In all patients, both analyzed variables progressively ameliorated, with benefits lasting until the last follow-up. The trend of the scores during the follow-up showed significant statistical differences. No side effects occurred. To our knowledge, this is the first study on injections of type I porcine collagen for the treatment of Morton's neuroma. Future research is needed to confirm the positive trend achieved in this MN mini-series.
    Language English
    Publishing date 2023-07-12
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12144640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Case Report: Postacute Rehabilitation of Guillain-Barré Syndrome and Cerebral Vasculitis-Like Pattern Accompanied by SARS-CoV-2 Infection.

    Colonna, Stefano / Sciumé, Luciana / Giarda, Federico / Innocenti, Alessandro / Beretta, Giovanna / Dalla Costa, Davide

    Frontiers in neurology

    2021  Volume 11, Page(s) 602554

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2021-01-07
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2020.602554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Myoelectrically Controlled FES to Enhance Tenodesis Grip in People With Cervical Spinal Cord Lesion: A Usability Study.

    Thorsen, Rune / Dalla Costa, Davide / Beghi, Ettore / Ferrarin, Maurizio

    Frontiers in neuroscience

    2020  Volume 14, Page(s) 412

    Abstract: People with tetraplegia are often lacking grip strength, causing impairment in activities of daily living. For them, improving hand function is a priority because it is important for autonomy and participation in daily life. A tendon transfer surgery may ...

    Abstract People with tetraplegia are often lacking grip strength, causing impairment in activities of daily living. For them, improving hand function is a priority because it is important for autonomy and participation in daily life. A tendon transfer surgery may be an option to improve the tenodesis grip, but it is an invasive procedure. Alternatively a similar effect can be produced, using a non-invasive method. We have previously described how myoelectrically controlled functional electrical stimulation (MeCFES) can be efficient for enhancing grip strength, using a one channel research prototype with wired connections to surface electrodes. In this paper we focus on the usability for activities of daily living and how it can fulfill an actual need. We recruited 27 participants with a cervical spinal cord lesion (C5-C7) for this trial. They tested the device in 12 sessions of 2 h each, in which the participants performed self selected activities involving the tenodesis grip. User centered outcomes were validated questionnaires: the Individually Prioritized Problem Assessment (IPPA) and the Quebec User Evaluation of Satisfaction with Assistive Technology (QUEST). Furthermore, they were asked if they found the device useful for continued use in daily life. The device facilitated prioritized activities for all participants. The IPPA change score was 4.6 on average (STD:3.5, effect size:1.3), meaning that the system greatly facilitated problematic tasks and the large effect size evinces that this was a meaningful improvement of hand function. It compares to the impact that a mobility device like a wheelchair has on daily living. Fourteen subjects found the system useful, expressing the need for such a neuroprosthesis. Examples of acquiring new abilities while using the device, indicate that the method could have a therapeutic use as well. Furthermore, results from the IPPA questionnaire are indicating what issues people with tetraplegia may hope to solve with a neuroprosthesis for the hand. The satisfaction of the device (QUEST) indicates that further effort in development should address wearability, eliminate wires, and improve the fitting procedure.
    Language English
    Publishing date 2020-05-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2020.00412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Non-invasive estimation of

    Frabasile, Lorenzo / Amendola, Caterina / Buttafava, Mauro / Chincarini, Matteo / Contini, Davide / Cozzi, Bruno / De Zani, Donatella / Guerri, Giulia / Lacerenza, Michele / Minero, Michela / Petrizzi, Lucio / Qiu, Lina / Rabbogliatti, Vanessa / Rossi, Emanuela / Spinelli, Lorenzo / Straticò, Paola / Vignola, Giorgio / Zani, Davide Danilo / Dalla Costa, Emanuela /
    Torricelli, Alessandro

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 1243325

    Abstract: Biosensors applied in veterinary medicine serve as a noninvasive method to determine the health status of animals and, indirectly, their level of welfare. Near infrared spectroscopy (NIRS) has been suggested as a technology with this application. This ... ...

    Abstract Biosensors applied in veterinary medicine serve as a noninvasive method to determine the health status of animals and, indirectly, their level of welfare. Near infrared spectroscopy (NIRS) has been suggested as a technology with this application. This study presents preliminary
    Language English
    Publishing date 2023-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1243325
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  5. Article ; Online: Brainstem lesion causing paroxysmal ataxia, dysarthria, diplopia and hemifacial spasm (PADDHS).

