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Article ; Online: Expanding the Spectrum of Ocular Dipping With Ping-Pong Gaze.

Gudenkauf, Julie C / Taga, Arens / Zhang, Jiaying / Gold, Daniel

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

2023

Language	English
Publishing date	2023-12-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1189901-3
ISSN	1536-5166 ; 1070-8022
ISSN (online)	1536-5166
ISSN	1070-8022
DOI	10.1097/WNO.0000000000002063
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Zs.A 1670: Show issues

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Article ; Online: Comprehensive evaluation of the resistance to shoot shriveling before and after sprouting in different varieties of Ping’ou hybrid hazelnut

Haizhe Gao / Zhiguo Jia / Lirong Zhang / Zhang Li

Frontiers in Forests and Global Change, Vol

2024 Volume 6

Abstract: IntroductionThe hybrid hazelnut is an important fruit tree species known for its high productivity and disease resistance. However, during the growth process of hybrid hazelnuts, issues such as branch withering and bud wrinkling have attracted ... ...

Abstract	IntroductionThe hybrid hazelnut is an important fruit tree species known for its high productivity and disease resistance. However, during the growth process of hybrid hazelnuts, issues such as branch withering and bud wrinkling have attracted significant attention. These phenomena severely impact the normal development and yield of the plants. This study aimed to investigate the relationship between the resistance to shoot emergence and physiological changes in six hazel tree varieties by comprehensively analyzing their resistance to shoot emergence.MethodSix widely cultivated hazelnut hybrid varieties were selected for physiological measurements and field surveys using one-year-old branches and buds as test materials. The resistance to shoot emergence of different hazel tree varieties was evaluated through correlation analysis, principal component analysis, and membership function evaluation.ResultsThe results showed that the length and width of hazel buds gradually increased while the thickness first increased and then decreased before and after bud burst. The carbohydrate levels of the ‘Dawei’, ‘Pingou 110’, and ‘84–237’ varieties were significantly higher than those of other varieties. The content of reducing sugars and starch in hazel buds generally increased and then decreased during the bud burst process, while α-amylase activity showed a decreasing trend followed by an increasing trend. The antioxidative enzyme activity of ‘Dawei’ was significantly higher than that of other varieties on different sampling dates. The soluble protein content, POD enzyme activity, and CAT enzyme activity of hazel buds for the six varieties gradually decreased. The moisture content of ‘Pingou 210’ shoots was significantly higher than that of other varieties during the peak emergence period. The correlation analysis results showed that the bud burst rate of hazel trees was positively correlated with the length, width, thickness, reducing sugar content, starch content, POD enzyme activity, CAT enzyme activity, and shoot ...
Keywords	Ping’ou hybrid hazelnut ; germinating buds ; shoot shriveling ; physiological changes ; comprehensive assessment ; Forestry ; SD1-669.5 ; Environmental sciences ; GE1-350
Subject code	571
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Anti-inflammatory effect of Yu-Ping-Feng-San

Yang, Zhong-Shan / Yan, Jin-Yuan / Han, Ni-Ping / Zhou, Wei / Cheng, Yu / Zhang, Xiao-Mei / Li, Ning / Yuan, Jia-Li

Iranian journal of basic medical sciences

2016 Volume 19, Issue 9, Page(s) 993–1002

Abstract: Objectives: Yu-Ping-Feng-San (YPFS) is a classical traditional Chinese medicine that is widely ...

