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  1. Article: "I've smoked weed with my daughter": Cannabis Use within Families Affected by Parental Opioid Misuse.

    Powell, Terrinieka W / Offiong, Asari / Lewis, Quiana / Prioleau, Morgan / Smith, Bianca / Johnson, Renee M

    Children and youth services review

    2023  Volume 155

    Abstract: Youth with parents who use opioids are more likely to engage in early substance use, especially cannabis use. The purpose of this study was to describe the context of cannabis use among families affected by parental opioid misuse. We conducted 25 in- ... ...

    Abstract Youth with parents who use opioids are more likely to engage in early substance use, especially cannabis use. The purpose of this study was to describe the context of cannabis use among families affected by parental opioid misuse. We conducted 25 in-depth interviews with families affected by parental opioid misuse. Participants were parents with a history of opioid misuse and young adults (ages 18-24) who had parents with a history of opioid misuse. Interviews were digitally recorded and professionally transcribed. Data were analyzed inductively using a qualitative content analytic approach. Familial cannabis use was common among young people and their parents. Participants described familial cannabis use as a bonding activity that felt safe and lightened the mood. Additional research is needed to understand the complex role that cannabis use may play in families affected by opioid misuse. Strategies for intergenerational substance use prevention are discussed.
    Language English
    Publishing date 2023-10-15
    Publishing country England
    Document type Journal Article
    ISSN 0190-7409
    ISSN 0190-7409
    DOI 10.1016/j.childyouth.2023.107235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Field evaluation of semi-automated moisture estimation from geophysics using machine learning.

    Terry, Neil / Day-Lewis, Frederick D / Lane, John W / Johnson, Carole D / Werkema, Dale

    Vadose zone journal : VZJ

    2023  Volume 22, Issue 2

    Abstract: Geophysical methods can provide three-dimensional (3D), spatially continuous estimates of soil moisture. However, point-to-point comparisons of geophysical properties to measure soil moisture data are frequently unsatisfactory, resulting in geophysics ... ...

    Abstract Geophysical methods can provide three-dimensional (3D), spatially continuous estimates of soil moisture. However, point-to-point comparisons of geophysical properties to measure soil moisture data are frequently unsatisfactory, resulting in geophysics being used for qualitative purposes only. This is because (1) geophysics requires models that relate geophysical signals to soil moisture, (2) geophysical methods have potential uncertainties resulting from smoothing and artifacts introduced from processing and inversion, and (3) results from multiple geophysical methods are not easily combined within a single soil moisture estimation framework. To investigate these potential limitations, an irrigation experiment was performed wherein soil moisture was monitored through time, and several surface geophysical datasets indirectly sensitive to soil moisture were collected before and after irrigation: ground penetrating radar, electrical resistivity tomography (ERT), and frequency domain electromagnetics (FDEM). Data were exported in both raw and processed form, and then snapped to a common 3D grid to facilitate moisture prediction by standard calibration techniques, multivariate regression, and machine learning. A combination of inverted ERT data, raw FDEM, and inverted FDEM data was most informative for predicting soil moisture using a random regression forest model (one-thousand 60/40 training/test cross-validation folds produced root mean squared errors ranging from 0.025-0.046 cm
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2088189-7
    ISSN 1539-1663
    ISSN 1539-1663
    DOI 10.1002/vzj2.20246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sterility of antibiotic-admixed peritoneal dialysis solution over time.

    Tan, Ken-Soon / Rogers, Robyn / Shephard, Deanna / Lewis, Amanda / George, Narelle / Johnson, David W

    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

    2023  , Page(s) 8968608231213736

    Abstract: Background: Intraperitoneal antibiotics may be required daily for up to three weeks to treat peritoneal dialysis (PD)-related peritonitis. In some jurisdictions, antibiotic-admixed PD solutions are required to be used within 24 h due to concerns ... ...

