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  1. Article ; Online: Bilateral ankle syndesmosis injury: a rare case report.

    Kang, Laurant / Helms, Emily / Broadhead, Matthew

    Orthopedic reviews

    2022  Volume 14, Issue 3, Page(s) 35494

    Abstract: This report describes a case of bilateral acute ankle syndesmosis injuries in a 15-year-old male basketball player. The patient had a background of previous inversion injuries but no symptoms of chronic pain or instability. The case report illustrates ... ...

    Abstract This report describes a case of bilateral acute ankle syndesmosis injuries in a 15-year-old male basketball player. The patient had a background of previous inversion injuries but no symptoms of chronic pain or instability. The case report illustrates the importance of clinical suspicion when evaluating acute syndesmosis injuries in conjunction with radiographic assessments in primary care. This is the first reported case of such injury in bilateral limbs.
    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2508171-8
    ISSN 2035-8164 ; 2035-8164
    ISSN (online) 2035-8164
    ISSN 2035-8164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bilateral ankle syndesmosis injury: a rare case report.

    Kang, Laurant / Helms, Emily / Broadhead, Matthew

    Orthopedic reviews

    2022  Volume 14, Issue 4, Page(s) 35494

    Abstract: This report describes a case of bilateral acute ankle syndesmosis injuries in a 15-year-old male basketball player. The patient had a background of previous inversion injuries but no symptoms of chronic pain or instability. The case report illustrates ... ...

    Abstract This report describes a case of bilateral acute ankle syndesmosis injuries in a 15-year-old male basketball player. The patient had a background of previous inversion injuries but no symptoms of chronic pain or instability. The case report illustrates the importance of clinical suspicion when evaluating acute syndesmosis injuries in conjunction with radiographic assessments in primary care. This is the first reported case of such injury in bilateral limbs.
    Language English
    Publishing date 2022-05-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2508171-8
    ISSN 2035-8164 ; 2035-8164
    ISSN (online) 2035-8164
    ISSN 2035-8164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Bilateral neck of femur fractures in a paediatric patient with graves' disease.

    Hoswell, Roseanna / Broadhead, Matthew L / Tewari, Sandeep

    Journal of paediatrics and child health

    2017  Volume 53, Issue 7, Page(s) 726–727

    MeSH term(s) Adolescent ; Bone Density ; Femoral Neck Fractures/diagnostic imaging ; Femoral Neck Fractures/etiology ; Femur Neck/diagnostic imaging ; Graves Disease/complications ; Humans ; Male ; Osteoporosis/etiology ; Tomography, X-Ray Computed
    Language English
    Publishing date 2017-06-30
    Publishing country Australia
    Document type Case Reports ; Letter
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.13543
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 227: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Trauma and Stem Cells: Biology and Potential Therapeutic Implications.

    Thurairajah, Kabilan / Broadhead, Matthew L / Balogh, Zsolt J

    International journal of molecular sciences

    2017  Volume 18, Issue 3

    Abstract: Trauma may cause irreversible tissue damage and loss of function despite current best practice. Healing is dependent both on the nature of the injury and the intrinsic biological capacity of those tissues for healing. Preclinical research has highlighted ...

    Abstract Trauma may cause irreversible tissue damage and loss of function despite current best practice. Healing is dependent both on the nature of the injury and the intrinsic biological capacity of those tissues for healing. Preclinical research has highlighted stem cell therapy as a potential avenue for improving outcomes for injuries with poor healing capacity. Additionally, trauma activates the immune system and alters stem cell behaviour. This paper reviews the current literature on stem cells and its relevance to trauma care. Emphasis is placed on understanding how stem cells respond to trauma and pertinent mechanisms that can be utilised to promote tissue healing. Research involving notable difficulties in trauma care such as fracture non-union, cartilage damage and trauma induced inflammation is discussed further.
    MeSH term(s) Animals ; Cell Differentiation ; Humans ; Inflammation/etiology ; Multiple Organ Failure/etiology ; Muscles/pathology ; Muscles/physiology ; Neovascularization, Physiologic ; Regeneration ; Stem Cell Research ; Stem Cells/cytology ; Stem Cells/physiology ; Wound Healing/physiology ; Wounds and Injuries/etiology ; Wounds and Injuries/pathology ; Wounds and Injuries/therapy
    Language English
    Publishing date 2017-03-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms18030577
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  5. Article ; Online: Multiple Femoral and Tibial Avulsion Fractures in a Skeletally Mature Patient Secondary to Knee Dislocation: A Case Report.

