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  1. Article ; Online: Resetting tolerance in autoimmune disease.

    Muraro, Paolo A

    Science (New York, N.Y.)

    2023  Volume 380, Issue 6644, Page(s) 470–471

    Abstract: Autologous hematopoietic stem cell transplantation is effective, but mechanisms are elusive. ...

    Abstract Autologous hematopoietic stem cell transplantation is effective, but mechanisms are elusive.
    MeSH term(s) Humans ; Autoimmune Diseases/therapy ; Hematopoietic Stem Cell Transplantation ; Immune Tolerance ; Transplantation, Autologous
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adg7489
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  2. Article ; Online: Can we identify patients at risk of severe reactions to food?

    Anagnostou, Aikaterini / Muraro, Antonella

    Expert review of clinical immunology

    2023  Volume 19, Issue 12, Page(s) 1427–1430

    MeSH term(s) Humans ; Anaphylaxis ; Food Hypersensitivity ; Allergens ; Epinephrine
    Chemical Substances Allergens ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Editorial
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2023.2265069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: How to diagnose IgE-mediated food allergy.

    Lieberman, Jay / Muraro, Antonella / Blaiss, Michael

    Archives of disease in childhood. Education and practice edition

    2024  

    Abstract: Immunoglobulin E (IgE)-mediated food allergy is an immune response, typically to a food protein. Accurate diagnosis reduces unnecessary dietary restrictions and economic and psychological burden on patients and caregivers but relies on a rigorous ... ...

    Abstract Immunoglobulin E (IgE)-mediated food allergy is an immune response, typically to a food protein. Accurate diagnosis reduces unnecessary dietary restrictions and economic and psychological burden on patients and caregivers but relies on a rigorous clinical history, specific IgE diagnostic tests and, where needed, oral food challenge. Increased awareness is needed around which patients to test for IgE-mediated food allergy, as well as terms commonly associated with IgE-mediated food allergy testing, in order to optimise patient diagnosis and management. Herein, we describe approaches to diagnosis of IgE-mediated food allergy, appropriate interpretation of results and risks of overtesting.
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2148818-6
    ISSN 1743-0593 ; 1743-0585
    ISSN (online) 1743-0593
    ISSN 1743-0585
    DOI 10.1136/archdischild-2023-325938
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  4. Article ; Online: Should autologous hematopoietic stem cell transplantation be offered as a first-line disease modifying therapy to patients with multiple sclerosis?

    Mariottini, Alice / Muraro, Paolo A / Saccardi, Riccardo

    Multiple sclerosis and related disorders

    2023  Volume 78, Page(s) 104932

    Abstract: In multiple sclerosis (MS), progression independent of new focal inflammation may commence shortly after disease onset, and it is increasingly revealed that the risk of disability accrual is reduced by early use of high-efficacy disease-modifying ... ...

    Abstract In multiple sclerosis (MS), progression independent of new focal inflammation may commence shortly after disease onset, and it is increasingly revealed that the risk of disability accrual is reduced by early use of high-efficacy disease-modifying therapies (HE-DMTs). People with aggressive MS may therefore benefit from early treatment with autologous haematopoietic stem cell transplantation (AHSCT), a procedure inducing maximal immunosuppression followed by immune reconstitution, demonstrated to be superior to DMTs in one randomized clinical trial. However, in current practice prior failure to HE-DMTs is typically required to establish the indication for AHSCT. In the present article, the available evidence on the potential role of AHSCT as first-line treatment in aggressive MS and the rationale for its early use will be summarized. Proposed definitions of aggressive MS that could help identifying MS patients eligible for early treatment with AHSCT will also be discussed.
    Language English
    Publishing date 2023-08-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2023.104932
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  5. Article ; Online: Haematopoietic Stem Cell Transplantation for the Treatment of Multiple Sclerosis: Recent Advances.

    Mariottini, Alice / De Matteis, Eleonora / Cencioni, Maria Teresa / Muraro, Paolo A

    Current neurology and neuroscience reports

    2023  Volume 23, Issue 9, Page(s) 507–520

    Abstract: Purpose of review: Autologous haematopoietic stem cell transplantation (AHSCT) is increasingly considered a treatment option for patients with multiple sclerosis (MS), an autoimmune demyelinating and degenerative disease of the central nervous system ( ... ...

