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Article: Comorbidity of Dissociative Motor Disorder with Organic Impairment - Case Report.

Mastelić, Tonći / Uglešić, Boran / Divić, Kristina / Lasić, Davor

2021 Volume 33, Issue Suppl 4, Page(s) 671–673

MeSH term(s)	Comorbidity ; Conversion Disorder ; Dissociative Disorders ; Humans
Language	English
Publishing date	2021-10-30
Publishing country	Croatia
Document type	Case Reports ; Journal Article
ZDB-ID	1067580-2
ISSN	0353-5053
ISSN	0353-5053
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Article: Comparison of Negative Pressure Wound Therapy (NPWT) and Classical Wet to Moist Dressing (WtM) in the Treatment of Complicated Extremity Wounds in Children.

Slavkovic, Milan / Zivanovic, Dragoljub / Dučić, Siniša / Lasić, Valentina / Bukvić, Nado / Nikolić, Harry / Martinović, Vlatka

Children (Basel, Switzerland)

2023 Volume 10, Issue 2

Abstract: Treating complicated wounds in the pediatric population using traditional wet to moist wound dressing methods is not always appropriate due to the frequent need to change dressings daily or even a number of times a day, causing distress to the patient. ... ...

Abstract	Treating complicated wounds in the pediatric population using traditional wet to moist wound dressing methods is not always appropriate due to the frequent need to change dressings daily or even a number of times a day, causing distress to the patient. Topical negative pressure is a method that allows for fewer dressings and provides localized benefits, thus accelerating wound healing. The merits of this therapy have been proven in studies on adults, but research on the pediatric population is scarce. Here we intend to present the results of negative pressure wound therapy (NPWT) on 34 pediatric patients (study group) and compare them with 24 patients (control group) treated with the traditional wet to moist dressing for complicated wounds. The results show that topical negative pressure wound therapy is a safe method that downgrades a wound from a complicated to a simple one and allows definitive coverage using a simpler technique with fewer wound dressings. The scars of the patients in the study group exhibited a better result on a visual scar scale. The patients in the control group had a shorter hospital stay. Based on the recorded results, we were able to make treatment recommendations.
Language	English
Publishing date	2023-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10020298
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Article: SUICIDE ATTEMPTS ARE ASSOCIATED WITH PERSONALITY DIMENSIONS IN CROATIAN WAR VETERANS WITH POSTTRAUMATIC STRESS DISORDER.

Jakšić, Nenad / Šimunović Filipčić, Ivona / Aukst Margetić, Branka / Šagud, Marina / Marčinko, Darko / Lasić, Davor / Jakovljević, Miro

Psychiatria Danubina

2023 Volume 35, Issue 3, Page(s) 320–327

Abstract: Background: Patients with combat-related posttraumatic stress disorder (PTSD) have an increased frequency of suicide ideations, but also a higher risk of suicide attempts. Of all the known predisposing risk factors of suicide attempts in this population, ...

Abstract	Background: Patients with combat-related posttraumatic stress disorder (PTSD) have an increased frequency of suicide ideations, but also a higher risk of suicide attempts. Of all the known predisposing risk factors of suicide attempts in this population, personality dimensions are one of the least investigated. The main aim of this study was to examine if personality traits, namely temperament and character dimensions and trait impulsivity, are associated with suicide attempts in war veterans with PTSD. Subjects and methods: his sample included 178 Croatian male war veterans (mean age 49.20 years) treated for PTSD at the Department of Psychiatry and Psychological Medicine, University Hospital Center Zagreb. These patients were assessed with the M.I.N.I. diagnostic interview and they filled out several self-report scales: the Beck Depression Inventory-Second Edition (BDI-II), the Temperament and Character Inventory-Revised (TCI-R), the Barratt Impulsiveness Scale-11 (BIS-11), and the Satisfaction with Life Scale (SWLS). Results: It was found that 42 (24%) Croatian war veterans with PTSD had a previous suicide attempt. Comparison between the two groups (participants with vs. those without history of suicide attempts) revealed that patients with previous suicide attempts are less educated and more often unemployed, have a longer duration of psychiatric treatment and more psychiatric hospitalizations, and exhibit higher levels of depression and lower life satisfaction. In multivariate logistic regression analyses, temperament dimension Harm Avoidance and character dimension Self-transcendence were unique predictors of suicide attempts, above the influence of age, education level and length of treatment. Conclusions: Croatian war veterans with PTSD have a substantial risk of suicide attempts. In addition to the role of some sociodemographic and clinical factors, it seems that certain personality dimensions are uniquely associated with suicide behaviours among these individuals.
MeSH term(s)	Humans ; Male ; Middle Aged ; Suicide, Attempted/psychology ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/psychology ; Veterans/psychology ; Croatia/epidemiology ; Temperament
Language	English
Publishing date	2023-11-02
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1067580-2
ISSN	0353-5053
ISSN	0353-5053
DOI	10.24869/psyd.2023.320
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Article ; Online: Thieno-Thiazolostilbenes, Thienobenzo-Thiazoles, and Naphtho-Oxazoles: Computational Study and Cholinesterase Inhibitory Activity.