    Broadhead, Matthew L / Lim, Han K / Ek, Eugene T H / Chia, Andrew

    JBJS case connector

    2017  Volume 3, Issue 3 Suppl 7, Page(s) e89

    Language English
    Publishing date 2017-11-24
    Publishing country United States
    Document type Journal Article
    ISSN 2160-3251
    ISSN (online) 2160-3251
    DOI 10.2106/JBJS.CC.L.00279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Differential gene expression associated with a floral scent polymorphism in the evening primrose Oenothera harringtonii (Onagraceae).

    Bechen, Lindsey L / Johnson, Matthew G / Broadhead, Geoffrey T / Levin, Rachel A / Overson, Rick P / Jogesh, Tania / Fant, Jeremie B / Raguso, Robert A / Skogen, Krissa A / Wickett, Norman J

    BMC genomics

    2022  Volume 23, Issue 1, Page(s) 124

    Abstract: Background: Plant volatiles play an important role in both plant-pollinator and plant-herbivore interactions. Intraspecific polymorphisms in volatile production are ubiquitous, but studies that explore underlying differential gene expression are rare. ... ...

    Abstract Background: Plant volatiles play an important role in both plant-pollinator and plant-herbivore interactions. Intraspecific polymorphisms in volatile production are ubiquitous, but studies that explore underlying differential gene expression are rare. Oenothera harringtonii populations are polymorphic in floral emission of the monoterpene (R)-(-)-linalool; some plants emit (R)-(-)-linalool (linalool+ plants) while others do not (linalool- plants). However, the genes associated with differential production of this floral volatile in Oenothera are unknown. We used RNA-Seq to broadly characterize differential gene expression involved in (R)-(-)-linalool biosynthesis. To identify genes that may be associated with the polymorphism for this trait, we used RNA-Seq to compare gene expression in six different Oenothera harringtonii tissues from each of three linalool+ and linalool- plants.
    Results: Three clusters of differentially expressed genes were enriched for terpene synthase activity: two were characterized by tissue-specific upregulation and one by upregulation only in plants with flowers that produce (R)-(-)-linalool. A molecular phylogeny of all terpene synthases identified two putative (R)-(-)-linalool synthase transcripts in Oenothera harringtonii, a single allele of which is found exclusively in linalool+ plants.
    Conclusions: By using a naturally occurring polymorphism and comparing different tissues, we were able to identify candidate genes putatively involved in the biosynthesis of (R)-(-)-linalool. Expression of these genes in linalool- plants, while low, suggests a regulatory polymorphism, rather than a population-specific loss-of-function allele. Additional terpene biosynthesis-related genes that are up-regulated in plants that emit (R)-(-)-linalool may be associated with herbivore defense, suggesting a potential economy of scale between plant reproduction and defense.
    MeSH term(s) Flowers/genetics ; Gene Expression ; Gene Expression Regulation, Plant ; Odorants ; Oenothera ; Oenothera biennis ; Onagraceae
    Language English
    Publishing date 2022-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-022-08370-6
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  7. Article ; Online: Trauma and Stem Cells

    Kabilan Thurairajah / Matthew L. Broadhead / Zsolt J. Balogh

    International Journal of Molecular Sciences, Vol 18, Iss 3, p

    Biology and Potential Therapeutic Implications

    2017  Volume 577

    Abstract: Trauma may cause irreversible tissue damage and loss of function despite current best practice. Healing is dependent both on the nature of the injury and the intrinsic biological capacity of those tissues for healing. Preclinical research has highlighted ...

