LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 30

Search options

  1. Article ; Online: The Intestinal Microbiome and the Metabolic Syndrome-How Its Manipulation May Affect Metabolic-Associated Fatty Liver Disease (MAFLD).

    Malnick, Stephen D H / Ohayon Michael, Sheral

    Current issues in molecular biology

    2023  Volume 45, Issue 9, Page(s) 7197–7211

    Abstract: Metabolic-associated fatty liver disease (MAFLD) is now the predominant liver disease worldwide consequent to the epidemic of obesity. The intestinal microbiome (IM), consisting of the bacteria, fungi, archaea, and viruses residing in the ... ...

    Abstract Metabolic-associated fatty liver disease (MAFLD) is now the predominant liver disease worldwide consequent to the epidemic of obesity. The intestinal microbiome (IM), consisting of the bacteria, fungi, archaea, and viruses residing in the gastrointestinal tract, plays an important role in human metabolism and preserving the epithelial barrier function. Disturbances in the IM have been shown to influence the development and progression of MAFLD and play a role in the development of metabolic syndrome (MS). The main treatment for MAFLD involves lifestyle changes, which also influence the IM. Manipulation of the IM by fecal microbial transplantation (FMT) has been approved for the treatment of recurrent
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2000024-8
    ISSN 1467-3045 ; 1467-3037
    ISSN (online) 1467-3045
    ISSN 1467-3037
    DOI 10.3390/cimb45090455
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5122: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Checkpoint Inhibitors and Hepatotoxicity

    Stephen D. H. Malnick / Ali Abdullah / Manuela G. Neuman

    Biomedicines, Vol 9, Iss 2, p

    2021  Volume 101

    Abstract: ... their antibodies may enhance the immune system’s response to tumors. Currently, immunomodulatory agents have been ...

    Abstract Uncontrolled immune response to a pathogen or any protein can lead to tissue damage and autoimmune diseases, that represent aberrant immune responses of the individual to its own cells and/or proteins. The immune checkpoint system is the regulatory mechanism that controls immune responses. Tumor cells escape the immune surveillance mechanism, avoiding immune detection and elimination by activating these checkpoints and suppressing the anti-tumor response, thus allowing formation of tumors. Antigenic modulation facilitates masking and contributes to the escape of tumor cells. In addition, there are growing cell promoters, like transforming growth factor β (TGF-β), contributing to escape mechanisms. Targeting the immunological escape of malignant cells is the basis of immune oncology. Checkpoint inhibitors, cytokines and their antibodies may enhance the immune system’s response to tumors. Currently, immunomodulatory agents have been designed, evaluated in clinical trials and have been approved by both European and United States Drug Agencies. The present review is a reflection of the increasingly important role of the checkpoint inhibitors. Our aim is to review the side effects with the emphasis on hepatic adverse reactions of these novel biological drug interventions.
    Keywords checkpoint inhibitors ; hepatotoxicity ; drug induced liver injury ; tumor cells ; immunological escape ; malignant cells ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Liraglutide-Induced Hepatotoxicity

    Yaakov Maor / David Ergaz / Stephen D. H. Malnick / Ehud Melzer / Manuela G. Neuman

    Biomedicines, Vol 9, Iss 2, p

    2021  Volume 106

    Abstract: ... associated with the drug’s mechanism of action. Personalized medicine and therapeutic pharmacovigilance ...

    Abstract A 52-year-old woman with a BMI of 31.2 kg/m 2 was treated with the glucagon-like peptide 1 (GLP-1) agonist liraglutide as part of her weight-reduction program. Following this, she developed an idiosyncratic drug-related liver injury (IDILI). Advances in noninvasive techniques enabled this diagnosis to be established. By employing easily quantifiable methods based on serum biomarkers, we could explore a wide variety of endpoints in assessing personalized DILI. In addition, we can test endpoints that are associated with the drug’s mechanism of action. Personalized medicine and therapeutic pharmacovigilance of incretin-based hypoglycemic agents are needed to ensure the safety of patients.
    Keywords drug-induced liver injury ; liraglutide-induced immune hepatitis ; lymphocyte toxicity assay ; personalized medicine ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Cryptogenic stroke and atrial fibrillation.