Mlakić, Milena / Đurčević, Ema / Odak, Ilijana / Barić, Danijela / Juričević, Ines / Šagud, Ivana / Burčul, Franko / Lasić, Zlata / Marinić, Željko / Škorić, Irena

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 9

Abstract: Naphtho-triazoles and thienobenzo-triazoles have so far proven to be very potent inhibitors of the enzyme butyrylcholinesterase (BChE). Based on these results, in this work, new thienobenzo-thiazoles were designed and synthesized, and their potential ... ...

Abstract	Naphtho-triazoles and thienobenzo-triazoles have so far proven to be very potent inhibitors of the enzyme butyrylcholinesterase (BChE). Based on these results, in this work, new thienobenzo-thiazoles were designed and synthesized, and their potential inhibitory activity was tested and compared with their analogs, naphtho-oxazoles. The synthesis was carried out by photochemical cyclization of thieno-thiazolostilbenes obtained in the first reaction step. Several thienobenzo-thiazoles and naphtho-oxazoles have shown significant potential as BChE inhibitors, together with the phenolic thiazolostilbene being the most active of all tested compounds. These results are significant as BChE has been attracting growing attention due to its positive role in the treatment of Alzheimer's disease. Computational examination based on the DFT approach enabled the characterization of the geometry and electronic structure of the studied molecules. Furthermore, the molecular docking study, accompanied by additional optimization of complexes ligand-active site, offered insight into the structure and stabilizing interactions in the complexes of studied molecules and BChE.
MeSH term(s)	Butyrylcholinesterase/chemistry ; Molecular Docking Simulation ; Thiazoles/pharmacology ; Thiazoles/chemistry ; Oxazoles ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemistry ; Acetylcholinesterase/metabolism ; Structure-Activity Relationship
Chemical Substances	Butyrylcholinesterase (EC 3.1.1.8) ; Thiazoles ; Oxazoles ; Cholinesterase Inhibitors ; Acetylcholinesterase (EC 3.1.1.7)
Language	English
Publishing date	2023-04-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28093781
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Article ; Online: COVID-19 vaccination uptake in people with multiple sclerosis compared to the general population.

Mayer, Dijana / Barun, Barbara / Lazibat, Karla / Lasić, Slava / Adamec, Ivan / Gabelić, Tereza / Krbot Skorić, Magdalena / Habek, Mario

Acta neurologica Belgica

2023 Volume 123, Issue 6, Page(s) 2269–2275

Abstract: Objective: To determine the COVID-19 vaccine uptake among people with multiple sclerosis (pwMS) compared to the general population in Croatia.: Methods: Data from all pwMS entered in the MS Base register until March 24th, 2022 were extracted ... ...

Abstract	Objective: To determine the COVID-19 vaccine uptake among people with multiple sclerosis (pwMS) compared to the general population in Croatia. Methods: Data from all pwMS entered in the MS Base register until March 24th, 2022 were extracted including age, sex, MS phenotype, disease-modifying therapy (DMT), and date of COVID-19 vaccination. Data on the general population of Croatia were obtained from the vaccination register of the Croatian Institute of Public Health. Results: 64.4% pwMS were fully COVID-19 vaccinated which was comparable to 66.3% of the general population. More pwMS were fully vaccinated in the age group 20-24 (74.1% vs 51.7%), and fewer pwMS were fully vaccinated in the age group 65-69 (33.3% vs 80.4%) compared to the general population of the same age group, respectively. PwMS who received at least one dose of any COVID-19 vaccine were older (40.5 vs 37.6 years, p = 0.01), had higher EDSS (2.0 vs 1.0, p = 0.025), and had longer disease duration (6.39 vs 5.35 years, p = 0.02), were more likely to have progressive disease course (p = 0.049) and were on high efficacy DMTs (p = 0.045) compared to unvaccinated pwMS. Longer disease duration positively predicted vaccine uptake. Conclusion: Croatia has suboptimal COVID-19 vaccination uptake without a significant difference between the general population and pwMS.
MeSH term(s)	Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/therapeutic use ; Multiple Sclerosis ; Vaccination ; Croatia/epidemiology
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-06-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-023-02296-w
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Article ; Online: New resveratrol analogs as improved biologically active structures: Design, synthesis and computational modeling.

