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Article ; Online: Chronic lung disease in paediatric patients

Rania S. M. Ibrahim / Mona A. F. Hafez

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 53, Iss 1, Pp 1-

Does magnetic resonance imaging has a role?

2022 Volume 7

Abstract: Abstract Background Pediatric chronic lung disease (CLD) refers to a range of distinct clinical and pathological disorders that affect children. High-resolution CT (HRCT) is critical for detecting and characterizing parenchymal abnormalities as well as ... ...

Abstract	Abstract Background Pediatric chronic lung disease (CLD) refers to a range of distinct clinical and pathological disorders that affect children. High-resolution CT (HRCT) is critical for detecting and characterizing parenchymal abnormalities as well as determining their nature and distribution. Although magnetic resonance imaging (MRI) shows promising results, however, due to its poor spatial resolution and signal-to-noise ratio, imaging of the lung parenchyma remains a challenge. As a result, in addition to the initial CT, a follow-up MRI is required. The goal of this paper is to highlight the main imaging features of children with CLD and to evaluate the efficacy of MRI lungs in the diagnosis and monitoring of pediatric CLD. Results There was a strong positive correlation between CT and MRI, with a significant P-value. Findings of HRCT and MRI showed a qualitative agreement of 78% complete agreement. MRI helped primary diagnosis in 54% of cases compared to CT in 91% of cases. Conclusion MRI lungs are an equivalent technique to HRCT in assessing pediatric CLD; using the modified Helbich–Bhalla score, a strong correlation is obvious between both in the overall assessment. MRI is beneficial for case surveillance rather than primary diagnosis.
Keywords	Chronic lung disease ; Magnetic resonance imaging ; Computed tomography ; Pediatric ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The mean severity score and its correlation with common computed tomography chest manifestations in Egyptian patients with COVID-2019 pneumonia

Mona A. F. Hafez

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 51, Iss 1, Pp 1-

2020 Volume 9

Abstract: Abstract Background Computed tomography (CT) is one of the main diagnostic tools for early detection and management of coronavirus disease 2019 (COVID-19) pneumonia. This study aims to highlight the commonly encountered CT findings in patients with COVID- ...

Abstract	Abstract Background Computed tomography (CT) is one of the main diagnostic tools for early detection and management of coronavirus disease 2019 (COVID-19) pneumonia. This study aims to highlight the commonly encountered CT findings in patients with COVID-19 pneumonia in Egypt and the mean severity score and its correlation with the imaging findings. This study involved 200 patients with pathologically confirmed COVID-19 infection; non-contrast CT chest was performed for all cases; in addition, CT findings and severity score (CT-SS) were then assessed using descriptive analysis, and the correlation between the CT findings and disease severity was assessed. Results The ground-glass densities and peripheral adhesions were the most typical CT findings. Prominent interlobular septations; bronchial thickening/dilatation; CT signs of crazy-paving, halo, and reversed halo; and reactive mediastinal lymphadenopathy were significantly correlated with disease severity. The mean CT-SS of Egyptian patients with COVID-19 pneumonia was 11.2 (mild to moderate severity). Conclusion Multislice CT played a vital role in the early identification of Egyptian patients with COVID-19 pneumonia. The assessment of the CT severity score of COVID-19 is essential for the extent of pneumonia involvement to help clinicians achieve the purpose of early diagnosis and accurate treatment.
Keywords	Computed tomography ; COVID-19 pneumonia ; Chest ; Egyptian ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Refining the phenotypic spectrum of CCDC88A-related PEHO-like syndrome.

Issa, Mahmoud Y / Hafez, Mona A / Mounir, Samir M / Abdel Ghafar, Sherif F / Zaki, Maha S / Abdel-Hamid, Mohamed S

American journal of medical genetics. Part A

2023 Volume 194, Issue 2, Page(s) 226–232

Abstract: Progressive encephalopathy with edema, hypsarrhythmia, and optic atrophy (PEHO) and PEHO-like syndromes are very rare infantile disorders characterized by profound intellectual disability, hypotonia, convulsions, optic, and progressive brain atrophy. ... ...

