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  1. Article ; Online: Antidiabetic drugs for IBD: a long but promising road ahead for drug repositioning to target intestinal inflammation.

    Shinzaki, Shinichiro / Sato, Toshiyuki / Fukui, Hirokazu

    Journal of gastroenterology

    2023  Volume 58, Issue 6, Page(s) 598–599

    MeSH term(s) Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Drug Repositioning ; Diabetes Mellitus, Type 2 ; Inflammatory Bowel Diseases/drug therapy ; Inflammation/drug therapy ; Dipeptidyl-Peptidase IV Inhibitors
    Chemical Substances Hypoglycemic Agents ; Dipeptidyl-Peptidase IV Inhibitors
    Language English
    Publishing date 2023-03-24
    Publishing country Japan
    Document type Editorial
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-023-01983-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 620: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Regulatory T cells Are Increased and Correlate With Mast Cells in Eosinophilic Esophagitis.

    Chen, Junji / Oshima, Tadayuki / Tomita, Toshihiko / Fukui, Hirokazu / Shinzaki, Shinichiro

    Journal of neurogastroenterology and motility

    2024  Volume 30, Issue 1, Page(s) 29–37

    Abstract: Background/aims: The incidence of eosinophilic esophagitis (EoE) has been increasing recently. The role of regulatory T cells (Tregs) and correlations with other inflammatory cells in EoE remain unknown. We aim to clarify the role of Tregs and their ... ...

    Abstract Background/aims: The incidence of eosinophilic esophagitis (EoE) has been increasing recently. The role of regulatory T cells (Tregs) and correlations with other inflammatory cells in EoE remain unknown. We aim to clarify the role of Tregs and their correlations with inflammatory cells in EoE patients.
    Methods: Biopsies from controls and EoE patients before and after treatments were analyzed. Eosinophil infiltration was evaluated by hematoxylin and eosin staining. Immunohistochemical staining was performed to examine infiltration of T cells, Tregs, and mast cells. Gene expressions of chemokines were evaluated by reverse transcription-quantitative polymerase chain reaction.
    Results: Tregs and mast cells were increased in the esophageal epithelial layers of EoE patients. After treatments, Tregs and mast cells were decreased when histologic remission was achieved. Infiltration of Tregs correlated significantly with numbers of eosinophils and mast cells. Filaggrin mRNA was decreased in patients with EoE before treatment and upregulated after treatment, even when histologic remission was not achieved.
    Conclusions: Tregs were increased in esophageal epithelium of patients with EoE, and correlated with mast cell infiltration.
    Language English
    Publishing date 2024-01-04
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2573719-3
    ISSN 2093-0887 ; 2093-0879
    ISSN (online) 2093-0887
    ISSN 2093-0879
    DOI 10.5056/jnm23040
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  3. Article ; Online: Reg family proteins contribute to inflammation and pancreatic stellate cells activation in chronic pancreatitis.

    Chen, Wenting / Imasaka, Mai / Lee, Miyu / Fukui, Hirokazu / Nishiura, Hiroshi / Ohmuraya, Masaki

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 12201

    Abstract: Chronic pancreatitis (CP) is a disease characterized by the inflammation and destruction of pancreatic tissue, leading to the replacement of functional tissue with fibrotic tissue. The regenerating gene (Reg) family proteins have recently been implicated ...

    Abstract Chronic pancreatitis (CP) is a disease characterized by the inflammation and destruction of pancreatic tissue, leading to the replacement of functional tissue with fibrotic tissue. The regenerating gene (Reg) family proteins have recently been implicated in the repair and regeneration of inflamed pancreatic tissue, though the exact mechanisms of their involvement in the pathogenesis of CP are not yet fully understood. To investigate the role of Reg family proteins in CP, we generated global knockout mice (Reg
    MeSH term(s) Mice ; Animals ; Pancreatic Stellate Cells/metabolism ; Pancreatitis, Chronic/metabolism ; Pancreas/metabolism ; Inflammation/pathology ; Mice, Knockout ; Collagen/metabolism ; Cytokines/metabolism ; Regeneration ; Fibrosis ; Lithostathine/genetics ; Lithostathine/metabolism
    Chemical Substances Collagen (9007-34-5) ; Cytokines ; Reg1 protein, mouse ; Lithostathine
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-39178-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Non-cardiac Chest Pain in Japan: Prevalence, Impact, and Consultation Behavior - A Population-based Study.