    Ferrante, Enrico / Marazzi, Maria Raffaella / Trimboli, Michele / Dalla Costa, Davide / Erminio, Cristina / Nobili, Lino

    Epileptic disorders : international epilepsy journal with videotape

    2019  Volume 21, Issue 4, Page(s) 389–390

    MeSH term(s) Aged ; Ataxia/etiology ; Brain Stem/physiopathology ; Diplopia/etiology ; Dysarthria/etiology ; Electroencephalography ; Hemifacial Spasm/etiology ; Humans ; Male
    Language English
    Publishing date 2019-05-20
    Publishing country France
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 2086797-9
    ISSN 1950-6945 ; 1294-9361
    ISSN (online) 1950-6945
    ISSN 1294-9361
    DOI 10.1684/epd.2019.1080
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5740: Show issues Location:
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  6. Article ; Online: The management of a COVID-free inpatient rehabilitation in a large COVID-19 hospital in Milan during the outbreak.

    Dalla Costa, Davide / Giarda, Federico / Sciumè, Luciana / Rogliani, Rosa / Lumastro, Rosaria / Ciriolo, Salvatore / Beretta, Giovanna

    European journal of physical and rehabilitation medicine

    2020  Volume 56, Issue 5, Page(s) 690–692

    MeSH term(s) Adult ; Aged ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disease Management ; Disease Outbreaks/statistics & numerical data ; Female ; Hospitalization/statistics & numerical data ; Humans ; Infection Control/methods ; Inpatients/statistics & numerical data ; Italy ; Male ; Middle Aged ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Rehabilitation/methods ; Treatment Outcome
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country Italy
    Document type Letter
    ZDB-ID 2426908-6
    ISSN 1973-9095 ; 1973-9087
    ISSN (online) 1973-9095
    ISSN 1973-9087
    DOI 10.23736/S1973-9087.20.06460-6
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1388: Show issues Location:
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  7. Article ; Online: TSH-receptor autoantibodies in patients with chronic thyroiditis and hypothyroidism.

    Giannone, Mariella / Dalla Costa, Miriam / Sabbadin, Chiara / Garelli, Silvia / Salvà, Monica / Masiero, Stefano / Plebani, Mario / Faggian, Diego / Gallo, Nicoletta / Presotto, Fabio / Bertazza, Loris / Nacamulli, Davide / Censi, Simona / Mian, Caterina / Betterle, Corrado

    Clinical chemistry and laboratory medicine

    2022  Volume 60, Issue 7, Page(s) 1020–1030

    Abstract: Objectives: The reported prevalence of TSH-receptor (TSHR) autoantibodies (TRAb) in patients with chronic thyroiditis (CT) range from 0 to 48%. The objective was to study the prevalence of TRAb in patients with CT and hypothyroidism and to correlate it ... ...

    Abstract Objectives: The reported prevalence of TSH-receptor (TSHR) autoantibodies (TRAb) in patients with chronic thyroiditis (CT) range from 0 to 48%. The objective was to study the prevalence of TRAb in patients with CT and hypothyroidism and to correlate it with gender, age, thyroid dimensions, TSH levels, and autoimmune diseases.
    Methods: The study comprised 245 patients with CT and hypothyroidism (median age 42 years, 193 females, 52 males) and 123 Italian healthy subjects matched for sex and age as controls. TRAb were tested with ELISA using a >2.5 IU/L cut off for positivity. TSHR blocking (TBAb) and TSHR stimulating autoantibodies (TSAb) were measured in 12 TRAb-positive patients using bioassays with Chinese hamster ovary (CHO) cells expressing wild-type or R255D-mutated TSHR.
    Results: TRAb positivity was found in 32/245 (13.1%) patients and significantly correlated (p<0.05) with TSH levels. TRAb positivity was significantly higher in males vs. females (p=0.034), in females 16-45 years of age vs. >45 years of age (p<0.05) and in patients with reduced vs. normal/increased thyroid dimensions (p<0.05). Linear regression analysis showed a correlation between TRAb concentrations with age (p<0.05) and TRAb concentrations with TSH (p<0.01). In bioassay with TSHR-R255D all 12 patients tested were TBAb-positive while 33% were also TSAb-positive suggesting the presence of a mixture of TRAbs with different biological activities in some patients.
    Conclusions: TRAb have been found in patients with CT and hypothyroidism. A mixture of TBAb and TSAb was found in some patients and this may contribute to the pathogenesis of thyroid dysfunction during the course of the disease.
    MeSH term(s) Adult ; Animals ; Autoantibodies ; CHO Cells ; Cricetinae ; Cricetulus ; Female ; Hashimoto Disease ; Humans ; Hypothyroidism ; Male ; Receptors, Thyrotropin ; Thyroiditis ; Thyrotropin
    Chemical Substances Autoantibodies ; Receptors, Thyrotropin ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2022-05-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2022-0162
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: The management of a COVID-free inpatient rehabilitation in a large COVID-19 hospital in Milan during the outbreak