Abstract	Progressive encephalopathy with edema, hypsarrhythmia, and optic atrophy (PEHO) and PEHO-like syndromes are very rare infantile disorders characterized by profound intellectual disability, hypotonia, convulsions, optic, and progressive brain atrophy. Many causative genes for PEHO and PEHO-like syndromes have been identified including CCDC88A. So far, only five patients from two unrelated families with biallelic CCDC88A variants have been reported in the literature. Herein, we describe a new family from Egypt with a lethal epileptic encephalopathy. Our patient was the youngest child born to a highly consanguineous couple and had a family history of five deceased sibs with the same condition. She presented with postnatal microcephaly, poor visual responsiveness, and epilepsy. Her brain MRI showed abnormal cortical gyration with failure of opercularization of the insula, hypogenesis of corpus callosum, colpocephaly, reduced white matter, hypoplastic vermis, and brain stem. Whole exome sequencing identified a new homozygous frameshift variant in CCDC88A gene (c.1795_1798delACAA, p.Thr599ValfsTer4). Our study presents the third reported family with this extremely rare disorder. We also reviewed all described cases to better refine the phenotypic spectrum associated with biallelic loss of function variants in the CCDC88A gene.
MeSH term(s)	Humans ; Child ; Female ; Spasms, Infantile/genetics ; Brain Edema/genetics ; Optic Atrophy/genetics ; Syndrome ; Microfilament Proteins/genetics ; Vesicular Transport Proteins/genetics ; Neurodegenerative Diseases
Chemical Substances	CCDC88A protein, human ; Microfilament Proteins ; Vesicular Transport Proteins
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2108614-X
ISSN	1552-4833 ; 0148-7299 ; 1552-4825
ISSN (online)	1552-4833
ISSN	0148-7299 ; 1552-4825
DOI	10.1002/ajmg.a.63425
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Article ; Online: Effects on root axes and resorption of simultaneous intrusion and retraction of maxillary central and lateral incisors using mini-implant supported three-piece burstone base arch: A prospective observational study.

Albelasy, Nehal F / Montasser, Mona A / Hafez, Ahmad M / Abdelnaby, Yasser L

International orthodontics

2021 Volume 20, Issue 1, Page(s) 100595

Abstract: Objective: Prospective morphometric evaluation of the positional changes and root resorption of maxillary central and lateral incisors undergoing simultaneous intrusion and retraction (SIR) using mini-implant supported 3-piece Burstone base arch.: ... ...

Abstract	Objective: Prospective morphometric evaluation of the positional changes and root resorption of maxillary central and lateral incisors undergoing simultaneous intrusion and retraction (SIR) using mini-implant supported 3-piece Burstone base arch. Materials and methods: Bracket head type mini-implants were inserted between the maxillary second premolar and first permanent molar. After maxillary canine retraction, SIR of maxillary incisors was begun using mini-implant supported 3-piece Burstone arch. A segmental CBCT was taken before and after SIR of the maxillary four incisors. Data collected were analysed using Paired t test, ANOVA test, independent sample t test and Pearson's correlation test. Results: Sixteen patients of 17.9±1.94 years mean age with class II division 1 malocclusion, deep bite≥4mm and overjet 5-8mm were selected. All mini-implants showed good stability during treatment with no looseness. Increasing the vertical end of the anterior segment up to 10mm led to controlled tipping and partial bodily retraction of the maxillary central and lateral incisors. The centre of resistance (CRe) of the four maxillary incisors was retracted 2.38±0.77mm and intruded 2.76±1.0mm with a mean change in axial inclination of 9.76±3.45°. The mean amount of root resorption of the four incisors was 1.29±0.59mm over a mean period of 6.2 months. Conclusions: The mini-implant supported 3-piece Burstone base arch had a pronounced effect on SIR of flared maxillary incisors with clinically insignificant amount of root resorption.
MeSH term(s)	Humans ; Incisor ; Maxilla/diagnostic imaging ; Orthodontic Anchorage Procedures ; Prospective Studies ; Root Resorption/diagnostic imaging ; Tooth Movement Techniques
Language	English
Publishing date	2021-11-19
Publishing country	France
Document type	Journal Article ; Observational Study
ISSN	1879-680X
ISSN (online)	1879-680X
DOI	10.1016/j.ortho.2021.10.003
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Article ; Online: Novel biomarkers for subtle myocardial involvement in type I diabetes mellitus.

El-Saiedi, Sonia A / Hafez, Mona H / Sedky, Yasser M / Sharaf, Sahar A / Kamel, Mona S / AbdelMassih, Antoine F

Cardiovascular endocrinology & metabolism

2020 Volume 10, Issue 3, Page(s) 175–181

Abstract: Background: Evaluation of certain biomarkers could be used to predict left ventricular (LV) and right ventricular (RV) function impairment in children with type 1 diabetes mellitus. The aim of this study was to determine the best cardiac biomarker for ... ...

