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  1. Article: Schaltkreismodell der Drogensucht: Pathophysiologie und Therapiemöglichkeiten. Der Träger des "Otto Naegeli-Preises" 2020, Prof. Dr. med. Christian Lüscher, gibt Einblick in die Forschung seiner Arbeitsgruppe

    Lüscher, C.

    Swiss medical forum

    2022  Volume 22, Issue 23/24, Page(s) 378

    Language German
    Document type Article
    ZDB-ID 2220114-2
    ISSN 1661-6138
    Database Current Contents Medicine

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  2. Article: Die Suchtfalle. Drogen wie Kokain und Heroin blockieren über neuronale Lernmechanismen unsere Fähigkeit, bewusste Entscheidungen zu treffen. Was dabei genau an den Nervenzellen vor sich geht, untersucht Christian Lüscher, Neurobiologe an der Universität Genf

    Lüscher, Christian

    Gehirn & Geist

    2009  Volume -, Issue 12, Page(s) 48

    Language German
    Document type Article
    ZDB-ID 2072879-7
    ISSN 1618-8519
    Database Current Contents Medicine

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    Zs.A 5667: Show issues Location:
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  3. Article ; Online: Invariant inhibition to calculate prediction errors?

    Creed, Meaghan C / Loureiro, Michaël / Lüscher, Christian

    Trends in neurosciences

    2023  Volume 46, Issue 4, Page(s) 257–259

    Abstract: The ventral tegmental area (VTA) has a pivotal role in motivated behavior. Much of the research on the VTA has focused on the mesocorticolimbic dopamine projections and their role in the computation of a 'reward prediction error' (RPE) for reward-guided ... ...

    Abstract The ventral tegmental area (VTA) has a pivotal role in motivated behavior. Much of the research on the VTA has focused on the mesocorticolimbic dopamine projections and their role in the computation of a 'reward prediction error' (RPE) for reward-guided learning. In a recent study, Zhou et al. report that VTA GABA neurons, the axons of which innervate the ventral pallidum (VP), have a unique role in signaling reward value to the basal ganglia and guiding reward seeking.
    MeSH term(s) Humans ; Ventral Tegmental Area/physiology ; Basal Ganglia ; Dopamine ; Reward
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2023-01-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 282488-7
    ISSN 1878-108X ; 0378-5912 ; 0166-2236
    ISSN (online) 1878-108X
    ISSN 0378-5912 ; 0166-2236
    DOI 10.1016/j.tins.2023.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: 'Ups, downs, and sideways' of dopamine in drug addiction.

    Lüscher, Christian / Pascoli, Vincent

    Trends in neurosciences

    2021  Volume 44, Issue 8, Page(s) 593–594

    MeSH term(s) Dopamine ; Humans ; Neuronal Plasticity ; Substance-Related Disorders
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2021-08-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 282488-7
    ISSN 1878-108X ; 0378-5912 ; 0166-2236
    ISSN (online) 1878-108X
    ISSN 0378-5912 ; 0166-2236
    DOI 10.1016/j.tins.2021.06.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Bugs R Us: Restoring sociability with microbiota in autism.

    Bellone, Camilla / Lüscher, Christian

    Cell reports. Medicine

    2021  Volume 2, Issue 4, Page(s) 100256

    Abstract: In a recent publication ... ...

    Abstract In a recent publication in
    MeSH term(s) Animals ; Autistic Disorder ; Bacteria ; Disease Models, Animal ; Membrane Proteins ; Mice ; Mice, Knockout ; Microbiota ; Nerve Tissue Proteins
    Chemical Substances CNTNAP2 protein, mouse ; Membrane Proteins ; Nerve Tissue Proteins
    Language English
    Publishing date 2021-04-20
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2021.100256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Consolidating the Circuit Model for Addiction.

    Lüscher, Christian / Janak, Patricia H

    Annual review of neuroscience

    2021  Volume 44, Page(s) 173–195

    Abstract: Addiction is a disease characterized by compulsive drug seeking and consumption observed in 20-30% of users. An addicted individual will favor drug reward over natural rewards, despite major negative consequences. Mechanistic research on rodents modeling ...

