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Article ; Online: Splenic Lesions and Other Findings in Kaposiform Lymphangiomatosis.

Suárez-Vilela, Dimas / Izquierdo, Francisco M / Honrado, Emiliano / Díez-Tascón, Cristina

The American journal of surgical pathology

2023 Volume 47, Issue 5, Page(s) 631–633

MeSH term(s)	Humans ; Hemangioendothelioma/pathology
Language	English
Publishing date	2023-02-16
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	752964-8
ISSN	1532-0979 ; 0147-5185
ISSN (online)	1532-0979
ISSN	0147-5185
DOI	10.1097/PAS.0000000000002026
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Article ; Online: Chronic lymphocytic leukemia and Richter transformation skin involvement recruited by herpesvirus infection.

Izquierdo, Francisco M / Suárez-Vilela, Dimas / de la Hera-Magallanes, Ana / Honrado, Emiliano

Journal of cutaneous pathology

2020 Volume 48, Issue 5, Page(s) 713–716

MeSH term(s)	Aged, 80 and over ; Cell Transformation, Neoplastic/pathology ; Diagnosis, Differential ; Fatal Outcome ; Female ; Herpesviridae Infections/complications ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Lymphoma, Large B-Cell, Diffuse/etiology ; Lymphoma, Large B-Cell, Diffuse/pathology ; Lymphoma, Large B-Cell, Diffuse/virology ; Pleural Effusion, Malignant/complications ; Simplexvirus/isolation & purification ; Skin Diseases/pathology ; Skin Diseases/virology ; Ulcer/diagnosis ; Ulcer/virology
Language	English
Publishing date	2020-11-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	187078-6
ISSN	1600-0560 ; 0303-6987
ISSN (online)	1600-0560
ISSN	0303-6987
DOI	10.1111/cup.13906
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Zs.A 1043: Show issues

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Article: Relationship between Aldehyde Dehydrogenase, PD-L1 and Tumor-Infiltrating Lymphocytes with Pathologic Response and Survival in Breast Cancer.

López Flores, Mariana / Honrado Franco, Emiliano / Sánchez Cousido, Luis Felipe / Minguito-Carazo, Carlos / Sanz Guadarrama, Oscar / López González, Laura / Vallejo Pascual, María Eva / Molina de la Torre, Antonio José / García Palomo, Andrés / López González, Ana

Cancers

2022 Volume 14, Issue 18

Abstract: Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell (CSC) marker related to clinical outcomes in breast cancer (BC). The aim of this study was to analyze the relationship between ALDH1A1, programmed death ligand 1 (PD-L1) and tumor-infiltrating ... ...

Abstract	Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell (CSC) marker related to clinical outcomes in breast cancer (BC). The aim of this study was to analyze the relationship between ALDH1A1, programmed death ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in triple negative (TN) and human epidermal growth factor receptor 2-positive (HER2+) BC tumors, and its association with clinicopathological characteristics and outcomes. A retrospective, historical cohort study of patients diagnosed with early or locally advanced BC treated with neoadjuvant chemotherapy was conducted. ALDH1A1, PD-L1 expression and TILs were assessed using immunohistochemistry. A total of 75 patients were analyzed (42.7% TN, 57.3% HER2+ tumors). ALDH1A1+ was related to HTILs (p = 0.005) and PD-L1+ tumors (p = 0.004). ALDH1A1+ tumors presented higher CD3+ (p = 0.008), CD4+ (p = 0.005), CD8+ (p = 0.003) and CD20+ (p = 0.006) TILs. ALDH1A1+ (p = 0.018), PD-L1+ (p = 0.004) and HTILs (p < 0.001) were related to smaller tumors. ALDH1A1+ was related to pathologic complete response (pCR) (p = 0.048). At the end of the follow-up (54.4 [38.3−87.6] months), 47 patients (62.7%) remained disease-free, and 20 (26.7%) had died. HTILs were related to improved disease-free survival (p = 0.027). ALDH1A1+ was related to PD-L1+ and HITLs, that might be related to higher pCR rates with neoadjuvant therapy.
Language	English
Publishing date	2022-09-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14184418
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Article ; Online: Intraneural hybrid granular cell tumor-perineurioma.

