LIVIVO - Search results -

Search results

Result 1 - 10 of total 40

Search options

Article: Early bicarbonate loading and dantroline for ziprasidone/haloperidol-induced neuroleptic malignant syndrome.

Strawn, Jeffrey R / Keck, Paul E

2006 Volume 67, Issue 4, Page(s) 677

MeSH term(s)	Adolescent ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Autistic Disorder ; Combined Modality Therapy ; Dantrolene/therapeutic use ; Disruptive, Impulse Control, and Conduct Disorders/complications ; Drug Administration Schedule ; Fluid Therapy/methods ; Haloperidol/adverse effects ; Haloperidol/therapeutic use ; Humans ; Male ; Muscle Relaxants, Central/therapeutic use ; Neuroleptic Malignant Syndrome/drug therapy ; Neuroleptic Malignant Syndrome/etiology ; Piperazines/adverse effects ; Piperazines/therapeutic use ; Self-Injurious Behavior/drug therapy ; Sodium Bicarbonate/administration & dosage ; Sodium Bicarbonate/therapeutic use ; Thiazoles/adverse effects ; Thiazoles/therapeutic use
Chemical Substances	Antipsychotic Agents ; Muscle Relaxants, Central ; Piperazines ; Thiazoles ; ziprasidone (6UKA5VEJ6X) ; Sodium Bicarbonate (8MDF5V39QO) ; Dantrolene (F64QU97QCR) ; Haloperidol (J6292F8L3D)
Language	English
Publishing date	2006-05-01
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	716287-x
ISSN	1555-2101 ; 0160-6689
ISSN (online)	1555-2101
ISSN	0160-6689
DOI	10.4088/jcp.v67n0420e
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 108: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 247: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Neuroleptic malignant syndrome.

Strawn, Jeffrey R / Keck, Paul E / Caroff, Stanley N

The American journal of psychiatry

2007 Volume 164, Issue 6, Page(s) 870–876

MeSH term(s)	Adult ; Amantadine ; Antiparkinson Agents/therapeutic use ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Benzodiazepines/therapeutic use ; Bromocriptine/therapeutic use ; Dantrolene/therapeutic use ; Diagnosis, Differential ; Dopamine/physiology ; Electroconvulsive Therapy ; Female ; Humans ; Lorazepam/therapeutic use ; Muscle Relaxants, Central/therapeutic use ; Neuroleptic Malignant Syndrome/diagnosis ; Neuroleptic Malignant Syndrome/drug therapy ; Neuroleptic Malignant Syndrome/physiopathology ; Risk Factors
Chemical Substances	Antiparkinson Agents ; Antipsychotic Agents ; Muscle Relaxants, Central ; Benzodiazepines (12794-10-4) ; Bromocriptine (3A64E3G5ZO) ; Amantadine (BF4C9Z1J53) ; Dantrolene (F64QU97QCR) ; Lorazepam (O26FZP769L) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2007-06
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	280045-7
ISSN	1535-7228 ; 0002-953X
ISSN (online)	1535-7228
ISSN	0002-953X
DOI	10.1176/ajp.2007.164.6.870
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui I Zs.30: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Efficacy and safety of low- and high-dose cariprazine in acute and mixed mania associated with bipolar I disorder: a double-blind, placebo-controlled study.

Calabrese, Joseph R / Keck, Paul E / Starace, Anju / Lu, Kaifeng / Ruth, Adam / Laszlovszky, István / Németh, György / Durgam, Suresh

The Journal of clinical psychiatry

2015 Volume 76, Issue 3, Page(s) 284–292

Abstract: Objective: This phase 3 trial evaluated the efficacy, safety, and tolerability of low- and high-dose cariprazine in patients meeting DSM-IV-TR criteria for acute manic or mixed episodes associated with bipolar I disorder.: Method: This multicenter, ... ...

