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Article ; Online: Venetoclax activity in a patient with central nervous system involvement by chronic lymphocytic leukaemia.

Soumerai, Jacob D / Takvorian, Ronald W / Sohani, Aliyah R / Abramson, Jeremy S / Ferry, Judith A

The Lancet. Haematology

2022 Volume 9, Issue 10, Page(s) e796

MeSH term(s)	Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Central Nervous System ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/complications ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Sulfonamides/therapeutic use
Chemical Substances	Bridged Bicyclo Compounds, Heterocyclic ; Sulfonamides ; venetoclax (N54AIC43PW)
Language	English
Publishing date	2022-09-29
Publishing country	England
Document type	Journal Article
ISSN	2352-3026
ISSN (online)	2352-3026
DOI	10.1016/S2352-3026(22)00098-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neurobiological sensitivity to unpredictable threat and familial risk for the internalizing and externalizing spectra in adolescents.

Beatty, Clare C / Ferry, Rachel A / Eaton, Nicholas R / Klein, Daniel N / Nelson, Brady D

Psychological medicine

2022 Volume 53, Issue 12, Page(s) 5395–5404

Abstract: Background: Adolescence is a key developmental period for the emergence of psychiatric disorders. However, there is still no consensus on the core mechanisms of dysfunction in youth. Neurobiological sensitivity to unpredictable threat has been ... ...

Abstract	Background: Adolescence is a key developmental period for the emergence of psychiatric disorders. However, there is still no consensus on the core mechanisms of dysfunction in youth. Neurobiological sensitivity to unpredictable threat has been associated with several psychiatric disorders in adults. The present study examined adolescent defensive motivation (startle reflex) and attention (event-related potentials) in anticipation of unpredictable threat in relation to both adolescent and maternal (i.e. familial risk) internalizing and externalizing spectra. Methods: The sample included 395 15-year-old adolescents and their biological mothers. Adolescent startle potentiation and probe P300 suppression (indicating increased attention to threat) were measured in anticipation of predictable and unpredictable threat. Adolescent and maternal lifetime history of psychiatric disorders were assessed via semi-structured diagnostic interviews, and confirmatory factor analysis was used to model internalizing and externalizing spectra. Results: The adolescent internalizing spectrum was positively associated with adolescent startle potentiation and probe P300 suppression to unpredictable threat. Conversely, the adolescent externalizing spectrum was negatively associated with adolescent P300 suppression to unpredictable threat. The maternal internalizing spectrum was positively associated with adolescent startle potentiation to unpredictable threat and P300 suppression to both predictable and unpredictable threat. The maternal externalizing spectrum was negatively associated with adolescent startle potentiation to unpredictable threat and P300 suppression to both predictable and unpredictable threat. Adolescent and maternal internalizing and externalizing spectra were independently related to adolescent startle potentiation and P300 suppression. Conclusions: Adolescent neurobiological sensitivity to unpredictable threat is associated with both personal history and familial risk for the internalizing and externalizing spectra.
MeSH term(s)	Adult ; Female ; Humans ; Adolescent ; Genetic Predisposition to Disease ; Evoked Potentials ; Motivation ; Mental Disorders ; Reflex, Startle ; Mothers
Language	English
Publishing date	2022-08-19
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291722002434
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Article ; Online: Dental procedure induced cerebellar haemorrhage with visual tilt and unsuspected CADASIL.

Mortazavi, Siavash / Ambati, Ravi / Dharsono, Ferry / Prentice, David

BMJ case reports

2023 Volume 16, Issue 8

Abstract: A man in his late 60s had vertigo and vision tilt following a dental procedure. A cerebellar haemorrhage and cerebral microbleeds (CMBs) were diagnosed on imaging. Subsequent testing revealed CADASIL (cerebral autosomal dominant arteriopathy with ... ...

