LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 331

Search options

  1. Article: Behaviour change in clinicians: When the triple tell'em don't work.

    Zarnegar, Roxaneh

    British journal of pain

    2023  Volume 17, Issue 5, Page(s) 424–425

    Language English
    Publishing date 2023-09-07
    Publishing country England
    Document type Editorial
    ZDB-ID 2670872-3
    ISSN 2049-4645 ; 2049-4637
    ISSN (online) 2049-4645
    ISSN 2049-4637
    DOI 10.1177/20494637231201716
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Informed consent in anaesthesia.

    Zarnegar, R

    British journal of anaesthesia

    2018  Volume 120, Issue 4, Page(s) 883–884

    MeSH term(s) Anesthesia ; Anesthesiology ; Informed Consent
    Language English
    Publishing date 2018-02-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2018.01.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.80: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Nociception related biomolecules in the adult human saliva: A scoping review with additional quantitative focus on cortisol.

    Zarnegar, Roxaneh / Vounta, Angeliki / Li, Qiuyuan / Ghoreishizadeh, Sara S

    Molecular pain

    2024  Volume 20, Page(s) 17448069241237121

    Abstract: Nociception related salivary biomolecules can be useful patients who are not able to self-report pain. We present the existing evidence on this topic using the PRISMA-ScR guidelines and a more focused analysis of cortisol change after cold pain induction ...

    Abstract Nociception related salivary biomolecules can be useful patients who are not able to self-report pain. We present the existing evidence on this topic using the PRISMA-ScR guidelines and a more focused analysis of cortisol change after cold pain induction using the direction of effect analysis combined with risk of bias analysis using ROBINS-I. Five data bases were searched systematically for articles on adults with acute pain secondary to disease, injury, or experimentally induced pain. Forty three articles met the inclusion criteria for the general review and 11 of these were included in the cortisol-cold pain analysis. Salivary melatonin, kallikreins, pro-inflammatory cytokines, soluable TNF-α receptor II, secretory IgA, testosterone, salivary α-amylase (sAA) and, most commonly, cortisol have been studied in relation to acute pain. There is greatest information about cortisol and sAA which both rise after cold pain when compared with other modalities. Where participants have been subjected to both pain and stress, stress is consistently a more reliable predictor of salivary biomarker change than pain. There remain considerable challenges in identifying biomarkers that can be used in clinical practice to guide the measurement of nociception and treatment of pain. Standardization of methodology and researchers' greater awareness of the factors that affect salivary biomolecule concentrations are needed to improve our understanding of this field towards creating a clinically relevant body of evidence.
    MeSH term(s) Adult ; Humans ; Hydrocortisone/analysis ; Acute Pain ; Saliva/chemistry ; Nociception ; Salivary alpha-Amylases/analysis ; Biomarkers ; Stress, Psychological
    Chemical Substances Hydrocortisone (WI4X0X7BPJ) ; Salivary alpha-Amylases (EC 3.2.1.1) ; Biomarkers
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2174252-2
    ISSN 1744-8069 ; 1744-8069
    ISSN (online) 1744-8069
    ISSN 1744-8069
    DOI 10.1177/17448069241237121
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Exploring the role of chitinase-3-like protein 1 in recurrence patterns among patients with differentiated thyroid cancer

    Greenberg, Jacques / Zarnegar, Rasa

    The Journal of pathology

    2020  Volume 252, Issue 4, Page(s) 343–345

    Abstract: Our understanding of the oncogenic drivers involved in thyroid cancers continues to expand. In a recent issue of this journal, Cheng et al explore the role of chitinase-3-like protein 1 (CHI3L1) in the development of thyroid cancer and its recurrence. ... ...

    Abstract Our understanding of the oncogenic drivers involved in thyroid cancers continues to expand. In a recent issue of this journal, Cheng et al explore the role of chitinase-3-like protein 1 (CHI3L1) in the development of thyroid cancer and its recurrence. They show increased levels of CHI3L1 in papillary and anaplastic thyroid malignancies (PTC and ATC, respectively) but baseline expression of the protein in benign thyroid pathologies. These were most pronounced in PTCs with BRAF mutations. High levels of CHI3L1 were shown to be associated with a higher likelihood of extrathyroidal extension and lymph node metastasis, more advanced TNM stage, a higher frequency of harboring a BRAF
    MeSH term(s) Carcinoma, Papillary ; Chitinase-3-Like Protein 1 ; Chitinases ; Humans ; Mutation ; Neoplasm Recurrence, Local ; Proto-Oncogene Proteins B-raf/genetics ; Thyroid Neoplasms ; United Kingdom
    Chemical Substances Chitinase-3-Like Protein 1 ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Chitinases (EC 3.2.1.14)
    Language English
    Publishing date 2020-10-14
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.5550
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.12: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Calcimimetics: Mechanisms of persistent commercial pressures on prescription of medications.