Izquierdo, Francisco M / Suárez-Vilela, Dimas / Honrado, Emiliano

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

2013 Volume 121, Issue 7, Page(s) 678–680

MeSH term(s)	Adult ; Cell Proliferation ; Cell Shape ; Claudin-1/metabolism ; Granular Cell Tumor/metabolism ; Granular Cell Tumor/pathology ; Humans ; Immunohistochemistry ; Male ; Mucin-1/metabolism ; Nerve Sheath Neoplasms/metabolism ; Nerve Sheath Neoplasms/pathology
Chemical Substances	Claudin-1 ; Mucin-1
Language	English
Publishing date	2013-07
Publishing country	Denmark
Document type	Case Reports ; Letter
ZDB-ID	93340-5
ISSN	1600-0463 ; 0903-4641
ISSN (online)	1600-0463
ISSN	0903-4641
DOI	10.1111/apm.12038
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Article ; Online: DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling.

Mellid, Sara / García, Fernando / Leandro-García, Luis Javier / Díaz-Talavera, Alberto / Martínez-Montes, Ángel Mario / Gil, Eduardo / Calsina, Bruna / Monteagudo, María / Letón, Rocío / Roldán-Romero, Juan María / Santos, María / Lanillos, Javier / Valdivia, Carlos / Martínez-Puente, Natalia / de Nicolás-Hernández, Javier / Jiménez, Scherezade / Pérez-Martínez, Manuel / Honrado, Emiliano / Coloma, Javier /

Cerezo, Ana / Santiveri, Clara María / Esteller, Manel / Campos-Olivas, Ramón / Caleiras, Eduardo / Montero-Conde, Cristina / Rodríguez-Antona, Cristina / Muñoz, Javier / Robledo, Mercedes / Cascón, Alberto

Cancer communications (London, England)

2023 Volume 43, Issue 7, Page(s) 838–843

MeSH term(s)	Humans ; Pheochromocytoma/genetics ; Proteome/genetics ; Paraganglioma/genetics ; Mutation ; Adrenal Gland Neoplasms/genetics
Chemical Substances	Proteome
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ISSN	2523-3548
ISSN (online)	2523-3548
DOI	10.1002/cac2.12427
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Article ; Online: Metastatic clear cell renal cell carcinoma to the thyroid gland: A clinico-pathological and immunohistochemical study of 8 cases and review of the literature.

Queipo, Francisco Javier / Panizo, Angel / Yagüe, Adriana / Ruiz-Azua, Yerani / Rodriguez, Irene / Gutiérrez-Pecharroman, Ana / Honrado, Emiliano

Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia

2018 Volume 52, Issue 2, Page(s) 81–86

Abstract: When a patient with a previous history of neoplasm presents with a thyroid lesion, the possibility of it being metastatic should always be considered. In this series, we present the clinicopathological and immunohistochemical features of the thyroid ... ...

Abstract	When a patient with a previous history of neoplasm presents with a thyroid lesion, the possibility of it being metastatic should always be considered. In this series, we present the clinicopathological and immunohistochemical features of the thyroid metastases diagnosed in our department over the past 30 years. Here we present eight thyroidal metastases from clear cell renal cell carcinoma (ccRCCC), including a tumor to tumor metastasis, the patients being 2 men and 6 women with a median age of 62 years. The majority had a past history of goiter and a single and palpable metastasis. In one patient the thyroid metastases were the first sign of the ccRCCC. In the available cases, the metastasis showed positivity to PAX8 and CAIX and negativity to TTF1 and thyroglobulin. The median time from the detection of the primary renal tumor to thyroid metastasis and from thyroidectomy to last follow up were 84.17 and 54.50 months, respectively. After a median follow up of 158.50 months none of the patients had died from ccRCCC. Renal cell carcinoma (RCC) is the most frequent malignant neoplasm of the kidney and its incidence has increased over recent decades. In a clinical series, up to 1-3% of the oncologic thyroidectomies were due to thyroid metastases and the most frequent metastasizing tumor was RCC, followed by lung and breast cancer.
MeSH term(s)	Aged ; Carcinoma, Renal Cell/pathology ; Carcinoma, Renal Cell/secondary ; Female ; Humans ; Immunohistochemistry ; Kidney Neoplasms/pathology ; Male ; Middle Aged ; Thyroid Neoplasms/secondary
Language	English
Publishing date	2018-11-01
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	2463888-2
ISSN	1988-561X ; 1699-8855
ISSN (online)	1988-561X
ISSN	1699-8855
DOI	10.1016/j.patol.2018.08.004
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Article ; Online: Perineurial cells in granular cell tumors and neoplasms with perineural invasion: an immunohistochemical study.

Izquierdo, Francisco / Suárez-Vilela, Dimas / Honrado, Emiliano

The American Journal of dermatopathology

2012 Volume 34, Issue 8, Page(s) 800–809

Abstract: Granular cell tumors (GCT) are nerve sheath neoplasms composed of Schwann cells with granular cytoplasm. Perineurial cells are the cellular component of the perineurium and of perineuriomas, neoplasms supposedly derived from perineurial cells. However, ... ...

