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Article ; Online: The vitamin B

Tat, John / Chang, Stephen C / Link, Cole D / Razo-Lopez, Suelen / Ingerto, Michael J / Katebian, Behdod / Chan, Adriano / Kalyanaraman, Hema / Pilz, Renate B / Boss, Gerry R

Clinical toxicology (Philadelphia, Pa.)

2023 Volume 61, Issue 4, Page(s) 212–222

Abstract: Context: The azide anion (N: Results: We found cobinamide bound azide with a moderate affinity (K: Conclusion: We conclude cobinamide likely acted by neutralizing both oxidative stress and nitric oxide, and that it should be given further ... ...

Abstract	Context: The azide anion (N Results: We found cobinamide bound azide with a moderate affinity (K Conclusion: We conclude cobinamide likely acted by neutralizing both oxidative stress and nitric oxide, and that it should be given further consideration as an azide antidote.
MeSH term(s)	Mice ; Animals ; Vitamin B 12 ; Drosophila melanogaster/metabolism ; Azides/metabolism ; Antidotes/pharmacology ; Nitric Oxide ; Electron Transport Complex IV/metabolism ; Cobamides ; Hypotension ; Adenosine Triphosphate ; Vitamins ; Mammals/metabolism
Chemical Substances	Vitamin B 12 (P6YC3EG204) ; cobinamide (13497-85-3) ; Azides ; Antidotes ; Nitric Oxide (31C4KY9ESH) ; Electron Transport Complex IV (EC 1.9.3.1) ; Cobamides ; Adenosine Triphosphate (8L70Q75FXE) ; Vitamins
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	204476-6
ISSN	1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
ISSN (online)	1556-9519
ISSN	0009-9309 ; 0731-3810 ; 1556-3650
DOI	10.1080/15563650.2023.2185125
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Article: B

Meger, Filip / Kwok, Alexander C W / Gilch, Franziska / Willcox, Dominic R / Hendy, Alex J / Nicholson, Kieran / Bage, Andrew D / Langer, Thomas / Hunt, Thomas A / Thomas, Stephen P

Beilstein journal of organic chemistry

2022 Volume 18, Page(s) 1332–1337

Abstract: The reduction of nitriles to primary amines is a useful transformation in organic synthesis, however, it often relies upon stoichiometric reagents or transition-metal catalysis. Herein, a borane-catalysed hydroboration of nitriles to give primary amines ... ...

Abstract	The reduction of nitriles to primary amines is a useful transformation in organic synthesis, however, it often relies upon stoichiometric reagents or transition-metal catalysis. Herein, a borane-catalysed hydroboration of nitriles to give primary amines is reported. Good yields (48-95%) and chemoselectivity (e.g., ester, nitro, sulfone) were observed. DFT calculations and mechanistic studies support the proposal of a double
Language	English
Publishing date	2022-09-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2192461-2
ISSN	1860-5397
ISSN	1860-5397
DOI	10.3762/bjoc.18.138
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Article: Development of A Standardized Opsonophagocytosis Killing Assay for Group B

Leung, Stephanie / Collett, Clare F / Allen, Lauren / Lim, Suzanna / Maniatis, Pete / Bolcen, Shanna J / Alston, Bailey / Patel, Palak Y / Kwatra, Gaurav / Hall, Tom / Thomas, Stephen / Taylor, Stephen / Le Doare, Kirsty / Gorringe, Andrew

Vaccines

2023 Volume 11, Issue 11

Abstract: ... important for protection against invasive group B ...

Abstract	The placental transfer of antibodies that mediate bacterial clearance via phagocytes is likely important for protection against invasive group B
Language	English
Publishing date	2023-11-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11111703
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Book ; Online: B C, Before Computers : On Information Technology from Writing to the Age of Digital Data

Robertson, Stephen

2020

Keywords	Computing & information technology ; Information theory ; Educational equipment & technology, computer-aided learning (CAL) ; Biography & True Stories ; Information technology: general issues ; history of computer developments ; digital age ; computer ; information technology revolution ; data processing ; cryptography ; visual art ; music ; postal system
Size	1 electronic resource (170 pages)
Publisher	Open Book Publishers
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021030620
ISBN	9781800641068 ; 1800641060
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: The aflatoxin B

Minko, Irina G / Kellum, Andrew H / Stone, Michael P / Lloyd, R Stephen

Environmental and molecular mutagenesis

2023 Volume 65 Suppl 1, Page(s) 9–13

Abstract: Dietary exposure to aflatoxin B ...