Abstract	A man in his late 60s had vertigo and vision tilt following a dental procedure. A cerebellar haemorrhage and cerebral microbleeds (CMBs) were diagnosed on imaging. Subsequent testing revealed CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). The role of the dental procedure as a trigger for intracerebral haemorrhage (ICH) is discussed. The incidence of CMBs and ICH in CADASIL is discussed. A summary of the causes and pathology associated with visual tilt is documented.
MeSH term(s)	Male ; Humans ; CADASIL/complications ; CADASIL/diagnosis ; Cerebral Hemorrhage/etiology ; Cerebral Hemorrhage/complications ; Cerebral Infarction/complications ; Incidence ; Dentistry ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-08-02
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2022-253965
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Article ; Online: Daptomycin Physiology-Based Pharmacokinetic Modeling to Predict Drug Exposure and Pharmacodynamics in Skin and Bone Tissues.

Garreau, Romain / Montange, Damien / Grillon, Antoine / Jehl, François / Ferry, Tristan / Bourguignon, Laurent / Goutelle, Sylvain

Clinical pharmacokinetics

2022 Volume 61, Issue 10, Page(s) 1443–1456

Abstract: Background and objective: Daptomycin has been recommended in the treatment of bone and joint infection. Previous work showed that the approved dosage of daptomycin may be insufficient to achieve optimal exposure in patients with bone and joint infection. ...

Abstract	Background and objective: Daptomycin has been recommended in the treatment of bone and joint infection. Previous work showed that the approved dosage of daptomycin may be insufficient to achieve optimal exposure in patients with bone and joint infection. However, those studies assumed that bone exposure was similar to steady-state daptomycin-free plasma concentrations. We sought to establish a physiologically based pharmacokinetic (PBPK) model of daptomycin to describe the dynamics of daptomycin disposition in bone and skin tissue. Methods: A PBPK model of daptomycin was built using PK-Sim<sup>®</sup>. Daptomycin concentrations in plasma and bone were obtained from three previously published studies. Physicochemical drug characteristics, mass balance, anthropometrics, and experimental data were used to build and refine the PBPK model. Internal validation of the PBPK model was performed using the usual diagnostic plots. The final PBPK model was then used to run simulations with doses of 6, 8, 10, and 12 mg/kg/24 h. Pharmacokinetic profiles were simulated in 1000 subjects and the probabilities of target attainment for the area under the concentration-time curve over the bacterial minimum inhibitory concentration were computed in blood, skin, and bone compartments. Results: The final model showed a good fit of all datasets with an absolute average fold error between 0.5 and 2 for all pharmacokinetic quantities in blood, skin and bone tissues. Results of dosing simulations showed that doses ≥10 mg/kg should be used in the case of bacteremia caused by Staphylococcus aureus with a minimum inhibitory concentration >0.5 mg/L or Enterococcus faecalis with a minimum inhibitory concentration >1 mg/L, while doses ≥12 mg/kg should be used in the case of bone and joint infection or complicated skin infection. When considering a lower minimum inhibitory concentration, doses of 6-8 mg/kg would likely achieve a sufficient success rate. However, in the case of infections caused by E. faecalis with a minimum inhibitory concentration >2 mg/L, a higher dosage and combination therapy would be necessary to maximize efficacy. Conclusions: We developed the first daptomycin PBPK/pharmacodynamic model for bone and joint infection, which confirmed that a higher daptomycin dosage is needed to optimize exposure in bone tissue. However, such higher dosages raise safety concerns. In this setting, therapeutic drug monitoring and model-informed precision dosing appear necessary to ensure the right exposure on an individual basis.
MeSH term(s)	Anti-Bacterial Agents ; Bone and Bones ; Daptomycin/pharmacology ; Humans ; Microbial Sensitivity Tests ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology
Chemical Substances	Anti-Bacterial Agents ; Daptomycin (NWQ5N31VKK)
Language	English
Publishing date	2022-08-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	197627-8
ISSN	1179-1926 ; 0312-5963
ISSN (online)	1179-1926
ISSN	0312-5963
DOI	10.1007/s40262-022-01168-5
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Article ; Online: Development of Android-based health media applications as promotional media in improving COVID-19 preventive behavior in the community

Ira Purnamasari / Ferry Effendy / Lailatun Ni’mah / Dede Nasrullah

Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya, Vol 7, Iss

2023 Volume 1

Abstract: ... in the community. This research method used an exploratory design with an R&D approach which consists of 2 stages ...