Abstract	Objectives: Yu-Ping-Feng-San (YPFS) is a classical traditional Chinese medicine that is widely used for treatment of the diseases in respiratory systems, including chronic obstructive pulmonary disease (COPD) recognized as chronic inflammatory disease. However, the molecular mechanism remains unclear. Here we detected the factors involved in transforming growth factor beta 1 (TGF-β1)/Smad2 signaling pathway and inflammatory cytokines, to clarify whether YPFS could attenuate inflammatory response dependent on TGF-β1/Smad2 signaling in COPD rats or cigarette smoke extract (CSE)-treated human bronchial epithelial (Beas-2B) cells. Materials and methods: The COPD rat model was established by exposure to cigarette smoke and intratracheal instillation of lipopolysaccharide, YPFS was administered to the animals. The efficacy of YPFS was evaluated by comparing the severity of pulmonary pathological damage, pro-inflammation cytokines, collagen related genes and the activation of TGF-β1/Smad2 signaling pathway. Furthermore, CSE-treated cells were employed to confirm whether the effect of YPFS was dependent on the TGF-β1/Smad2 signaling via knockdown Smad2 (Si-RNA), or pretreatment with the inhibitor of TGF-β1. Results: Administration of YPFS effectively alleviated injury of lung, suppressed releasing of pro-inflammatory cytokines and collagen deposition in COPD animals ( Conclusion: YPFS accomplished anti-inflammatory effects mainly by suppressing phosphorylation of Smad2, TGF-β1/Smad2 signaling pathway was required for YPFS-mediated anti-inflammation in COPD rats or CSE-treated Beas-2B cells.
Language	English
Publishing date	2016-10-17
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2500485-2
ISSN	2008-3874 ; 2008-3866
ISSN (online)	2008-3874
ISSN	2008-3866
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Article: Tang-Ping-San Decoction Remodel Intestinal Flora and Barrier to Ameliorate Type 2 Diabetes Mellitus in Rodent Model.

Yin, Wen / Zhang, Si-Qi / Pang, Wen-Lin / Chen, Xiao-Jiao / Wen, Jing / Hou, Jiong / Wang, Cui / Song, Li-Yun / Qiu, Zhen-Ming / Liang, Peng-Tao / Yuan, Jia-Li / Yang, Zhong-Shan / Bian, Yao

Diabetes, metabolic syndrome and obesity : targets and therapy

2022 Volume 15, Page(s) 2563–2581

Abstract: ... metabolic diseases and promote the progression of T2DM. Tang-ping-san (TPS) decoction can effectively treat T2DM ...

Abstract	Purpose: Type 2 diabetes mellitus (T2DM) is a complex genetic disease associated with genetic and environmental factors. Previous studies have shown that changes in the gut microbiota may affect the development of host metabolic diseases and promote the progression of T2DM. Tang-ping-san (TPS) decoction can effectively treat T2DM. However, its specific mechanisms must be evaluated. Patients and methods: In the present study, we established an animal model of T2DM using a high‑fat diet (HFD) with intraperitoneal injection streptozotocin injection. Results: The therapeutic effect of TPS decoction on T2DM in mice was initially evaluated. TPS decoction was found to improve hyperglycemia, hyperlipidemia, insulin resistance, and pathological liver, pancreatic, and colon changes. Moreover, it reduced the pro-inflammatory cytokine levels. Based on 16SrRNA sequencing, TPS decoction reduced the Conclusion: TPS decoction improves T2DM and liver function and reduces the risk of hyperglycemia, hyperlipidemia, insulin resistance, pathological organ changes, and inflammatory reactions. The mechanism of TPS decoction in T2DM can be correlated with the reversal of gut microbiota dysfunction and repair of the intestinal mucosal barrier.
Language	English
Publishing date	2022-08-20
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494854-8
ISSN	1178-7007
ISSN	1178-7007
DOI	10.2147/DMSO.S375572
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Article ; Online: Ping weisan alleviates chronic colitis in mice by regulating intestinal microbiota composition.

Zhang, Zecai / Cao, Hongyang / Shen, Peng / Liu, Jiuxi / Cao, Yongguo / Zhang, Naisheng

Journal of ethnopharmacology

2020 Volume 255, Page(s) 112715

Abstract: Ethnopharmacological relevance: Ping weisan (PWS), a complex formulation used ...

