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Article ; Online: Longitudinal changes in visceral and subcutaneous adipose tissue and metabolic syndrome: Results from the Multicultural Community Health Assessment Trial (M-CHAT).

Tu, Andrew W / Humphries, Karin H / Lear, Scott A

2017 Volume 11 Suppl 2, Page(s) S957–S961

Abstract: ... In total, 598 adults of the Multicultural Community Health Assessment Trial (M-CHAT) were included ...

Abstract	Aim: Few studies have examined whether longitudinal changes in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), independent of each other, are associated with the risk of developing metabolic syndrome (MetS). The objective of this study was to examine the longitudinal effects of VAT and SAT on MetS and metabolic risk factors in a multi-ethnic sample of Canadians followed for 5-years. Materials and methods: In total, 598 adults of the Multicultural Community Health Assessment Trial (M-CHAT) were included in this study. Assessments of body composition using computed tomography (CT) and metabolic risk factors were conducted at baseline, 3-, and 5-years. Mixed-effects logistic regression was used to model the longitudinal effects of VAT and SAT on MetS and metabolic risk factors. Results: There were significant between-person (cross-sectional) effects such that for every 10cm Conclusions: This study found a direct relationship between longitudinal change in VAT and MetS risk independent of changes in SAT. Clinical practice should focus on the reduction of VAT to improve cardiovascular health outcomes.
MeSH term(s)	Adult ; Body Composition ; Cross-Sectional Studies ; Female ; Humans ; Intra-Abdominal Fat/metabolism ; Logistic Models ; Male ; Metabolic Syndrome/etiology ; Middle Aged ; Risk Factors ; Subcutaneous Fat/metabolism
Language	English
Publishing date	2017-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2273766-2
ISSN	1878-0334 ; 1871-4021
ISSN (online)	1878-0334
ISSN	1871-4021
DOI	10.1016/j.dsx.2017.07.022
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Why Lévy Foraging does not need to be 'unshackled' from Optimal Foraging Theory: Comment on "Liberating Lévy walk research from the shackles of optimal foraging" by A.M. Reynolds.

Humphries, Nicolas E

Physics of life reviews

2015 Volume 14, Page(s) 102–104

MeSH term(s)	Animals ; Behavior, Animal ; Humans ; Movement
Language	English
Publishing date	2015-09
Publishing country	Netherlands
Document type	Comment ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2148883-6
ISSN	1873-1457 ; 1571-0645
ISSN (online)	1873-1457
ISSN	1571-0645
DOI	10.1016/j.plrev.2015.05.001
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Article ; Online: Federal Oversight of Laboratory-Developed Tests.

Pierce, Virginia M / Humphries, Romney M

The New England journal of medicine

2024 Volume 390, Issue 5, Page(s) 482–483

Language	English
Publishing date	2024-01-31
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2314290
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Article ; Online: Ad Hoc Antimicrobial Susceptibility Testing from MALDI-TOF MS Spectra in the Clinical Microbiology Laboratory.

Humphries, Romney M

Clinical chemistry

2022 Volume 68, Issue 9, Page(s) 1118–1120

MeSH term(s)	Anti-Infective Agents ; Clinical Laboratory Services ; Humans ; Laboratories ; Microbial Sensitivity Tests ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2022-03-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80102-1
ISSN	1530-8561 ; 0009-9147
ISSN (online)	1530-8561
ISSN	0009-9147
DOI	10.1093/clinchem/hvac044
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Article: Visceral adipose tissue accumulation differs according to ethnic background: results of the Multicultural Community Health Assessment Trial (M-CHAT).

Lear, Scott A / Humphries, Karin H / Kohli, Simi / Chockalingam, Arun / Frohlich, Jiri J / Birmingham, C Laird

The American journal of clinical nutrition

2007 Volume 86, Issue 2, Page(s) 353–359

Abstract: ... and body mass index (BMI; in kg/m(2)) range. Total abdominal adipose tissue (TAT), subcutaneous ...

