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  1. Article: Correction: "It's not you, it's me": identity disturbance as the main contributor to interpersonal problems in pathological narcissism.

    Biberdzic, Marko / Tan, Junhao / Day, Nicholas J S

    Borderline personality disorder and emotion dysregulation

    2023  Volume 10, Issue 1, Page(s) 8

    Language English
    Publishing date 2023-03-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2766243-3
    ISSN 2051-6673
    ISSN 2051-6673
    DOI 10.1186/s40479-023-00214-3
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  2. Article ; Online: Intravenous Doxycycline, Azithromycin, or Both for Severe Scrub Typhus. Reply.

    Varghese, George M / Mukaka, Mavuto / Day, Nicholas P J

    The New England journal of medicine

    2023  Volume 388, Issue 23, Page(s) 2204–2205

    MeSH term(s) Humans ; Doxycycline/therapeutic use ; Azithromycin/therapeutic use ; Scrub Typhus/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Administration, Intravenous
    Chemical Substances Doxycycline (N12000U13O) ; Azithromycin (83905-01-5) ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2303757
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  3. Article: "It's not you, it's me": identity disturbance as the main contributor to interpersonal problems in pathological narcissism.

    Biberdzic, Marko / Tan, Junhao / Day, Nicholas J S

    Borderline personality disorder and emotion dysregulation

    2023  Volume 10, Issue 1, Page(s) 3

    Abstract: Background: Core impairments in self and other functioning typify individuals with personality disorder. While interpersonal dysfunction is a known element of narcissistic disorders, empirical research investigating intrapersonal elements is lacking. ... ...

    Abstract Background: Core impairments in self and other functioning typify individuals with personality disorder. While interpersonal dysfunction is a known element of narcissistic disorders, empirical research investigating intrapersonal elements is lacking. The aim of this study was to investigate the internal representations of individuals with grandiose and vulnerable features, as manifested through their attachment styles, and the specific role of identity disturbance in explaining the relationship between pathological narcissism and maladaptive interpersonal functioning.
    Methods: A sample of 270 university students completed the Brief Pathological Narcissism Inventory (B-PNI), the Severity Indices of Personality Problems (SIPP), the Relationship Questionnaire (RQ), and the Inventory of Interpersonal Problems (IIP-32).
    Results: Both vulnerable and grandiose narcissism were positively associated with both fearful and preoccupied attachment, and negatively associated with secure attachment, whilst grandiose narcissism was also positively associated with dismissive attachment. Furthermore, unstable representations of self, poor self-reflective functioning, and low sense of purpose fully mediated the relationship between interpersonal problems and grandiose narcissism while partially mediating the relationship between interpersonal problems and vulnerable narcissism.
    Conclusions: Overall, our findings suggest that for individuals presenting with narcissistic features, capacity for adaptive interpersonal functioning is grounded by deficits in identity integration. Implications of these findings are discussed.
    Language English
    Publishing date 2023-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2766243-3
    ISSN 2051-6673
    ISSN 2051-6673
    DOI 10.1186/s40479-022-00209-6
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  4. Article ; Online: The effects of acute normobaric hypoxia on standing balance while dual-tasking with and without visual input.

    Tonellato, Marshall H / Cates, Valerie C / Dickenson, Jessica A / Day, Trevor A / Strzalkowski, Nicholas D J

    European journal of applied physiology

    2024  

    Abstract: Purpose: To investigate the influence of acute normobaric hypoxia on standing balance under single and dual-task conditions, both with and without visual input.: Methods: 20 participants (7 female, 20-31 years old) stood on a force plate for 16, 90-s ...

    Abstract Purpose: To investigate the influence of acute normobaric hypoxia on standing balance under single and dual-task conditions, both with and without visual input.
    Methods: 20 participants (7 female, 20-31 years old) stood on a force plate for 16, 90-s trials across four balance conditions: single-task (quiet stance) or dual-task (auditory Stroop test), with eyes open or closed. Trials were divided into four oxygen conditions where the fraction of inspired oxygen (F
    Results: Significant decreases in oxygen saturation and P
    Conclusion: These findings suggest that acute normobaric hypoxia has a minimal impact on standing balance and does not influence auditory Stroop test or dual-task performance. Further investigation with longer exposure is required to understand the impact and time course of normobaric hypoxia on standing balance.
    Language English
    Publishing date 2024-04-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124793-1
    ISSN 1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
    ISSN (online) 1439-6327 ; 1432-1025
    ISSN 0301-5548 ; 1439-6319
    DOI 10.1007/s00421-024-05469-4
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  5. Article: Orthopaedic Hand Patient Support Systems Have Valuable Insight to Patient Function and Pain.