    Brunaud, L / Zarnegar, R / Frimat, L

    Journal of visceral surgery

    2020  Volume 157, Issue 3, Page(s) 171–173

    MeSH term(s) Calcimimetic Agents/therapeutic use ; Commerce ; Drug Prescriptions ; Humans ; Hyperparathyroidism, Secondary/drug therapy ; Hyperparathyroidism, Secondary/surgery ; Parathyroidectomy
    Chemical Substances Calcimimetic Agents
    Language English
    Publishing date 2020-01-27
    Publishing country France
    Document type Editorial
    ISSN 1878-7886
    ISSN (online) 1878-7886
    DOI 10.1016/j.jviscsurg.2020.01.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Tools to support the automation of systematic reviews: a scoping review.

    Khalil, Hanan / Ameen, Daniel / Zarnegar, Armita

    Journal of clinical epidemiology

    2021  Volume 144, Page(s) 22–42

    Abstract: ... that LitSuggest, Rayyan, Abstractr, BIBOT, R software, RobotAnalyst, DistillerSR, ExaCT and NetMetaXL have ...

    Abstract Objective: The objectives of this scoping review are to identify the reliability and validity of the available tools, their limitations and any recommendations to further improve the use of these tools.
    Study design: A scoping review methodology was followed to map the literature published on the challenges and solutions of conducting evidence synthesis using the JBI scoping review methodology.
    Results: A total of 47 publications were included in the review. The current scoping review identified that LitSuggest, Rayyan, Abstractr, BIBOT, R software, RobotAnalyst, DistillerSR, ExaCT and NetMetaXL have potential to be used for the automation of systematic reviews. However, they are not without limitations. The review also identified other studies that employed algorithms that have not yet been developed into user friendly tools. Some of these algorithms showed high validity and reliability but their use is conditional on user knowledge of computer science and algorithms.
    Conclusion: Abstract screening has reached maturity; data extraction is still an active area. Developing methods to semi-automate different steps of evidence synthesis via machine learning remains an important research direction. Also, it is important to move from the research prototypes currently available to professionally maintained platforms.
    MeSH term(s) Automation ; Humans ; Machine Learning ; Reproducibility of Results ; Software ; Systematic Reviews as Topic
    Language English
    Publishing date 2021-12-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2021.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.206: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: A Novel Humanized Model of NASH and Its Treatment With META4, A Potent Agonist of MET.

    Ma, Jihong / Tan, Xinping / Kwon, Yongkook / Delgado, Evan R / Zarnegar, Arman / DeFrances, Marie C / Duncan, Andrew W / Zarnegar, Reza

    Cellular and molecular gastroenterology and hepatology

    2021  Volume 13, Issue 2, Page(s) 565–582

    Abstract: Background & aims: Nonalcoholic fatty liver disease is a frequent cause of hepatic dysfunction and is now a global epidemic. This ailment can progress to an advanced form called nonalcoholic steatohepatitis (NASH) and end-stage liver disease. Currently, ...

    Abstract Background & aims: Nonalcoholic fatty liver disease is a frequent cause of hepatic dysfunction and is now a global epidemic. This ailment can progress to an advanced form called nonalcoholic steatohepatitis (NASH) and end-stage liver disease. Currently, the molecular basis of NASH pathogenesis is poorly understood, and no effective therapies exist to treat NASH. These shortcomings are due to the paucity of experimental NASH models directly relevant to humans.
    Methods: We used chimeric mice with humanized liver to investigate nonalcoholic fatty liver disease in a relevant model. We carried out histologic, biochemical, and molecular approaches including RNA-Seq. For comparison, we used side-by-side human NASH samples.
    Results: Herein, we describe a "humanized" model of NASH using transplantation of human hepatocytes into fumarylacetoacetate hydrolase-deficient mice. Once fed a high-fat diet, these mice develop NAFLD faithfully, recapitulating human NASH at the histologic, cellular, biochemical, and molecular levels. Our RNA-Seq analyses uncovered that a variety of important signaling pathways that govern liver homeostasis are profoundly deregulated in both humanized and human NASH livers. Notably, we made the novel discovery that hepatocyte growth factor (HGF) function is compromised in human and humanized NASH at several levels including a significant increase in the expression of the HGF antagonists known as NK1/NK2 and marked decrease in HGF activator. Based on these observations, we generated a potent, human-specific, and stable agonist of human MET that we have named META4 (Metaphor) and used it in the humanized NASH model to restore HGF function.
    Conclusions: Our studies revealed that the humanized NASH model recapitulates human NASH and uncovered that HGF-MET function is impaired in this disease. We show that restoring HGF-MET function by META4 therapy ameliorates NASH and reinstates normal liver function in the humanized NASH model. Our results show that the HGF-MET signaling pathway is a dominant regulator of hepatic homeostasis.
    MeSH term(s) Animals ; Diet, High-Fat ; Hepatocytes/metabolism ; Mice ; Non-alcoholic Fatty Liver Disease/pathology
    Language English
    Publishing date 2021-10-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2021.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: ASO Author Reflections: Outcomes of Gastroesophageal Neuroendocrine Tumors.

