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Article ; Online: Preventing polyspermy in mammalian eggs-Contributions of the membrane block and other mechanisms.

Evans, Janice P

2020 Volume 87, Issue 3, Page(s) 341–349

Abstract: The egg's blocks to polyspermy (fertilization of an egg by more than one sperm) were originally identified in marine and aquatic species with external fertilization, but polyspermy matters in mammalian reproduction too. Embryonic triploidy is a ... ...

Abstract	The egg's blocks to polyspermy (fertilization of an egg by more than one sperm) were originally identified in marine and aquatic species with external fertilization, but polyspermy matters in mammalian reproduction too. Embryonic triploidy is a noteworthy event associated with pregnancy complications and loss. Polyspermy is a major cause of triploidy with up to 80% of triploid conceptuses being the result of dispermic fertilization. The mammalian female reproductive tract regulates the number of sperm that reach the site of fertilization, but mammals also utilize egg-based blocks to polyspermy. The egg-based blocks occur on the mammalian egg coat (the zona pellucida) and the egg plasma membrane, with apparent variation between different mammalian species regarding the extent to which one or both are used. The zona pellucida block to polyspermy has some similarities to the slow block in water-dwelling species, but the mammalian membrane block to polyspermy differs substantially from the fast electrical block that has been characterized in marine and aquatic species. This review discusses what is known about the incidence of polyspermy in mammals and about the mammalian membrane block to polyspermy, as well as notes some lesser-characterized potential mechanisms contributing to polyspermy prevention in mammals.
MeSH term(s)	Animals ; Calcium/metabolism ; Calcium Signaling/physiology ; Cell Membrane/metabolism ; Female ; Humans ; Male ; Oocytes/metabolism ; Oocytes/ultrastructure ; Sperm-Ovum Interactions/physiology ; Spermatozoa/metabolism ; Triploidy ; Zona Pellucida/metabolism
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-03-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	20321-x
ISSN	1098-2795 ; 1040-452X
ISSN (online)	1098-2795
ISSN	1040-452X
DOI	10.1002/mrd.23331
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Article ; Online: Oscillations in PP1 activity are essential for accurate progression through mammalian oocyte meiosis.

Camlin, Nicole J / Venkatachalam, Ilakkiya / Evans, Janice P

Cell cycle (Georgetown, Tex.)

2023 Volume 22, Issue 13, Page(s) 1614–1636

Abstract: Tightly controlled fluctuations in kinase and phosphatase activity play important roles in regulating M-phase transitions. Protein Phosphatase 1 (PP1) is one of these phosphatases, with oscillations in PP1 activity driving mitotic M-phase. Evidence from ... ...

Abstract	Tightly controlled fluctuations in kinase and phosphatase activity play important roles in regulating M-phase transitions. Protein Phosphatase 1 (PP1) is one of these phosphatases, with oscillations in PP1 activity driving mitotic M-phase. Evidence from a variety of experimental systems also points to roles in meiosis. Here, we report that PP1 is important for M-phase transitions through mouse oocyte meiosis. We employed a unique small-molecule approach to inhibit or activate PP1 at distinct phases of mouse oocyte meiosis. These studies show that temporal control of PP1 activity is essential for the G2/M transition, metaphase I/anaphase I transition, and the formation of a normal metaphase II oocyte. Our data also reveal that inappropriate activation of PP1 is more deleterious at the G2/M transition than at prometaphase I-to-metaphase I, and that an active pool of PP1 during prometaphase is vital for metaphase I/anaphase I transition and metaphase II chromosome alignment. Taken together, these results establish that loss of oscillations in PP1 activity causes a range of severe meiotic defects, pointing to essential roles for PP1 in female fertility, and more broadly, M-phase regulation.
MeSH term(s)	Female ; Mice ; Animals ; Meiosis ; Oocytes/metabolism ; Metaphase ; Anaphase ; Mitosis ; Protein Phosphatase 1/metabolism ; Mammals
Chemical Substances	Protein Phosphatase 1 (EC 3.1.3.16)
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.1080/15384101.2023.2225924
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Article ; Online: Auxin-inducible protein degradation as a novel approach for protein depletion and reverse genetic discoveries in mammalian oocytes†.

Camlin, Nicole J / Evans, Janice P

Biology of reproduction

2019 Volume 101, Issue 4, Page(s) 704–718

Abstract: The disruption of protein expression is a major approach used for investigating protein function in mammalian oocytes. This is often achieved with RNAi/morpholino-mediated knockdown or gene knockout, leading to long-term loss of proteins of interest. ... ...