    Chen, Junji / Oshima, Tadayuki / Kondo, Takashi / Tomita, Toshihiko / Fukui, Hirokazu / Shinzaki, Shinichiro / Miwa, Hiroto

    Journal of neurogastroenterology and motility

    2023  Volume 29, Issue 4, Page(s) 446–454

    Abstract: Background/aims: Non-cardiac chest pain (NCCP) is defined as recurring angina-like retrosternal chest pain of non-cardiac origin. Information about the epidemiology of NCCP in Japan is lacking. We aim to determine the prevalence and characteristics of ... ...

    Abstract Background/aims: Non-cardiac chest pain (NCCP) is defined as recurring angina-like retrosternal chest pain of non-cardiac origin. Information about the epidemiology of NCCP in Japan is lacking. We aim to determine the prevalence and characteristics of NCCP in the Japanese general population.
    Methods: Two internet-based surveys were conducted among the general population in March 2017. Questions investigated the characteristics of symptoms associated with chest pain and consultation behavior. Quality of life, anxiety, depression, and gastroesophageal reflux disease were analyzed.
    Results: Five percent of the survey respondents reported chest pain. Subjects with chest pain showed higher frequencies of anxiety and depression and lower quality of life. Among subjects with chest pain, approximately 30% had sought medical attention for their symptoms. Among all consulters, 70% were diagnosed with NCCP. Females were less likely to seek consultations for chest pain than males. Further, severity and frequency of chest pain, lower physical health component summary score, and more frequent gastroesophageal reflux disease were associated with consultation behavior. Subjects with NCCP and cardiac chest pain experienced similar impacts on quality of life, anxiety, and depression. Among subjects with NCCP, 82% visited a primary-care physician and 15% were diagnosed with reflux esophagitis.
    Conclusions: The prevalence of chest pain in this sample of a Japanese general population was 5%. Among all subjects with chest pain, less than one-third consulted physicians, approximately 70% of whom were diagnosed with NCCP. Sex and both the severity and frequency of chest pain were associated with consultation behavior.
    Language English
    Publishing date 2023-10-09
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2573719-3
    ISSN 2093-0887 ; 2093-0879
    ISSN (online) 2093-0887
    ISSN 2093-0879
    DOI 10.5056/jnm22184
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Meta-Analysis: Placebo Response and Its Determinants in Functional Dyspepsia.

    Huang, Xinyi / Oshima, Tadayuki / Tomita, Toshihiko / Fukui, Hirokazu / Miwa, Hiroto

    The American journal of gastroenterology

    2022  Volume 116, Issue 11, Page(s) 2184–2196

    Abstract: Introduction: Placebo response rates are relatively higher in clinical trials of disorders of brain-gut interaction. However, placebo response in functional dyspepsia (FD) has not been well described. Minimizing placebo response is important in drug ... ...