Mlakić, Milena / Odak, Ilijana / Barić, Danijela / Talić, Stanislava / Šagud, Ivana / Štefanić, Zoran / Molčanov, Krešimir / Lasić, Zlata / Kovačević, Borislav / Škorić, Irena

Bioorganic chemistry

2023 Volume 143, Page(s) 106965

Abstract: New analogs of the well-known bioactive trihydroxy-stilbene resveratrol were synthesized to investigate their potential biological activity. The focus was on assessing their ability to inhibit cholinesterase enzymes (ChEs) and their antioxidative ... ...

Abstract	New analogs of the well-known bioactive trihydroxy-stilbene resveratrol were synthesized to investigate their potential biological activity. The focus was on assessing their ability to inhibit cholinesterase enzymes (ChEs) and their antioxidative properties, which were thoroughly examined. New resveratrol analogs were synthesized through Wittig or McMurry reaction in moderate-to-good yields. In all synthetic pathways, mixtures of cis- and trans-isomers were obtained, then separated by chromatography, and trans-isomers were isolated as targeted structures. The stilbene derivatives underwent evaluation for antioxidant activity (AOA) using DPPH and CUPRAC assay, and their potential to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) was also measured. The biological tests have shown that the same compounds exhibited significant antioxidative and butyrylcholinesterase inhibitory potential, as evidenced by lower IC
MeSH term(s)	Butyrylcholinesterase/metabolism ; Acetylcholinesterase/metabolism ; Cholinesterase Inhibitors/chemistry ; Resveratrol/pharmacology ; Molecular Docking Simulation ; Structure-Activity Relationship ; Antioxidants/pharmacology
Chemical Substances	Butyrylcholinesterase (EC 3.1.1.8) ; Acetylcholinesterase (EC 3.1.1.7) ; Cholinesterase Inhibitors ; Resveratrol (Q369O8926L) ; Antioxidants
Language	English
Publishing date	2023-11-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2023.106965
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Article ; Online: Mental Health of Patients Hospitalized Due to Covid-19.

Glavina, Trpimir / Marasović, Tonka Borovina / Žuljević, Marija Franka / Rakušić, Mihaela / Mustapić, Marina / Barišić, Tanja / Uglešić, Boran / Ivelja, Mirela Pavičić / Kozina, Slavica / Lasić, Davor / Mastelić, Tonći

Clinical neuropsychiatry

2024 Volume 20, Issue 6, Page(s) 479–485

Abstract: Objective: The COVID-19 pandemic has imposed numerous challenges on the mental health of the population of each affected country. The mental health of patients hospitalized due to COVID-19 was particularly at risk. The goal of this research was to ... ...

Abstract	Objective: The COVID-19 pandemic has imposed numerous challenges on the mental health of the population of each affected country. The mental health of patients hospitalized due to COVID-19 was particularly at risk. The goal of this research was to examine the occurrence of mental disorders in such patients and what were the risk factors for poorer mental health during hospital treatment for COVID-19. Method: We included 135 subjects treated for COVID-19 who were discharged during January 2022. We collected their sociodemographic data as well as data on somatic comorbidities and treatment during hospitalization. We monitored how many patients were hospitalized with a psychiatric diagnosis and therapy, and how many of them started using psychotropic drugs during hospitalization. Those data were recorded both at the time of discharge and again one year later. Results: Statistical analysis showed that the number of patients using psychotropic drugs increased 4x (n=11 (8.1%) at admission vs. n=44 (32.6%) in hospital) during hospital treatment due to COVID-19. There was an increase in the use of all psychotropic drugs except for antidepressants; specifically, there was a 3.3x increase in treatment with anxiolytics (5.2% at admission vs. 17.0% in hospital), a 3.4x increase in treatment with antipsychotics (5.2% vs. 17.8%), and an 8x increase in treatment with hypnotics (0.7% vs. 5.9%). Their use decreased close to baseline after discharge. Conclusions: Our research showed that hospitalization due to COVID-19 leads to deterioration of mental health. We assume that there is a fear of death in the background, which can be well explained by the "landscape of fear" theory.
Language	English
Publishing date	2024-01-26
Publishing country	Italy
Document type	Journal Article
ISSN	2385-0787
ISSN (online)	2385-0787
DOI	10.36131/cnfioritieditore20230602
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Article: A Method of High-Resolution Radiotherapy Delivery Fluences with a Pair of Fields with Orthogonal Collimator Settings: A Study on Ten Head-and-Neck Cancer Patients.

Galić, Stipe / Kovačević, Marin / Lasić, Ivan / Brkić, Hrvoje / Faj, Dario

Journal of medical physics

2020 Volume 45, Issue 1, Page(s) 36–43

Abstract: Context: Introduction of dual-layer multileaf collimator (MLC) radiotherapy linear accelerators into clinical practice is an important development in advanced external beam radiotherapy. A method of delivering comparable high-resolution fluences with a ... ...