    Washnock-Schmid, E A / Livingston, Nicholas / Latack, Katie / Wrobel, Nancy / Day, Charles S

    Journal of patient experience

    2024  Volume 11, Page(s) 23743735241240876

    Abstract: Patient-reported outcome measures (PROs) are increasingly used in clinical assessment. Research on how patient support systems contribute to physician understanding of patient condition is limited. Thus, insights from significant others may provide value, ...

    Abstract Patient-reported outcome measures (PROs) are increasingly used in clinical assessment. Research on how patient support systems contribute to physician understanding of patient condition is limited. Thus, insights from significant others may provide value, especially when concerns exist regarding patient response validity. Patients recruited from the pre-operative environment undergoing orthopaedic hand procedures responded to PROMIS-Pain Interference (PI), PROMIS-Upper Extremity (UE), PROMIS-Depression (D), and QuickDASH. They then selected a significant other (SO) to do the same. Patients and SOs were also asked to complete the West Haven-Yale Multidimensional Pain Inventory (WHYMPI) as a measure of support-related responses. Patient and SO responses were compared, and support-related responses were added in subsequent analyses to examine their effect on SO PRO assessment.
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2857285-3
    ISSN 2374-3743 ; 2374-3735
    ISSN (online) 2374-3743
    ISSN 2374-3735
    DOI 10.1177/23743735241240876
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  6. Article ; Online: Have we really failed to roll back malaria?

    White, Nicholas J / Day, Nicholas P J / Ashley, Elizabeth A / Smithuis, Frank M / Nosten, Francois H

    Lancet (London, England)

    2022  Volume 399, Issue 10327, Page(s) 799–800

    MeSH term(s) Humans ; Malaria/epidemiology ; Malaria/prevention & control ; World Health Organization
    Language English
    Publishing date 2022-02-17
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)00175-1
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  7. Article ; Online: Simultaneous and enantiospecific quantification of primaquine and carboxyprimaquine in human plasma using liquid chromatography-tandem mass spectrometry.

    Hanpithakpong, Warunee / Day, Nicholas P J / White, Nicholas J / Tarning, Joel

    Malaria journal

    2022  Volume 21, Issue 1, Page(s) 169

    Abstract: Background: The enantiomers of the 8-aminoquinoline anti-malarial primaquine have different pharmacological properties. Development of an analytical method for simultaneous quantification of the enantiomers of primaquine and its metabolite, ... ...

    Abstract Background: The enantiomers of the 8-aminoquinoline anti-malarial primaquine have different pharmacological properties. Development of an analytical method for simultaneous quantification of the enantiomers of primaquine and its metabolite, carboxyprimaquine, will support clinical pharmacometric assessments.
    Methods: A simple and sensitive method consisting of liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was developed for simultaneous and enantiospecific determination of primaquine and its metabolite, carboxyprimaquine, in human plasma. Stable isotopes were used as internal standards to compensate for potential interference and matrix effects. Plasma samples (100 µL) were precipitated with 1% formic acid in acetonitrile followed by phospholipid removal solid phase extraction. Primaquine and carboxyprimaquine enantiomers were separated on a Chiralcel OD-3R (150 mm × 4.6 mm; I.D. 3 μm) column using a LC gradient mode. For separation of racemic primaquine and carboxyprimaquine, the LC method was modified and validated using a reverse phase column (Hypersil Gold 100 mm × 4.6 mm; I.D. 3 µm) and a mobile phase composed of 10 mM ammonium acetate buffer, pH 3.5 and acetonitrile in the isocratic mode. Method validation was performed according to regulatory guidelines.
    Results: The calibration range was set to 0.571-260 ng/mL and 2.44-2,500 ng/mL for primaquine and carboxyprimaquine enantiomers, respectively, resulting in a correlation coefficient (r
    Conclusions: Simple, sensitive and accurate LC-MS/MS methods for the quantification of enantiomeric and racemic primaquine and carboxyprimaquine in human plasma were validated successfully and implemented in clinical routine drug analysis.
    MeSH term(s) Acetonitriles ; Chromatography, High Pressure Liquid ; Chromatography, Liquid/methods ; Humans ; Primaquine/analogs & derivatives ; Reproducibility of Results ; Tandem Mass Spectrometry/methods
    Chemical Substances Acetonitriles ; 8-(3-carboxy-1-methylpropylamino)-6-methoxyquinoline (77229-68-6) ; Primaquine (MVR3634GX1)
    Language English
    Publishing date 2022-06-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091229-8
    ISSN 1475-2875 ; 1475-2875
    ISSN (online) 1475-2875
    ISSN 1475-2875
    DOI 10.1186/s12936-022-04191-w
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  8. Article ; Online: Cost-effectiveness analysis of a multiplex lateral flow rapid diagnostic test for acute non-malarial febrile illness in rural Cambodia and Bangladesh.