Abstract	Dietary exposure to aflatoxin B
MeSH term(s)	Animals ; Mutagens/toxicity ; Aflatoxin B1/toxicity ; DNA Adducts/genetics ; Guanine ; Mutagenesis ; Liver Neoplasms/pathology ; Imidazoles/adverse effects
Chemical Substances	Mutagens ; Aflatoxin B1 (9N2N2Y55MH) ; DNA Adducts ; Guanine (5Z93L87A1R) ; Imidazoles
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	639145-x
ISSN	1098-2280 ; 0893-6692
ISSN (online)	1098-2280
ISSN	0893-6692
DOI	10.1002/em.22556
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Article: Population genetics of group B

Jamrozy, Dorota / Gopal Rao, Guduru / Feltwell, Theresa / Lamagni, Theresa / Khanna, Priya / Efstratiou, Androulla / Parkhill, Julian / Bentley, Stephen D

Frontiers in microbiology

2023 Volume 14, Page(s) 1185753

Abstract: Introduction: Maternal immunization against Group B : Methods: In this study we characterized ...

Abstract	Introduction: Maternal immunization against Group B Methods: In this study we characterized the population structure of GBS isolates from maternal carriage ( Results: The isolates clustered into nine clonal complexes (CCs) but the majority (95%) belonged to five lineages: CC1 (26%), CC19 (26%), CC23 (20%), CC17 (13%) and CC8/10 (10%). Nine serotypes were identified, the most common were serotypes III (26%), V (21%), II (19%) and Ia (19%). Other serotypes (Ib, IV, VI, VII, IX) represented less than 10% of all isolates each. Intra-lineage serotype diversity was observed in all major CCs but was highest in CC1, which revealed nine serotypes. Nearly all isolates (99%) carried at least one of the four alpha family protein genes ( Conclusion: Our study showed high prevalence of GBS vaccine targets among isolates from pregnant women in London. However, the observed serotype diversity in CC1 and high prevalence of MLS
Language	English
Publishing date	2023-05-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1185753
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Article ; Online: The impact of hypoxia on B cells in COVID-19.

EBioMedicine

2022 Volume 77, Page(s) 103878

Abstract: ... and a pronounced reduction in B cells, the latter important in defence against SARS-CoV-2 ... This presentation resembles the phenotype of mice with VHL-deficient B cells, in which Hypoxia-Inducible Factors are ... constitutively active, suggesting hypoxia might drive B cell abnormalities in COVID-19.: Methods: Detailed B ...

Abstract	Background: Prominent early features of COVID-19 include severe, often clinically silent, hypoxia and a pronounced reduction in B cells, the latter important in defence against SARS-CoV-2. This presentation resembles the phenotype of mice with VHL-deficient B cells, in which Hypoxia-Inducible Factors are constitutively active, suggesting hypoxia might drive B cell abnormalities in COVID-19. Methods: Detailed B cell phenotyping was undertaken by flow-cytometry on longitudinal samples from patients with COVID-19 across a range of severities (NIHR Cambridge BioResource). The impact of hypoxia on the transcriptome was assessed by single-cell and whole blood RNA sequencing analysis. The direct effect of hypoxia on B cells was determined through immunisation studies in genetically modified and hypoxia-exposed mice. Findings: We demonstrate the breadth of early and persistent defects in B cell subsets in moderate/severe COVID-19, including reduced marginal zone-like, memory and transitional B cells, changes also observed in B cell VHL-deficient mice. These findings were associated with hypoxia-related transcriptional changes in COVID-19 patient B cells, and similar B cell abnormalities were seen in mice kept in hypoxic conditions. Interpretation: Hypoxia may contribute to the pronounced and persistent B cell pathology observed in acute COVID-19 pneumonia. Assessment of the impact of early oxygen therapy on these immune defects should be considered, as their correction could contribute to improved outcomes. Funding: Evelyn Trust, Addenbrooke's Charitable Trust, UKRI/NIHR, Wellcome Trust.
MeSH term(s)	Animals ; COVID-19 ; Humans ; Hypoxia ; Mice ; Oxygen ; Pneumonia ; SARS-CoV-2
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2022-02-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2022.103878
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Article ; Online: Immune boosting by B.1.1.529