Abstract	Background: It was suggested that body fat distribution differs across ethnic groups, and this may be important when considering risk of disease. Previous studies have not adequately investigated differences in discrete regions of abdominal adiposity across ethnic groups. Objective: We compared the relation between abdominal adipose tissue and total body fat between persons living in Canada of Aboriginal, Chinese, and South Asian origin with persons of European origin. Design: Healthy Aboriginal, Chinese, European, and South Asian participants (n = 822) aged between 30 and 65 y were matched by sex, ethnicity, and body mass index (BMI; in kg/m(2)) range. Total abdominal adipose tissue (TAT), subcutaneous abdominal adipose tissue (SAT), visceral adipose tissue (VAT), total body fat mass, lifestyle, and demographics were assessed. Relations between BMI and total body fat, TAT, SAT, and VAT and between total body fat and TAT, SAT, and VAT were investigated. Results: BMI significantly underestimated VAT in all non-European groups. Throughout a range of total body fat mass, VAT was not significantly different between the Aboriginals and the Europeans. With total body fat >9.1 kg, Chinese participants had increasingly greater amounts of VAT than did the Europeans (P for interaction = 0.008). South Asians had less VAT with total body fat >37.4 kg but more VAT below that amount than did Europeans (P for interaction < 0.001). Conclusion: Compared with Europeans, the Chinese and South Asian cohorts had a relatively greater amount of abdominal adipose tissue, and this difference was more pronounced with VAT. No significant differences were observed between the Aboriginals and the Europeans.
MeSH term(s)	Adipose Tissue/anatomy & histology ; Adult ; Aged ; American Indian or Alaska Native ; Asian People ; Body Composition ; Body Mass Index ; British Columbia ; Demography ; Ethnicity ; Female ; Humans ; Male ; Middle Aged ; Patient Selection ; Viscera ; White People
Language	English
Publishing date	2007-04-18
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	280048-2
ISSN	1938-3207 ; 0002-9165
ISSN (online)	1938-3207
ISSN	0002-9165
DOI	10.1093/ajcn/86.2.353
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Article ; Online: RCEM best practice guideline: suspected cannabinoid hyperemesis syndrome in emergency departments.

Humphries, Christopher / Gillings, Marianne

Emergency medicine journal : EMJ

2024 Volume 41, Issue 5, Page(s) 328–331

Abstract: Cannabinoid hyperemesis syndrome (CHS) is an episodic syndrome of cyclic vomiting in the context of the prolonged use of cannabis. The Royal College of Emergency Medicine Toxicology Special Interest Group has produced guidance to support emergency ... ...

Abstract	Cannabinoid hyperemesis syndrome (CHS) is an episodic syndrome of cyclic vomiting in the context of the prolonged use of cannabis. The Royal College of Emergency Medicine Toxicology Special Interest Group has produced guidance to support emergency medicine clinicians with the recognition and treatment of people experiencing CHS.Considerations regarding recognition, investigation and communication are discussed, and recommendations regarding treatment options (which include haloperidol and capsaicin) are made. There is a focus on making recommendations on the best available evidence.
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2040124-3
ISSN	1472-0213 ; 1472-0205
ISSN (online)	1472-0213
ISSN	1472-0205
DOI	10.1136/emermed-2024-213886
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Article: Habitat and plant diversity of Trifolium tumens (Steven ex M. Bieb.) collected in Azerbaijan and its characterisation and field evaluation in Tasmania, Australia

Hall, E. J. / Hughes, S. J. / Humphries, A. W. / Corkrey, R.

Crop & pasture science

2013 Volume 64, Issue 4, Page(s) 374

Language	English
Document type	Article
ZDB-ID	2472536-5
ISSN	1836-0947
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Visceral adipose tissue, a potential risk factor for carotid atherosclerosis: results of the Multicultural Community Health Assessment Trial (M-CHAT).

Lear, Scott A / Humphries, Karin H / Kohli, Simi / Frohlich, Jiri J / Birmingham, C Laird / Mancini, G B John

Stroke

2007 Volume 38, Issue 9, Page(s) 2422–2429

Abstract: ... <25, 25 to 29.9, or > or =30 kg/m(2)) were assessed for VAT (by computed tomography scan ...

Abstract	Background and purpose: The association between abdominal obesity and atherosclerosis is believed to be due to excess visceral adipose tissue (VAT), which is associated with traditional risk factors. We hypothesized that VAT is an independent risk factor for atherosclerosis. Methods: Healthy men and women (N=794) matched for ethnicity (aboriginal, Chinese, European, and South Asian) and body mass index range (<25, 25 to 29.9, or > or =30 kg/m(2)) were assessed for VAT (by computed tomography scan), carotid atherosclerosis (by ultrasound), total body fat, cardiovascular risk factors, lifestyle, and demographics. Results: VAT was associated with carotid intima-media thickness (IMT), plaque area, and total area (IMT area and plaque area combined) after adjusting for demographics, family history, smoking, and percent body fat in men and women. In men, VAT was associated with IMT and total area after adjusting for insulin, glucose, homocysteine, blood pressure, and lipids. This association remained significant with IMT after further adjustment for either waist circumference or the waist-to-hip ratio. In women, VAT was no longer associated with IMT or total area after adjusting for risk factors. Conclusions: VAT is the primary region of adiposity associated with atherosclerosis and likely represents an additional risk factor for carotid atherosclerosis in men. Most but not all of this risk can be reflected clinically by either the waist circumference or waist-hip ratio measures.
MeSH term(s)	Adult ; Aged ; Arteriosclerosis/etiology ; Arteriosclerosis/pathology ; Body Composition ; Body Mass Index ; Carotid Arteries/diagnostic imaging ; Carotid Arteries/pathology ; Ethnic Groups ; Female ; Humans ; Intra-Abdominal Fat/anatomy & histology ; Male ; Middle Aged ; Obesity/complications ; Risk Factors ; Statistics as Topic ; Ultrasonography ; Waist-Hip Ratio
Language	English
Publishing date	2007-09
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.107.484113
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Article: Study design of the Multicultural Community Health Assessment Trial (M-CHAT): a comparison of body fat distribution in four distinct populations.