    Malnick, Stephen D H / Somin, Marina / Goland, Sorel

    The New England journal of medicine

    2014  Volume 371, Issue 13, Page(s) 1259–1260

    MeSH term(s) Atrial Fibrillation/diagnosis ; Electrocardiography, Ambulatory ; Female ; Humans ; Ischemic Attack, Transient/etiology ; Male ; Stroke/etiology
    Language English
    Publishing date 2014-09-25
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1409495#SA2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.34: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: The medical complications of obesity.

    Malnick, S D H / Knobler, H

    QJM : monthly journal of the Association of Physicians

    2006  Volume 99, Issue 9, Page(s) 565–579

    MeSH term(s) Adolescent ; Adult ; Aged ; Cardiovascular Diseases/etiology ; Digestive System Diseases/etiology ; Female ; Female Urogenital Diseases/etiology ; Genital Diseases, Male/etiology ; Humans ; Male ; Metabolic Diseases/etiology ; Middle Aged ; Neoplasms/etiology ; Obesity/complications ; Osteoarthritis/etiology ; Postoperative Complications/etiology ; Pregnancy ; Respiratory Tract Diseases/etiology ; Risk Factors
    Language English
    Publishing date 2006-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 1460-2725 ; 0033-5622
    ISSN (online) 1460-2393
    ISSN 1460-2725 ; 0033-5622
    DOI 10.1093/qjmed/hcl085
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Alcohol: basic and translational research; 15th annual Charles Lieber &1st Samuel French satellite symposium.

    Neuman, Manuela G / Seitz, Helmut K / Tuma, Pamela L / Osna, Natalia A / Casey, Carol A / Kharbanda, Kusum K / Cohen, Lawrence B / Malnick, Steve D H / Adhikari, Raghabendra / Mitra, Ramyajit / Dagur, Raghubendra Singh / Ganesan, Murali / Srinivas, Chava / Madan Kumar, Arumugam / New-Aaron, Moses / Poluektova, Larisa / Thomes, Paul G / Rasineni, Karuna / Opris, Mihai /
    Teschke, Rolf

    Experimental and molecular pathology

    2022  Volume 126, Page(s) 104750

    Abstract: ... Professors C.S. Lieber and S.W. French. The invited speakers described pharmacological, toxicological and ...

    Abstract The present review is based on the research presented at the symposium dedicated to the legacy of the two scientists that made important discoveries in the field of alcohol-induced liver damage: Professors C.S. Lieber and S.W. French. The invited speakers described pharmacological, toxicological and patho-physiological effects of alcohol misuse. Moreover, genetic biomarkers determining adverse drug reactions due to interactions between therapeutics used for chronic or infectious diseases and alcohol exposure were discussed. The researchers presented their work in areas of alcohol-induced impairment in lipid protein trafficking and endocytosis, as well as the role of lipids in the development of fatty liver. The researchers showed that alcohol leads to covalent modifications that promote hepatic dysfunction and injury. We concluded that using new advanced techniques and research ideas leads to important discoveries in science.
    MeSH term(s) Ethanol ; Humans ; Liver ; Liver Diseases, Alcoholic/genetics ; Translational Research, Biomedical
    Chemical Substances Ethanol (3K9958V90M)
    Language English
    Publishing date 2022-02-19
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 207655-x
    ISSN 1096-0945 ; 0014-4800
    ISSN (online) 1096-0945
    ISSN 0014-4800
    DOI 10.1016/j.yexmp.2022.104750
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 183: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Non-alcoholic fatty liver: a common manifestation of a metabolic disorder.

    Malnick, S D H / Beergabel, M / Knobler, H

    QJM : monthly journal of the Association of Physicians

    2003  Volume 96, Issue 10, Page(s) 699–709

    MeSH term(s) Algorithms ; Antioxidants/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Fatty Liver/diagnosis ; Fatty Liver/metabolism ; Fatty Liver/therapy ; Humans ; Hyperlipidemias/complications ; Hypolipidemic Agents/therapeutic use ; Insulin Resistance/physiology ; Liver Transplantation/methods ; Obesity/complications ; Prevalence ; Risk Factors ; Ursodeoxycholic Acid/therapeutic use
    Chemical Substances Antioxidants ; Hypolipidemic Agents ; Ursodeoxycholic Acid (724L30Y2QR)
    Language English
    Publishing date 2003-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 1460-2725 ; 0033-5622
    ISSN (online) 1460-2393
    ISSN 1460-2725 ; 0033-5622
    DOI 10.1093/qjmed/hcg120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.131: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article: [Shared residency training in internal medicine--a need for the 21st century].