Reynolds, Catherine J / Pade, Corinna / Gibbons, Joseph M / Otter, Ashley D / Lin, Kai-Min / Muñoz Sandoval, Diana / Pieper, Franziska P / Butler, David K / Liu, Siyi / Joy, George / Forooghi, Nasim / Treibel, Thomas A / Manisty, Charlotte / Moon, James C / Semper, Amanda / Brooks, Tim / McKnight, Áine / Altmann, Daniel M / Boyton, Rosemary J /

Abbass, Hakam / Abiodun, Aderonke / Alfarih, Mashael / Alldis, Zoe / Amin, Oliver E / Andiapen, Mervyn / Artico, Jessica / Augusto, João B / Baca, Georgina L / Bailey, Sasha N L / Bhuva, Anish N / Boulter, Alex / Bowles, Ruth / Bracken, Olivia V / O'Brien, Ben / Bullock, Natalie / Captur, Gabriella / Carr, Olivia / Champion, Nicola / Chan, Carmen / Chandran, Aneesh / Coleman, Tom / Couto de Sousa, Jorge / Couto-Parada, Xose / Cross, Eleanor / Cutino-Moguel, Teresa / D'Arcangelo, Silvia / Davies, Rhodri H / Douglas, Brooke / Di Genova, Cecilia / Dieobi-Anene, Keenan / Diniz, Mariana O / Ellis, Anaya / Feehan, Karen / Finlay, Malcolm / Fontana, Marianna / Francis, Sasha / Gillespie, David / Gilroy, Derek / Hamblin, Matt / Harker, Gabrielle / Hemingway, Georgia / Hewson, Jacqueline / Heywood, Wendy / Hickling, Lauren M / Hicks, Bethany / Hingorani, Aroon D / Howes, Lee / Itua, Ivie / Jardim, Victor / Lee, Wing-Yiu Jason / Jensen, Melaniepetra / Jones, Jessica / Jones, Meleri / Kapil, Vikas / Kelly, Caoimhe / Kurdi, Hibba / Lambourne, Jonathan / Lloyd, Aaron / Louth, Sarah / Maini, Mala K / Mandadapu, Vineela / Menacho, Katia / Mfuko, Celina / Mills, Kevin / Millward, Sebastian / Mitchelmore, Oliver / Moon, Christopher / Moon, James / Murray, Sam M / Noursadeghi, Mahdad / Otter, Ashley / Palma, Susana / Parker, Ruth / Patel, Kush / Pawarova, Mihaela / Petersen, Steffen E / Piniera, Brian / Rannigan, Lisa / Rapala, Alicja / Richards, Amy / Robathan, Matthew / Rosenheim, Joshua / Rowe, Cathy / Royds, Matthew / Sackville West, Jane / Sambile, Genine / Schmidt, Nathalie M / Selman, Hannah / Seraphim, Andreas / Simion, Mihaela / Smit, Angelique / Sugimoto, Michelle / Swadling, Leo / Taylor, Stephen / Temperton, Nigel / Thomas, Stephen / Thornton, George D / Tucker, Art / Varghese, Ann / Veerapen, Jessry / Vijayakumar, Mohit / Warner, Tim / Welch, Sophie / White, Hannah / Wodehouse, Theresa / Wynne, Lucinda / Zahedi, Dan / Chain, Benjamin

Science (New York, N.Y.)

2022 Volume 377, Issue 6603, Page(s) eabq1841

Abstract: The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 ... to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech ... B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated ...

Abstract	The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple-vaccinated individuals, but the magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCWs who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529.
MeSH term(s)	Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; B-Lymphocytes/immunology ; BNT162 Vaccine/immunology ; BNT162 Vaccine/therapeutic use ; COVID-19/immunology ; COVID-19/prevention & control ; Cross Reactions ; Humans ; Immunization, Secondary ; Mice ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; T-Lymphocytes/immunology
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abq1841
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Article ; Online: Influenza B virus neuraminidase

Thi Hoai Thu Do / Adam K. Wheatley / Stephen J. Kent / Marios Koutsakos

Expert Review of Vaccines, Vol 23, Iss 1, Pp 39-

a potential target for next-generation vaccines?

