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Book ; Online: Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions

David Bikle, Daniel / Xie, Zhongjian / Wang, Xiangbing

2020

Keywords	Medicine ; Endocrinology ; vitamin D binding protein ; total 25-hydroxyvitamin D ; free 25-hydroxyvitamin D ; 1 ; 25-dihydroxyvitamin D ; bioavailable 25-hydroxyvitamin D
Size	1 electronic resource (86 pages)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021230282
ISBN	9782889635788 ; 2889635783
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Vitamin D Regulation of Immune Function.

Bikle, Daniel D

Current osteoporosis reports

2022 Volume 20, Issue 3, Page(s) 186–193

Abstract: Purpose of review: To review the mechanisms by which vitamin D and its metabolites regulate ... other respiratory infections and encourage further research into the role that vitamin D supplementation plays in preventing ... treating such infections.: Recent findings: Vitamin D deficiency is associated with an increased risk ...

Abstract	Purpose of review: To review the mechanisms by which vitamin D and its metabolites regulate the immune system to facilitate the ability of the body to prevent and/or treat SARS-CoV2 and other respiratory infections and encourage further research into the role that vitamin D supplementation plays in preventing/treating such infections. Recent findings: Vitamin D deficiency is associated with an increased risk of SARS-CoV2 and other respiratory infections. Clinical trials in general demonstrate that correction of vitamin D deficiency reduces the risk of hospitalization, ICU admission, and death from SARS-CoV2 infection. The airway epithelium and alveolar macrophages express the enzyme, CYP27B1, that produces the active metabolite of vitamin D, 1,25(OH)
MeSH term(s)	COVID-19 ; Humans ; Immunity, Innate/physiology ; RNA, Viral ; SARS-CoV-2 ; Vitamin D/metabolism ; Vitamin D Deficiency/complications
Chemical Substances	RNA, Viral ; Vitamin D (1406-16-2)
Language	English
Publishing date	2022-05-04
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2186581-4
ISSN	1544-2241 ; 1544-1873
ISSN (online)	1544-2241
ISSN	1544-1873
DOI	10.1007/s11914-022-00732-z
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Article ; Online: Role of vitamin D and calcium signaling in epidermal wound healing.

Bikle, D D

Journal of endocrinological investigation

2022 Volume 46, Issue 2, Page(s) 205–212

Abstract: Purpose: This review will discuss the role of vitamin D and calcium signaling in the epidermal ... of wound healing in general and the roles of calcium and vitamin D in wound healing in particular were reviewed ... the wound and regenerate the epidermis. The vitamin D and calcium sensing receptors (VDR and CaSR ...

Abstract	Purpose: This review will discuss the role of vitamin D and calcium signaling in the epidermal wound response with particular focus on the stem cells of the epidermis and hair follicle that contribute to the wounding response. Methods: Selected publications relevant to the mechanisms of wound healing in general and the roles of calcium and vitamin D in wound healing in particular were reviewed. Results: Following wounding the stem cells of the hair follicle and interfollicular epidermis are activated to proliferate and migrate to the wound where they take on an epidermal fate to re-epithelialize the wound and regenerate the epidermis. The vitamin D and calcium sensing receptors (VDR and CaSR, respectively) are expressed in the stem cells of the hair follicle and epidermis where they play a critical role in enabling the stem cells to respond to wounding. Deletion of Vdr and/or Casr from these cells delays wound healing. The VDR is regulated by co-regulators such as the Med 1 complex and other transcription factors such as Ctnnb (beta-catenin) and p63. The formation of the Cdh1/Ctnn (E-cadherin/catenin) complex jointly stimulated by vitamin D and calcium plays a critical role in the activation, migration, and re-epithelialization processes. Conclusion: Vitamin D and calcium signaling are critical for the ability of epidermal and hair follicle stem cells to respond to wounding. Vitamin D deficiency with the accompanying decrease in calcium signaling can result in delayed and/or chronic wounds, a major cause of morbidity, loss of productivity, and medical expense.
MeSH term(s)	Humans ; Vitamin D/metabolism ; Calcium/metabolism ; Calcium Signaling ; Epidermis/injuries ; Epidermis/metabolism ; Wound Healing ; Vitamins/metabolism
Chemical Substances	Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP) ; Vitamins
Language	English
Publishing date	2022-08-13
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	432272-1
ISSN	1720-8386 ; 0391-4097 ; 1121-1369
ISSN (online)	1720-8386
ISSN	0391-4097 ; 1121-1369
DOI	10.1007/s40618-022-01893-5
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Article ; Online: Vitamin D regulation of immune function during covid-19.