Abstract	Background: Evaluation of certain biomarkers could be used to predict left ventricular (LV) and right ventricular (RV) function impairment in children with type 1 diabetes mellitus. The aim of this study was to determine the best cardiac biomarker for prediction of diabetic cardiomyopathy. Methodology: This study was designed as case-control study. A total of 55 children with type 1 diabetes mellitus (group/G1) and 55 healthy controls (G2) were subjected to echocardiography including 3D-Speckle Tracking Echocardiography and tissue Doppler imaging for assessment of RV and LV systolic and diastolic functions. As well as HbA1c, troponin I, brain natriuretic peptide (BNP), plasma cardiotrophin (CT-1), activin-A, transforming growth factor-β, and human insulin-like growth factor binding protein-7 (IGFBP-7) measurements. Results: Diabetic patients showed RV and LV systo-diastolic dysfunction compared to controls, the best predictor of LV systolic dysfunction was CT-1 (sensitivity: 69%, while IGFBP-7 was found to be the best predictor of RV systolic dysfunction (sensitivity: 63%). BNP was found to the best predictor of diastolic RV and LV dysfunction (sensitivity: 82% for both). Conclusion: CT-1 has proven to be a diagnostic superiority in LV systolic dysfunction whilst BNP continues to prove every day through our study and through many others that it is the chief marker of diastolic dysfunction and HFpEF. This potential accuracy and the increasing availability of BNP in the outpatient setting make it clear that it should be used as a screening test for diabetic patients.
Language	English
Publishing date	2020-11-19
Publishing country	United States
Document type	Journal Article
ISSN	2574-0954
ISSN (online)	2574-0954
DOI	10.1097/XCE.0000000000000240
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Article ; Online: The prevalence and the adding value of fetal MRI imaging in midline cerebral anomalies

Rehab M. E. Raafat / Tamer M. Abdelrahman / Mona A. F. Hafez

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 51, Iss 1, Pp 1-

2020 Volume 8

Abstract: Abstract Background Foetal MR imaging is widely accepted as an adjunct to foetal ultrasonography; however, there are many controversies regarding its importance and indications. Therefore, this study aimed to evaluate foetuses with different midline ... ...

Abstract	Abstract Background Foetal MR imaging is widely accepted as an adjunct to foetal ultrasonography; however, there are many controversies regarding its importance and indications. Therefore, this study aimed to evaluate foetuses with different midline cerebral abnormalities, to determine the prevalence of these anomalies, to define the role of foetal MRI, and to compare MRI and ultrasound (US) result with postnatal MRI findings. Seventy-eight pregnant women who had foetuses with CNS abnormalities detected by sonogram were included. Foetuses with midline anomalies were selected and evaluated by anomaly scan foetal US, pre- and postnatal MRI. Results Midline brain anomalies were found in 47.4% of foetuses with brain anomalies. Holoprosencephaly was found in 24.3% of midline anomaly foetuses, corpus callosum abnormalities (ACC) were detected in 40.5%, midline intracranial mass lesions in 2.7%, and midline posterior fossa anomalies in 32.4%. An agreement between MRI and US in the main diagnosis was in 56.76% of cases; MRI added information to US findings in 43.2% of cases, and US added information to MRI findings in 8.1% of cases. Conclusion In evaluating midline cerebral anomalies, US and MRI are complementary techniques. US is the primary survey, and MRI can add additional information and/or change the main diagnosis.
Keywords	Foetal ultrasound ; Foetal MRI ; Midline anomalies ; Brain ; Posterior fossa ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluating the role of ultrasound in chest trauma

Youssriah Y. Sabri / Mona A.F. Hafez / Khaled M. Kamel / Dina A. Abbas

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 49, Iss 4, Pp 986-

Common complications and computed tomography comparative evaluation

2018 Volume 992

Abstract: Objective: to establish the role of transthoracic ultrasound as a bed-side, available, and affordable technique for imaging chest trauma patients and compared its sensitivity, specificity and accuracy for detecting chest trauma sequelae and complications ...

