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Article ; Online: E-Suture: Mixed-Conducting Suture for Medical Devices.

Rauhala, Onni J / Ma, Liang / Wisniewski, Duncan J / Shao, Shan / Schumacher, Brandon / Lopez, Jose Ferrero / Kaspers, Mara / Zhao, Zifang / Gelinas, Jennifer N / Khodagholy, Dion

Advanced healthcare materials

2023 , Page(s) e2302613

Abstract: ... carriers. Here, a mixed-conducting suture, the e-suture, is presented. Composed of silk, the conducting ... polymers,the resulting e-suture has mixed-conducting properties at the interface with biological tissue ... as well as effective insulation along its length. The e-suture can be mechanically integrated ...

Abstract	Modern implantable bioelectronics demand soft, biocompatible components that make robust, low-impedance connections with the body and circuit elements. Concurrently, such technologies must demonstrate high efficiency, with the ability to interface between the body's ionic and external electronic charge carriers. Here, a mixed-conducting suture, the e-suture, is presented. Composed of silk, the conducting polymer poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), and insulating jacketing polymers,the resulting e-suture has mixed-conducting properties at the interface with biological tissue as well as effective insulation along its length. The e-suture can be mechanically integrated into electronics, enabling the acquisition of biopotentials such as electrocardiograms, electromyograms, and local field potentials (LFP). Chronic, in vivo acquisition of LFP with e-sutures remains stable for months with robust brain activity patterns. Furthermore, e-sutures can establish electrophoretic-based local drug delivery, potentially offering enhanced anatomical targeting and decreased side effects associated with systemic administration, while maintaining an electrically conducting interface for biopotential monitoring. E-sutures expand on the conventional role of sutures and wires by providing a soft, biocompatible, and mechanically sound structure that additionally has multifunctional capacity for sensing, stimulation, and drug delivery.
Language	English
Publishing date	2023-12-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202302613
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Article ; Online: A Novel Xeno-Free Method to Isolate Human Endometrial Mesenchymal Stromal Cells (E-MSCs) in Good Manufacturing Practice (GMP) Conditions.

Canosa, Stefano / Mareschi, Katia / Marini, Elena / Carosso, Andrea Roberto / Castiglia, Sara / Rustichelli, Deborah / Ferrero, Ivana / Gennarelli, Gianluca / Bussolati, Benedetta / Nocifora, Alberto / Asnaghi, Valentina / Bergallo, Massimiliano / Isidoro, Ciro / Benedetto, Chiara / Revelli, Alberto / Fagioli, Franca

International journal of molecular sciences

2022 Volume 23, Issue 4

Abstract: ... of endometrial mesenchymal stromal cells (E-MSCs). Due to this, the autologous infusion of E-MSCs has been ... and to validate a novel xeno-free method to culture human E-MSCs. Six E-MSCs cell samples were ... isolated after mechanical tissue homogenization and cultured using human platelet lysate. E-MSCs were ...

Abstract	The cyclic regeneration of human endometrium is guaranteed by the proliferative capacity of endometrial mesenchymal stromal cells (E-MSCs). Due to this, the autologous infusion of E-MSCs has been proposed to support endometrial growth in a wide range of gynecological diseases. We aimed to compare two different endometrial sampling methods, surgical curettage and vacuum aspiration biopsy random assay (VABRA), and to validate a novel xeno-free method to culture human E-MSCs. Six E-MSCs cell samples were isolated after mechanical tissue homogenization and cultured using human platelet lysate. E-MSCs were characterized for the colony formation capacity, proliferative potential, and multilineage differentiation. The expression of mesenchymal and stemness markers were tested by FACS analysis and real-time PCR, respectively. Chromosomal alterations were evaluated by karyotype analysis, whereas tumorigenic capacity and invasiveness were tested by soft agar assay. Both endometrial sampling techniques allowed efficient isolation and expansion of E-MSCs using a xeno-free method, preserving their mesenchymal and stemness phenotype, proliferative potential, and limited multi-lineage differentiation ability during the culture. No chromosomal alterations and invasive/tumorigenic capacity were observed. Herein, we report the first evidence of efficient E-MSCs isolation and culture in Good Manufacturing Practice compliance conditions, suggesting VABRA endometrial sampling as alternative to surgical curettage.
MeSH term(s)	Adult ; Biomarkers/metabolism ; Bone Marrow Cells/cytology ; Cell Culture Techniques/methods ; Cell Differentiation/physiology ; Cell Proliferation/physiology ; Cells, Cultured ; Endometrium/cytology ; Endometrium/metabolism ; Female ; Humans ; Mesenchymal Stem Cells/cytology ; Young Adult
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23041931
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Article ; Online: Measurement of the Cross Sections of Ξ_{c}^{0} and Ξ_{c}^{+} Baryons and of the Branching-Fraction Ratio BR(Ξ_{c}^{0}→Ξ^{-}e^{+}ν_{e})/BR(Ξ_{c}^{0}→Ξ^{-}π^{+}) in pp Collisions at sqrt[s]=13 TeV.