Abstract	Objective: This phase 3 trial evaluated the efficacy, safety, and tolerability of low- and high-dose cariprazine in patients meeting DSM-IV-TR criteria for acute manic or mixed episodes associated with bipolar I disorder. Method: This multicenter, randomized, double-blind, placebo-controlled, parallel-group, fixed/flexible-dose study was conducted from February 2010 to December 2011. Patients were randomly assigned to placebo, cariprazine 3-6 mg/d, or cariprazine 6-12 mg/d for 3 weeks of double-blind treatment. Primary and secondary efficacy parameters were change from baseline to week 3 in Young Mania Rating Scale (YMRS) total score and Clinical Global Impressions-Severity of Illness (CGI-S) score, respectively. Post hoc analysis examined change from baseline to week 3 in YMRS single items. Results: A total of 497 patients were randomized; 74% completed the study. The least squares mean difference (LSMD) for change from baseline to week 3 in YMRS total score was statistically significant in favor of both cariprazine groups versus placebo (LSMD [95% CI]: 3-6 mg/d, -6.1 [-8.4 to -3.8]; 6-12 mg/d, -5.9 [-8.2, -3.6]; P < .001 [both]). Both cariprazine treatment groups showed statistically significant superiority to placebo on all 11 YMRS single items (all comparisons, P < .05). Change from baseline in CGI-S scores was statistically significantly greater in both cariprazine groups compared with placebo (LSMD [95% CI]: 3-6 mg/d, -0.6 [-0.9 to -0.4]; 6-12 mg/d, -0.6 [-0.9 to -0.3]; P < .001 [both]). The most common (≥ 5% and twice the rate of placebo) treatment-related adverse events for cariprazine were akathisia (both groups) and nausea, constipation, and tremor (6-12 mg/d only). Conclusions: Results of this study demonstrated that both low- and high-dose cariprazine were more effective than placebo in the treatment of acute manic or mixed episodes associated with bipolar I disorder. Cariprazine was generally well tolerated, although the incidence of akathisia was greater with cariprazine than with placebo. Trial registration: ClinicalTrials.gov identifier: NCT01058668.
MeSH term(s)	Adolescent ; Adult ; Aged ; Akathisia, Drug-Induced/etiology ; Bipolar Disorder/drug therapy ; Dopamine Agonists/administration & dosage ; Dopamine Agonists/adverse effects ; Dopamine Agonists/pharmacology ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Piperazines/administration & dosage ; Piperazines/adverse effects ; Piperazines/pharmacology ; Placebos/administration & dosage ; Placebos/adverse effects ; Placebos/pharmacology ; Remission Induction ; Severity of Illness Index ; Treatment Outcome ; Young Adult
Chemical Substances	Dopamine Agonists ; Piperazines ; Placebos ; cariprazine (F6RJL8B278)
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Clinical Trial, Phase III ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	716287-x
ISSN	1555-2101 ; 0160-6689
ISSN (online)	1555-2101
ISSN	0160-6689
DOI	10.4088/JCP.14m09081
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 108: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 247: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Sodium oxybate in the treatment of binge eating disorder: An open-label, prospective study

McElroy, Susan L / Guerdjikova, Anna I / Winstanley, Erin L / O'Melia, Anne M / Mori, Nicole / Keck, Paul E. Jr / Hudson, James I

International journal of eating disorders. 2011 Apr., v. 44, no. 3

2011

Abstract: OBJECTIVE: To assess preliminarily the effectiveness of sodium oxybate in binge eating disorder. METHOD: This was an open-label, prospective, 16-week, flexible dose study of sodium oxybate in binge eating disorder. The primary outcome was binge eating ... ...

Abstract	OBJECTIVE: To assess preliminarily the effectiveness of sodium oxybate in binge eating disorder. METHOD: This was an open-label, prospective, 16-week, flexible dose study of sodium oxybate in binge eating disorder. The primary outcome was binge eating episode frequency. RESULTS: Twelve individuals received sodium oxybate, 10 completed at least one postbaseline evaluation, and five completed the study. Mean dose at endpoint was 7.1 (2.0) g/day. Sodium oxybate was associated with significant reductions in frequency of binge days and binge episodes, as well as measures of clinical severity, eating pathology, obsessive-compulsive symptoms, food cravings, body mass index, and body weight. Nine participants had remission of binge eating and five lost ≥5% of their baseline weight; all five of the latter participants had remission of binge eating. DISCUSSION: In this open-label trial, sodium oxybate was effective in binge eating disorder, but associated with high a discontinuation rate. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:262-268)
Language	English
Dates of publication	2011-04
Size	p. 262-268.
Publishing place	Wiley Subscription Services, Inc., A Wiley Company
Document type	Article
ZDB-ID	603170-5
ISSN	1098-108X ; 0276-3478
ISSN (online)	1098-108X
ISSN	0276-3478
DOI	10.1002/eat.20798
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 1749: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Pharmacologic treatment considerations in co-occurring bipolar and anxiety disorders.