Abstract	Ethnopharmacological relevance: Ping weisan (PWS), a complex formulation used in traditional Chinese medicine, is first described in 1107 AD and published in the Prescriptions of Taiping Benevolent Dispensary. We have previously confirmed that PWS has the effect of alleviating DSS-induced chronic ulcerative colitis (UC) in mice. Aim of the study: We aimed to examine whether PWS protects mice from chronic UC by regulating intestinal microbiota composition. Materials and methods: Chronic colitis was induced in C57BL/6 mice with 2.5% DSS in drinking water. PWS (8 g/kg) was orally administered throughout the experiment. Body weight changes, stool consistency and myeloperoxidase (MPO) activity were measured in these mice. Interleukin-17A (IL-17A) and interferon gamma (IFN-γ) mRNA levels were detected by qRT-PCR. The alterations of fecal microflora were investigated by 16S rRNA sequencing. Furthermore, intestinal tight junction protein including occludin, and serum lipopolysaccharide (LPS) level were also detected. Results: PWS relieved DSS-induced loss of body weight, and improved stool consistency and MPO activity in mice. The levels of IL-17A and IFN-γ mRNA were also reduced after treatment with PWS. PWS not only regulated occludin level but also decreased serum LPS. We further showed DSS-induced changes in intestinal microbial composition and richness are significantly regulated by PWS. PWS treatment significantly decreased the abundance of Bacteroidetes, but increased the abundance of Firmicutes in chronic UC mice induced by DSS. Conclusions: Combining with our previous results, we found that PWS could exert anti-UC role by rebalancing intestinal bacteria.
MeSH term(s)	Animals ; Chronic Disease ; Colitis/chemically induced ; Colitis/metabolism ; Colitis/microbiology ; Colitis/prevention & control ; Colon/drug effects ; Colon/metabolism ; Colon/microbiology ; Dextran Sulfate ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Dysbiosis ; Gastrointestinal Agents/pharmacology ; Gastrointestinal Microbiome/drug effects ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; Interleukin-17/genetics ; Interleukin-17/metabolism ; Lipopolysaccharides/blood ; Male ; Mice, Inbred C57BL ; Occludin/genetics ; Occludin/metabolism ; Peroxidase/metabolism ; Weight Loss/drug effects
Chemical Substances	Drugs, Chinese Herbal ; Gastrointestinal Agents ; IFNG protein, mouse ; Il17a protein, mouse ; Interleukin-17 ; Lipopolysaccharides ; Occludin ; Ocln protein, mouse ; ping wei san ; Interferon-gamma (82115-62-6) ; Dextran Sulfate (9042-14-2) ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	2020-02-27
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.112715
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Zs.A 1494: Show issues

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Article ; Online: Pricing analysis of structured financial products of Ping An Bank

WANG Yang / ZHAO Dan / ZHANG Jizhou / FU Yi

Journal of Shanghai Normal University (Natural Sciences), Vol 49, Iss 5, Pp 533-

2020 Volume 540

Abstract: ... In this paper, the financial product of Ping An Bank's wealth structured(100% guaranteed linked interest rate ...

Abstract	As a high yield and low risk investment method, financial products cater to the needs of investors.In this paper, the financial product of Ping An Bank's wealth structured(100% guaranteed linked interest rate)asset management open 98-day RMB 002 series is taken as the research object.The mathematical model is established by using the discounted cash flow model and the LIBOR market model.The theoretical price of the product is calculated by using Monte Carlo simulation.By comparing the theoretical price with the actual price, it is concluded that the expected yield of the financial product is consistent with the highest yield mentioned in the product description.This shows that the value of the financial product is underestimated.
Keywords	structured financial products ; discounted cash flow model ; libor market model ; monte carlo simulation ; pricing ; Science (General) ; Q1-390
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	Academic Journals Center of Shanghai Normal University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Trace N-doped manganese dioxide cooperated with Ping-pong chrysanthemum-like NiAl-layered double hydroxide on cathode for improving bioelectrochemical performance of microbial fuel cell.

Xu, Yuling / Zhang, Xinyi / Liu, Yanyan / Wei, Yushan / Lan, Feng / Wang, Renjun / Yang, Yuewei / Chen, Junfeng

Bioresource technology

2023 Volume 381, Page(s) 129139

Abstract: Trace N-doped manganese dioxide ( ... ...

Abstract	Trace N-doped manganese dioxide (MnO
MeSH term(s)	Oxides/chemistry ; Bioelectric Energy Sources ; Manganese Compounds/chemistry ; Electrodes ; Hydroxides
Chemical Substances	manganese dioxide (TF219GU161) ; Oxides ; Manganese Compounds ; hydroxide ion (9159UV381P) ; Hydroxides
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1065195-0
ISSN	1873-2976 ; 0960-8524
ISSN (online)	1873-2976
ISSN	0960-8524
DOI	10.1016/j.biortech.2023.129139
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Article ; Online: Efficacy and safety of Xiao-ai-ping injection add-on therapy to chemotherapy in patients with non-small cell lung cancer: A systematic review and meta-analysis.