    Abstract Background: Intraperitoneal antibiotics may be required daily for up to three weeks to treat peritoneal dialysis (PD)-related peritonitis. In some jurisdictions, antibiotic-admixed PD solutions are required to be used within 24 h due to concerns regarding microbial contamination and growth. This requires patients to attend the PD unit daily or alternatively for staff to perform home delivery with associated transport, staffing and cost implications.
    Objective: The aim of this study was to determine if significant microbial growth occurs in PD solutions following their injection with antibiotic or sterile water.
    Methods: Twelve PD solution bags were admixed with cefazolin sodium 1 g, diluted in 10 mL sterile water, while a further 12 PD solution bags were admixed with 10 mL sterile water using aseptic technique (AT) under supervision. All bags were stored at room temperature. Three bags from each experimental group were sampled for microbiologic culture at 0-, 24-, 48- and 72-h intervals.
    Results: One sterile water admixed bag sampled at 24 h yielded a
    Conclusions: Antibiotic-admixed PD solutions prepared using AT and stored at room temperature remained sterile for up to 72 h. This suggests that patients can be safely issued with a supply of antibiotic-admixed PD bags for up to three days at a time.
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645010-6
    ISSN 1718-4304 ; 0896-8608
    ISSN (online) 1718-4304
    ISSN 0896-8608
    DOI 10.1177/08968608231213736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Malnutrition, sarcopenia and cachexia: exploring prevalence, overlap, and perceptions in older adults with cancer.

    Bullock, Alex F / Patterson, Michael J / Paton, Lewis W / Currow, David C / Johnson, Miriam J

    European journal of clinical nutrition

    2024  

    Abstract: Background: Older adults with cancer are a growing population requiring tailored care to achieve optimum treatment outcomes. Their care is complicated by under-recognised and under-treated wasting disorders: malnutrition, sarcopenia, and cachexia. We ... ...

    Abstract Background: Older adults with cancer are a growing population requiring tailored care to achieve optimum treatment outcomes. Their care is complicated by under-recognised and under-treated wasting disorders: malnutrition, sarcopenia, and cachexia. We aimed to investigate the prevalence, overlap, and patients' views and experiences of malnutrition, sarcopenia, and cachexia, in older adults with cancer.
    Methods: Mixed-methods study with cross-sectional study and qualitative interviews. Interviews were thematically analysed through a phenomenological lens, with feedback loop analysis investigating relationships between themes and findings synthesised using modified critical interpretative synthesis.
    Findings: n = 30 were screened for malnutrition, sarcopenia, and cachexia, n = 8 completed semi-structured interviews. Eighteen (60.0%) were malnourished, 16 (53.3%) sarcopenic, and 17 (56.7%) cachexic. One or more condition was seen in 80%, and all three in 30%. In univariate analysis, Rockwood clinical frailty score (OR 2.94 [95% CI: 1.26-6.89, p = 0.013]) was associated with sarcopenia, reported percentage meal consumption (OR 2.28 [95% CI: 1.24-4.19, p = 0.008]), and visible wasting (OR 8.43 [95% CI: 1.9-37.3] p = 0.005) with malnutrition, and percentage monthly weight loss (OR 8.71 [95% CI: 1.87-40.60] p = 0.006) with cachexia. Screening tools identified established conditions rather than 'risk'. Nutritional and functional problems were often overlooked, overshadowed, and misunderstood by both patients and (in patients' perceptions) by clinicians; misattributed to ageing, cancer, or comorbidities. Patients viewed these conditions as both personal impossibilities, yet accepted inevitabilities.
    Conclusion: Perceptions, identification, and management of these conditions needs to improve, and their importance recognised by clinicians and patients so those truly 'at risk' are identified whilst conditions are more remediable to interventions.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 639358-5
    ISSN 1476-5640 ; 0954-3007
    ISSN (online) 1476-5640
    ISSN 0954-3007
    DOI 10.1038/s41430-024-01433-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prognosis of Periodic and Rhythmic Patterns in Adult and Pediatric Populations.

    Lewis, Dalila W / Johnson, Emily L

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2018  Volume 35, Issue 4, Page(s) 303–308

    Abstract: Although electrographic seizures are known to have an outcome on clinical prognosis, the implications of periodic and rhythmic patterns are less clear. The outcomes of adults with these patterns have been reported and are often poor; however, the ... ...