2024 Volume 48

Abstract: ABSTRACTIntroduction Influenza B viruses (IBV) cause a significant health and economic burden ... the design of next-generation influenza B vaccines. We discuss how antibodies recognize broadly ...

Abstract	ABSTRACTIntroduction Influenza B viruses (IBV) cause a significant health and economic burden annually. Due to lower antigenic drift rate, less extensive antigenic diversity, and lack of animal reservoirs, the development of highly effective universal vaccines against IBV might be in reach. Current seasonal influenza vaccines are formulated to induce antibodies against the Hemagglutinin (HA) protein, but their effectiveness is reduced by mismatch between vaccine and circulating strains.Areas covered Given antibodies against the Neuraminidase (NA) have been associated with protection during influenza infection, there is considerable interest in the development of NA-based influenza vaccines. This review summarizes insights into the role of NA-based immunity against IBV and highlights knowledge gaps that should be addressed to inform the design of next-generation influenza B vaccines. We discuss how antibodies recognize broadly cross-reactive epitopes on the NA and the lack of understanding of IBV NA antigenic evolution which would benefit vaccine development in the future.Expert opinion Demonstrating NA antibodies as correlates of protection for IBV in humans would be paramount. Determining the extent of IBV NA antigenic evolution will be informative. Finally, it will be critical to determine optimal strategies for incorporating the appropriate NA antigens in existing clinically approved vaccine formulations.
Keywords	Antibodies ; influenza B virus ; neuraminidase ; universal vaccines ; antigenic evolution ; Internal medicine ; RC31-1245
Language	English
Publishing date	2024-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Structural basis of paralog-specific KDM2A/B nucleosome recognition.

Spangler, Cathy J / Skrajna, Aleksandra / Foley, Caroline A / Nguyen, Anh / Budziszewski, Gabrielle R / Azzam, Dalal N / Arteaga, Eyla C / Simmons, Holly C / Smith, Charlotte B / Wesley, Nathaniel A / Wilkerson, Emily M / McPherson, Jeanne-Marie E / Kireev, Dmitri / James, Lindsey I / Frye, Stephen V / Goldfarb, Dennis / McGinty, Robert K

Nature chemical biology

2023 Volume 19, Issue 5, Page(s) 624–632

Abstract: ... of KDM2A/B, or any related JumonjiC (JmjC) domain lysine demethylase, remain unclear. We used a covalent ...

Abstract	The nucleosome acidic patch is a major interaction hub for chromatin, providing a platform for enzymes to dock and orient for nucleosome-targeted activities. To define the molecular basis of acidic patch recognition proteome wide, we performed an amino acid resolution acidic patch interactome screen. We discovered that the histone H3 lysine 36 (H3K36) demethylase KDM2A, but not its closely related paralog, KDM2B, requires the acidic patch for nucleosome binding. Despite fundamental roles in transcriptional repression in health and disease, the molecular mechanisms governing nucleosome substrate specificity of KDM2A/B, or any related JumonjiC (JmjC) domain lysine demethylase, remain unclear. We used a covalent conjugate between H3K36 and a demethylase inhibitor to solve cryogenic electron microscopy structures of KDM2A and KDM2B trapped in action on a nucleosome substrate. Our structures show that KDM2-nucleosome binding is paralog specific and facilitated by dynamic nucleosomal DNA unwrapping and histone charge shielding that mobilize the H3K36 sequence for demethylation.
MeSH term(s)	Nucleosomes ; Lysine ; Histones/metabolism ; Chromatin ; Jumonji Domain-Containing Histone Demethylases/chemistry
Chemical Substances	Nucleosomes ; Lysine (K3Z4F929H6) ; Histones ; Chromatin ; Jumonji Domain-Containing Histone Demethylases (EC 1.14.11.-)
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2202962-X
ISSN	1552-4469 ; 1552-4450
ISSN (online)	1552-4469
ISSN	1552-4450
DOI	10.1038/s41589-023-01256-y
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