Bikle, Daniel D

Reviews in endocrine & metabolic disorders

2022 Volume 23, Issue 2, Page(s) 279–285

Abstract: ... epithelia constitutively expresses CYP27B1, the enzyme producing the active vitamin D metabolite, 1,25(OH) ...

Abstract	Covid-19 has to date infected a confirmed 275 million people with 5.4 million, now dead, with the count rising every day. Although the virus, SARS-CoV2, causing Covid-19 infects many cells in the body, its infection of the upper and lower respiratory tract (upper airway epithelia and pulmonary alveolar pneumocytes and macrophages) causing what is now called a cytokine storm in the lungs is the major cause of morbidity and mortality. This results from a dysregulation of the innate immune system with an outpouring of proinflammatory cytokines and chemokines leading to abnormal activation of the adaptive immune pathway. Airway epithelia constitutively expresses CYP27B1, the enzyme producing the active vitamin D metabolite, 1,25(OH)
MeSH term(s)	COVID-19 ; Humans ; Immunity, Innate ; RNA, Viral ; SARS-CoV-2 ; Vitamin D
Chemical Substances	RNA, Viral ; Vitamin D (1406-16-2)
Language	English
Publishing date	2022-01-29
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2185718-0
ISSN	1573-2606 ; 1389-9155
ISSN (online)	1573-2606
ISSN	1389-9155
DOI	10.1007/s11154-021-09707-4
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Article ; Online: Vitamin D and malabsorptive gastrointestinal conditions: A bidirectional relationship?

Giustina, Andrea / di Filippo, Luigi / Allora, Agnese / Bikle, Daniel D / Cavestro, Giulia Martina / Feldman, David / Latella, Giovanni / Minisola, Salvatore / Napoli, Nicola / Trasciatti, Silvia / Uygur, Melin / Bilezikian, John P

Reviews in endocrine & metabolic disorders

2023 Volume 24, Issue 2, Page(s) 121–138

Abstract: This paper is one of the outcomes of the 5th International Conference "Controversies in Vitamin D ... started in 2017. The scope of these meetings is to discuss controversial issues about vitamin D ... data with the medical and academic community. Vitamin D and malabsorptive gastrointestinal conditions ...

Abstract	This paper is one of the outcomes of the 5th International Conference "Controversies in Vitamin D" held in Stresa, Italy from 15 to 18 September 2021 as part of a series of annual meetings which was started in 2017. The scope of these meetings is to discuss controversial issues about vitamin D. Publication of the outcomes of the meeting in international journals allows a wide sharing of the most recent data with the medical and academic community. Vitamin D and malabsorptive gastrointestinal conditions was one of the topics discussed at the meeting and focus of this paper. Participants to the meeting were invited to review available literature on selected issues related to vitamin D and gastrointestinal system and to present their topic to all participants with the aim to initiate a discussion on the main outcomes of which are reported in this document. The presentations were focused on the possible bidirectional relationship between vitamin D and gastrointestinal malabsorptive conditions such as celiac disease, inflammatory bowel diseases (IBDs) and bariatric surgery. In fact, on one hand the impact of these conditions on vitamin D status was examined and on the other hand the possible role of hypovitaminosis D on pathophysiology and clinical course of these conditions was also evaluated. All examined malabsorptive conditions severely impair vitamin D status. Since vitamin D has known positive effects on bone this in turn may contribute to negative skeletal outcomes including reduced bone mineral density, and increased risk of fracture which may be mitigated by vitamin D supplementation. Due to the immune and metabolic extra-skeletal effects there is the possibility that low levels of vitamin D may negatively impact on the underlying gastrointestinal conditions worsening its clinical course or counteracting the effect of treatment. Therefore, vitamin D status assessment and supplementation should be routinely considered in all patients affected by these conditions. This concept is strengthened by the existence of a possible bidirectional relationship through which poor vitamin D status may negatively impact on clinical course of underlying disease. Sufficient elements are available to estimate the desired threshold vitamin D level above which a favourable impact on the skeleton in these conditions may be obtained. On the other hand, ad hoc controlled clinical trials are needed to better define this threshold for obtaining a positive effect of vitamin D supplementation on occurrence and clinical course of malabsorptive gastrointestinal diseases.
MeSH term(s)	Humans ; Vitamin D/physiology ; Vitamin D Deficiency/epidemiology ; Fractures, Bone/drug therapy ; Bone and Bones ; Disease Progression
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2023-02-23
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2185718-0
ISSN	1573-2606 ; 1389-9155
ISSN (online)	1573-2606
ISSN	1389-9155
DOI	10.1007/s11154-023-09792-7
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Article ; Online: Vitamin D and Long COVID: Is There a Role in Prevention or Treatment?