    Abstract Addiction is a disease characterized by compulsive drug seeking and consumption observed in 20-30% of users. An addicted individual will favor drug reward over natural rewards, despite major negative consequences. Mechanistic research on rodents modeling core components of the disease has identified altered synaptic transmission as the functional substrate of pathological behavior. While the initial version of a circuit model for addiction focused on early drug adaptive behaviors observed in all individuals, it fell short of accounting for the stochastic nature of the transition to compulsion. The model builds on the initial pharmacological effect common to all addictive drugs-an increase in dopamine levels in the mesolimbic system. Here, we consolidate this early model by integrating circuits underlying compulsion and negative reinforcement. We discuss the genetic and epigenetic correlates of individual vulnerability. Many recent data converge on a gain-of-function explanation for circuit remodeling, revealing blueprints for novel addiction therapies.
    MeSH term(s) Behavior, Addictive ; Drug-Seeking Behavior ; Humans ; Reinforcement, Psychology ; Reward ; Substance-Related Disorders
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 282459-0
    ISSN 1545-4126 ; 0147-006X
    ISSN (online) 1545-4126
    ISSN 0147-006X
    DOI 10.1146/annurev-neuro-092920-123905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1433: Show issues Location:
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  7. Article ; Online: The Emergence of a Circuit Model for Addiction.

    Lüscher, Christian

    Annual review of neuroscience

    2016  Volume 39, Page(s) 257–276

    Abstract: Addiction is a disease of altered behavior. Addicts use drugs compulsively and will continue to do so despite negative consequences. Even after prolonged periods of abstinence, addicts are at risk of relapse, particularly when cues evoke memories that ... ...

    Abstract Addiction is a disease of altered behavior. Addicts use drugs compulsively and will continue to do so despite negative consequences. Even after prolonged periods of abstinence, addicts are at risk of relapse, particularly when cues evoke memories that are associated with drug use. Rodent models mimic many of the core components of addiction, from the initial drug reinforcement to cue-associated relapse and continued drug intake despite negative consequences. Rodent models have also enabled unprecedented mechanistic insight into addiction, revealing plasticity of glutamatergic synaptic transmission evoked by the strong activation of mesolimbic dopamine-a defining feature of all addictive drugs-as a neural substrate for these drug-adaptive behaviors. Cell type-specific optogenetic manipulations have allowed both identification of the relevant circuits and design of protocols to reverse drug-evoked plasticity and to establish links of causality with drug-adaptive behaviors. The emergence of a circuit model for addiction will open the door for novel therapies, such as deep brain stimulation.
    Language English
    Publishing date 2016-07-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 282459-0
    ISSN 1545-4126 ; 0147-006X
    ISSN (online) 1545-4126
    ISSN 0147-006X
    DOI 10.1146/annurev-neuro-070815-013920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Towards on-skin analysis of sweat for managing disorders of substance abuse.

    Brasier, Noe / Sempionatto, Juliane R / Bourke, Steven / Havenith, George / Schaffarczyk, Dietmar / Goldhahn, Jörg / Lüscher, Christian / Gao, Wei

    Nature biomedical engineering

    2024  

    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article
    ISSN 2157-846X
    ISSN (online) 2157-846X
    DOI 10.1038/s41551-024-01187-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bugs R Us

    Camilla Bellone / Christian Lüscher

    Cell Reports Medicine, Vol 2, Iss 4, Pp 100256- (2021)

    Restoring sociability with microbiota in autism

    2021  

    Abstract: In a recent publication in Cell, Buffington et al. provide a fascinating example of hologenomic behavioral regulation in an autism mouse model.1 The authors report that gut bacteria from wild-type mice rescue the social deficit of Cntnap2 knockout mice. ...

    Abstract In a recent publication in Cell, Buffington et al. provide a fascinating example of hologenomic behavioral regulation in an autism mouse model.1 The authors report that gut bacteria from wild-type mice rescue the social deficit of Cntnap2 knockout mice.
    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: "L'addiction represente le côté obscur de l'apprentissage".

    Lüscher, Christian

    Revue medicale suisse

    2014  Volume 10, Issue 412-413, Page(s) 5–8

    Title translation Addiction represents the dark side of Learning.
    MeSH term(s) Compulsive Behavior/complications ; Compulsive Behavior/psychology ; Conditioning (Psychology)/physiology ; Deep Brain Stimulation ; Humans ; Learning/physiology ; Neurology/trends ; Neuronal Plasticity/physiology ; Psychiatry/trends ; Reward ; Street Drugs ; Substance-Related Disorders/etiology ; Substance-Related Disorders/psychology ; Video Games
    Chemical Substances Street Drugs
    Language French
    Publishing date 2014-01-15
    Publishing country Switzerland
    Document type Interview
    ZDB-ID 2177010-4
    ISSN 1660-9379
    ISSN 1660-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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