Acharya, S / Adamová, D / Adler, A / Adolfsson, J / Aglieri Rinella, G / Agnello, M / Agrawal, N / Ahammed, Z / Ahmad, S / Ahn, S U / Ahuja, I / Akbar, Z / Akindinov, A / Al-Turany, M / Alam, S N / Aleksandrov, D / Alessandro, B / Alfanda, H M / Alfaro Molina, R /

Ali, B / Ali, Y / Alici, A / Alizadehvandchali, N / Alkin, A / Alme, J / Alt, T / Altenkamper, L / Altsybeev, I / Anaam, M N / Andrei, C / Andreou, D / Andronic, A / Angeletti, M / Anguelov, V / Antinori, F / Antonioli, P / Anuj, C / Apadula, N / Aphecetche, L / Appelshäuser, H / Arcelli, S / Arnaldi, R / Arsene, I C / Arslandok, M / Augustinus, A / Averbeck, R / Aziz, S / Azmi, M D / Badalà, A / Baek, Y W / Bai, X / Bailhache, R / Bailung, Y / Bala, R / Balbino, A / Baldisseri, A / Balis, B / Ball, M / Banerjee, D / Barbera, R / Barioglio, L / Barlou, M / Barnaföldi, G G / Barnby, L S / Barret, V / Bartels, C / Barth, K / Bartsch, E / Baruffaldi, F / Bastid, N / Basu, S / Batigne, G / Batyunya, B / Bauri, D / Bazo Alba, J L / Bearden, I G / Beattie, C / Belikov, I / Bell Hechavarria, A D C / Bellini, F / Bellwied, R / Belokurova, S / Belyaev, V / Bencedi, G / Beole, S / Bercuci, A / Berdnikov, Y / Berdnikova, A / Berenyi, D / Bergmann, L / Besoiu, M G / Betev, L / Bhaduri, P P / Bhasin, A / Bhat, I R / Bhat, M A / Bhattacharjee, B / Bhattacharya, P / Bianchi, L / Bianchi, N / Bielčík, J / Bielčíková, J / Biernat, J / Bilandzic, A / Biro, G / Biswas, S / Blair, J T / Blau, D / Blidaru, M B / Blume, C / Boca, G / Bock, F / Bogdanov, A / Boi, S / Bok, J / Boldizsár, L / Bolozdynya, A / Bombara, M / Bond, P M / Bonomi, G / Borel, H / Borissov, A / Bossi, H / Botta, E / Bratrud, L / Braun-Munzinger, P / Bregant, M / Broz, M / Bruno, G E / Buckland, M D / Budnikov, D / Buesching, H / Bufalino, S / Bugnon, O / Buhler, P / Buthelezi, Z / Butt, J B / Bysiak, S A / Caffarri, D / Cai, M / Caines, H / Caliva, A / Calvo Villar, E / Camacho, J M M / Camacho, R S / Camerini, P / Canedo, F D M / Carnesecchi, F / Caron, R / Castillo Castellanos, J / Casula, E A R / Catalano, F / Ceballos Sanchez, C / Chakraborty, P / Chandra, S / Chapeland, S / Chartier, M / Chattopadhyay, S / Chauvin, A / Chavez, T G / Cheshkov, C / Cheynis, B / Chibante Barroso, V / Chinellato, D D / Cho, S / Chochula, P / Christakoglou, P / Christensen, C H / Christiansen, P / Chujo, T / Cicalo, C / Cifarelli, L / Cindolo, F / Ciupek, M R / Clai, G / Cleymans, J / Colamaria, F / Colburn, J S / Colella, D / Collu, A / Colocci, M / Concas, M / Conesa Balbastre, G / Conesa Del Valle, Z / Contin, G / Contreras, J G / Coquet, M L / Cormier, T M / Cortese, P / Cosentino, M R / Costa, F / Costanza, S / Crochet, P / Cruz-Torres, R / Cuautle, E / Cui, P / Cunqueiro, L / Dainese, A / Damas, F P A / Danisch, M C / Danu, A / Das, I / Das, P / Das, S / Dash, S / De, S / De Caro, A / de Cataldo, G / De Cilladi, L / de Cuveland, J / De Falco, A / De Gruttola, D / De Marco, N / De Martin, C / De Pasquale, S / Deb, S / Degenhardt, H F / Deja, K R / Dello Stritto, L / Delsanto, S / Deng, W / Dhankher, P / Di Bari, D / Di Mauro, A / Diaz, R A / Dietel, T / Ding, Y / Divià, R / Dixit, D U / Djuvsland, Ø / Dmitrieva, U / Do, J / Dobrin, A / Dönigus, B / Dordic, O / Dubey, A K / Dubla, A / Dudi, S / Dukhishyam, M / Dupieux, P / Dzalaiova, N / Eder, T M / Ehlers, R J / Eikeland, V N / Elia, D / Erazmus, B / Ercolessi, F / Erhardt, F / Erokhin, A / Ersdal, M R / Espagnon, B / Eulisse, G / Evans, D / Evdokimov, S / Fabbietti, L / Faggin, M / Faivre, J / Fan, F / Fantoni, A / Fasel, M / Fecchio, P / Feliciello, A / Feofilov, G / Fernández Téllez, A / Ferrero, A / Ferretti, A / Feuillard, V J G / Figiel, J / Filchagin, S / Finogeev, D / Fionda, F M / Fiorenza, G / Flor, F / Flores, A N / Foertsch, S / Foka, P / Fokin, S / Fragiacomo, E / Frajna, E / Fuchs, U / Funicello, N / Furget, C / Furs, A / Gaardhøje, J J / Gagliardi, M / Gago, A M / Gal, A / Galvan, C D / Ganoti, P / Garabatos, C / Garcia, J R A / Garcia-Solis, E / Garg, K / Gargiulo, C / Garibli, A / Garner, K / Gasik, P / Gauger, E F / Gautam, A / Gay Ducati, M B / Germain, M / Ghosh, J / Ghosh, P / Ghosh, S K / Giacalone, M / Gianotti, P / Giubellino, P / Giubilato, P / Glaenzer, A M C / Glässel, P / Goh, D J Q / Gonzalez, V / González-Trueba, L H / Gorbunov, S / Gorgon, M / Görlich, L / Gotovac, S / Grabski, V / Graczykowski, L K / Greiner, L / Grelli, A / Grigoras, C / Grigoriev, V / Grigoryan, A / Grigoryan, S / Groettvik, O S / Grosa, F / Grosse-Oetringhaus, J F / Grosso, R / Guardiano, G G / Guernane, R / Guilbaud, M / Gulbrandsen, K / Gunji, T / Gupta, A / Gupta, R / Guzman, I B / Guzman, S P / Gyulai, L / Habib, M K / Hadjidakis, C / Halimoglu, G / Hamagaki, H / Hamar, G / Hamid, M / Hannigan, R / Haque, M R / Harlenderova, A / Harris, J W / Harton, A / Hasenbichler, J A / Hassan, H / Hatzifotiadou, D / Hauer, P / Havener, L B / Hayashi, S / Heckel, S T / Hellbär, E / Helstrup, H / Herman, T / Hernandez, E G / Herrera Corral, G / Herrmann, F / Hetland, K F / Hillemanns, H / Hills, C / Hippolyte, B / Hofman, B / Hohlweger, B / Honermann, J / Hong, G H / Horak, D / Hornung, S / Horzyk, A / Hosokawa, R / Hristov, P / Huang, C / Hughes, C / Huhn, P / Humanic, T J / Hushnud, H / Husova, L A / Hutson, A / Hutter, D / Iddon, J P / Ilkaev, R / Ilyas, H / Inaba, M / Innocenti, G M / Ippolitov, M / Isakov, A / Islam, M S / Ivanov, M / Ivanov, V / Izucheev, V / Jablonski, M / Jacak, B / Jacazio, N / Jacobs, P M / Jadlovska, S / Jadlovsky, J / Jaelani, S / Jahnke, C / Jakubowska, M J / Janik, M A / Janson, T / Jercic, M / Jevons, O / Jonas, F / Jones, P G / Jowett, J M / Jung, J / Jung, M / Junique, A / Jusko, A / Kaewjai, J / Kalinak, P / Kalweit, A / Kaplin, V / Kar, S / Karasu Uysal, A / Karatovic, D / Karavichev, O / Karavicheva, T / Karczmarczyk, P / Karpechev, E / Kazantsev, A / Kebschull, U / Keidel, R / Keijdener, D L D / Keil, M / Ketzer, B / Khabanova, Z / Khan, A M / Khan, S / Khanzadeev, A / Kharlov, Y / Khatun, A / Khuntia, A / Kileng, B / Kim, B / Kim, D / Kim, D J / Kim, E J / Kim, J / Kim, J S / Kim, M / Kim, S / Kim, T / Kirsch, S / Kisel, I / Kiselev, S / Kisiel, A / Kitowski, J P / Klay, J L / Klein, J / Klein, S / Klein-Bösing, C / Kleiner, M / Klemenz, T / Kluge, A / Knospe, A G / Kobdaj, C / Köhler, M K / Kollegger, T / Kondratyev, A / Kondratyeva, N / Kondratyuk, E / Konig, J / Konigstorfer, S A / Konopka, P J / Kornakov, G / Koryciak, S D / Koska, L / Kotliarov, A / Kovalenko, O / Kovalenko, V / Kowalski, M / Králik, I / Kravčáková, A / Kreis, L / Krivda, M / Krizek, F / Krizkova Gajdosova, K / Kroesen, M / Krüger, M / Kryshen, E / Krzewicki, M / Kučera, V / Kuhn, C / Kuijer, P G / Kumaoka, T / Kumar, D / Kumar, L / Kumar, N / Kundu, S / Kurashvili, P / Kurepin, A / Kurepin, A B / Kuryakin, A / Kushpil, S / Kvapil, J / Kweon, M J / Kwon, J Y / Kwon, Y / La Pointe, S L / La Rocca, P / Lai, Y S / Lakrathok, A / Lamanna, M / Langoy, R / Lapidus, K / Larionov, P / Laudi, E / Lautner, L / Lavicka, R / Lazareva, T / Lea, R / Lee, J / Lehrbach, J / Lemmon, R C / León Monzón, I / Lesser, E D / Lettrich, M / Lévai, P / Li, X / Li, X L / Lien, J / Lietava, R / Lim, B / Lim, S H / Lindenstruth, V / Lindner, A / Lippmann, C / Liu, A / Liu, J / Lofnes, I M / Loginov, V / Loizides, C / Loncar, P / Lopez, J A / Lopez, X / López Torres, E / Luhder, J R / Lunardon, M / Luparello, G / Ma, Y G / Maevskaya, A / Mager, M / Mahmoud, T / Maire, A / Malaev, M / Malik, Q W / Malinina, L / Mal'Kevich, D / Mallick, N / Malzacher, P / Mandaglio, G / Manko, V / Manso, F / Manzari, V / Mao, Y / Mareš, J / Margagliotti, G V / Margotti, A / Marín, A / Markert, C / Marquard, M / Martin, N A / Martinengo, P / Martinez, J L / Martínez, M I / Martínez García, G / Masciocchi, S / Masera, M / Masoni, A / Massacrier, L / Mastroserio, A / Mathis, A M / Matonoha, O / Matuoka, P F T / Matyja, A / Mayer, C / Mazuecos, A L / Mazzaschi, F / Mazzilli, M / Mazzoni, M A / Mdhluli, J E / Mechler, A F / Meddi, F / Melikyan, Y / Menchaca-Rocha, A / Meninno, E / Menon, A S / Meres, M / Mhlanga, S / Miake, Y / Micheletti, L / Migliorin, L C / Mihaylov, D L / Mikhaylov, K / Mishra, A N / Miśkowiec, D / Modak, A / Mohanty, A P / Mohanty, B / Mohisin Khan, M / Moravcova, Z / Mordasini, C / Moreira De Godoy, D A / Moreno, L A P / Morozov, I / Morsch, A / Mrnjavac, T / Muccifora, V / Mudnic, E / Mühlheim, D / Muhuri, S / Mulligan, J D / Mulliri, A / Munhoz, M G / Munzer, R H / Murakami, H / Murray, S / Musa, L / Musinsky, J / Myers, C J / Myrcha, J W / Naik, B / Nair, R / Nandi, B K / Nania, R / Nappi, E / Naru, M U / Nassirpour, A F / Nath, A / Nattrass, C / Neagu, A / Nellen, L / Nesbo, S V / Neskovic, G / Nesterov, D / Nielsen, B S / Nikolaev, S / Nikulin, S / Nikulin, V / Noferini, F / Noh, S / Nomokonov, P / Norman, J / Novitzky, N / Nowakowski, P / Nyanin, A / Nystrand, J / Ogino, M / Ohlson, A / Okorokov, V A / Oleniacz, J / Oliveira Da Silva, A C / Oliver, M H / Onnerstad, A / Oppedisano, C / Ortiz Velasquez, A / Osako, T / Oskarsson, A / Otwinowski, J / Oyama, K / Pachmayer, Y / Padhan, S / Pagano, D / Paić, G / Palasciano, A / Pan, J / Panebianco, S / Pareek, P / Park, J / Parkkila, J E / Pathak, S