Bikle, Daniel D

The Journal of clinical endocrinology and metabolism

2023 Volume 109, Issue 1, Page(s) e430–e431

MeSH term(s)	Humans ; Vitamin D/therapeutic use ; COVID-19 ; Post-Acute COVID-19 Syndrome ; Vitamins/therapeutic use ; Immunity, Innate
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2023-06-04
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgad338
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Article ; Online: Highlights from the 24th workshop on vitamin D in Austin, September 2022.

Meyer, Mark B / Bernal-Mizrachi, Carlos / Bikle, Daniel D / Biyani, Madhu / Campbell, Moray J / Chaudhari, Snehal N / Christakos, Sylvia / Ingles, Sue A / Knuth, Megan M / Lee, Seong Min / Lisse, Thomas S / Liu, Eva S / Piec, Isabelle / Plum, Lori A / Rao, Sudhaker D / Reynolds, Carmen J / Thacher, Tom D / White, John H / Cantorna, Margherita T

The Journal of steroid biochemistry and molecular biology

2023 Volume 228, Page(s) 106247

Abstract: The 24th Workshop on Vitamin D was held September 7-9, 2022 in Austin, Texas and covered a wide ... diversity of research in the vitamin D field from across the globe. Here, we summarize the meeting ...

Abstract	The 24th Workshop on Vitamin D was held September 7-9, 2022 in Austin, Texas and covered a wide diversity of research in the vitamin D field from across the globe. Here, we summarize the meeting, individual sessions, awards and presentations given.
MeSH term(s)	Humans ; Vitamin D ; Vitamin D Deficiency ; Vitamins
Chemical Substances	Vitamin D (1406-16-2) ; Vitamins
Language	English
Publishing date	2023-01-10
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1049188-0
ISSN	1879-1220 ; 0960-0760
ISSN (online)	1879-1220
ISSN	0960-0760
DOI	10.1016/j.jsbmb.2023.106247
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Article ; Online: Vitamin D Assays.

Bikle, Daniel D

Frontiers of hormone research

2018 Volume 50, Page(s) 14–30

Abstract: The number of requests for vitamin D metabolite measurements has increased dramatically over ... of 25-hydroxyvitamin D (25[OH]D) and to a lesser extent 1,25-dihydroxyvitamin D (1,25[OH]2D) dominates ... for measurement of total vitamin D metabolite levels, these metabolites circulate in blood tightly bound ...