    Abstract Introduction: Placebo response rates are relatively higher in clinical trials of disorders of brain-gut interaction. However, placebo response in functional dyspepsia (FD) has not been well described. Minimizing placebo response is important in drug development. We therefore conducted a meta-analysis to determine placebo response in trials for FD and to identify factors affecting placebo response rates.
    Methods: PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched to identify double-blinded randomized controlled trials (RCTs) comparing medication with placebo in patients with FD. Both symptom improvement and complete relief were considered as separate primary endpoints in the analysis. Proportions of placebo patients experiencing any symptom improvement or complete relief were calculated. Dropouts after randomization for any reason were assumed to represent treatment failure for data extraction and analysis. Placebo response was pooled by a random-effects model, and effects of trial characteristics on the magnitude of placebo response were evaluated.
    Results: In 58 eligible placebo-controlled RCTs of FD from 52 selected citations, 6,732 of 17,890 participants in all trials received placebo. Pooled placebo response rates for symptom improvement and complete relief were 44.3% and 15.6%, respectively. The placebo response rate was lower when improvements were assessed for ≥8 weeks. Trials assessing complete symptom relief showed lower placebo response rates even in trials for <8 weeks.
    Discussion: Our systematic review and meta-analysis showed that pooled placebo response rates in double-blinded RCTs of FD depended on efficacy criteria. Trials assessing complete symptom relief showed stable low placebo response rates in short-term trials.
    MeSH term(s) Clinical Trials as Topic ; Dyspepsia/drug therapy ; Humans ; Placebo Effect
    Language English
    Publishing date 2022-06-29
    Publishing country United States
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000001397
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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.36: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Equation of states for dense ice up to 80 GPa at low-temperature conditions.

    Fukui, Hiroshi / Kadobayashi, Hirokazu / Abe, Hirotaka / Takahashi, Ryunosuke / Wadati, Hiroki / Hirao, Naohisa

    The Journal of chemical physics

    2022  Volume 156, Issue 6, Page(s) 64504

    Abstract: We have measured the lattice volume of ice VIII in different pressure-temperature pathways and found that the volume depends on the pathway, implying that deviatoric stress makes the volume larger. Dense ice is in the ice VIII phase with the molar volume ...

    Abstract We have measured the lattice volume of ice VIII in different pressure-temperature pathways and found that the volume depends on the pathway, implying that deviatoric stress makes the volume larger. Dense ice is in the ice VIII phase with the molar volume of 6.56 cm
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0084278
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    In stock of ZB MED Bonn / Germany

    Z 4' 49/16: Show issues

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  7. Article: Efficacy of Serotonin Type 3 Receptor Antagonist Ramosetron on Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)-Like Symptoms in Patients with Quiescent Inflammatory Bowel Disease: A Randomized, Double-Blind, Placebo-Controlled Trial.

    Tomita, Toshihiko / Fukui, Hirokazu / Morishita, Daisuke / Mori, Sumire / Oshima, Tadayuki / Shinzaki, Shinichiro / Miwa, Hiroto

    Journal of clinical medicine

    2022  Volume 11, Issue 23

    Abstract: Patients with quiescent inflammatory bowel disease (IBD) frequently suffer diarrhea-predominant irritable bowel syndrome (IBS-D)-like symptoms, such as abdominal pain or stool irregularities. Here, we assessed the effect of ramosetron, a serotonin type 3 ...

    Abstract Patients with quiescent inflammatory bowel disease (IBD) frequently suffer diarrhea-predominant irritable bowel syndrome (IBS-D)-like symptoms, such as abdominal pain or stool irregularities. Here, we assessed the effect of ramosetron, a serotonin type 3 (5-HT
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11236882
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  8. Article: Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels.

    Huang, Xinyi / Oshima, Tadayuki / Tomita, Toshihiko / Fukui, Hirokazu / Miwa, Hiroto

    Biology

    2021  Volume 10, Issue 3

    Abstract: Gastrointestinal (GI) disorders such as celiac disease and inflammatory bowel disease are attributed to intestinal barrier disruption. Imbalance of cytokines has been reported in the intestinal epithelium of patients with GI disorders. Short-chain fatty ... ...