P / Patra, R N / Paul, B / Pazzini, J / Pei, H / Peitzmann, T / Peng, X / Pereira, L G / Pereira Da Costa, H / Peresunko, D / Perez, G M / Perrin, S / Pestov, Y / Petráček, V / Petrovici, M / Pezzi, R P / Piano, S / Pikna, M / Pillot, P / Pinazza, O / Pinsky, L / Pinto, C / Pisano, S / Płoskoń, M / Planinic, M / Pliquett, F / Poghosyan, M G / Polichtchouk, B / Politano, S / Poljak, N / Pop, A / Porteboeuf-Houssais, S / Porter, J / Pozdniakov, V / Prasad, S K / Preghenella, R / Prino, F / Pruneau, C A / Pshenichnov, I / Puccio, M / Qiu, S / Quaglia, L / Quishpe, R E / Ragoni, S / Rakotozafindrabe, A / Ramello, L / Rami, F / Ramirez, S A R / Ramos, A G T / Rancien, T A / Raniwala, R / Raniwala, S / Räsänen, S S / Rath, R / Ravasenga, I / Read, K F / Redelbach, A R / Redlich, K / Rehman, A / Reichelt, P / Reidt, F / Reme-Ness, H A / Renfordt, R / Rescakova, Z / Reygers, K / Riabov, A / Riabov, V / Richert, T / Richter, M / Riegler, W / Riggi, F / Ristea, C / Rode, S P / Rodríguez Cahuantzi, M / Røed, K / Rogalev, R / Rogochaya, E / Rogoschinski, T S / Rohr, D / Röhrich, D / Rojas, P F / Rojas Torres, S / Rokita, P S / Ronchetti, F / Rosano, A / Rosas, E D / Rossi, A / Rotondi, A / Roy, A / Roy, P / Roy, S / Rubini, N / Rueda, O V / Rui, R / Rumyantsev, B / Russek, P G / Rustamov, A / Ryabinkin, E / Ryabov, Y / Rybicki, A / Rytkonen, H / Rzesa, W / Saarimaki, O A M / Sadek, R / Sadovsky, S / Saetre, J / Šafařík, K / Saha, S K / Saha, S / Sahoo, B / Sahoo, P / Sahoo, R / Sahoo, S / Sahu, D / Sahu, P K / Saini, J / Sakai, S / Sambyal, S / Samsonov, V / Sarkar, D / Sarkar, N / Sarma, P / Sarti, V M / Sas, M H P / Schambach, J / Scheid, H S / Schiaua, C / Schicker, R / Schmah, A / Schmidt, C / Schmidt, H R / Schmidt, M O / Schmidt, M / Schmidt, N V / Schmier, A R / Schotter, R / Schukraft, J / Schutz, Y / Schwarz, K / Schweda, K / Scioli, G / Scomparin, E / Seger, J E / Sekiguchi, Y / Sekihata, D / Selyuzhenkov, I / Senyukov, S / Seo, J J / Serebryakov, D / Šerkšnytė, L / Sevcenco, A / Shaba, T J / Shabanov, A / Shabetai, A / Shahoyan, R / Shaikh, W / Shangaraev, A / Sharma, A / Sharma, H / Sharma, M / Sharma, N / Sharma, S / Sheibani, O / Shigaki, K / Shimomura, M / Shirinkin, S / Shou, Q / Sibiriak, Y / Siddhanta, S / Siemiarczuk, T / Silva, T F / Silvermyr, D / Simonetti, G / Singh, B / Singh, R / Singh, V K / Singhal, V / Sinha, T / Sitar, B / Sitta, M / Skaali, T B / Skorodumovs, G / Slupecki, M / Smirnov, N / Snellings, R J M / Soncco, C / Song, J / Songmoolnak, A / Soramel, F / Sorensen, S / Sputowska, I / Stachel, J / Stan, I / Steffanic, P J / Stiefelmaier, S F / Stocco, D / Storehaug, I / Storetvedt, M M / Stylianidis, C P / Suaide, A A P / Sugitate, T / Suire, C / Suljic, M / Sultanov, R / Šumbera, M / Sumberia, V / Sumowidagdo, S / Swain, S / Szabo, A / Szarka, I / Tabassam, U / Taghavi, S F / Taillepied, G / Takahashi, J / Tambave, G J / Tang, S / Tang, Z / Tarhini, M / Tarzila, M G / Tauro, A / Tejeda Muñoz, G / Telesca, A / Terlizzi, L / Terrevoli, C / Tersimonov, G / Thakur, S / Thomas, D / Tieulent, R / Tikhonov, A / Timmins, A R / Tkacik, M / Toia, A / Topilskaya, N / Toppi, M / Torales-Acosta, F / Tork, T / Trifiró, A / Tripathy, S / Tripathy, T / Trogolo, S / Trombetta, G / Trubnikov, V / Trzaska, W H / Trzcinski, T P / Trzeciak, B A / Tumkin, A / Turrisi, R / Tveter, T S / Ullaland, K / Uras, A / Urioni, M / Usai, G L / Vala, M / Valle, N / Vallero, S / van der Kolk, N / van Doremalen, L V R / van Leeuwen, M / Vande Vyvre, P / Varga, D / Varga, Z / Varga-Kofarago, M / Vargas, A / Vasileiou, M / Vasiliev, A / Vázquez Doce, O / Vechernin, V / Vercellin, E / Vergara Limón, S / Vermunt, L / Vértesi, R / Verweij, M / Vickovic, L / Vilakazi, Z / Villalobos Baillie, O / Vino, G / Vinogradov, A / Virgili, T / Vislavicius, V / Vodopyanov, A / Volkel, B / Völkl, M A / Voloshin, K / Voloshin, S A / Volpe, G / von Haller, B / Vorobyev, I / Voscek, D / Vrláková, J / Wagner, B / Wang, C / Wang, D / Weber, M / Weelden, R J G V / Wegrzynek, A / Wenzel, S C / Wessels, J P / Wiechula, J / Wikne, J / Wilk, G / Wilkinson, J / Willems, G A / Windelband, B / Winn, M / Witt, W E / Wright, J R / Wu, W / Wu, Y / Xu, R / Yalcin, S / Yamaguchi, Y / Yamakawa, K / Yang, S / Yano, S / Yin, Z / Yokoyama, H / Yoo, I-K / Yoon, J H / Yuan, S / Yuncu, A / Zaccolo, V / Zaman, A / Zampolli, C / Zanoli, H J C / Zardoshti, N / Zarochentsev, A / Závada, P / Zaviyalov, N / Zbroszczyk, H / Zhalov, M / Zhang, S / Zhang, X / Zhang, Y / Zherebchevskii, V / Zhi, Y / Zhou, D / Zhou, Y / Zhu, J / Zhu, Y / Zichichi, A / Zinovjev, G / Zurlo, N