Lear, Scott A / Birmingham, C Laird / Chockalingam, Arun / Humphries, Karin H

Ethnicity & disease

2006 Volume 16, Issue 1, Page(s) 96–100

Abstract: Objective: To outline the study design of the Multicultural Community Health Assessment Trial (M ...

Abstract	Objective: To outline the study design of the Multicultural Community Health Assessment Trial (M-CHAT). The purpose of the study is to compare the relationship between visceral adipose tissue (VAT) and total body fat in men and women of Aboriginal, Chinese, and South Asian origin with a similar group of men and women of European origin. Design: A total of 200 apparently healthy men and women between the ages of 30 and 65 will be recruited from each of the local Aboriginal, Chinese, and South Asian and European communities. Within each sex/ethnic group, an equal representation of participants will have a body mass index between 18.5 to 24.9, 25 to 29.9 and >30. Each participant will undergo an assessment for VAT, total body fat, metabolic risk factors, physical activity, diet, quality of life, and sociodemographics. Main outcome measures: The primary outcome of this study is the relationship between VAT and total body fat in each of the Aboriginal, Chinese, and South Asian cohorts; this relationship will be compared to the European cohort after adjustment for age, sex, socioeconomic status, smoking status, physical activity, diet, and body mass index. Conclusions: This study will be the first to identify differences in body fat distribution in these populations. We anticipate that in populations of Aboriginal, Chinese, and South Asian origin, a greater proportion of total body fat will be deposited as VAT compared to those of European origin.
MeSH term(s)	Adult ; Aged ; Body Composition ; Body Mass Index ; British Columbia ; Cultural Diversity ; Ethnic Groups ; Female ; Humans ; Male ; Middle Aged
Language	English
Publishing date	2006
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1274267-3
ISSN	1945-0826 ; 1049-510X
ISSN (online)	1945-0826
ISSN	1049-510X
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Article: Habitat and plant diversity of Trifolium tumens (Steven ex M. Bieb.) collected in Azerbaijan and its characterisation and field evaluation in Tasmania, Australia

Hall, E. J / Hughes, S. J / Humphries, A. W / Corkrey, R

Crop & pasture science. 2013, v. 64, no. 4

2013

Abstract: Trifolium tumens (Talish clover) is a perennial legume species not previously domesticated for use in world agriculture. It is native to areas of the eastern Mediterranean, Caucasus and mountainous areas of the Middle East with a warm temperate or cool ... ...

Abstract	Trifolium tumens (Talish clover) is a perennial legume species not previously domesticated for use in world agriculture. It is native to areas of the eastern Mediterranean, Caucasus and mountainous areas of the Middle East with a warm temperate or cool Mediterranean environment. The species has been identified by pasture researchers in Australia as a having sufficient drought and grazing tolerance to fill a gap created by the lack of a well adapted perennial legume for dryland pasture systems across low rainfall (450 to 750mm annual average rainfall), temperate regions of Australia. The need to expand available genetic diversity of this species resulted in a germplasm collecting mission to Azerbaijan in 2004. The successful mission collected seed from 35 populations of T. tumens across 7 agro ecological zones, including 5 climatic zones. This collection increased the number of accessions held in ex situ local and international collections from 21 to 56. The range of adaptation and frequency of the collection of T. tumens was far greater than expected with accessions found at altitudes ranging from 12 to 1700m above sea level, in soils with pH (1:5H20) ranging between 5.0 and 9.0 and rainfall varying from 300 to 1300mm. T. tumens was found growing alongside a diverse range of companion species in heavily grazed lowland pastures up to lightly grazed alpine meadows. This material has been characterised by the Tasmanian Institute of Agriculture (TIA), with promising accessions contributing to a breeding program to develop a commercial cultivar adapted to temperate environments (<750mm rainfall).
Keywords	Mediterranean climate ; Trifolium ; alpine meadows ; cultivars ; drought tolerance ; ecological zones ; forage legumes ; genetic variation ; habitats ; legumes ; pastures ; rain ; scientific expeditions ; seed collecting ; soil pH ; species diversity ; temperate zones ; Azerbaijan ; Middle East ; Tasmania
Language	English
Size	p. 374-387.
Publishing place	CSIRO Publishing
Document type	Article
ZDB-ID	2472536-5
ISSN	1836-0947
ISSN	1836-0947
DOI	10.1071/CP13040
Database	NAL-Catalogue (AGRICOLA)

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