    Abstract Gastrointestinal (GI) disorders such as celiac disease and inflammatory bowel disease are attributed to intestinal barrier disruption. Imbalance of cytokines has been reported in the intestinal epithelium of patients with GI disorders. Short-chain fatty acids (SCFAs), derived from the fermentation of dietary fiber in the intestine, have been reported to benefit the intestinal barrier. Accordingly, we evaluated the effect of specific SCFAs on intestinal barrier function under cytokine-stimulated conditions. Caco-2 cells were cultured on insert membranes to generate monolayers, which then were used to investigate the effects of SCFAs. Tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), or interleukin-13 (IL-13) was added to the basolateral side of the membrane while SCFAs were added to the apical side. After a 24 h stimulation, transepithelial electrical resistance (TEER) was measured, and the protein levels of claudin-1, claudin-2, claudin-3, claudin-4, occludin, and zonula occludens-1 (ZO-1) were evaluated by Western blot. Butyrate, but not acetate, propionate, or succinate, ameliorated the TNF-α/IFN-γ-induced decrease in TEER. TNF-α/IFN-γ stimulation significantly increased the protein level of claudin-2 and decreased the level of claudin-3. Butyrate significantly attenuated the upregulation of claudin-2 induced by TNF-α/IFN-γ. Butyrate blocked the decrease in TEER and the upregulation of claudin-2 induced by IL-13 without changing the level of other tight junction proteins. Our results suggested that butyrate is the main component of SCFAs to alleviate barrier dysfunction and that claudin-2 is the major target of this SCFA.
    Language English
    Publishing date 2021-03-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10030205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Esophageal Mucosal Permeability as a Surrogate Measure of Cure in Eosinophilic Esophagitis.

    Chen, Junji / Oshima, Tadayuki / Huang, Xinyi / Tomita, Toshihiko / Fukui, Hirokazu / Miwa, Hiroto

    Journal of clinical medicine

    2022  Volume 11, Issue 14

    Abstract: This study aimed to evaluate the relationship of esophageal epithelial permeability with mast cell infiltration and IgG4 deposits as well as chemokine levels in eosinophilic esophagitis (EoE) patients before and after treatment. Biopsies from controls ... ...

    Abstract This study aimed to evaluate the relationship of esophageal epithelial permeability with mast cell infiltration and IgG4 deposits as well as chemokine levels in eosinophilic esophagitis (EoE) patients before and after treatment. Biopsies from controls and EoE patients before and after treatment were analyzed. Hematoxylin and eosin staining was used to show eosinophil infiltration. Paracellular permeability of the esophageal epithelium was assessed using surface biotinylation. Immunohistochemical staining was performed to examine mast cell infiltration and IgG4 deposits. Gene expression of chemokines was evaluated by qRT-PCR. Esophageal epithelial infiltration of mast cells, IgG4 deposits, and permeability were significantly increased in EoE patients. Levels of interleukin-13, calpain-14, and eotaxin-3 mRNAs were significantly upregulated, while filaggrin, serine peptidase inhibitor Kazal type 7 (SPINK7), and involucrin mRNAs were significantly downregulated in EoE patients. In patients achieving histologic remission diagnosed by eosinophil counts, a subset of EoE patients with unchanged permeability after treatment showed increases in mast cell infiltration, IgG4 deposits, and interleukin-13, calpain-14, filaggrin, and SPINK7 expression, with decreased eotaxin-3 and involucrin. Other EoE patients with decreased permeability displayed decreased eotaxin-3, involucrin, and mast cell infiltration, no IgG4 deposits, and increased IL-13, calpain-14, filaggrin, and SPINK7. Increased permeability of the esophagus in EoE patients without eosinophil infiltration after treatment was associated with mast cell infiltration and IgG4 deposits.
    Language English
    Publishing date 2022-07-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11144246
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  10. Article: [Gender differences in cardiovascular surgery].

    Fukui, Toshihiro / Okamoto, Ken / Tazume, Hirokazu / Koga, Ayumi

    Nihon rinsho. Japanese journal of clinical medicine

    2018  Volume 74 Suppl 6, Page(s) 563–567

    MeSH term(s) Cardiovascular Diseases/surgery ; Humans ; Sex Characteristics
    Language Japanese
    Publishing date 2018-12-13
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 429: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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