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Book ; Online ; E-Book: Ketogenic diet therapies for epilepsy and other conditions

Kossoff, Eric H. / Turner, Zahava / Cervenka, Mackenzie C. / Henry, Bobbie J.

2021

Author's details	Eric H. Kossoff, Zahava Turner, Mackenzie C. Cervenka, Bobbie J. Barron
Keywords	Epilepsy / diet therapy ; Diet, Ketogenic ; Diet, High-Protein Low-Carbohydrate
Language	English
Size	1 Online-Ressource (xviii, 302 Seiten), Illustrationen
Edition	Seventh edition
Publisher	Demos Health
Publishing place	New York
Publishing country	United States
Document type	Book ; Online ; E-Book
Note	Preceded by The ketogenic and modified Atkins diets / Eric H. Kossoff, Zahava Turner, Sarah Doerrer, Mackenzie C. Cervenka, Bobbie J. Henry. Sixth edition. [2016] ; Seventh edition
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020809063
ISBN	978-0-8261-4959-6 ; 9780826149589 ; 0-8261-4959-6 ; 0826149588
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: The Modified Atkins Diet for Epilepsy: Two Decades of an "Alternative" Ketogenic Diet Therapy.

Kossoff, Eric H

Pediatric neurology

2023 Volume 147, Page(s) 82–87

Abstract: In 2003, the first case series of six patients treated with an Atkins diet for epilepsy was published in the journal Neurology. The concept was a simple, outpatient-initiated diet in which ketosis could be maintained by eating high-fat foods while ... ...

Abstract	In 2003, the first case series of six patients treated with an Atkins diet for epilepsy was published in the journal Neurology. The concept was a simple, outpatient-initiated diet in which ketosis could be maintained by eating high-fat foods while tracking and limiting daily carbohydrate counts based on food ingredient labels. Twenty years later, after dozens of studies encompassing hundreds of patients, including several randomized controlled trials, the Modified Atkins Diet is a proven method of providing ketogenic dietary therapy for epilepsy. It is a diet therapy of choice for adolescents and adults, is being investigated for new-onset epilepsy, and is researched for neurological conditions other than epilepsy. Adverse effects do exist but may be less common than the classic ketogenic diet. This review will cover the history, clinical trials, implementation, current utilization, and future directions of this "alternative" ketogenic diet therapy on its 20-year anniversary.
MeSH term(s)	Adolescent ; Adult ; Humans ; Diet, High-Protein Low-Carbohydrate/adverse effects ; Diet, Ketogenic/adverse effects ; Epilepsy/diet therapy ; Ketosis/diet therapy
Language	English
Publishing date	2023-07-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639164-3
ISSN	1873-5150 ; 0887-8994
ISSN (online)	1873-5150
ISSN	0887-8994
DOI	10.1016/j.pediatrneurol.2023.07.014
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Article ; Online: Special thanks to Dr. Steven Schachter on behalf of myself and the ketogenic diet community.

Kossoff, Eric H

Epilepsy & behavior : E&B

2022 , Page(s) 108699

Language	English
Publishing date	2022-04-16
Publishing country	United States
Document type	Letter
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2022.108699
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Article ; Online: Let food be thy medicine. The interaction between ketogenic diet therapy and anti-seizure medications: A systematic review.

Armeno, Marisa L / Kossoff, Eric H

Epileptic disorders : international epilepsy journal with videotape

2023 Volume 25, Issue 1, Page(s) 18–27

Abstract: Ketogenic diet therapy (KDT) is a nonpharmacological treatment that has been demonstrated to be effective in reducing seizures in patients with drug-resistant epilepsy. As the majority of patients on KDT are also receiving anti-seizure medications (ASMs), ...

Abstract	Ketogenic diet therapy (KDT) is a nonpharmacological treatment that has been demonstrated to be effective in reducing seizures in patients with drug-resistant epilepsy. As the majority of patients on KDT are also receiving anti-seizure medications (ASMs), questions about their combination often arise. KDT is typically implemented as an add-on, and not a substitute for ASMs. Drug monitoring and specific laboratory studies may be helpful in specific cases of cotherapy. Valproate, topiramate, zonisamide, and lamotrigine may be potentially problematic with KDT, but the evidence for this is not conclusive. ASM reduction is usually attempted after 1 month of KDT if a child is showing seizure reduction (but weaning ASMs does not require seizure freedom). Failure to wean an ASM does not mean KDT has failed and adding a new ASM may be beneficial in those cases after several months of KDT fine-tuning. The purpose of this review was to discuss the evidence for possible negative (or positive) pharmacodynamic interactions between KDT and ASMs. In addition, practical suggestions for the weaning or adding of ASMs in patients on KDT are provided.
MeSH term(s)	Child ; Humans ; Epilepsy/drug therapy ; Diet, Ketogenic ; Anticonvulsants/pharmacology ; Anticonvulsants/therapeutic use ; Valproic Acid/therapeutic use ; Topiramate ; Ketone Bodies/therapeutic use
Chemical Substances	Anticonvulsants ; Valproic Acid (614OI1Z5WI) ; Topiramate (0H73WJJ391) ; Ketone Bodies
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	2086797-9
ISSN	1950-6945 ; 1294-9361
ISSN (online)	1950-6945
ISSN	1294-9361
DOI	10.1002/epd2.20055
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Article ; Online: Changes in pediatric referrals after the 2009 ketogenic diet consensus recommendations.

