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  1. Article ; Online: Cell adhesion molecules as therapeutic targets: interview with Professor Michael P Schön. Interviewed by Emma Quigley.

    Schön, Michael P

    Expert opinion on therapeutic targets

    2006  Volume 10, Issue 6, Page(s) 799–802

    Abstract: Professor Michael P Schön (University of Würzburg) was interviewed by Emma Quigley (Commissioning ... Editor, Expert Opinion) on 17th October 2006. Professor Michael P Schön currently holds the position ...

    Abstract Professor Michael P Schön (University of Würzburg) was interviewed by Emma Quigley (Commissioning Editor, Expert Opinion) on 17th October 2006. Professor Michael P Schön currently holds the position of Professor of Dermatology and Experimental Biomedicine at the University of Würzburg. He received his MD degree in 1992 from the University of Ulm in Germany. His internationally successful scientific career has led him to study dermatology and immunology at the University of Berlin, Harvard Medical School, the University of Düsseldorf and the University of Magdeburg. With various research awards and certificates in dermatology, immunology and dermatopathology, Professor Schön has published > 100 papers. He has also been a guest editor and on the Editorial Board of various publications.
    MeSH term(s) Anti-Inflammatory Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Cell Adhesion Molecules/antagonists & inhibitors ; Cell Adhesion Molecules/metabolism ; Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism
    Chemical Substances Anti-Inflammatory Agents ; Antineoplastic Agents ; Cell Adhesion Molecules
    Language English
    Publishing date 2006-11-09
    Publishing country England
    Document type Interview
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1517/14728222.10.6.799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5244: Show issues Location:
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  2. Article ; Online: Die Zecke und ich: Parasiten-Wirt-Interaktionen zwischen Zecken und Menschen.

    Schön, Michael P

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2022  Volume 20, Issue 6, Page(s) 818–855

    Language English
    Publishing date 2022-01-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14821_g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6148: Show issues Location:
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  3. Article ; Online: The tick and I: Parasite-host interactions between ticks and humans.

    Schön, Michael P

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2022  Volume 20, Issue 6, Page(s) 818–853

    Abstract: Ticks, particularly hard ticks (Ixodidae), which are among the most important vectors of dangerous infectious agents, feed on their hosts for extended periods of time. With this lifestyle, numerous adaptations have evolved in ticks and their hosts, the ... ...

    Abstract Ticks, particularly hard ticks (Ixodidae), which are among the most important vectors of dangerous infectious agents, feed on their hosts for extended periods of time. With this lifestyle, numerous adaptations have evolved in ticks and their hosts, the pharmacological importance of which is increasingly being recognized. Many bioactive substances in tick saliva are being considered as the basis of new drugs. For example, components of tick cement can be developed into tissue adhesives or wound closures. Analgesic and antipruritic salivary components inhibit histamine or bradykinin, while other tick-derived molecules bind opioid or cannabinoid receptors. Tick saliva inhibits the extrinsic, intrinsic, or common pathway of blood coagulation with implications for the treatment of thromboembolic diseases. It contains vasodilating substances and affects wound healing. The broad spectrum of immunomodulatory and immunosuppressive effects of tick saliva, such as inhibition of chemokines or cellular immune responses, allows development of drugs against inflammation in autoimmune diseases and/or infections. Finally, modern vaccines against ticks can curb the spread of serious infections. The medical importance of the complex tick-host interactions is increasingly being recognized and translated into first clinical applications. Using selected examples, an overview of the mutual adaptations of ticks and hosts is given here, focusing on their significance to medical advance.
    MeSH term(s) Animals ; Host-Parasite Interactions ; Humans ; Ixodidae/physiology ; Saliva ; Ticks/physiology
    Language English
    Publishing date 2022-06-08
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Psoriasis und nichtalkoholische Fettleber.

    Schön, Michael P

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2021  Volume 19, Issue 4, Page(s) 503–504

    Language English
    Publishing date 2021-04-16
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14469_g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Psoriasis and non-alcoholic fatty liver disease.

    Schön, Michael P

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2021  Volume 19, Issue 4, Page(s) 503–504

    MeSH term(s) Humans ; Metabolic Syndrome ; Non-alcoholic Fatty Liver Disease/diagnosis ; Non-alcoholic Fatty Liver Disease/therapy ; Psoriasis/diagnosis ; Risk Factors
    Language English
    Publishing date 2021-04-16
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14469
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  6. Article ; Online: Melanocyte Density in the Diagnosis of Melanoma In Situ in Sun-Damaged Skin.

    Löper, Rieke / Schön, Michael P / Mitteldorf, Christina

    The American Journal of dermatopathology

    2024  

    Abstract: Abstract: Histologic differentiation between melanoma in situ in chronically sun-damaged skin (CSDS) [lentigo maligna (LM)] and CSDS without malignancy is difficult because signs of melanocyte activation and proliferation are found in both. A ... ...

    Abstract Abstract: Histologic differentiation between melanoma in situ in chronically sun-damaged skin (CSDS) [lentigo maligna (LM)] and CSDS without malignancy is difficult because signs of melanocyte activation and proliferation are found in both. A potentially reliable and quantifiable criterion is melanocyte density (MD). Here, we evaluated whether and to what extent MD allows the distinction between LM and CSDS, which is particularly relevant for the evaluation of borderline cases and surgical margins.Articles assessing MD in LM and/or CSDS were evaluated in a systematic review. The results were categorized and compared according to staining. Cutoff values were included whenever stated.Twenty articles matched the selection criteria. Six hundred forty-four samples of CSDS and 227 samples of LM were considered. In each individual study, mean MD scores were higher for LM than for CSDS. However, looking at the overall study situation, it becomes clear that the data are very heterogeneous and show overlaps. Therefore, no reliable orientation value can be derived. Only 1 article defined a cutoff value.The data of MD in LM in contrast to CSDS were sparse, and a defined cutoff value was only mentioned in 1 article for microphthalmia-associated transcription factor, which cannot yet be generalized. Especially regarding the importance for the definition of surgical resection margins, this unsatisfactory data set highlights the need for further studies. More precise diagnostic criteria could spare some patients extensive and possibly disfiguring surgery.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Psoriasis / 2

    Schön, Michael P.

    (Clinics in dermatology ; 26,5)

    2008  

    Author's details guest ed.: Michael P. Schön
    Series title Clinics in dermatology ; 26,5
    Psoriasis
    Collection Psoriasis
    Language English
    Size S. 417 - 580 : Ill.
    Publisher Elsevier
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT016061007
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 972 -26,5- verfügbar in Königswinter Königswinter

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  8. Article ; Online: First episode of generalized pustular psoriasis or acute generalized exanthematous pustulosis? A case study.

    Cramer, Neda / Buhl, Timo / Schön, Michael P / Mössner, Rotraut

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2024  

    Language English
    Publishing date 2024-03-15
    Publishing country Germany
    Document type Letter
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.15332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Psoriasis / 1

    Schön, Michael P.

    (Clinics in dermatology ; 25,6)

    2007  

    Author's details guest ed.: Michael P. Schön
    Series title Clinics in dermatology ; 25,6
    Psoriasis
    Collection Psoriasis
    Language English
    Size S. 501 - 634 : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT015383448
    Database Catalogue ZB MED Medicine, Health

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