Physical review letters

2022 Volume 127, Issue 27, Page(s) 272001

Abstract: ... both the semileptonic decay (Ξ^{-}e^{+}ν_{e}) and the hadronic decay (Ξ^{-}π^{+}) channels. The Ξ_{c}^{+} baryon was ... e^{+}ν_{e})/BR(Ξ_{c}^{0}→Ξ^{-}π^{+})=1.38±0.14(stat)±0.22(syst) was measured with a total uncertainty ... processes are involved in charm hadronization in electron-positron (e^{+}e^{-}) and hadronic collisions. ...

Abstract	The p_{T}-differential cross sections of prompt charm-strange baryons Ξ_{c}^{0} and Ξ_{c}^{+} were measured at midrapidity (\|y\|<0.5) in proton-proton (pp) collisions at a center-of-mass energy sqrt[s]=13 TeV with the ALICE detector at the LHC. The Ξ_{c}^{0} baryon was reconstructed via both the semileptonic decay (Ξ^{-}e^{+}ν_{e}) and the hadronic decay (Ξ^{-}π^{+}) channels. The Ξ_{c}^{+} baryon was reconstructed via the hadronic decay (Ξ^{-}π^{+}π^{+}) channel. The branching-fraction ratio BR(Ξ_{c}^{0}→Ξ^{-}e^{+}ν_{e})/BR(Ξ_{c}^{0}→Ξ^{-}π^{+})=1.38±0.14(stat)±0.22(syst) was measured with a total uncertainty reduced by a factor of about 3 with respect to the current world average reported by the Particle Data Group. The transverse momentum (p_{T}) dependence of the Ξ_{c}^{0}- and Ξ_{c}^{+}-baryon production relative to the D^{0} meson and to the Σ_{c}^{0,+,++}- and Λ_{c}^{+}-baryon production are reported. The baryon-to-meson ratio increases toward low p_{T} up to a value of approximately 0.3. The measurements are compared with various models that take different hadronization mechanisms into consideration. The results provide stringent constraints to these theoretical calculations and additional evidence that different processes are involved in charm hadronization in electron-positron (e^{+}e^{-}) and hadronic collisions.
Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.272001
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Article ; Online: The E LiBANS project: Thermal and epithermal neutron sources based on a medical Linac.