Stainman, Rebecca S / Turner, Zahava / Kossoff, Eric H

Epilepsy & behavior : E&B

2024 Volume 155, Page(s) 109791

Abstract: Background: In 2009, the International Ketogenic Diet Study Group published recommendations for children receiving ketogenic diet (KD) therapy for epilepsy. The document included a table listing epilepsy syndromes and conditions in which the KD has been ...

Abstract	Background: In 2009, the International Ketogenic Diet Study Group published recommendations for children receiving ketogenic diet (KD) therapy for epilepsy. The document included a table listing epilepsy syndromes and conditions in which the KD has been particularly beneficial, hoping that physicians would refer children for the KD sooner. Purpose: To measure the impact of these 2009 recommendations on referral practice, we compared children initiated on the KD at Johns Hopkins Hospital (JHH) 10 years before and after the recommendations. Results: Overall, children referred to the KD who met indications increased from the pre- to post-recommendation group, 44 % (112/256) to 69 % (175/255) (p < 0.001), with JHH neurologists specifically referring more frequently (10/112, 9 % to 58/175, 33 %) (p < 0.01). Referrals increased for Glut-1 deficiency (0 % to 2.4 %, p = 0.015), Dravet syndrome (0 % to 6.7 %, p < 0.01), Rett syndrome (0.4 % to 3 %, p = 0.018), and formula-fed only status (16 % to 31 %, p < 0.01). The chances of > 50 % seizure reduction for all children referred improved slightly between decades (56 % to 61 %, p = 0.30). Conclusions: Following the 2009 recommendations, our study shows there was an increase in referrals for children with indications at our center. Referrals from neurologists at our own institution increased the most. Ketogenic diet efficacy improved slightly over time but did not reach significance.
Language	English
Publishing date	2024-04-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010587-3
ISSN	1525-5069 ; 1525-5050
ISSN (online)	1525-5069
ISSN	1525-5050
DOI	10.1016/j.yebeh.2024.109791
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Article ; Online: Intravenous ketogenic diet: guidelines for ketogenic parenteral therapy.

Kossoff, Eric H

Developmental medicine and child neurology

2019 Volume 62, Issue 1, Page(s) 7

MeSH term(s)	Child ; Diet, Ketogenic ; Humans ; Parenteral Nutrition
Language	English
Publishing date	2019-06-21
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	80369-8
ISSN	1469-8749 ; 0012-1622
ISSN (online)	1469-8749
ISSN	0012-1622
DOI	10.1111/dmcn.14305
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Article ; Online: Dietary Treatments for Epilepsy.

Haridas, Babitha / Kossoff, Eric H

Neurologic clinics

2022 Volume 40, Issue 4, Page(s) 785–797

Abstract: The ketogenic diet is one of the four major treatments for epilepsy, along with antiseizure medications, neuromodulation, and surgery. Ketogenic diet therapy has been proven to be a safe and effective antiseizure regimen for a century. There are multiple ...

Abstract	The ketogenic diet is one of the four major treatments for epilepsy, along with antiseizure medications, neuromodulation, and surgery. Ketogenic diet therapy has been proven to be a safe and effective antiseizure regimen for a century. There are multiple methods to administer the diet and the initiation should be individualized for each patient. The diet has been shown to be an effective treatment of choice for Glut1 deficiency, pyruvate dehydrogenase deficiency, infantile spasms, and superrefractory status epilepticus among others. This review discusses the administration of ketogenic diet therapy and highlights its role for specific epilepsy syndromes.
MeSH term(s)	Humans ; Glucose Transporter Type 1 ; Epilepsy/drug therapy ; Diet, Ketogenic ; Carbohydrate Metabolism, Inborn Errors ; Ketone Bodies/therapeutic use ; Diet ; Treatment Outcome
Chemical Substances	Glucose Transporter Type 1 ; Ketone Bodies
Language	English
Publishing date	2022-09-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1013148-6
ISSN	1557-9875 ; 0733-8619
ISSN (online)	1557-9875
ISSN	0733-8619
DOI	10.1016/j.ncl.2022.03.009
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Article ; Online: Ketogenic Diet: Parental Experiences and Expectations.