Abstract	The disruption of protein expression is a major approach used for investigating protein function in mammalian oocytes. This is often achieved with RNAi/morpholino-mediated knockdown or gene knockout, leading to long-term loss of proteins of interest. However, these methods have noteworthy limitations, including (a) slow protein turnover can prohibit use of these approaches; (b) essential roles in early events precludes characterization of functions in subsequent events; (c) extended protein loss can allow time for compensatory mechanisms and other unanticipated events that confound interpretation of results. The work presented here examines the use of auxin-inducible degradation, a powerful new approach that overcomes these limitations through the depletion of one's protein of interest through controllable ubiquitin-mediated degradation. This method has been employed in yeast and mammalian cell lines, and here we demonstrate the utility of auxin-inducible degradation in mouse oocytes at multiple stages of meiosis, through degradation of exogenously expressed EGFP. We also evaluate important parameters for experimental design for use of this system in oocytes. This study thus expands the toolkit of researchers in oocyte biology, establishing the use of this unique and versatile approach for depleting proteins in oocytes, and providing researchers with valuable information to make use of this system.
MeSH term(s)	Animals ; Cells, Cultured ; Cloning, Organism/methods ; Cloning, Organism/veterinary ; Female ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; In Vitro Oocyte Maturation Techniques/methods ; In Vitro Oocyte Maturation Techniques/veterinary ; Indoleacetic Acids/pharmacology ; Mammals ; Meiosis/drug effects ; Meiosis/genetics ; Mice ; Oocytes/drug effects ; Oocytes/metabolism ; Organisms, Genetically Modified ; Proteolysis/drug effects ; Reverse Genetics/methods ; Reverse Genetics/veterinary
Chemical Substances	Indoleacetic Acids ; enhanced green fluorescent protein ; Green Fluorescent Proteins (147336-22-9)
Language	English
Publishing date	2019-07-11
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1093/biolre/ioz113
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Article ; Online: SELEX screen for zona pellucida-binding DNA aptamers.

Miller, Paul S / Evans, Janice P

Biology of reproduction

2018 Volume 99, Issue 5, Page(s) 903–904

MeSH term(s)	Animals ; Aptamers, Nucleotide/metabolism ; Female ; Gene Transfer Techniques ; Mice ; Oocytes ; Pregnancy ; RNA, Small Interfering/administration & dosage ; Zona Pellucida/metabolism
Chemical Substances	Aptamers, Nucleotide ; RNA, Small Interfering
Language	English
Publishing date	2018-04-12
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	1118-6
ISSN	1529-7268 ; 0006-3363
ISSN (online)	1529-7268
ISSN	0006-3363
DOI	10.1093/biolre/ioy123
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Article ; Online: Micropipette Aspiration of Oocytes to Assess Cortical Tension.

Evans, Janice P / Robinson, Douglas N

Methods in molecular biology (Clifton, N.J.)

2018 Volume 1818, Page(s) 163–171

Abstract: Just as it is important to understand the cell biology of signaling pathways, it is valuable also to understand mechanical forces in cells. The field of mechanobiology has a rich history, including study of cellular mechanics during mitosis and meiosis ... ...

Abstract	Just as it is important to understand the cell biology of signaling pathways, it is valuable also to understand mechanical forces in cells. The field of mechanobiology has a rich history, including study of cellular mechanics during mitosis and meiosis in echinoderm oocytes and zygotes dating back to the 1930s. This chapter addresses the use of micropipette aspiration (MPA) to assess cellular mechanics, specifically cortical tension, in mammalian oocytes.
MeSH term(s)	Animals ; Biomechanical Phenomena ; Female ; Meiosis ; Mice ; Micromanipulation/instrumentation ; Mitosis ; Oocytes/cytology ; Oocytes/physiology ; Stress, Mechanical ; Surface Tension
Language	English
Publishing date	2018-06-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-4939-8603-3_17
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Article ; Online ; Conference proceedings: "Feeling the force" in reproduction: Mechanotransduction in reproductive processes.

Evans, Janice P / Leppert, Phyllis C

Connective tissue research

2016 Volume 57, Issue 3, Page(s) 236–244

Abstract: Reproductive biologists are well-versed in many types of biochemical signaling, and indeed, there are almost innumerable examples in reproduction, including steroid and peptide hormone signaling, receptor-ligand and secondary messenger-mediated signaling, ...