Keck, Paul E / Strawn, Jeffrey R / McElroy, Susan L

The Journal of clinical psychiatry

2006 Volume 67 Suppl 1, Page(s) 8–15

Abstract: Background: Anxiety disorders are among the most commonly co-occurring psychiatric syndromes with bipolar disorder. The presence of co-occurring anxiety disorders has important prognostic and treatment implications.: Method: Using the PaperChase ... ...

Abstract	Background: Anxiety disorders are among the most commonly co-occurring psychiatric syndromes with bipolar disorder. The presence of co-occurring anxiety disorders has important prognostic and treatment implications. Method: Using the PaperChase database augmented by a manual search of the literature, we identified 122 publications that consisted of reports regarding pharmacologic agents used in the treatment of bipolar disorder also assessing the efficacy of these agents in anxiety disorders, treatment studies of patients with comorbid bipolar disorder and specific anxiety disorders, and studies of novel antiepileptic agents in the treatment of anxiety symptoms or disorders. Results: No randomized controlled trials have been conducted in patients with bipolar disorder and any co-occurring anxiety disorder. Among agents with antimanic or mood-stabilizing effects, evidence of efficacy from placebo-controlled trials exists for valproate in the treatment of panic disorder; lamotrigine, risperidone, and olanzapine in posttraumatic stress disorder; and risperidone, olanzapine, and quetiapine as adjunctive treatment in selective serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. Antidepressants from virtually every class have efficacy in the treatment of most anxiety disorders but present the challenge of minimizing switch risk when used in conjunction with a moodstabilizer. Among novel antiepileptic agents without proven thymoleptic properties studied in randomized controlled trials in anxiety disorders, gabapentin and pregabalin had efficacy in the treatment of social anxiety disorder, and pregabalin in the treatment of generalized anxiety disorder. Conclusion: In the absence of controlled trials in patients with comorbid bipolar and anxiety disorders, the initial goals of treatment include mood stabilization and selection of thymoleptic agents with efficacy in the co-occurring anxiety disorder.
MeSH term(s)	Anticonvulsants/therapeutic use ; Antidepressive Agents/therapeutic use ; Antimanic Agents/therapeutic use ; Antipsychotic Agents/therapeutic use ; Anxiety Disorders/drug therapy ; Anxiety Disorders/epidemiology ; Bipolar Disorder/drug therapy ; Bipolar Disorder/epidemiology ; Clinical Trials as Topic/statistics & numerical data ; Comorbidity ; Drug Therapy, Combination ; Humans ; Panic Disorder/drug therapy ; Phobic Disorders/drug therapy ; Placebos ; Prognosis ; Serotonin Uptake Inhibitors/therapeutic use ; Treatment Outcome
Chemical Substances	Anticonvulsants ; Antidepressive Agents ; Antimanic Agents ; Antipsychotic Agents ; Placebos ; Serotonin Uptake Inhibitors
Language	English
Publishing date	2006
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	716287-x
ISSN	1555-2101 ; 0160-6689
ISSN (online)	1555-2101
ISSN	0160-6689
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 108: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 247: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus the Netherlands and Germany

Post, Robert M. / Leverich, Gabriele S. / Altshuler, Lori L. / Frye, Mark A. / Suppes, Trisha / Keck, Paul E., Jr. / McElroy, Susan L. / Nolen, Willem A. / Kupka, Ralph / Grunze, Heinz / Walden, Joerg / Rowe, Mike

International Clinical Psychopharmacology

2011 Volume 26, Issue 2, Page(s) 96–106

Abstract: Increased early-onset bipolar illness was seen in the US compared with the Netherlands and Germany (abbreviated here as Europe), but other clinical characteristics, medication use, and treatment response have not been systematically explored. Outpatients ...