    Malnick, Stephen D H / Mildiner, Sorcha / Jotkowitz, Ian

    Harefuah

    2007  Volume 146, Issue 11, Page(s) 857–9, 909

    Abstract: The crisis that has enveloped internal medicine over the past decade has resulted in difficulties in attracting the best and brightest graduates to this specialization. Since an increasing number of graduates are female, there is often a conflict between ...

    Abstract The crisis that has enveloped internal medicine over the past decade has resulted in difficulties in attracting the best and brightest graduates to this specialization. Since an increasing number of graduates are female, there is often a conflict between raising a family and completing demanding postgraduate medical training. We suggest that serious consideration be given to part-time training in internal medicine in Israel. This article outlines our proposal and reports experience in other countries that supports the concept of postgraduate training in a part-time position. We suggest that this idea is suited to internal medicine and should be seriously considered by the regulatory authorities.
    MeSH term(s) Female ; Humans ; Internal Medicine/education ; Internal Medicine/trends ; Internship and Residency/trends ; Israel ; Male ; Physicians, Women/statistics & numerical data
    Language Hebrew
    Publishing date 2007-11
    Publishing country Israel
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 953872-0
    ISSN 0017-7768
    ISSN 0017-7768
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 291: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: An unusual case of endocarditis.

    Malnick, Stephen D H / Shimoni, Sara / Zimhony, Oren

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2006  Volume 174, Issue 8, Page(s) 1087–1088

    MeSH term(s) Adult ; Ductus Arteriosus, Patent/complications ; Ductus Arteriosus, Patent/surgery ; Endocarditis, Bacterial/diagnosis ; Female ; Heart Murmurs/etiology ; Humans ; Lung Diseases/etiology ; Pulmonary Artery/pathology
    Language English
    Publishing date 2006-04-10
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.051592
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.136: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Chronic ischaemic bowel diseases in the aged--go with the flow.

    Korotinski, Svetlana / Katz, Allan / Malnick, Stephen D H

    Age and ageing

    2005  Volume 34, Issue 1, Page(s) 10–16

    Abstract: Background: Intestinal ischaemia is caused by a reduction in intestinal blood flow. This entity is being increasingly recognised as a cause of abdominal symptoms but is often not diagnosed accurately. Chronic mesenteric ischaemia (intestinal angina) ... ...

    Abstract Background: Intestinal ischaemia is caused by a reduction in intestinal blood flow. This entity is being increasingly recognised as a cause of abdominal symptoms but is often not diagnosed accurately. Chronic mesenteric ischaemia (intestinal angina) refers to chronic post-prandial abdominal pain caused by intestinal hypoperfusion usually related to atherosclerosis. Colonic ischaemia refers to colonic injury as a result of hypoperfusion and is also referred to as ischaemic colitis.
    Methods: Review of the English-language medical literature, with the key words diagnosis, treatment, chronic mesenteric ischaemia and colonic ischaemia.
    Conclusion: There is a lack of evidence based on randomised controlled clinical trials for both the diagnosis and treatment of mesenteric ischaemia. A high index of clinical suspicion is important to facilitate rapid diagnosis. Chronic mesenteric ischaemia can be accurately diagnosed by non-invasive CT and MRI techniques, and less so by duplex ultrasound. In order to confirm the diagnosis, demonstration of the involvement of at least two of the main splanchnic vessels is required. Successful treatment involving both percutaneous and surgical revascularisation is available. Colonic ischaemia requires sequential diagnostic techniques and the majority of cases resolve with supportive treatment. More severe cases may require surgical intervention.
    MeSH term(s) Aged ; Chronic Disease ; Colitis, Ischemic/diagnosis ; Colitis, Ischemic/therapy ; Humans ; Intestines/blood supply ; Ischemia/diagnosis ; Ischemia/etiology ; Ischemia/therapy
    Language English
    Publishing date 2005-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186788-x
    ISSN 1468-2834 ; 0002-0729
    ISSN (online) 1468-2834
    ISSN 0002-0729
    DOI 10.1093/ageing/afh226
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 877: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 448: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top