Abstract	Reproductive biologists are well-versed in many types of biochemical signaling, and indeed, there are almost innumerable examples in reproduction, including steroid and peptide hormone signaling, receptor-ligand and secondary messenger-mediated signaling, signaling regulated by membrane channels, and many others. Among reproductive scientists, a perhaps lesser-known but comparably important mode of signaling is mechanotransduction: the concept that cells can sense and respond to externally applied or internally generated mechanical forces. Given the cell shape changes and tissue morphogenesis events that are components of many phenomena in reproductive function, it should be no surprise that mechanotransduction has major impacts in reproductive health and pathophysiology. The conference on "Mechanotransduction in the Reproductive Tract" was a valuable launch pad to bring this hot issue in development, cell biology, biophysics, and tissue regeneration to the realm of reproductive biology. The goal of the meeting was to stimulate interest and increased mechanotransduction research in the reproductive field by presenting a broad spectrum of responses impacted by this process. The meeting highlighted the importance of convening expert investigators, students, fellows, and young investigators from a number of research areas resulting in cross-fertilization of ideas and suggested new avenues for study. The conference included talks on tissue engineering, stem cells, and several areas of reproductive biology, from uterus and cervix to the gametes. Specific reproductive health-relevant areas, including uterine fibroids, gestation and parturition, and breast tissue morphogenesis, received particular attention.
MeSH term(s)	Biomechanical Phenomena ; Humans ; Mechanotransduction, Cellular ; Morphogenesis ; Reproduction ; Signal Transduction ; Stem Cells/cytology ; Tissue Engineering
Language	English
Publishing date	2016-05
Publishing country	England
Document type	Congresses
ZDB-ID	185551-7
ISSN	1607-8438 ; 0091-1690 ; 0300-8207
ISSN (online)	1607-8438
ISSN	0091-1690 ; 0300-8207
DOI	10.3109/03008207.2016.1146715
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Zs.A 1093: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Sperm-egg interaction.

Evans, Janice P

Annual review of physiology

2011 Volume 74, Page(s) 477–502

Abstract: A crucial step of fertilization is the sperm-egg interaction that allows the two gametes to fuse and create the zygote. In the mouse, CD9 on the egg and IZUMO1 on the sperm stand out as critical players, as Cd9(-/-) and Izumo1(-/-) mice are healthy but ... ...

Abstract	A crucial step of fertilization is the sperm-egg interaction that allows the two gametes to fuse and create the zygote. In the mouse, CD9 on the egg and IZUMO1 on the sperm stand out as critical players, as Cd9(-/-) and Izumo1(-/-) mice are healthy but infertile or severely subfertile due to defective sperm-egg interaction. Moreover, work on several nonmammalian organisms has identified some of the most intriguing candidates implicated in sperm-egg interaction. Understanding of gamete membrane interactions is advancing through characterization of in vivo and in vitro fertilization phenotypes, including insights from less robust phenotypes that highlight potential supporting (albeit not absolutely essential) players. An emerging theme is that there are varied roles for gamete molecules that participate in sperm-egg interactions. Such roles include not only functioning as fusogens, or as adhesion molecules for the opposite gamete, but also functioning through interactions in cis with other proteins to regulate membrane order and functionality.
MeSH term(s)	Animals ; Egg Proteins/genetics ; Egg Proteins/metabolism ; Female ; Fertilization/genetics ; Fertilization/physiology ; Humans ; Immunoglobulins/genetics ; Integrins/genetics ; Integrins/physiology ; Male ; Membrane Proteins/genetics ; Mice ; Mice, Knockout ; Ovum/physiology ; Phosphatidylinositols/chemistry ; Pregnancy ; Sperm-Ovum Interactions/physiology ; Spermatozoa/physiology ; Tetraspanin 29/physiology ; Tetraspanins/physiology
Chemical Substances	Egg Proteins ; IZUMO1 protein, human ; Immunoglobulins ; Integrins ; Izumo1 protein, mouse ; Membrane Proteins ; Phosphatidylinositols ; Tetraspanin 29 ; Tetraspanins
Language	English
Publishing date	2011-11-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	207933-1
ISSN	1545-1585 ; 0066-4278
ISSN (online)	1545-1585
ISSN	0066-4278
DOI	10.1146/annurev-physiol-020911-153339
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Article ; Online: Egg integrins: back in the game of mammalian fertilization.

Evans, Janice P

ACS chemical biology

2009 Volume 4, Issue 5, Page(s) 321–323

Abstract: Recent data provide insights into the function of egg integrins in mammalian fertilization and address some of the controversies regarding the involvement of these molecules in sperm-egg interaction. ...

Abstract	Recent data provide insights into the function of egg integrins in mammalian fertilization and address some of the controversies regarding the involvement of these molecules in sperm-egg interaction.
MeSH term(s)	Animals ; Humans ; Integrin beta Chains/physiology ; Ovum/chemistry ; Sperm-Ovum Interactions
Chemical Substances	Integrin beta Chains
Language	English
Publishing date	2009-05-08
Publishing country	United States
Document type	Comment ; Editorial ; Research Support, N.I.H., Extramural
ISSN	1554-8937
ISSN (online)	1554-8937
DOI	10.1021/cb900110q
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Article ; Online: Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity.