Abstract	Increased early-onset bipolar illness was seen in the US compared with the Netherlands and Germany (abbreviated here as Europe), but other clinical characteristics, medication use, and treatment response have not been systematically explored. Outpatients with bipolar disorder were treated naturalistically and followed prospectively at four sites in the US and three in Europe. Data and clinical characteristics were collected from patient questionnaires, and medication usage and good-to-excellent response to treatment for at least 6 months ascertained from daily clinician ratings on the National Institutes of Mental Health-Life Chart Method. Almost all clinical characteristics earlier associated with a poor treatment response were more prevalent in the US than in Europe, including early onset, environmental adversity, rapid cycling, more than 20 prior episodes, comorbid anxiety and substance abuse disorders, and a positive parental history for an affective disorder. Lithium was used more frequently in Europe than in the US and had a higher rate of success, whereas valproate was used more in the US, with a trend toward higher success in Europe. Antidepressants were used more in the US, but had extremely low success rates. Many other agents were deployed differently on the two continents, but success rates were consistently lower in the US than in Europe. In conclusion, clinical characteristics and patterns of medication usage and effectiveness differed markedly in the two continents suggesting the need for uncovering explanations and considering the two populations as heterogeneous in the future pharmacological studies. Int Clin Psychopharmacol 26:96-106 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Keywords	Antidepressant Drugs ; Antidepressiva ; Bipolar Disorder ; Bipolare Störung ; Client Characteristics ; Comorbidity ; Cross Cultural Differences ; Familiengeschichte ; Family History ; Interkulturelle Unterschiede ; Ko-Morbidität ; Krankheitsbeginn ; Merkmale von Klientinnen und Klienten ; Onset (Disorders) ; Risikofaktoren ; Risk Factors ; Therapieergebnisse ; Treatment Outcomes
Language	English
Document type	Article
ZDB-ID	632837-4
ISSN	1473-5857 ; 0268-1315
ISSN (online)	1473-5857
ISSN	0268-1315
DOI	10.1097/YIC.0b013e3283409419
Database	PSYNDEX

In stock of ZB MED Cologne/Königswinter

Zs.A 2162: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Heritability and genome-wide SNP linkage analysis of temperament in bipolar disorder.

Greenwood, Tiffany A / Badner, Judith A / Byerley, William / Keck, Paul E / McElroy, Susan L / Remick, Ronald A / Sadovnick, A Dessa / Akiskal, Hagop S / Kelsoe, John R

Journal of affective disorders

2013 Volume 150, Issue 3, Page(s) 1031–1040

Abstract: Background: The many attempts to identify genes for bipolar disorder (BD) have met with limited success, which has generally been attributed to genetic heterogeneity and small gene effects. However, it is also possible that the categorical phenotypes ... ...

Abstract	Background: The many attempts to identify genes for bipolar disorder (BD) have met with limited success, which has generally been attributed to genetic heterogeneity and small gene effects. However, it is also possible that the categorical phenotypes used in genetic studies of BD are not the most informative or biologically relevant. We have explored aspects of temperament as quantitative phenotypes for BD through the use of the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A), which is designed to assess lifelong, milder aspects of bipolar symptomatology and defines five temperaments: hyperthymic, dysthymic, cyclothymic, irritable, and anxious. Methods: We compared temperament scores between diagnostic groups and assessed heritability in a sample of 101 families collected for genetic studies of BD. A genome-wide SNP linkage study was then performed in the subset of 51 families for which genetic data was available. Results: Significant group differences were observed between BD subjects, their first-degree relatives, and independent controls, and all five temperaments were found to be significantly heritable, with heritabilities ranging from 21% for the hyperthymic to 52% for the irritable temperaments. Suggestive evidence for linkage was observed for the hyperthymic (chromosomes 1q44, 2p16, 6q16, and 14q23), dysthymic (chromosomes 3p21 and 13q34), and irritable (chromosome 6q24) temperaments. Limitations: The relatively small size of our linkage sample likely limited our ability to reach genome-wide significance in this study. Conclusions: While not genome-wide significant, these results suggest that aspects of temperament may prove useful in the identification of genes underlying BD susceptibility.
MeSH term(s)	Adult ; Bipolar Disorder/genetics ; Bipolar Disorder/psychology ; Cross-Cultural Comparison ; Female ; Genetic Linkage ; Genome-Wide Association Study ; Humans ; Irritable Mood ; Male ; Personality Inventory/statistics & numerical data ; Polymorphism, Single Nucleotide ; Psychometrics/statistics & numerical data ; Reproducibility of Results ; Surveys and Questionnaires ; Temperament
Language	English
Publishing date	2013-06-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2013.05.035
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1485: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Heritability and linkage analysis of personality in bipolar disorder.