Monti, V / Costa, M / Durisi, E / Ferrero, M / Menzio, L / Sans-Planell, O / Visca, L / Bedogni, R / Treccani, M / Alikaniotis, K / Giannini, G

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2020 Volume 166, Page(s) 109363

Abstract: The E_LIBANS project (INFN) aims at producing neutron facilities for interdisciplinary irradiation ...

Abstract	The E_LIBANS project (INFN) aims at producing neutron facilities for interdisciplinary irradiation purposes among which pre-clinical research for BNCT. After the successful setting-up of the thermal neutron source based on a medical LINAC, a similar apparatus for epithermal neutrons has been developed. Both structures are based on an Elekta 18 MV coupled with a photoconverter-moderator system which deploys the (γ,n) reaction to convert the X-rays into neutrons. This communication describes the two neutron sources and the results obtained in their characterization.
MeSH term(s)	Animals ; Boron Neutron Capture Therapy/instrumentation ; Boron Neutron Capture Therapy/statistics & numerical data ; Computer Simulation ; Equipment Design ; Humans ; Italy ; Neutrons ; Particle Accelerators/instrumentation
Language	English
Publishing date	2020-08-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1142596-9
ISSN	1872-9800 ; 0883-2889 ; 0969-8043
ISSN (online)	1872-9800
ISSN	0883-2889 ; 0969-8043
DOI	10.1016/j.apradiso.2020.109363
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Article ; Online: INTENSE THERMAL NEUTRON FIELDS FROM A MEDICAL-TYPE LINAC: THE E_LIBANS PROJECT.

Costa, M / Durisi, E / Ferrero, M / Monti, V / Visca, L / Anglesio, S / Bedogni, R / Gomez-Ros, J M / Romano, M / Planell, O Sans / Treccani, M / Bortot, D / Pola, A / Alikaniotis, K / Giannini, G

Radiation protection dosimetry

2018 Volume 180, Issue 1-4, Page(s) 273–277

Abstract: The e_LiBANS project aims at producing intense thermal neutron fields for diverse interdisciplinary ... of the e_LiBANS project and describes the results of the benchmark experiment. ...

Abstract	The e_LiBANS project aims at producing intense thermal neutron fields for diverse interdisciplinary irradiation purposes. It makes use of a reconditioned medical electron LINAC, recently installed at the Physics Department and INFN in Torino, coupled to a dedicated photo-converter, developed within this collaboration, that uses (γ,n) reaction within high Z targets. Produced neutrons are then moderated to thermal energies and concentrated in an irradiation volume. To measure and to characterize in real time the intense field inside the cavity new thermal neutron detectors were designed with high radiation resistance, low noise and very high neutron-to-photon discrimination capability. This article offers an overview of the e_LiBANS project and describes the results of the benchmark experiment.
MeSH term(s)	Electrons ; Equipment Design ; Gamma Rays ; Interdisciplinary Research ; Linear Models ; Neutrons ; Particle Accelerators ; Photons ; Radiation Dosage ; Radiometry/instrumentation
Language	English
Publishing date	2018-01-08
Publishing country	England
Document type	Journal Article
ZDB-ID	225912-6
ISSN	1742-3406 ; 0144-8420
ISSN (online)	1742-3406
ISSN	0144-8420
DOI	10.1093/rpd/ncx281
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Article: Reparación laparoscópica de la hernia inguinal e hidrocele en edad pediátrica. Nuestra experiencia en los últimos años.

Larreina de la Fuente, L / Villalón Ferrero, F / Urbistondo Galarraga, A / Etxart Lopetegi, E / Chocarro Amatriain, G / González Temprano, N / Ramos García, J L / Fernández-Ibieta, M / Villanueva Mateo, A

Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica

2018 Volume 31, Issue 3, Page(s) 125–129

Abstract: Introduction: Laparoscopic inguinal hernia and hydrocele repair has become an alternative to the more frequently used inguinal approach. We describe our experience with the laparoscopic technique.: Material and methods: Retrospective study of ... ...

Title translation	Laparoscopic repair of inguinal hernia and communicating hydrocele in children. Our experience in the last years.
Abstract	Introduction: Laparoscopic inguinal hernia and hydrocele repair has become an alternative to the more frequently used inguinal approach. We describe our experience with the laparoscopic technique. Material and methods: Retrospective study of laparoscopic inguinal hernia and hydrocele repair performed during the period between 2003-2016. We included patients < 14 years, with communicating hydrocele and/or indirect inguinal hernia diagnosis (N = 39). We have studied two cohorts; group A patients with indirect inguinal hernia (N = 31) and group B patients with communicating hydrocele (N = 8). We used intraperitoneal laparoscopic approach, performing herniorrhaphy of the internal inguinal orifice without resection of the hernial sac. The main outcome measurements were surgical indication and postoperative complications. Results: The indication for laparoscopic repair was bilateral defects (46.2%), unilateral defects (28.2%), defects associated with umbilical hernia (23.1%) and associated with another pathology (2.6%). In group A the rate of complications that required new admission was 3.2% and the recurrence rate was 9.7%. In group B, was 12.5% and 12.5% respectively. We have not observed a significant relationship with respect to patient age, laterality or suture used and the rate of complications in any of the groups. Conclusions: Despite the limitations of our study given the small sample size and retrospective nature, the complication rate (15%) is higher than that published in the literature. This makes us take a step back to reassess our indications and technique, and not forget that the laparoscopic approach is not a technique without risks and requires a learning curve.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Female ; Hernia, Inguinal/surgery ; Herniorrhaphy/methods ; Humans ; Infant ; Laparoscopy/methods ; Male ; Peritoneal Diseases/pathology ; Peritoneal Diseases/surgery ; Postoperative Complications/epidemiology ; Recurrence ; Retrospective Studies ; Testicular Hydrocele/surgery ; Treatment Outcome
Language	Spanish
Publishing date	2018-08-03
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1214833-7
ISSN	2445-2807 ; 0214-1221
ISSN (online)	2445-2807
ISSN	0214-1221
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Article ; Online: Estimulación del área de la rama izquierda en un paciente con bloqueo de la rama derecha e insuficiencia cardíaca