    Dalla Costa, Davide / Giarda, Federico / Sciumè, Luciana / Rogliani, Rosa / Lumastro, Rosaria / Ciriolo, Salvatore / Beretta, Giovanna

    Eur J Phys Rehabil Med

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #646273
    Database COVID19

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  9. Article: Induction of Terpene Biosynthesis in Berries of Microvine Transformed with

    Dalla Costa, Lorenza / Emanuelli, Francesco / Trenti, Massimiliano / Moreno-Sanz, Paula / Lorenzi, Silvia / Coller, Emanuela / Moser, Sergio / Slaghenaufi, Davide / Cestaro, Alessandro / Larcher, Roberto / Gribaudo, Ivana / Costantini, Laura / Malnoy, Mickael / Grando, M Stella

    Frontiers in plant science

    2018  Volume 8, Page(s) 2244

    Abstract: Terpenoids, especially monoterpenes, are major aroma-impact compounds in grape and wine. Previous studies highlighted a key regulatory role for grapevine 1-deoxy-D-xylulose 5-phosphate synthase 1 (VvDXS1), the first enzyme of the methylerythritol ... ...

    Abstract Terpenoids, especially monoterpenes, are major aroma-impact compounds in grape and wine. Previous studies highlighted a key regulatory role for grapevine 1-deoxy-D-xylulose 5-phosphate synthase 1 (VvDXS1), the first enzyme of the methylerythritol phosphate pathway for isoprenoid precursor biosynthesis. Here, the parallel analysis of
    Language English
    Publishing date 2018-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711035-7
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2017.02244
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  10. Article ; Online: MiR-125a-3p timely inhibits oligodendroglial maturation and is pathologically up-regulated in human multiple sclerosis.

    Lecca, Davide / Marangon, Davide / Coppolino, Giusy T / Méndez, Aida Menéndez / Finardi, Annamaria / Costa, Gloria Dalla / Martinelli, Vittorio / Furlan, Roberto / Abbracchio, Maria P

    Scientific reports

    2016  Volume 6, Page(s) 34503

    Abstract: In the mature central nervous system (CNS), oligodendrocytes provide support and insulation to axons thanks to the production of a myelin sheath. During their maturation to myelinating cells, oligodendroglial precursors (OPCs) follow a very precise ... ...

    Abstract In the mature central nervous system (CNS), oligodendrocytes provide support and insulation to axons thanks to the production of a myelin sheath. During their maturation to myelinating cells, oligodendroglial precursors (OPCs) follow a very precise differentiation program, which is finely orchestrated by transcription factors, epigenetic factors and microRNAs (miRNAs), a class of small non-coding RNAs involved in post-transcriptional regulation. Any alterations in this program can potentially contribute to dysregulated myelination, impaired remyelination and neurodegenerative conditions, as it happens in multiple sclerosis (MS). Here, we identify miR-125a-3p, a developmentally regulated miRNA, as a new actor of oligodendroglial maturation, that, in the mammalian CNS regulates the expression of myelin genes by simultaneously acting on several of its already validated targets. In cultured OPCs, over-expression of miR-125a-3p by mimic treatment impairs while its inhibition with an antago-miR stimulates oligodendroglial maturation. Moreover, we show that miR-125a-3p levels are abnormally high in the cerebrospinal fluid of MS patients bearing active demyelinating lesions, suggesting that its pathological upregulation may contribute to MS development, at least in part by blockade of OPC differentiation leading to impaired repair of demyelinated lesions.
    Language English
    Publishing date 2016-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep34503
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