Greenwood, Tiffany A / Badner, Judith A / Byerley, William / Keck, Paul E / McElroy, Susan L / Remick, Ronald A / Dessa Sadovnick, A / Kelsoe, John R

Journal of affective disorders

2013 Volume 151, Issue 2, Page(s) 748–755

Abstract: Background: The many attempts that have been made to identify genes for bipolar disorder (BD) have met with limited success, which may reflect an inadequacy of diagnosis as an informative and biologically relevant phenotype for genetic studies. Here we ... ...

Abstract	Background: The many attempts that have been made to identify genes for bipolar disorder (BD) have met with limited success, which may reflect an inadequacy of diagnosis as an informative and biologically relevant phenotype for genetic studies. Here we have explored aspects of personality as quantitative phenotypes for bipolar disorder through the use of the Temperament and Character Inventory (TCI), which assesses personality in seven dimensions. Four temperament dimensions are assessed: novelty seeking (NS), harm avoidance (HA), reward dependence (RD), and persistence (PS). Three character dimensions are also included: self-directedness (SD), cooperativeness (CO), and self-transcendence (ST). Methods: We compared personality scores between diagnostic groups and assessed heritability in a sample of 101 families collected for genetic studies of BD. A genome-wide SNP linkage analysis was then performed in the subset of 51 families for which genetic data was available. Results: Significant group differences were observed between BD subjects, their first-degree relatives, and independent controls for all but RD and PS, and all but HA and RD were found to be significantly heritable in this sample. Linkage analysis of the heritable dimensions produced several suggestive linkage peaks for NS (chromosomes 7q21 and 10p15), PS (chromosomes 6q16, 12p13, and 19p13), and SD (chromosomes 4q35, 8q24, and 18q12). Limitations: The relatively small size of our linkage sample likely limited our ability to reach genome-wide significance in this study. Conclusions: While not genome-wide significant, these results suggest that aspects of personality may prove useful in the identification of genes underlying BD susceptibility.
MeSH term(s)	Adult ; Bipolar Disorder/genetics ; Bipolar Disorder/psychology ; Depressive Disorder, Major/genetics ; Endophenotypes ; Family ; Female ; Genetic Linkage ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Humans ; Male ; Middle Aged ; Personality/genetics ; Personality Inventory ; Polymorphism, Single Nucleotide ; Temperament
Language	English
Publishing date	2013-08-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2013.06.015
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1485: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Relationship of open acute mania treatment to blinded maintenance outcome in bipolar I disorder.

McElroy, Susan L / Bowden, Charles L / Collins, Michelle A / Wozniak, Patricia J / Keck, Paul E / Calabrese, Joseph R

Journal of affective disorders

2008 Volume 107, Issue 1-3, Page(s) 127–133

Abstract: Background: Most bipolar treatment guidelines recommend that acutely effective therapy be continued as maintenance treatment, unless contraindicated. No published studies have statistically evaluated the relationship between the outcomes in maintenance ... ...