Abstract	Granular cell tumors (GCT) are nerve sheath neoplasms composed of Schwann cells with granular cytoplasm. Perineurial cells are the cellular component of the perineurium and of perineuriomas, neoplasms supposedly derived from perineurial cells. However, perineurial cells have also been found in other Schwann cell-derived tumors. These cells have not been well studied in GCTs. We studied the presence of perineurial cells in a series of 24 GCTs with EMA, claudin-1, and Glut-1, which are immunohistochemical markers for perineurial cells. Three cases lacked nerve fascicles. Three cases showed no perineurial proliferation (grade 0), 7 showed grade 1 proliferation, and 11 showed grade 2 proliferation. For comparison, we studied 17 cases of neoplasms with perineural invasion (PNI): 7 cutaneous neoplasms [squamous cell carcinomas (n = 3), cutaneous lymphoma, malignant melanoma, eccrine carcinoma, congenital neurotropic nevus (n = 1 each)] and 10 noncutaneous tumors [prostatic (n = 2), gastric (n = 2), and colonic (n = 2) adenocarcinomas; invasive ductal carcinoma of breast (n = 2); urothelial carcinoma of bladder (n = 1); and oral squamous cell carcinoma (n = 1)] with the same antibodies for perineurial cells. We found perineurial cell proliferation in 10 cases, 6 grade 1, and 4 grade 2. These perineurial cells were limited to the areas around the nerve fascicles. Most of the tumor was devoid of perineurial cells. Thus, it was interpreted more as a hyperplastic or reactive phenomenon than a neoplastic component. Claudin-1 was the most sensitive of the 3 markers that we used. Such proliferation was less intense in non-GCTs. In conclusion, proliferation of perineurial cells in GCTs and neoplasms with PNI is a common finding that had not been previously studied. It seems to be a non-neoplastic phenomenon.
MeSH term(s)	Adolescent ; Adult ; Biomarkers, Tumor/analysis ; Child ; Female ; Granular Cell Tumor/metabolism ; Granular Cell Tumor/pathology ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Nerve Sheath Neoplasms/metabolism ; Nerve Sheath Neoplasms/pathology ; Peripheral Nerves/metabolism ; Peripheral Nerves/pathology ; Satellite Cells, Perineuronal/metabolism ; Satellite Cells, Perineuronal/pathology ; Schwann Cells/pathology ; Young Adult
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2012-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	448469-1
ISSN	1533-0311 ; 0193-1091
ISSN (online)	1533-0311
ISSN	0193-1091
DOI	10.1097/DAD.0b013e31824ba93b
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Zs.A 1518: Show issues

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Article: Co-occurrence of mutations in

Mellid, Sara / Gil, Eduardo / Letón, Rocío / Caleiras, Eduardo / Honrado, Emiliano / Richter, Susan / Palacios, Nuria / Lahera, Marcos / Galofré, Juan C / López-Fernández, Adriá / Calatayud, Maria / Herrera-Martínez, Aura D / Galvez, María A / Matias-Guiu, Xavier / Balbín, Milagros / Korpershoek, Esther / Lim, Eugénie S / Maletta, Francesca / Lider, Sofia /

Fliedner, Stephanie M J / Bechmann, Nicole / Eisenhofer, Graeme / Canu, Letizia / Rapizzi, Elena / Bancos, Irina / Robledo, Mercedes / Cascón, Alberto

Frontiers in endocrinology

2023 Volume 13, Page(s) 1070074

Abstract: Introduction: The percentage of patients diagnosed with pheochromocytoma and paraganglioma (altogether PPGL) carrying known germline mutations in one of the over fifteen susceptibility genes identified to date has dramatically increased during the last ... ...