    Gray, Katherine D / Zarnegar, Rasa

    Annals of surgical oncology

    2018  Volume 25, Issue Suppl 3, Page(s) 868–869

    MeSH term(s) Databases, Factual ; Humans ; Neuroendocrine Tumors
    Language English
    Publishing date 2018-11-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-018-6902-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: The patient acceptability of a remotely delivered pain management programme for people with persistent musculoskeletal pain: A qualitative evaluation.

    Booth, Gregory / Zala, Sonia / Mitchell, Chloe / Zarnegar, Roxaneh / Lucas, Andrew / Gilbert, Anthony W

    British journal of pain

    2022  Volume 16, Issue 6, Page(s) 581–592

    Abstract: Introduction: Remotely delivered pain management programmes have been offered in place of in-person programmes by many chronic pain services since the onset of the COVID-19 pandemic. There is a lack of evidence regarding the acceptability of these ... ...

    Abstract Introduction: Remotely delivered pain management programmes have been offered in place of in-person programmes by many chronic pain services since the onset of the COVID-19 pandemic. There is a lack of evidence regarding the acceptability of these programmes. In this evaluation, we have explored patients' acceptability of a remotely delivered pain management programme for patients with persistent musculoskeletal pain.
    Methods: Qualitative data were collected using focus groups with participants who had previously attended the remote pain management programme. Data were analysed using abductive analysis.
    Results: Three focus groups were conducted with a total of 13 participants. The programmme was either entirely acceptable, had some acceptable components or was not acceptable to patients. Factors leading to the programme being acceptable include learning to manage pain from home, receiving high quality care from home, enhancing the potential of rehabilitation using technology, enabling attendance on a pain management programme from home, overcoming social distancing requirements of COVID-19 using technology, and virtual peer support. Factors leading to the programme not being acceptable include having an inappropriate home environment for virtual therapy, communication challenges with virtual therapy, technological issues and concerns regarding the quality of care.
    Conclusions: There is a spectrum of acceptability with respect to the remote programme. The factors that influence this are dynamic, individual and situational. Hybrid programmes have the potential to enhance access to pain management programmes and improve patient experience and programme outcomes in the future.
    Language English
    Publishing date 2022-06-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2670872-3
    ISSN 2049-4645 ; 2049-4637
    ISSN (online) 2049-4645
    ISSN 2049-4637
    DOI 10.1177/20494637221106411
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Determining Optimal Nonlinear Regression Models for Studying the Kinetics of Fatty Acid Ruminal Biohydrogenation In Vitro.

    Zarnegar, Zohreh / Ebrahimi, Seyed Hadi / Rohani, Abbas / Jensen, Søren Krogh / Lashkari, Saman / Valizadeh, Reza / Naserian, Abbas Ali

    ACS omega

    2023  Volume 8, Issue 50, Page(s) 48451–48464

    Abstract: The accurate estimation of in vitro ruminal biohydrogenation (BH) kinetics of fatty acids (FA) allows for a more accurate understanding of their dynamics and develop targeted strategies to enhance desirable FA bypass. This study comprises a comprehensive ...

    Abstract The accurate estimation of in vitro ruminal biohydrogenation (BH) kinetics of fatty acids (FA) allows for a more accurate understanding of their dynamics and develop targeted strategies to enhance desirable FA bypass. This study comprises a comprehensive evaluation of 33 nonlinear regression models to determine the most suitable model for accurately estimating the in vitro BH kinetics of individual FA. The data set utilized in the present research originates from a recent investigation on the effects of micronization and vitamin E on the in vitro ruminal BH of rapeseed. For the nonlinear regression analysis, data comprising FA concentrations (expressed as g FA/100 g FA) at the conclusion of 2, 4, 8, 12, 24, and 48 h incubation periods were employed. The evaluation of nonlinear regression models focused on identifying the ideal model based on criteria including the highest
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c08241
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top