    Abstract Although electrographic seizures are known to have an outcome on clinical prognosis, the implications of periodic and rhythmic patterns are less clear. The outcomes of adults with these patterns have been reported and are often poor; however, the outcomes in pediatric populations are less well characterized and may be different than in the adult population, as the etiologies of periodic and rhythmic patterns may differ in children and adults. In adults, generalized periodic discharges are highly associated with toxic-metabolic disturbances, infection, and anoxic injury; 30% to 64% of patients have poor outcomes. By contrast, in pediatric patients, generalized periodic discharges are more commonly associated with refractory status epilepticus, with good outcomes in 50% to 77%. The underlying etiology of the periodic or rhythmic pattern has a large influence on overall morbidity and mortality.
    MeSH term(s) Brain/physiology ; Brain/physiopathology ; Electroencephalography ; Humans ; Periodicity ; Prognosis ; Seizures/diagnosis ; Seizures/etiology ; Seizures/physiopathology
    Language English
    Publishing date 2018-09-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000000442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Practical Overview of

    Mercer, Megan K / Revels, Jonathan W / Blacklock, Lisa C / Banks, Kevin P / Johnson, Lester S / Lewis, David H / Kuo, Phillip H / Wilson, Shannon / Elojeimy, Saeed

    Radiographics : a review publication of the Radiological Society of North America, Inc

    2024  Volume 44, Issue 2, Page(s) e230133

    Abstract: Parkinsonian syndromes are a heterogeneous group of progressive neurodegenerative disorders involving the nigrostriatal dopaminergic pathway and are characterized by a wide spectrum of motor and nonmotor symptoms. These syndromes are quite common and can ...

    Abstract Parkinsonian syndromes are a heterogeneous group of progressive neurodegenerative disorders involving the nigrostriatal dopaminergic pathway and are characterized by a wide spectrum of motor and nonmotor symptoms. These syndromes are quite common and can profoundly impact the lives of patients and their families. In addition to classic Parkinson disease, parkinsonian syndromes include multiple additional disorders known collectively as Parkinson-plus syndromes or atypical parkinsonism. These are characterized by the classic parkinsonian motor symptoms with additional distinguishing clinical features. Dopamine transporter SPECT has been developed as a diagnostic tool to assess the levels of dopamine transporters in the striatum. This imaging assessment, which uses iodine 123 (
    MeSH term(s) Humans ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Parkinsonian Disorders/diagnostic imaging ; Parkinsonian Disorders/metabolism ; Nortropanes ; Tomography, Emission-Computed, Single-Photon/methods ; Iodine Radioisotopes
    Chemical Substances Dopamine Plasma Membrane Transport Proteins ; ioflupane (VF232WE742) ; Nortropanes ; Iodine-123 (8YWR746RPQ) ; Iodine Radioisotopes
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603172-9
    ISSN 1527-1323 ; 0271-5333
    ISSN (online) 1527-1323
    ISSN 0271-5333
    DOI 10.1148/rg.230133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: A novel method for measuring the burden of breast cancer in neighborhoods.

    McIntire, Russell K / Juon, Hee-Soon / Keith, Scott W / Simone, Nicole L / Waters, Dexter / Lewis, Eleanor / Zeigler-Johnson, Charnita

    Preventive medicine reports

    2023  Volume 33, Page(s) 102218

    Abstract: Community-based breast cancer prevention efforts often focus on women who live in the same neighborhoods, as they tend to have similar demographic characteristics, health behaviors, and environmental exposures; yet little research describes methods of ... ...

    Abstract Community-based breast cancer prevention efforts often focus on women who live in the same neighborhoods, as they tend to have similar demographic characteristics, health behaviors, and environmental exposures; yet little research describes methods of selecting neighborhoods of focus for community-based cancer prevention interventions. Studies frequently use demographics from census data, or single breast cancer outcomes (e.g., mortality, morbidity) in order to choose neighborhoods of focus for breast cancer interventions, which may not be optimal. This study presents a novel method for measuring the burden of breast cancer among neighborhoods that could be used for selecting neighborhoods of focus. In this study, we 1) calculate a metric composed of multiple breast cancer outcomes to describe the burden of breast cancer in census tracts Philadelphia, PA, USA; 2) map the neighborhoods with the greatest breast cancer burden; and 3) compare census tracts with the highest burden of breast cancer to those with demographics sometimes used for geo-based prioritization, i.e., race and income. The results of our study showed that race or income may not be appropriate proxies for neighborhood breast cancer burden; comparing the breast cancer burden with demographics at the census tract level, we found few overlaps with the highest percentage African American or the lowest median incomes. Agencies implementing community-based breast cancer interventions should consider this method to inform the selection of neighborhoods for breast cancer prevention interventions, including education, screening, and treatment.
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2785569-7
    ISSN 2211-3355
    ISSN 2211-3355
    DOI 10.1016/j.pmedr.2023.102218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A Review of Theranostics: Perspectives on Emerging Approaches and Clinical Advancements.