Javier García-Seara / Teba González-Ferrero / Carlos Minguito-Carazo

Medicina Clínica Práctica, Vol 6, Iss 3, Pp 100388- (2023)

2023

Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Elsevier España
Document type	Article ; Online
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Article ; Online: Lung recruitment before surfactant administration in extremely preterm neonates with respiratory distress syndrome (IN-REC-SUR-E): a randomised, unblinded, controlled trial.

Vento, Giovanni / Ventura, Maria Luisa / Pastorino, Roberta / van Kaam, Anton H / Carnielli, Virgilio / Cools, Filip / Dani, Carlo / Mosca, Fabio / Polglase, Graeme / Tagliabue, Paolo / Boni, Luca / Cota, Francesco / Tana, Milena / Tirone, Chiara / Aurilia, Claudia / Lio, Alessandra / Costa, Simonetta / D'Andrea, Vito / Lucente, Mariella /

Nigro, Gabriella / Giordano, Lucio / Roma, Vincenzina / Villani, Paolo E / Fusco, Francesca P / Fasolato, Valeria / Colnaghi, Maria Rosa / Matassa, Piero G / Vendettuoli, Valentina / Poggi, Chiara / Del Vecchio, Antonio / Petrillo, Flavia / Betta, Pasqua / Mattia, Carmine / Garani, Giampaolo / Solinas, Agostina / Gitto, Eloisa / Salvo, Vincenzo / Gargano, Giancarlo / Balestri, Eleonora / Sandri, Fabrizio / Mescoli, Giovanna / Martinelli, Stefano / Ilardi, Laura / Ciarmoli, Elena / Di Fabio, Sandra / Maranella, Eugenia / Grassia, Carolina / Ausanio, Gaetano / Rossi, Vincenzo / Motta, Angela / Tina, Lucia G / Maiolo, Kim / Nobile, Stefano / Messner, Hubert / Staffler, Alex / Ferrero, Federica / Stasi, Ilaria / Pieragostini, Luisa / Mondello, Isabella / Haass, Cristina / Consigli, Chiara / Vedovato, Stefania / Grison, Alessandra / Maffei, Gianfranco / Presta, Giuseppe / Perniola, Roberto / Vitaliti, Marcello / Re, Maria P / De Curtis, Mario / Cardilli, Viviana / Lago, Paola / Tormena, Francesca / Orfeo, Luigi / Gizzi, Camilla / Massenzi, Luca / Gazzolo, Diego / Strozzi, Maria Chiara M / Bottino, Roberto / Pontiggia, Federica / Berardi, Alberto / Guidotti, Isotta / Cacace, Caterina / Meli, Valerio / Quartulli, Lorenzo / Scorrano, Antonio / Casati, Alessandra / Grappone, Lidia / Pillow, J Jane

The Lancet. Respiratory medicine

2020 Volume 9, Issue 2, Page(s) 159–166

Abstract: ... intubate-recruit-surfactant-extubate [IN-REC-SUR-E]), decreased the need for mechanical ventilation during ... the first 72 h of life compared with no recruitment manoeuvre (ie, intubate-surfactant-extubate [IN-SUR-E ... assigned (1:1) with a minimisation algorithm to IN-REC-SUR-E or IN-SUR-E using an interactive web-based ...

Abstract	Background: The importance of lung recruitment before surfactant administration has been shown in animal studies. Well designed trials in preterm infants are absent. We aimed to examine whether the application of a recruitment manoeuvre just before surfactant administration, followed by rapid extubation (intubate-recruit-surfactant-extubate [IN-REC-SUR-E]), decreased the need for mechanical ventilation during the first 72 h of life compared with no recruitment manoeuvre (ie, intubate-surfactant-extubate [IN-SUR-E]). Methods: We did a randomised, unblinded, controlled trial in 35 tertiary neonatal intensive care units in Italy. Spontaneously breathing extremely preterm neonates (24 + 0 to 27 + 6 weeks' gestation) reaching failure criteria for continuous positive airway pressure within the first 24 h of life were randomly assigned (1:1) with a minimisation algorithm to IN-REC-SUR-E or IN-SUR-E using an interactive web-based electronic system, stratified by clinical site and gestational age. The primary outcome was the need for mechanical ventilation in the first 72 h of life. Analyses were done in intention-to-treat and per-protocol populations, with a log-binomial regression model correcting for stratification factors to estimate adjusted relative risk (RR). This study is registered with ClinicalTrials.gov, NCT02482766. Findings: Of 556 infants assessed for eligibility, 218 infants were recruited from Nov 12, 2015, to Sept 23, 2018, and included in the intention-to-treat analysis. The requirement for mechanical ventilation during the first 72 h of life was reduced in the IN-REC-SUR-E group (43 [40%] of 107) compared with the IN-SUR-E group (60 [54%] of 111; adjusted RR 0·75, 95% CI 0·57-0·98; p=0·037), with a number needed to treat of 7·2 (95% CI 3·7-135·0). The addition of the recruitment manoeuvre did not adversely affect the safety outcomes of in-hospital mortality (19 [19%] of 101 in the IN-REC-SUR-E group vs 37 [33%] of 111 in the IN-SUR-E group), pneumothorax (four [4%] of 101 vs seven [6%] of 111), or grade 3 or worse intraventricular haemorrhage (12 [12%] of 101 vs 17 [15%] of 111). Interpretation: A lung recruitment manoeuvre just before surfactant administration improved the efficacy of surfactant treatment in extremely preterm neonates compared with the standard IN-SUR-E technique, without increasing the risk of adverse neonatal outcomes. The reduced need for mechanical ventilation during the first 72 h of life might facilitate implementation of a non-invasive respiratory support strategy. Funding: None.
MeSH term(s)	Airway Extubation/methods ; Critical Care/methods ; Female ; Humans ; Infant, Extremely Premature ; Infant, Newborn ; Intensive Care Units, Neonatal ; Intubation, Intratracheal/methods ; Italy ; Lung/physiopathology ; Male ; Pulmonary Surfactants/therapeutic use ; Respiration, Artificial/statistics & numerical data ; Respiratory Distress Syndrome, Newborn/therapy ; Treatment Outcome
Chemical Substances	Pulmonary Surfactants
Language	English
Publishing date	2020-07-17
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2686754-0
ISSN	2213-2619 ; 2213-2600
ISSN (online)	2213-2619
ISSN	2213-2600
DOI	10.1016/S2213-2600(20)30179-X
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Article ; Online: DEVELOPING RADIATION RESISTANT THERMAL NEUTRON DETECTORS FOR THE E_LIBANS PROJECT: PRELIMINARY RESULTS.