Li, Andong / Liu, Shilin / Zhang, Hui / Lin, Minghao / Guo, Lijiao / Yuan, Chengbo / Li, Zhenyu / Xu, Jianan / Wang, Tan

Medicine

2023 Volume 102, Issue 40, Page(s) e35483

Abstract: Background: Xiao-ai-ping injection (XAPI) combined with chemotherapy has potential efficacy and ...

Abstract	Background: Xiao-ai-ping injection (XAPI) combined with chemotherapy has potential efficacy and less side effects in the treatment of non-small cell lung cancer (NSCLC). At present, there are many clinical studies on XAPI combined with chemotherapy in the treatment of NSCLC, but the results are different. The purpose of this study was to evaluate the efficacy and safety of XAPI combined with chemotherapy in the treatment of NSCLC by meta-analysis system. Methods: The databases to be searched include PubMed, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang database, Chinese Scientific Journal Database, and so on. In addition, relevant journals and magazines will manually search in various fields as supplements. The search date is set from the establishment of the database until July 8, 2023. The 2 researchers will use Endnote X9 software for literature screening and data extraction and independently evaluate the quality. We then assessed the quality and risk of inclusion in the study and observed outcome indicators. Results: A total of 28 trials were included in this study, 1947 patients with NSCLC (974 receiving XAPI combined chemotherapy and 973 receiving chemotherapy alone). The results of meta-analysis showed that: Objective tumor response rate of NSCLC (P < .00001). Improvement in Karnofsky performance score of NSCLC (P < .00001). Quality of life score of NSCLC (P < .00001). The result of CD3 + (P < .00001). The result of CD4 + (P < .00001). The result of CD8 + (P < .00001). The result of CD4+/CD8 + (P = .0001). Leukopenia (P < .00001). Thrombocytopenia (P < .00001). Hemoglobin decrease (P < .00001). Liver function (P = .04). Nausea and vomiting (P < .00001). Conclusion: Our meta-analyses demonstrated that XAPI adjunct with chemotherapy can improve the patient quality of life, reduce adverse reactions, and enhanced immune function, the treatment is effective and high safety. Which suggests that it might be used for NSCLC. However, a large sample of randomized controlled trials are needed to further study the long-term efficacy of XAPI.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/pathology ; Lung Neoplasms/pathology ; Quality of Life ; Drugs, Chinese Herbal/adverse effects ; Thrombocytopenia/chemically induced
Chemical Substances	Marsdeniae tenacissimae extract ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000035483
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Article ; Online: Yu ping feng san for pediatric allergic rhinitis: A systematic review and meta-analysis of randomized controlled trials.

Liao, Yong / Zhong, Juan / Liu, Shuqin / Dai, Menglin / Liu, Yang / Li, Xinrong / Yang, Yepeng / Zhang, Dazheng / Lai, Dan / Lu, Tao / Zhang, Qinxiu / Zhao, Yu

Medicine

2021 Volume 100, Issue 13, Page(s) e24534

Abstract: Background: The potential treatment effects and safety of Yu ping feng san (YPFS) for pediatric ...

Abstract	Background: The potential treatment effects and safety of Yu ping feng san (YPFS) for pediatric allergic rhinitis (PAR) patients have yet to be studied systematically. Objectives: To assess the effects and safety of YPFS for treat pediatric patients, allergic rhinitis. Methods: We systematically searched PubMed, EMBASE (Excerpta Medical Database), Cochrane library, Chinese Cochrane Centre's Controlled Trials Register platform, Wanfang Chinese Digital Periodical and Conference Database, China National Knowledge Infrastructure Database, and VIP Chinese Science, from inception dates to November 1, 2019. Randomized controlled trials (RCTs) were included. The risk of bias in the trials was assessed in accordance with the Cochrane Handbook, version 5.1.0. RevMan 5.3 software was used to perform a meta-analysis. Grading of Recommendations Assessment, Development and Evaluation methodology was applied to evaluate the evidence quality for each outcome. The quality of evidence for each outcome measurement was low for 4 outcomes and very low for 5 outcomes. Results: A total of 10 RCTs involving 1069 participants (3-15 years old) fulfilled the inclusion criteria. After exclusion, 8 RCTs were pooled for efficacy assessment. The overall efficacy evaluation result did not show benefit for the experimental group (relative risk 0.32, CI 95% 0.24-0.45; P = .98;) Investigation of variation of serum IgA, immunoglobulin E, IgG in three studies in 2 groups returned no statistical significance. YPFS gave relatively better safety (relative risk 0.29, CI 95% 0.14-0.58; P = .0005; Fig. S8, http://links.lww.com/MD/F751) and lower recurrence rates than did Western medical therapy. Conclusions: Current evidence cannot support the routine use of YPFS for treatment of PAR. This may be due to poor-quality study-design limitations of the included YPFS studies. Our data showed that the use of YPFS for PAR is relatively safe compared to Western medical therapy, but a conclusion could not be drawn because only 5 studies were analyzed. Every study suffered from some methodological limitation. Therefore, further large, rigorously-designed studies are necessary to determine conclusively the utility of YPFS in PAR.
MeSH term(s)	Adolescent ; Child ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Male ; Randomized Controlled Trials as Topic ; Rhinitis, Allergic/drug therapy ; Treatment Outcome
Chemical Substances	Drugs, Chinese Herbal ; yu ping feng san
Language	English
Publishing date	2021-04-23
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000024534
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Article ; Online: UPLC-MS/MS for the Herb-Drug Interactions of Xiao-Ai-Ping Injection on Enasidenib in Rats Based on Pharmacokinetics.

Wang, Bo-Wen / Qiu, Cheng-Zheng / Tang, Chang-Qian / Zhang, Jia-Hui / Zhang, Yi / Du, Qi-Guang / Feng, Yi / Qiu, Xiang-Jun

BioMed research international

2021 Volume 2021, Page(s) 6636266

Abstract: ... the effect of Xiao-ai-ping injection (XAPI) on the pharmacokinetics of enasidenib in rats.: Methods ...

Abstract	Objective: To develop and validate a sensitive and rapid ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of enasidenib in rat plasma and to investigate the effect of Xiao-ai-ping injection (XAPI) on the pharmacokinetics of enasidenib in rats. Methods: The rat plasma was precipitated with acetonitrile, enasidenib and internal standard (IS) were separated on an Acquity UPLC BEH C18 column, and acetonitrile and 0.1% formic acid were used as the mobile phase in gradient mode. Enasidenib and IS were monitored and detected by multiple reaction monitoring (MRM) using tandem mass spectrometry in positive ion mode. 12 Sprague-Dawley (SD) rats were randomly divided into control group (group A) and experimental group (group B), 6 rats in each group. Group B was intramuscularly injected with XAPI (0.3 mL/kg) every morning, 7 days in a row. Group A was intramuscularly injected with normal saline, 7 days in a row. On the seventh day, enasidenib (10 mg/kg) was given to both groups 30 min after injection of normal saline (group A) or XAPI (group B), and the blood was collected at different time points such as 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 9, 12, 24, and 48 h. The concentration of enasidenib was detected by UPLC-MS/MS, and the main parameters of pharmacokinetic of enasidenib were calculated using the DAS 2.0 software. Results: Under the current experimental conditions, this UPLC method showed good linearity in the detection of enasidenib. Interday and intraday precision did not exceed 10%, the range of accuracy values were from -1.43% to 2.76%. The results of matrix effect, extraction recovery, and stability met the requirements of FDA approval guidelines of bioanalytical method validation. The Conclusion: An UPLC-MS/MS method for the determination of enasidenib in rat plasma was established. XAPI can inhibit the metabolism of enasidenib and increase the concentration of enasidenib in rats. It is suggested that when XAPI was combined with enasidenib, the herb-drug interaction and adverse reactions should be paid attention to, and the dosage should be adjusted if necessary.
MeSH term(s)	Aminopyridines/pharmacokinetics ; Aminopyridines/pharmacology ; Animals ; Chromatography, High Pressure Liquid ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/pharmacology ; Herb-Drug Interactions ; Male ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry ; Triazines/pharmacokinetics ; Triazines/pharmacology
Chemical Substances	Aminopyridines ; Drugs, Chinese Herbal ; Marsdeniae tenacissimae extract ; Triazines ; enasidenib (3T1SS4E7AG)
Language	English
Publishing date	2021-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2021/6636266
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