Abstract	Introduction: The percentage of patients diagnosed with pheochromocytoma and paraganglioma (altogether PPGL) carrying known germline mutations in one of the over fifteen susceptibility genes identified to date has dramatically increased during the last two decades, accounting for up to 35-40% of PPGL patients. Moreover, the application of NGS to the diagnosis of PPGL detects unexpected co-occurrences of pathogenic allelic variants in different susceptibility genes. Methods: Herein we uncover several cases with dual mutations in NF1 and other PPGL genes by targeted sequencing. We studied the molecular characteristics of the tumours with co-occurrent mutations, using omic tools to gain insight into the role of these events in tumour development. Results: Amongst 23 patients carrying germline NF1 mutations, targeted sequencing revealed additional pathogenic germline variants in DLST (n=1) and MDH2 (n=2), and two somatic mutations in H3-3A and PRKAR1A. Three additional patients, with somatic mutations in NF1 were found carrying germline pathogenic mutations in SDHB or DLST, and a somatic truncating mutation in ATRX. Two of the cases with dual germline mutations showed multiple pheochromocytomas or extra-adrenal paragangliomas - an extremely rare clinical finding in NF1 patients. Transcriptional and methylation profiling and metabolite assessment showed an "intermediate signature" to suggest that both variants had a pathological role in tumour development. Discussion: In conclusion, mutations affecting genes involved in different pathways (pseudohypoxic and receptor tyrosine kinase signalling) co-occurring in the same patient could provide a selective advantage for the development of PPGL, and explain the variable expressivity and incomplete penetrance observed in some patients.
MeSH term(s)	Humans ; Pheochromocytoma/pathology ; Genetic Predisposition to Disease ; Paraganglioma/pathology ; Mutation ; Adrenal Gland Neoplasms/diagnosis
Language	English
Publishing date	2023-01-25
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.1070074
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Article: Carcinoma sarcomatoide en paciente diagnosticado de síndrome de Sjögren.

Rascarachi, Gabriela / Honrado, Emiliano / Quiroga Prado, Luis

Gastroenterologia y hepatologia

2009 Volume 32, Issue 3, Page(s) 150–154

Abstract: Sarcomatoid carcinoma is an extremely rare small bowel tumor whose clinical manifestations are insidious and nonspecific, ranging from diffuse abdominal pain to gastrointestinal bleeding or intestinal occlusion. Thus, diagnostic delay is highly common ... ...

Title translation	Sarcomatoid carcinoma in a patient with Sjögren's syndrome.
Abstract	Sarcomatoid carcinoma is an extremely rare small bowel tumor whose clinical manifestations are insidious and nonspecific, ranging from diffuse abdominal pain to gastrointestinal bleeding or intestinal occlusion. Thus, diagnostic delay is highly common with poor treatment outcome and prognosis. To date, only 20 cases have been reported in the literature. We describe the case of a small bowel sarcomatoid carcinoma localized in the jejunum, with emphasis on the clinical and pathological features of this entity. The hypothetical association with Sjögren's syndrome, an autoimmune disease, is also discussed.
MeSH term(s)	Aged, 80 and over ; Carcinosarcoma/complications ; Carcinosarcoma/diagnosis ; Humans ; Jejunal Neoplasms/complications ; Jejunal Neoplasms/diagnosis ; Male ; Sjogren's Syndrome/complications
Language	Spanish
Publishing date	2009-03
Publishing country	Spain
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2008.09.023
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Zs.A 2044: Show issues

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Article ; Online: The role of EZH2 in overall survival of colorectal cancer: a meta-analysis.

Vilorio-Marqués, Laura / Martín, Vicente / Diez-Tascón, Cristina / González-Sevilla, María Francisca / Fernández-Villa, Tania / Honrado, Emiliano / Davila-Batista, Veronica / Molina, Antonio J

Scientific reports

2017 Volume 7, Issue 1, Page(s) 13806

Abstract: Enhancer of zeste homolog 2 (EZH2) is the catalitic subunit of polycomb repressive complex 2 and mediates gene silencing. EZH2 is overexpressed in many cancers and correlates with poor prognosis. The role of the gene EZH2 in colorectal cancer survival is ...

Abstract	Enhancer of zeste homolog 2 (EZH2) is the catalitic subunit of polycomb repressive complex 2 and mediates gene silencing. EZH2 is overexpressed in many cancers and correlates with poor prognosis. The role of the gene EZH2 in colorectal cancer survival is uncertainly, the aim of this study is clear this relationship. Relevant literaure was searched from electronic databases. A meta-analysis was performed with elegible studies which quantitatively evaluated the relationship between EZH2 overexpression and survival of patients with colorectal cancer. Survival data were aggregated and quantitatively analyzed. We performed a meta-analysis of 8 studies (n = 1059 patients) that evaluated the correlation between EZH2 overexpression and survival in patients with colorectal cancer. Combined hazard ratios suggested that EZH2 overexpression was associated with better prognosis of overall survival (OS) HR(hazard ratio) = 0.61 95% CI (0.38-0.84) We performed bias analysis according Egger and Begg,s test and we did not find publication bias. EZH2 overexpression indicates a better prognosis for colorectal cancer.
MeSH term(s)	Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/therapy ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Humans ; Prognosis ; Survival Rate
Chemical Substances	EZH2 protein, human (EC 2.1.1.43) ; Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43)
Language	English
Publishing date	2017-10-23
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-017-13670-z
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