Orr, Elizabeth / Whitney, Robyn / Nandeesha, Nandini / Kossoff, Eric H / RamachandranNair, Rajesh

Journal of child neurology

2024 , Page(s) 8830738241227066

Abstract: Background: The ketogenic diet may be difficult for some patients and their families to implement and can impact physical, emotional, and social well-being.: Methods: Through principles of fundamental qualitative description, we completed an ... ...

Abstract	Background: The ketogenic diet may be difficult for some patients and their families to implement and can impact physical, emotional, and social well-being. Methods: Through principles of fundamental qualitative description, we completed an exploratory study on parents' experiences and expectations on the use and efficacy of the ketogenic diet for children with medically refractory epilepsy. Results: Seventeen parents (10 mothers and 7 fathers) of 12 children with epilepsy participated. At the time of the interview, parents had experienced an average of 25 months of ketogenic diet treatment for their child (range 2 months to 98 months). Half of the caregivers learned about the ketogenic diet from their neurologist, whereas the remainder had heard about it from another source (ie, the internet). Most caregivers' (n = 13) diet expectations were related to seizure control. However, child development (n = 5) and quality of life (n = 5) were also crucial to some. Physical impacts of the diet were most commonly gastrointestinal for children (n = 9). Social and emotional effects were noted in some older children with typical development. Most caregivers described negative impacts on finances (n = 15), relationships (n = 14), and emotional well-being (ie, stress) (n = 12). Caregivers benefited from the ketogenic diet team's regular communication, close follow-up, and family-centered care. Conclusions: Despite the impacts that the ketogenic diet may have on caregivers' emotional and social well-being, the positive impacts of the diet were felt to outweigh any perceived risks. Effects (both positive and negative) on quality of life and child development (eg, social, emotional, cognitive) are essential for caregivers and require additional investigation.
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	639288-x
ISSN	1708-8283 ; 0883-0738
ISSN (online)	1708-8283
ISSN	0883-0738
DOI	10.1177/08830738241227066
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Article ; Online: Seizure mimics in children: An age-based approach.

Stainman, Rebecca S / Kossoff, Eric H

Current problems in pediatric and adolescent health care

2020 Volume 50, Issue 12, Page(s) 100894

Abstract: Background: In order to distinguish seizure mimics from seizures in children it is important to clarify the event duration, frequency, semiology, and any precipitating factors.: Methodology: This review provides a succinct and up-to-date overview ... ...

Abstract	Background: In order to distinguish seizure mimics from seizures in children it is important to clarify the event duration, frequency, semiology, and any precipitating factors. Methodology: This review provides a succinct and up-to-date overview aimed at general and subspecialty non-neurologist pediatric and adolescent health care providers to help guide a diagnostic approach when a child presents with paroxysmal events of unclear etiology. Results: In many cases, seizure mimics are consistently triggered by an event, location, or emotion, and often resolve with distraction or tactile stimulation. Suspicion should be raised for seizures when events occur out of deep sleep, there is a loss of consciousness with the event, movements are not suppressible, and there is a period of fatigue afterword (minutes to hours). Further, a past medical history of developmental delay (e.g. autism), developmental regression, or neurologic injury increases patients' risk for seizures. Conclusions: Common seizure mimics are highlighted in the age group in which they are most prevalent.
MeSH term(s)	Adolescent ; Apnea ; Child ; Child, Preschool ; Diagnosis, Differential ; Humans ; Infant ; Infant, Newborn ; Nervous System Diseases/diagnosis ; Nervous System Diseases/epidemiology ; Primary Health Care ; Referral and Consultation ; Seizures/complications ; Seizures/diagnosis ; Seizures/epidemiology ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/epidemiology ; Syncope
Language	English
Publishing date	2020-11-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2078029-1
ISSN	1538-3199 ; 0045-9380 ; 1538-5442
ISSN (online)	1538-3199
ISSN	0045-9380 ; 1538-5442
DOI	10.1016/j.cppeds.2020.100894
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Article ; Online: Adolescent-onset absence epilepsy years after resolution of childhood epilepsy with myoclonic-atonic seizures.

Berth, Sarah H / Kossoff, Eric H

Epilepsy & behavior reports

2019 Volume 12, Page(s) 100329

Abstract: We present a case series of three boys with childhood epilepsy with myoclonic-atonic seizures (EMAS) who achieved complete remission during childhood only to develop absence seizures during early adolescence. In all three cases, the recurrent seizures ... ...

Abstract	We present a case series of three boys with childhood epilepsy with myoclonic-atonic seizures (EMAS) who achieved complete remission during childhood only to develop absence seizures during early adolescence. In all three cases, the recurrent seizures resolved again with antiseizure drugs, and two are currently medication-free for a second time.
Language	English
Publishing date	2019-07-22
Publishing country	United States
Document type	Case Reports
ISSN	2589-9864
ISSN (online)	2589-9864
DOI	10.1016/j.ebr.2019.100329
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