Abstract	Context: Introduction of dual-layer multileaf collimator (MLC) radiotherapy linear accelerators into clinical practice is an important development in advanced external beam radiotherapy. A method of delivering comparable high-resolution fluences with a single-layer MLC is presented. Aims: The aims of this study are to present new algorithms and approaches to define high-resolution hypermodulated fluences, obtain orthogonal decomposition of fluences, and deliver them on a linear accelerator with single MLC from two perpendicular collimator settings. Materials and methods: High-resolution fluences were defined using Monte Carlo (MC) calculation. A novel use of a limited-memory, bounded, Broyden-Fletcher-Goldfarb-Shanno algorithm was used to decompose such fluences to ones deliverable with a pair of fields with mutually orthogonal collimator settings. Such a technique, here named cross motion leaf calculator (XMLC), is compared against single sliding window (SSW) technique typically used in intensity-modulated radiation therapy (IMRT). An electronic portal imaging device (EPID) is used, and the results were compared with gamma analysis. Furthermore, MC was used to determine dose distributions for computed tomography images of ten head-and-neck cancer patients. Results: Gamma analysis (3%, 3 mm) against ideal fluence is considerably more favorable to XMLC (94% ± 4%) versus SSW (76% ± 5%). Furthermore, the dose-volume histogram (DVH) analysis showed that XMLC enables delivery of fluences superior to that of IMRT and these results in clinically relevant enhancements in DVH results. Conclusions: At the time of writing of this study, there were more than 12,000 medical linear accelerators in clinical use, and XMLC can prove itself useful wherever linac is equipped with MLC but cannot delivery latest techniques, such as volumetric modulated arc therapy.
Language	English
Publishing date	2020-03-13
Publishing country	India
Document type	Journal Article
ZDB-ID	1193902-3
ISSN	1998-3913 ; 0971-6203
ISSN (online)	1998-3913
ISSN	0971-6203
DOI	10.4103/jmp.JMP_51_19
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Zs.B 2683: Show issues

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Article: Unauthorized Food Manipulation as a Criminal Offense: Food Authenticity, Legal Frameworks, Analytical Tools and Cases.

Jurica, Karlo / Brčić Karačonji, Irena / Lasić, Dario / Bursać Kovačević, Danijela / Putnik, Predrag

Foods (Basel, Switzerland)

2021 Volume 10, Issue 11

Abstract: Food fraud is a criminal intent motivated by economic gain to adulterate or misrepresent food ingredients and packaging. The development of a reliable food supply system is at great risk under globalization, but Food Business Operators (FBOs) have a ... ...

Abstract	Food fraud is a criminal intent motivated by economic gain to adulterate or misrepresent food ingredients and packaging. The development of a reliable food supply system is at great risk under globalization, but Food Business Operators (FBOs) have a legal obligation to implement and maintain food traceability and quality at all stages of food production, processing, and distribution. Incidents of food fraud have a strong negative impact on consumer confidence in the food industry. Therefore, local and international regulatory mechanisms are established to prevent or mitigate food fraud. This review brings new perspectives linking EU and US legislation, as well as new definitions and descriptions of the criminal aspect of food fraud incidents. It also describes certain new insights into the application of state-of-the-art methods and techniques that provide valuable tools for geographic, botanical, or other chemical markers of food authenticity. The review also provides an overview of the most common cases of food fraud worldwide from 2010 to 2020. Further research is needed to support the development of predictive models for innovative approaches to adulteration, especially when some valuable nutrients are replaced by toxic ingredients. A possible solution to minimize food fraud incidents is to increase the level of risk-based inspections, establish more productive monitoring and implementation of food protection systems in the supply chain, and implement better ingredient control and certification. National and international (e.g., regional) police offices for food fraud should be introduced, possessing knowledge and skills in food, food safety, food processing, and food products, as initial positive results have emerged in some countries.
Language	English
Publishing date	2021-10-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods10112570
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Book: Liposomes

Lasic, Danilo D.

from physics to applications

1993

Author's details	D.D.Lasic
Keywords	Liposomes / chemistry ; Liposomes / therapeutic use ; Liposom
Subject	Lipidvesikel ; Phospholipidvesikel
Language	English
Size	XVIII, 575 S. : Ill., graph. Darst.
Publisher	Elsevier
Publishing place	Amsterdam u.a.
Publishing country	Netherlands
Document type	Book
HBZ-ID	HT006134673
ISBN	0-444-89548-5 ; 978-0-444-89548-6
Database	Catalogue ZB MED Medicine, Health

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