    Abstract Purpose of review: Autologous haematopoietic stem cell transplantation (AHSCT) is increasingly considered a treatment option for patients with multiple sclerosis (MS), an autoimmune demyelinating and degenerative disease of the central nervous system (CNS). AHSCT persistently suppresses inflammation and improves the disease course in large proportions of patients with relapsing-remitting (RR) MS. Aim of this article is to review the relevant new knowledge published during the last 3 years.
    Recent findings: Laboratory studies reported confirmatory and new insights into the immunological and biomarker effects of AHSCT. Retrospective clinical studies confirmed excellent outcomes in RRMS, showing possible superior effectiveness over standard therapies and suggesting a possible benefit in early secondary progressive (SP) MS with inflammatory features. New data on risks of infertility and secondary autoimmunity were also reported. Further evidence on the high effectiveness and acceptable safety of AHSCT strengthens its position as a clinical option for aggressive RRMS. Further research is needed to better define its role in treatment-naïve and progressive forms of MS, ideally within randomised clinical trials (RCTs).
    MeSH term(s) Humans ; Multiple Sclerosis/therapy ; Retrospective Studies ; Multiple Sclerosis, Chronic Progressive ; Multiple Sclerosis, Relapsing-Remitting ; Hematopoietic Stem Cell Transplantation
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2057363-7
    ISSN 1534-6293 ; 1528-4042
    ISSN (online) 1534-6293
    ISSN 1528-4042
    DOI 10.1007/s11910-023-01290-2
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  6. Article ; Online: Physical activity of adolescents and the urban environment of Brazilian capitals: National School Health Survey, 2015.

    Ilídio da Silva, Juliana / Muraro, Ana Paula / Cristina de Souza Andrade, Amanda

    International journal of environmental health research

    2024  , Page(s) 1–12

    Abstract: This study aimed to evaluate the practice of physical activity (PA) among adolescents and its association with characteristics of the urban environment of Brazilian capitals. Study with adolescents from the 26 Brazilian capitals and the Federal District ... ...

    Abstract This study aimed to evaluate the practice of physical activity (PA) among adolescents and its association with characteristics of the urban environment of Brazilian capitals. Study with adolescents from the 26 Brazilian capitals and the Federal District participating in the National School Health Survey, 2015 edition. The association between regular practice of PA (≥300 minutes/week) and the dimensions of urban well-being (urban mobility, urban environmental conditions, urban housing conditions, urban collective services, and urban infrastructure) was examined using multilevel logistic regression. A total of 50,904 adolescents were evaluated, among which 20.7% were active. It was observed in the multiple model that adolescents who live in capitals with better urban environmental conditions, such as the presence of tree coverage, less open sewage, and less accumulated garbage around the houses, are more likely to be active (OR = 1.06; 95% CI:1.01;1.12). Adolescents who live in cities with less urban disorder are more likely to be active.
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1104887-6
    ISSN 1369-1619 ; 0960-3123
    ISSN (online) 1369-1619
    ISSN 0960-3123
    DOI 10.1080/09603123.2024.2312425
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    Zs.A 3517: Show issues Location:
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  7. Article ; Online: Antibody-mediated cell depletion therapies in multiple sclerosis.

    Mariottini, Alice / Muraro, Paolo A / Lünemann, Jan D

    Frontiers in immunology

    2022  Volume 13, Page(s) 953649

    Abstract: Development of disease-modifying therapies including monoclonal antibody (mAb)-based therapeutics for the treatment of multiple sclerosis (MS) has been extremely successful over the past decades. Most of the mAb-based therapies approved for MS deplete ... ...

    Abstract Development of disease-modifying therapies including monoclonal antibody (mAb)-based therapeutics for the treatment of multiple sclerosis (MS) has been extremely successful over the past decades. Most of the mAb-based therapies approved for MS deplete immune cell subsets and act through activation of cellular Fc-gamma receptors expressed by cytotoxic lymphocytes and phagocytes, resulting in antibody-dependent cellular cytotoxicity or by initiation of complement-mediated cytotoxicity. The therapeutic goal is to eliminate pathogenic immune cell components and to potentially foster the reconstitution of a new and healthy immune system. Ab-mediated immune cell depletion therapies include the CD52-targeting mAb alemtuzumab, CD20-specific therapeutics, and new Ab-based treatments which are currently being developed and tested in clinical trials. Here, we review recent developments in effector mechanisms and clinical applications of Ab-based cell depletion therapies, compare their immunological and clinical effects with the prototypic immune reconstitution treatment strategy, autologous hematopoietic stem cell transplantation, and discuss their potential to restore immunological tolerance and to achieve durable remission in people with MS.
    MeSH term(s) Alemtuzumab/therapeutic use ; Antibodies, Monoclonal/therapeutic use ; Antigens, CD20 ; Humans ; Immunotherapy/methods ; Multiple Sclerosis
    Chemical Substances Antibodies, Monoclonal ; Antigens, CD20 ; Alemtuzumab (3A189DH42V)
    Language English
    Publishing date 2022-09-12
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.953649
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  8. Article ; Online: Allergen immunotherapy for food allergy: Evidence and outlook.