Billon, Cyrielle / Sitaula, Sadichha / Banerjee, Subhashis / Welch, Ryan / Elgendy, Bahaa / Hegazy, Lamees / Oh, Tae Gyu / Kazantzis, Melissa / Chatterjee, Arindam / Chrivia, John / Hayes, Matthew E / Xu, Weiyi / Hamilton, Angelica / Huss, Janice M / Zhang, Lilei / Walker, John K / Downes, Michael / Evans, Ronald M / Burris, Thomas P

ACS chemical biology

2023 Volume 18, Issue 4, Page(s) 756–771

Abstract: Repetitive physical exercise induces physiological adaptations in skeletal muscle that improves exercise performance and is effective for the prevention and treatment of several diseases. Genetic evidence indicates that the orphan nuclear receptors ... ...

Abstract	Repetitive physical exercise induces physiological adaptations in skeletal muscle that improves exercise performance and is effective for the prevention and treatment of several diseases. Genetic evidence indicates that the orphan nuclear receptors estrogen receptor-related receptors (ERRs) play an important role in skeletal muscle exercise capacity. Three ERR subtypes exist (ERRα, β, and γ), and although ERRβ/γ agonists have been designed, there have been significant difficulties in designing compounds with ERRα agonist activity. Additionally, there are limited synthetic agonists that can be used to target ERRs
MeSH term(s)	Animals ; Mice ; Exercise Tolerance/drug effects ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal/metabolism ; Receptors, Estrogen/drug effects ; Receptors, Estrogen/metabolism ; Estrogens/chemistry ; Estrogens/pharmacology ; ERRalpha Estrogen-Related Receptor
Chemical Substances	Receptors, Estrogen ; Esrrg protein, mouse ; Estrogens
Language	English
Publishing date	2023-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1554-8937
ISSN (online)	1554-8937
DOI	10.1021/acschembio.2c00720
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Article ; Online: α-endosulfine (ENSA) regulates exit from prophase I arrest in mouse oocytes.

Matthews, Lauren M / Evans, Janice P

Cell cycle (Georgetown, Tex.)

2014 Volume 13, Issue 10, Page(s) 1639–1649

Abstract: Mammalian oocytes in ovarian follicles are arrested in meiosis at prophase I. This arrest is maintained until ovulation, upon which the oocyte exits from this arrest, progresses through meiosis I and to metaphase of meiosis II. The progression from ... ...

Abstract	Mammalian oocytes in ovarian follicles are arrested in meiosis at prophase I. This arrest is maintained until ovulation, upon which the oocyte exits from this arrest, progresses through meiosis I and to metaphase of meiosis II. The progression from prophase I to metaphase II, known as meiotic maturation, is mediated by signals that coordinate these transitions in the life of the oocyte. ENSA (α-endosulfine) and ARPP19 (cAMP-regulated phosphoprotein-19) have emerged as regulators of M-phase, with function in inhibition of protein phosphatase 2A (PP2A) activity. Inhibition of PP2A maintains the phosphorylated state of CDK1 substrates, thus allowing progression into and/or maintenance of an M-phase state. We show here ENSA in mouse oocytes plays a key role in the progression from prophase I arrest into M-phase of meiosis I. The majority of ENSA-deficient oocytes fail to exit from prophase I arrest. This function of ENSA in oocytes is dependent on PP2A, and specifically on the regulatory subunit PPP2R2D (also known as B55δ). Treatment of ENSA-deficient oocytes with Okadaic acid to inhibit PP2A rescues the defect in meiotic progression, with Okadaic acid-treated, ENSA-deficient oocytes being able to exit from prophase I arrest. Similarly, oocytes deficient in both ENSA and PPP2R2D are able to exit from prophase I arrest to an extent similar to wild-type oocytes. These data are evidence of a role for ENSA in regulating meiotic maturation in mammalian oocytes, and also have potential relevance to human oocyte biology, as mouse and human have genes encoding both Arpp19 and Ensa.
MeSH term(s)	Animals ; Female ; Intercellular Signaling Peptides and Proteins ; M Phase Cell Cycle Checkpoints ; Meiotic Prophase I/physiology ; Mice ; Okadaic Acid/pharmacology ; Oocytes/cytology ; Oocytes/drug effects ; Oocytes/metabolism ; Peptides/metabolism ; Phosphoproteins/metabolism ; Protein Phosphatase 2/antagonists & inhibitors ; Protein Phosphatase 2/metabolism
Chemical Substances	Intercellular Signaling Peptides and Proteins ; Peptides ; Phosphoproteins ; cyclic AMP-regulated phosphoprotein 19 ; endosulfine ; Okadaic Acid (1W21G5Q4N2) ; Ppp2r2d protein, mouse (EC 3.1.3.16) ; Protein Phosphatase 2 (EC 3.1.3.16)
Language	English
Publishing date	2014-03-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.4161/cc.28606
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