Abstract	Background: Most bipolar treatment guidelines recommend that acutely effective therapy be continued as maintenance treatment, unless contraindicated. No published studies have statistically evaluated the relationship between the outcomes in maintenance treatment and the principal acute agent. Methods: Post-hoc analysis of prophylactic results obtained during a 12-month maintenance study in recently manic patients assessed the relationship between open treatment and randomized maintenance treatment. Patients were grouped according to mood stabilizer (if any) received on the last day of the open-label, stabilization phase (divalproex, lithium, or no mood stabilizer), and the mood stabilizer to which they were randomly assigned in the double-blind, maintenance phase (divalproex, lithium, or placebo). Results: Patients treated with open-phase divalproex and randomized to divalproex maintenance therapy had a significantly longer period before development of a mood episode compared to those randomized to either placebo (Log-rank, p=0.05) or lithium (Log-rank, p=0.04), and better tolerability than those randomized to lithium. Patients treated with open-phase lithium showed no treatment-related differences in time to a mood episode after being randomized to lithium, divalproex, or placebo and tolerability was comparable in all groups. Limitations: Open treatment was selected by treating physicians, contributing to possible selection bias. More patients were randomized to divalproex than to lithium or placebo. The study was therefore better powered to detect divalproex effects. Conclusions: Acute response to divalproex predicted both superior prophylactic response and tolerability to divalproex, than to placebo (efficacy) and to lithium (efficacy and tolerability). Results could have implications for both clinical practice and clinical trial design.
MeSH term(s)	Acute Disease ; Adult ; Anticonvulsants/therapeutic use ; Bipolar Disorder/drug therapy ; Bipolar Disorder/prevention & control ; Bipolar Disorder/psychology ; Clinical Trials as Topic/statistics & numerical data ; Double-Blind Method ; Female ; Humans ; Lithium Compounds/therapeutic use ; Male ; Placebos ; Randomized Controlled Trials as Topic/statistics & numerical data ; Research Design ; Treatment Outcome ; Valproic Acid/therapeutic use
Chemical Substances	Anticonvulsants ; Lithium Compounds ; Placebos ; Valproic Acid (614OI1Z5WI)
Language	English
Publishing date	2008-04
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2007.08.014
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1485: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Atypical neuroleptic malignant syndrome: diagnostic controversies and considerations.

Picard, Lara S / Lindsay, Shane / Strawn, Jeffrey R / Kaneria, Rakesh M / Patel, Nick C / Keck, Paul E

Pharmacotherapy

2008 Volume 28, Issue 4, Page(s) 530–535

Abstract: Neuroleptic malignant syndrome (NMS) is a serious and potentially fatal adverse effect of antipsychotic drugs. The diagnosis of NMS commonly requires core symptoms of hyperthermia and muscle rigidity. Although diagnostic criteria for NMS have been ... ...

Abstract	Neuroleptic malignant syndrome (NMS) is a serious and potentially fatal adverse effect of antipsychotic drugs. The diagnosis of NMS commonly requires core symptoms of hyperthermia and muscle rigidity. Although diagnostic criteria for NMS have been established and are widely accepted and used, it should be recognized that atypical presentations pose a diagnostic dilemma, as hyperthermia and/or muscle rigidity may be absent or develop slowly over several days, leading to impairment or a significant delay in diagnosis and treatment. Evidence from case reports and retrospective evaluations supports a concept of atypical NMS, particularly with regard to treatment with atypical antipsychotics. However, it remains unclear whether these atypical presentations represent early or impending NMS. Furthermore, it is unclear whether dysfunction in other neurotransmitter systems, in addition to dopamine, may be involved in the pathogenesis of NMS induced by atypical antipsychotics. In patients receiving any antipsychotic, clinicians should carefully evaluate any features of NMS and should not prematurely exclude a diagnosis of NMS in cases where severe rigidity or hyperthermia is not initially apparent.
MeSH term(s)	Antipsychotic Agents/adverse effects ; Diagnosis, Differential ; Diagnostic and Statistical Manual of Mental Disorders ; Fever/etiology ; Humans ; Muscle Rigidity/etiology ; Neuroleptic Malignant Syndrome/diagnosis ; Neuroleptic Malignant Syndrome/physiopathology
Chemical Substances	Antipsychotic Agents
Language	English
Publishing date	2008-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	603158-4
ISSN	1875-9114 ; 0277-0008
ISSN (online)	1875-9114
ISSN	0277-0008
DOI	10.1592/phco.28.4.530
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1738: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 585: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito