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  1. Article ; Online: Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy.

    Yang, Pei-Chi / Moreno, Jonathan D / Jeng, Mao-Tsuen / Wehrens, Xander H T / Noskov, Sergei / Clancy, Colleen E

    The Journal of physiology

    2016  Volume 594, Issue 21, Page(s) 6433–6435

    Language English
    Publishing date 2016-11-01
    Publishing country England
    Document type Letter
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP273143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Anti-Ro/SSA Antibodies in Atrioventricular Block: Innocent Bystander or Mechanistic Driver?

    Keefe, Joshua A / Wehrens, Xander H T

    JACC. Clinical electrophysiology

    2023  Volume 9, Issue 8 Pt 3, Page(s) 1649–1651

    MeSH term(s) Humans ; Atrioventricular Block
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.04.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Endothelial cell dysfunction: the culprit for cardiac denervation in aging?

    Moore, Oliver M / Keefe, Joshua A / Wehrens, Xander H T

    The journal of cardiovascular aging

    2023  Volume 3, Issue 4

    Language English
    Publishing date 2023-10-14
    Publishing country United States
    Document type Journal Article
    ISSN 2768-5993
    ISSN (online) 2768-5993
    DOI 10.20517/jca.2023.36
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Variant-specific therapy for long QT syndrome type 3.

    Moore, Oliver M / Dorn, Lauren E / Wehrens, Xander H T

    Heart rhythm

    2023  Volume 20, Issue 5, Page(s) 718–719

    MeSH term(s) Humans ; Long QT Syndrome/diagnosis ; Long QT Syndrome/genetics ; Long QT Syndrome/therapy ; Phenotype ; Electrocardiography
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2023.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Ryanodine receptors

    Wehrens, Xander H. T.

    structure, function and dysfunction in clinical disease

    (Developments in cardiovascular medicine ; 254)

    2005  

    Author's details ed. by Xander H. T. Wehrens
    Series title Developments in cardiovascular medicine ; 254
    Collection
    Keywords Ryanodine Receptor Calcium Release Channel / physiology ; Ryanodine Receptor Calcium Release Channel / chemistry ; Ryanodin-Rezeptor
    Subject Ryanodin
    Language English
    Size XXI, 330 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT014296338
    ISBN 0-387-23187-0 ; 978-0-387-23187-7
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: Diagnosing atrial fibrillation: Can we do better than the ECG?

    Ho, Kevin S / Keefe, Joshua A / Wehrens, Xander H T

    Heart rhythm

    2022  Volume 19, Issue 9, Page(s) 1459–1460

    MeSH term(s) Atrial Fibrillation/diagnosis ; Electrocardiography ; Electrocardiography, Ambulatory ; Humans
    Language English
    Publishing date 2022-06-10
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2022.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Tachycardia and Atrial Fibrillation-Related Cardiomyopathies: Potential Mechanisms and Current Therapies.

    Keefe, Joshua A / Garber, Rebecca / McCauley, Mark D / Wehrens, Xander H T

    JACC. Heart failure

    2024  Volume 12, Issue 4, Page(s) 605–615

    Abstract: Atrial fibrillation (AF) is associated with an increased risk of new-onset ventricular contractile dysfunction, termed arrhythmia-induced cardiomyopathy (AIC). Although cardioembolic stroke remains the most feared and widely studied complication of AF, ... ...

    Abstract Atrial fibrillation (AF) is associated with an increased risk of new-onset ventricular contractile dysfunction, termed arrhythmia-induced cardiomyopathy (AIC). Although cardioembolic stroke remains the most feared and widely studied complication of AF, AIC is also a clinically important consequence of AF that portends significant morbidity and mortality to patients with AF. Current treatments are aimed at restoring sinus rhythm through catheter ablation and rate and rhythm control, but these treatments do not target the underlying molecular mechanisms driving the progression from AF to AIC. Here, we describe the clinical features of the various AIC subtypes, discuss the pathophysiologic mechanisms driving the progression from AF to AIC, and review the evidence surrounding current treatment options. In this review, we aim to identify key knowledge gaps that will enable the development of more effective AIC therapies that target cellular and molecular mechanisms.
    MeSH term(s) Humans ; Atrial Fibrillation/therapy ; Atrial Fibrillation/drug therapy ; Heart Failure/complications ; Cardiomyopathies/etiology ; Cardiomyopathies/therapy ; Tachycardia/complications ; Tachycardia/surgery ; Catheter Ablation/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2023.11.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Common disease-promoting signalling pathways in heart failure and atrial fibrillation: putative underlying mechanisms and potential therapeutic consequences.

    Keefe, Joshua A / Wehrens, Xander H T / Dobrev, Dobromir

    Cardiovascular research

    2022  Volume 118, Issue 11, Page(s) 2397–2399

    MeSH term(s) Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/physiopathology ; Heart Failure/physiopathology ; Heart Failure/therapy ; Humans
    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvac107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Unraveling the Mechanisms by Which Calpain Inhibition Prevents Heart Failure Development.

    Wehrens, Xander H T

    JACC. Basic to translational science

    2018  Volume 3, Issue 4, Page(s) 518–520

    Language English
    Publishing date 2018-08-28
    Publishing country United States
    Document type Editorial
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2018.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Gut microbiota: a key regulator of ageing-associated atrial fibrillation?

    Li, Na / Durgan, David J / Wehrens, Xander H T

    Cardiovascular research

    2021  Volume 118, Issue 3, Page(s) 657–659

    MeSH term(s) Aging ; Atrial Fibrillation/diagnosis ; Gastrointestinal Microbiome ; Humans
    Language English
    Publishing date 2021-11-26
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvab346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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