    Muraro, Antonella / Tropeano, Angelo / Giovannini, Mattia

    Allergologie select

    2022  Volume 6, Page(s) 285–292

    Abstract: Food allergy represents a significant health issue characterized by a sizeable epidemiological burden, involving up to 5% of adults and up to 8% of children in the Western world. The elimination diet of the trigger food is the cornerstone of food allergy ...

    Abstract Food allergy represents a significant health issue characterized by a sizeable epidemiological burden, involving up to 5% of adults and up to 8% of children in the Western world. The elimination diet of the trigger food is the cornerstone of food allergy management. However, novel treatment options are most wanted to provide alternative strategies for this potentially fatal medical condition. Allergen immunotherapy for food allergy (FA-AIT) is considered an immunomodulatory intervention where regular exposure to increasing doses of food is performed in the context of an allergist's supervised protocol. The main objective is to decrease reactivity, attenuate life-threatening allergic episodes and reduce frequent access to the emergency department. Achieving food tolerance off-treatment is, however, the ultimate aim. In this review, we aim to summarize FA-AIT evidence and outlook.
    Language English
    Publishing date 2022-11-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2893503-2
    ISSN 2512-8957 ; 2512-8957
    ISSN (online) 2512-8957
    ISSN 2512-8957
    DOI 10.5414/ALX02319E
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  9. Article: Allergen-Immuntherapie bei Nahrungsmittelallergien: Erkenntnisse und Ausblick

    Muraro, A. / Tropeano, A. / Glovannini, M.

    Allergologie

    2023  Volume 46, Issue 3, Page(s) 157

    Language German
    Document type Article
    ZDB-ID 547065-1
    ISSN 0344-5062
    Database Current Contents Medicine

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    Zs.A 1398: Show issues Location:
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  10. Article ; Online: Anxiety and food allergy: A review of the last two decades.

    Polloni, Laura / Muraro, Antonella

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2020  Volume 50, Issue 4, Page(s) 420–441

    Abstract: Food allergy (FA) is recognized as a growing public health burden affecting 5%-10% of children worldwide. Several unique features specific to FA elicit high levels of emotional distress and anxiety in patients and caregivers, the first among all the ... ...

    Abstract Food allergy (FA) is recognized as a growing public health burden affecting 5%-10% of children worldwide. Several unique features specific to FA elicit high levels of emotional distress and anxiety in patients and caregivers, the first among all the possibility of a life-threatening reaction. Anxiety disorders are highly prevalent in patients with chronic disease, but remain undertreated despite significant negative consequences on patient health. This review aimed to offer a comprehensive overview of literature data on FA and anxiety of the last two decades. A review of the medical and psychological literature from the year 2000 (MEDLINE, PubMed and PsycINFO) was done using the keywords "anxiety" and "food allergy." Clinical implications for disease management, various manifestations in different target groups, proper interventions and possible explanations on the nature of the association between FA and anxiety have been discussed, as well as limitations and further research directions. The relationship between FA and anxiety is attributed to FA-specific fears and anxiety, rather than a general propensity towards anxiety. Some anxiety-short-lived and related to key events-is to be expected and may even be helpful if it sustains allergen avoidance and preparedness to emergency. However, some data reported that increased anxiety did not improve adherence. Rather, high levels of anxiety have been demonstrated counterproductive and related to maladaptive coping. Further research is needed to elucidate the association between FA and anxiety, especially to understand biopsychosocial directions of the underlying mechanisms and to build proper, effective, standardized protocols of intervention. Clinicians must be aware of the association between FA and anxiety, understand their role in recognizing maladaptive anxiety and encouraging to seek psychological support when needed.
    MeSH term(s) Adaptation, Psychological ; Anxiety Disorders/epidemiology ; Anxiety Disorders/etiology ; Anxiety Disorders/psychology ; Anxiety Disorders/therapy ; Chronic Disease ; Food Hypersensitivity/complications ; Food Hypersensitivity/epidemiology ; Food Hypersensitivity/psychology ; Food Hypersensitivity/therapy ; Humans ; Prevalence ; Quality of Life
    Language English
    Publishing date 2020-01-06
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.13548
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