Abstract	The number of requests for vitamin D metabolite measurements has increased dramatically over the past decade leading commercial laboratories to develop rapid high throughput assays. The measurement of 25-hydroxyvitamin D (25[OH]D) and to a lesser extent 1,25-dihydroxyvitamin D (1,25[OH]2D) dominates these requests, but requests for multiple metabolite measurements in the same sample are also increasing. The most commonly used methods include immunoassays and liquid chromatography/mass spectrometry (LC-MS). Each method has its advantages and disadvantages, but with improvements in technology, especially in LC-MS, this method is gaining ascendance due to its greater precision and flexibility. The use of standards from the National Institutes of Standards and Technology has substantially reduced the variability from laboratory to laboratory, thereby improving the reliability of these measurements. Although the current demand is for measurement of total vitamin D metabolite levels, these metabolites circulate in blood tightly bound to vitamin D binding protein (DBP) and albumin with less than 1% free. The free concentration may be a more accurate indicator of vitamin D status especially in individuals with DBP levels that deviate from the normal population. Thus, methods to measure the free concentration at least of 25(OH)D are becoming available and may supplement if not replace measurements of total levels.
MeSH term(s)	Chromatography, Liquid/standards ; Humans ; Immunoassay/standards ; Tandem Mass Spectrometry/standards ; Vitamin D/analogs & derivatives ; Vitamin D/analysis
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2018-03-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	1662-3762 ; 0301-3073
ISSN (online)	1662-3762
ISSN	0301-3073
DOI	10.1159/000486062
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Article: The Vitamin D Receptor as Tumor Suppressor in Skin.

Bikle, Daniel D

Advances in experimental medicine and biology

2020 Volume 1268, Page(s) 285–306

Abstract: ... with sunlight exposure is generally regarded as causal for these malignancies, but UVB is also required for vitamin D ... vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH) ...

Abstract	Cutaneous malignancies including melanomas and keratinocyte carcinomas (KC) are the most common types of cancer, occurring at a rate of over one million per year in the United States. KC, which include both basal cell carcinomas and squamous cell carcinomas, are substantially more common than melanomas and form the subject of this chapter. Ultraviolet radiation (UVR), both UVB and UVA, as occurs with sunlight exposure is generally regarded as causal for these malignancies, but UVB is also required for vitamin D synthesis in the skin. Keratinocytes are the major cell in the epidermis. These cells not only produce vitamin D but contain the enzymatic machinery to metabolize vitamin D to its active metabolite, 1,25(OH)
MeSH term(s)	Humans ; Keratinocytes/metabolism ; Receptors, Calcitriol/metabolism ; Skin/cytology ; Skin/metabolism ; Skin Neoplasms/metabolism ; Tumor Suppressor Proteins/metabolism ; Ultraviolet Rays/adverse effects ; Vitamin D/metabolism
Chemical Substances	Receptors, Calcitriol ; Tumor Suppressor Proteins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2020-09-11
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-46227-7_14
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Article ; Online: Ligand-Independent Actions of the Vitamin D Receptor: More Questions Than Answers.

Bikle, Daniel D

JBMR plus

2021 Volume 5, Issue 12, Page(s) e10578

Abstract: Our predominant understanding of the actions of vitamin D involve binding of its ligand, 1,25(OH)D ... to the vitamin D receptor (VDR), which for its genomic actions binds to discrete regions of its target genes ... called vitamin D response elements. However, chromatin immunoprecipitation-sequencing (ChIP-seq) studies ...

Abstract	Our predominant understanding of the actions of vitamin D involve binding of its ligand, 1,25(OH)D, to the vitamin D receptor (VDR), which for its genomic actions binds to discrete regions of its target genes called vitamin D response elements. However, chromatin immunoprecipitation-sequencing (ChIP-seq) studies have observed that the VDR can bind to many sites in the genome without its ligand. The number of such sites and how much they coincide with sites that also bind the liganded VDR vary from cell to cell, with the keratinocyte from the skin having the greatest overlap and the intestinal epithelial cell having the least. What is the purpose of the unliganded VDR? In this review, I will focus on two clear examples in which the unliganded VDR plays a role. The best example is that of hair follicle cycling. Hair follicle cycling does not need 1,25(OH)
Language	English
Publishing date	2021-11-23
Publishing country	England
Document type	Journal Article ; Review
ISSN	2473-4039
ISSN (online)	2473-4039
DOI	10.1002/jbm4.10578
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