    Burkett, Brian J / Bartlett, David J / McGarrah, Patrick W / Lewis, Akeem R / Johnson, Derek R / Berberoğlu, Kezban / Pandey, Mukesh K / Packard, Annie T / Halfdanarson, Thorvardur R / Hruska, Carrie B / Johnson, Geoffrey B / Kendi, A Tuba

    Radiology. Imaging cancer

    2023  Volume 5, Issue 4, Page(s) e220157

    Abstract: Theranostics is the combination of two approaches-diagnostics and therapeutics-applied for decades in cancer imaging using radiopharmaceuticals or paired radiopharmaceuticals to image and selectively treat various cancers. The clinical use of ... ...

    Abstract Theranostics is the combination of two approaches-diagnostics and therapeutics-applied for decades in cancer imaging using radiopharmaceuticals or paired radiopharmaceuticals to image and selectively treat various cancers. The clinical use of theranostics has increased in recent years, with U.S. Food and Drug Administration (FDA) approval of lutetium 177 (
    MeSH term(s) United States ; Male ; Humans ; Precision Medicine ; Radiopharmaceuticals/therapeutic use ; Positron Emission Tomography Computed Tomography ; Radioisotopes/therapeutic use ; Neoplasms/diagnostic imaging ; Neoplasms/therapy
    Chemical Substances Radiopharmaceuticals ; Radioisotopes
    Language English
    Publishing date 2023-07-16
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2638-616X
    ISSN (online) 2638-616X
    DOI 10.1148/rycan.220157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Proteome-Wide Response of Dormant Caryopses of the Weed,

    Lewis, Ricky W / Okubara, Patricia A / Sullivan, Tarah S / Madden, Benjamin J / Johnson, Kenneth L / Charlesworth, M Cristine / Fuerst, E Patrick

    Phytopathology

    2022  Volume 112, Issue 5, Page(s) 1103–1117

    Abstract: Promoting seed decay is an ecological approach to reducing weed persistence in the soil seedbank. Previous work demonstrated ... ...

    Abstract Promoting seed decay is an ecological approach to reducing weed persistence in the soil seedbank. Previous work demonstrated that
    MeSH term(s) Avena ; Fusarium ; Heat-Shock Proteins/metabolism ; Plant Diseases ; Proteome ; Proteomics ; Seeds/physiology ; Soil
    Chemical Substances Heat-Shock Proteins ; Proteome ; Soil
    Language English
    Publishing date 2022-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208889-7
    ISSN 1943-7684 ; 0031-949X
    ISSN (online) 1943-7684
    ISSN 0031-949X
    DOI 10.1094/PHYTO-06-21-0234-R
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Improved Disease-Free Survival With Adjuvant Chemotherapy After Nephroureterectomy for Upper Tract Urothelial Cancer: Final Results of the POUT Trial.

    Birtle, Alison Jane / Jones, Robert / Chester, John / Lewis, Rebecca / Biscombe, Katie / Johnson, Mark / Blacker, Anthony / Bryan, Richard T / Catto, James W F / Choudhury, Ananya / Das, Prantik / Jagdev, Satinder / Powles, Thomas / Wagstaff, John / Cheung, Ka Ching / Cafferty, Fay / Hall, Emma

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2024  Volume 42, Issue 13, Page(s) 1466–1471

    Abstract: Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial ... ...

    Abstract Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in
    MeSH term(s) Humans ; Nephroureterectomy/methods ; Chemotherapy, Adjuvant ; Female ; Disease-Free Survival ; Male ; Aged ; Middle Aged ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/mortality ; Carcinoma, Transitional Cell/surgery ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Urologic Neoplasms/drug therapy ; Urologic Neoplasms/mortality ; Urologic Neoplasms/surgery ; Urologic Neoplasms/pathology ; Ureteral Neoplasms/drug therapy ; Ureteral Neoplasms/mortality ; Ureteral Neoplasms/surgery ; Ureteral Neoplasms/pathology ; Kidney Neoplasms/drug therapy ; Kidney Neoplasms/mortality ; Kidney Neoplasms/surgery ; Kidney Neoplasms/pathology
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Clinical Trial, Phase III ; Research Support, Non-U.S. Gov't ; Multicenter Study
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.23.01659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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