    Abstract Trauma may cause irreversible tissue damage and loss of function despite current best practice. Healing is dependent both on the nature of the injury and the intrinsic biological capacity of those tissues for healing. Preclinical research has highlighted stem cell therapy as a potential avenue for improving outcomes for injuries with poor healing capacity. Additionally, trauma activates the immune system and alters stem cell behaviour. This paper reviews the current literature on stem cells and its relevance to trauma care. Emphasis is placed on understanding how stem cells respond to trauma and pertinent mechanisms that can be utilised to promote tissue healing. Research involving notable difficulties in trauma care such as fracture non-union, cartilage damage and trauma induced inflammation is discussed further.
    Keywords trauma ; stem cells ; inflammation ; DAMP ; healing ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2017-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Clinical Features of High-Grade Extremity and Trunk Sarcomas in Patients Aged 80 Years and Older: Why Are Outcomes Inferior?

    Imanishi, Jungo / Chan, Lester W M / Broadhead, Matthew L / Pang, Grant / Ngan, Samuel Y / Slavin, John / Sharp, Stephen / Choong, Peter F M

    Frontiers in surgery

    2019  Volume 6, Page(s) 29

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2019-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2019.00029
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  9. Article ; Online: The ambition of the European Respiratory Journal continues: chapter 5.

    Humbert, Marc / Dinh-Xuan, Anh Tuan / Reeves, Elin L / Broadhead, Matthew G / Bullen, Neil J

    The European respiratory journal

    2017  Volume 49, Issue 1

    MeSH term(s) Access to Information ; Biomedical Research/methods ; Biomedical Research/trends ; Editorial Policies ; Europe ; Humans ; Journal Impact Factor ; Periodicals as Topic ; Pulmonary Medicine/methods ; Pulmonary Medicine/trends
    Language English
    Publishing date 2017-01-03
    Publishing country England
    Document type Editorial
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02393-2016
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

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  10. Article ; Online: Synaptic mechanisms underlying modulation of locomotor-related motoneuron output by premotor cholinergic interneurons.

    Nascimento, Filipe / Broadhead, Matthew James / Tetringa, Efstathia / Tsape, Eirini / Zagoraiou, Laskaro / Miles, Gareth Brian

    eLife

    2020  Volume 9

    Abstract: Spinal motor networks are formed by diverse populations of interneurons that set the strength and rhythmicity of behaviors such as locomotion. A small cluster of cholinergic interneurons, expressing the transcription factor Pitx2, modulates the intensity ...

    Abstract Spinal motor networks are formed by diverse populations of interneurons that set the strength and rhythmicity of behaviors such as locomotion. A small cluster of cholinergic interneurons, expressing the transcription factor Pitx2, modulates the intensity of muscle activation via 'C-bouton' inputs to motoneurons. However, the synaptic mechanisms underlying this neuromodulation remain unclear. Here, we confirm in mice that Pitx2
    MeSH term(s) Animals ; Cholinergic Neurons/physiology ; Female ; Homeodomain Proteins/metabolism ; Homeodomain Proteins/physiology ; Interneurons/physiology ; Locomotion/physiology ; Mice ; Mice, Inbred C57BL ; Motor Neurons/physiology ; Shab Potassium Channels/metabolism ; Shab Potassium Channels/physiology ; Synapses/physiology ; Transcription Factors/metabolism ; Transcription Factors/physiology ; Homeobox Protein PITX2
    Chemical Substances Homeodomain Proteins ; Kcnb1 protein, mouse ; Shab Potassium Channels ; Transcription Factors
    Language English
    Publishing date 2020-02-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.54170
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