    Chew, Rusheng / Painter, Chris / Pan-Ngum, Wirichada / Day, Nicholas Philip John / Lubell, Yoel

    The Lancet regional health. Southeast Asia

    2024  Volume 23, Page(s) 100389

    Abstract: Background: Multiplex lateral flow rapid diagnostic tests (LF-RDTs) may aid management of patients with acute non-malarial febrile illness (NMFI) in rural south and southeast Asia. We aimed to evaluate the cost-effectiveness in Cambodia and Bangladesh ... ...

    Abstract Background: Multiplex lateral flow rapid diagnostic tests (LF-RDTs) may aid management of patients with acute non-malarial febrile illness (NMFI) in rural south and southeast Asia. We aimed to evaluate the cost-effectiveness in Cambodia and Bangladesh of a putative, as-yet-undeveloped LF-RDT capable of diagnosing enteric fever and dengue, as well as measuring C-reactive protein (CRP) to guide antibiotic prescription, in primary care patients with acute NMFI.
    Methods: A country-specific decision tree model-based cost-effectiveness analysis was conducted from a health system plus limited societal perspective considering the cost of antimicrobial resistance. Parameters were based on data from a large observational study on the regional epidemiology of acute febrile illness, published studies, and procurement price lists. Costs were expressed in US$ (value in 2022), and cost-effectiveness evaluated by comparing incremental cost-effectiveness ratios with conservative opportunity cost-based willingness-to-pay thresholds and the more widely used threshold of per capita gross domestic product (GDP).
    Findings: Compared to standard of care, LF-RDT-augmented clinical assessment was dominant in Cambodia, being more effective and cost-saving. The cost per disability-adjusted life year (DALY) averted in Bangladesh was US$482, slightly above the conservative opportunity cost-based willingness-to-pay threshold of US$388 and considerably lower than the GDP-based threshold of US$2687. The intervention remained dominant in Cambodia and well below the GDP-based threshold in Bangladesh when antimicrobial resistance costs were disregarded.
    Interpretation: These findings provide guidance for academic, industry, and policymaker stakeholders involved in acute NMFI diagnostics. While definitive conclusions cannot be made in the absence of established thresholds, our results suggest that similar results are highly likely in some target settings and possible in others.
    Funding: Wellcome Trust, UK Government, Royal Australasian College of Physicians, and Rotary Foundation.
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article
    ISSN 2772-3682
    ISSN (online) 2772-3682
    DOI 10.1016/j.lansea.2024.100389
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  9. Article ; Online: Prevalence and genetic diversity of simian malaria in wild macaque populations across Thailand: Implications for human health.

    Karnchaisri, Kriangkrai / Day, Nicholas P J / Dondorp, Arjen M / Malaivijitnond, Suchinda / Imwong, Mallika

    Acta tropica

    2024  Volume 254, Page(s) 107187

    Abstract: Over the past year, P. falciparum infections have declined in Thailand, yet nonhuman primate malaria infections have correspondingly increased, including Plasmodium knowlesi and P. cynomolgi. Nevertheless, little is known about simian malaria in its ... ...