Abstract	Objective: to establish the role of transthoracic ultrasound as a bed-side, available, and affordable technique for imaging chest trauma patients and compared its sensitivity, specificity and accuracy for detecting chest trauma sequelae and complications to those of CT. Patients and methods: This study included 107 cases. All patients had chest trauma or polytrauma with chest involvement. Transthoracic ultrasound and MSCT of the chest were evaluated. The results were assessed and compared by statistical analysis. Results: Of the injuries, 13.1% were penetrating, and 86.9% were blunt trauma. With CT as the standard, the most common injury US detected injury was pleural in 60.7% of patients, with diagnostic accuracy of 93.4%. Parenchymal lesions were found in 39.3% of patients with a 64.4% US diagnostic accuracy. Chest wall lesions were found in 15.9% of patients with an 89.7% accuracy, and mediastinal lesions were detected in 9.3% with a 94.3% accuracy. Conclusion: Chest ultrasonography has significant value for diagnosing complications of blunt and penetrating chest trauma with acceptable sensitivity and high specificity, particularly for pleural lesions and rib fractures. Ultrasound overcomes the difficulties involved in radiological examinations of small children and uncooperative patients. Keywords: Trauma, Ultrasound, Chest, Computed tomography, Thorax
Keywords	Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2018-12-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Emphasizing the role of multi-detector computed tomography chest in the etiological diagnosis of pulmonary bronchiectasis

Youssriah Y. Sabri / Mona A.F. Hafez / Hebata-Allah H.M. Assal / Muna A.H. Al-Dura

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 49, Iss 3, Pp 645-

2018 Volume 651

Abstract: In this study we aimed to highlight the role of multi-slice computed tomography (MSCT) and high resolution computed tomography (HRCT) of the chest in the detection of pulmonary bronchiectatic lesions and to display the approach used in determining the ... ...

Abstract	In this study we aimed to highlight the role of multi-slice computed tomography (MSCT) and high resolution computed tomography (HRCT) of the chest in the detection of pulmonary bronchiectatic lesions and to display the approach used in determining the proper etiological diagnosis. Patients and methods: This study involved 62 patients; 36 females and 26 males, were referred to the radiology department for MSCT of the chest from the pulmonary department in the period from October 2016 – April 2017. Results: Pulmonary bronchiectatic lesions were classified according to bronchiectasis distribution; with bilateral lesions were more common in 62.5% of patients, classification according to morphological type with the cylindrical bronchiectasis was the most common shape in 37.5% of case, classification according to bronchiectasis etiology, most of cases were post inflammatory in 42.2% of cases, followed by traction bronchiectasis in 34.4% of cases. Then the diagnostic approach to reach different etiologies was displayed. Conclusion: The role of MDCT imaging in diagnosis and evaluation of bronchiectasis is crucial. Keywords: MDCT, Chest, Bronchiectasis
Keywords	Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2018-09-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neurotoxicity of organic solvents with emphasis on the role of iron.

Shahy, Eman M / Ibrahim, Khadiga S / Mahdy-Abdallah, Heba / Taha, Mona M / Saad-Hussien, Amal / Hafez, Salwa F

Journal of complementary & integrative medicine

2021 Volume 18, Issue 3, Page(s) 527–533

Abstract: Background: Exposure to organic solvents (OS) adversely affects different body systems, the central and peripheral nervous systems being the most susceptible ones.: Objectives: This study investigated the role of iron in association with some ... ...

Abstract	Background: Exposure to organic solvents (OS) adversely affects different body systems, the central and peripheral nervous systems being the most susceptible ones. Objectives: This study investigated the role of iron in association with some neurotransmitters for diagnosis of neurotoxicity of OS. Methods: The study included 90 workers, 50 occupationally exposed to OS and 40 representing control group. Blood samples were collected from the included subjects for determination of serum iron, total iron binding capacity (TIBC), serotonin and gamma-aminobutyric acid (GABA). Results: Revealed reduction in serotonin level and serum iron. However, the elevation in GABA and TIBC was observed. The duration of exposure was significantly correlated with iron and serotonin while it was positively correlated with GABA and TIBC. Conclusions: Elevated GABA and TIBC with decreased serotonin and serum iron can be used as early diagnostic measures to detect the neurotoxic effects of OS.
MeSH term(s)	Humans ; Iron ; Solvents/adverse effects ; Solvents/poisoning
Chemical Substances	Solvents ; Iron (E1UOL152H7)
Language	English
Publishing date	2021-02-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2197618-1
ISSN	1553-3840 ; 2194-6329
ISSN (online)	1553-3840
ISSN	2194-6329
DOI	10.1515/jcim-2019-0103
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Article: Copy Number Variations in Genetic Diagnosis of Congenital Adrenal Hyperplasia Children.

Tolba, Aisha / Mandour, Iman / Musa, Noha / Elmougy, Fatma / Hafez, Mona / Abdelatty, Sahar / Ibrahim, Amany / Soliman, Hend / Labib, Bahaaeldin / Elshiwy, Yasmine / Ramzy, Tarek / Elsharkawy, Marwa

Frontiers in genetics

2022 Volume 13, Page(s) 785570

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2022.785570
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