Treccani, M / Bedogni, R / Pola, A / Costa, M / Monti, V / Sans Planell, O / Romano, M / Durisi, E / Visca, D L / Bortot, D / Gomez-Ros, J M / Ferrero, M / Anglesio, S / Giannini, G / Alikaniotis, K

Radiation protection dosimetry

2018 Volume 180, Issue 1-4, Page(s) 304–308

Abstract: ... the thermal neutron cavity of the E_LIBANS project. Silicon and silicon carbide semiconductors, plus vented ...

Abstract	Radiation-resistant, gamma-insensitive, active thermal neutron detectors were developed to monitor the thermal neutron cavity of the E_LIBANS project. Silicon and silicon carbide semiconductors, plus vented air ion chambers, were chosen for this purpose. This communication describes the performance of these detectors, owing on the results of dedicated measurement campaigns.
MeSH term(s)	Carbon Compounds, Inorganic/chemistry ; Computer Simulation ; Equipment Design ; Neutrons ; Radiation Dosage ; Radiation Monitoring/instrumentation ; Radiation Monitoring/methods ; Radiation Protection/instrumentation ; Semiconductors/standards ; Silicon/chemistry ; Silicon Compounds/chemistry ; Temperature
Chemical Substances	Carbon Compounds, Inorganic ; Silicon Compounds ; silicon carbide (WXQ6E537EW) ; Silicon (Z4152N8IUI)
Language	English
Publishing date	2018-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	225912-6
ISSN	1742-3406 ; 0144-8420
ISSN (online)	1742-3406
ISSN	0144-8420
DOI	10.1093/rpd/ncx298
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Article ; Online: A Novel Xeno-Free Method to Isolate Human Endometrial Mesenchymal Stromal Cells (E-MSCs) in Good Manufacturing Practice (GMP) Conditions

Stefano Canosa / Katia Mareschi / Elena Marini / Andrea Roberto Carosso / Sara Castiglia / Deborah Rustichelli / Ivana Ferrero / Gianluca Gennarelli / Benedetta Bussolati / Alberto Nocifora / Valentina Asnaghi / Massimiliano Bergallo / Ciro Isidoro / Chiara Benedetto / Alberto Revelli / Franca Fagioli

International Journal of Molecular Sciences, Vol 23, Iss 1931, p

2022 Volume 1931

Abstract	The cyclic regeneration of human endometrium is guaranteed by the proliferative capacity of endometrial mesenchymal stromal cells (E-MSCs). Due to this, the autologous infusion of E-MSCs has been proposed to support endometrial growth in a wide range of gynecological diseases. We aimed to compare two different endometrial sampling methods, surgical curettage and vacuum aspiration biopsy random assay (VABRA), and to validate a novel xeno-free method to culture human E-MSCs. Six E-MSCs cell samples were isolated after mechanical tissue homogenization and cultured using human platelet lysate. E-MSCs were characterized for the colony formation capacity, proliferative potential, and multilineage differentiation. The expression of mesenchymal and stemness markers were tested by FACS analysis and real-time PCR, respectively. Chromosomal alterations were evaluated by karyotype analysis, whereas tumorigenic capacity and invasiveness were tested by soft agar assay. Both endometrial sampling techniques allowed efficient isolation and expansion of E-MSCs using a xeno-free method, preserving their mesenchymal and stemness phenotype, proliferative potential, and limited multi-lineage differentiation ability during the culture. No chromosomal alterations and invasive/tumorigenic capacity were observed. Herein, we report the first evidence of efficient E-MSCs isolation and culture in Good Manufacturing Practice compliance conditions, suggesting VABRA endometrial sampling as alternative to surgical curettage.
Keywords	endometrial mesenchymal stromal cells ; Good Manufacturing Practice (GMP) ; infertility ; Asherman’s syndrome ; endometrial thickness ; human platelet lysate (HPL) ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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