    Abstract Over the past year, P. falciparum infections have declined in Thailand, yet nonhuman primate malaria infections have correspondingly increased, including Plasmodium knowlesi and P. cynomolgi. Nevertheless, little is known about simian malaria in its natural macaque hosts, Macaca mulatta and Macaca fascicularis. This study aims to address several research questions, including the prevalence and distribution of simian malaria in these two Thai wild macaque species, variations in infection between different macaque species and between M. fascicularis subspecies, and the genetic composition of these pathogens. Blood samples were collected from 82 M. mulatta and 690 M. fascicularis across 15 locations in Thailand, as well as two locations in Vietnam and Myanmar. We employed quantitative real-time PCR targeting the Plasmodium genus-specific 18S ribosomal RNA (rRNA) gene to detect malaria infection, with a limit of detection set at 1,215.98 parasites per mL. We genotyped eight microsatellite markers, and the P. cynomolgi dihydrofolate reductase gene (DHFR) was sequenced (N = 29). In total, 100 of 772 samples (13 %) tested positive for malaria, including 45 (13 %) for P. cynomolgi, 37 (13 %) for P. inui, 16 (5 %) for P. coatneyi, and 2 (0.25 %) for Hepatocystis sp. in Saraburi, central and Ranong, southern Thailand. Notably, simian malaria infection was observed exclusively in M. fascicularis and not in M. mulatta (P = 0.0002). Particularly, P. cynomolgi was detected in 21.7 % (45/207) of M. f. fascicularis living in Wat Tham Phrapothisat, Saraburi Province. The infection with simian malaria was statistically different between M. fascicularis and M. mulatta (P = 0.0002) but not within M. fascicularis subspecies (P = 0.78). A haplotype network analysis revealed that P. cynomolgi shares a lineage with reference strains obtained from macaques. No mutation in the predicted binding pocket of PcyDHFR to pyrimethamine was observed. This study reveals a significant prevalence of simian malaria infection in M. fascicularis. The clonal genotypes of P. cynomolgi suggest in-reservoir breeding. These findings raise concerns about the potential spread of nonhuman primate malaria to humans and underscore the need for preventive measures.
    MeSH term(s) Animals ; Thailand/epidemiology ; Malaria/epidemiology ; Malaria/parasitology ; Malaria/veterinary ; Macaca fascicularis/parasitology ; Prevalence ; RNA, Ribosomal, 18S/genetics ; Genetic Variation ; Macaca mulatta/parasitology ; Genotype ; Microsatellite Repeats/genetics ; Monkey Diseases/parasitology ; Monkey Diseases/epidemiology ; Humans ; Myanmar/epidemiology ; Tetrahydrofolate Dehydrogenase/genetics ; Plasmodium knowlesi/genetics ; Plasmodium knowlesi/isolation & purification ; Plasmodium/genetics ; Plasmodium/classification ; Plasmodium/isolation & purification ; Vietnam/epidemiology ; DNA, Protozoan/genetics ; Plasmodium cynomolgi/genetics ; Plasmodium cynomolgi/classification ; Real-Time Polymerase Chain Reaction
    Chemical Substances RNA, Ribosomal, 18S ; Tetrahydrofolate Dehydrogenase (EC 1.5.1.3) ; DNA, Protozoan
    Language English
    Publishing date 2024-03-21
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 210415-5
    ISSN 1873-6254 ; 0001-706X
    ISSN (online) 1873-6254
    ISSN 0001-706X
    DOI 10.1016/j.actatropica.2024.107187
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  10. Article ; Online: Eliciting calcium transients with UV nanosecond laser stimulation in adult patient-derived glioblastoma brain cancer cells

    Mellor, Nicholas G / Chung, Sylvia A / Graham, E Scott / Day, Bryan W / Unsworth, Charles P

    Journal of neural engineering

    2023  Volume 20, Issue 6

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Humans ; Glioblastoma/drug therapy ; Calcium ; Cell Line ; Brain Neoplasms/drug therapy ; Lasers ; Cell Line, Tumor
    Chemical Substances Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-12-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/ad0e7d
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