Abstract	Corona Virus Disease 2019 (COVID-19) caused by SARS-CoV-2 became a worldwide pandemic. The spread of wrong information causes people to misperceive the information. The massive spread of the virus shows the lack of public knowledge about preventing the transmission of COVID-19. Intrapersonal factors, namely changes in individual behavior, are the main focus of breaking the chain of the spread of COVID-19. This study aims to develop an Android-based health education application for COVID-19 prevention behavior in the community. This research method used an exploratory design with an R&D approach which consists of 2 stages. The first stage was making a prototype application through 1) Evaluation of public knowledge and attitudes about COVID-19 prevention with a questionnaire in the form of a google form to find strategic issues; 2) Development and mapping of prototype content through Focus Group Discussions with nurses and expert consultations. The evaluation used a simple random sampling technique on 193 respondents. The second stage was socialization and application feasibility testing on 193 respondents. The results of the first stage were an overview of the implementation of health education that had not been maximized due to the risk of transmission, sufficient knowledge (52.8%), and negative attitudes (63.2%) toward the prevention of COVID-19, as well as a prototype system of health education in applications that include prevention COVID-19 prevention. It was followed by the second stage of socialization and application feasibility testing for users. This study concludes that the development of an android-based application supports effective health promotion efforts in conveying information to increase knowledge and attitudes toward COVID-19 prevention.
Keywords	health education ; android based application ; covid-19 prevention ; Medicine (General) ; R5-920
Subject code	360
Language	Indonesian
Publishing date	2023-01-01T00:00:00Z
Publisher	Universitas Muhammadiyah Surabaya
Document type	Article ; Online
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Article ; Online: What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms?

Attygalle, Ayoma D / Chan, John K C / Coupland, Sarah E / Du, Ming-Qing / Ferry, Judith A / de Jong, Daphne / Gratzinger, Dita / Lim, Megan S / Nicolae, Alina / Ott, German / Rosenwald, Andreas / Schuh, Anna / Siebert, Reiner

Journal of hematopathology

2024

Abstract: The classification of tumors is essential in the diagnosis and clinical management of patients with malignant neoplasms. The World Health Organization (WHO) provides a globally applicable classification scheme of neoplasms and it was updated several ... ...

Abstract	The classification of tumors is essential in the diagnosis and clinical management of patients with malignant neoplasms. The World Health Organization (WHO) provides a globally applicable classification scheme of neoplasms and it was updated several times. In this review, we briefly outline the cornerstones of the upcoming 5th edition of the World Health Organization Classification of Haematolymphoid Tumours on lymphoid neoplasms. As is adopted throughout the 5th edition of the WHO classification of tumors of all organ systems, entities are listed by a hierarchical system. For the first time, tumor-like lesions have been included in the classification, and modifications of nomenclature for some entities, revisions of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities are presented along with mesenchymal lesions specific to the stroma of lymph nodes and the spleen. In addition to specific outlines on constitutional and somatic genetic changes associated with given entities, a separate chapter on germline predisposition syndromes related to hematologic neoplasms has been added.
Language	English
Publishing date	2024-04-29
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2438687-X
ISSN	1865-5785 ; 1868-9256
ISSN (online)	1865-5785
ISSN	1868-9256
DOI	10.1007/s12308-024-00585-8
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Article ; Online: The fifth edition of the WHO classification of mature B-cell neoplasms: open questions for research.

Coupland, Sarah E / Du, Ming-Qing / Ferry, Judith A / de Jong, Daphne / Khoury, Joseph D / Leoncini, Lorenzo / Naresh, Kikkeri N / Ott, German / Siebert, Reiner / Xerri, Luc

The Journal of pathology

2024 Volume 262, Issue 3, Page(s) 255–270

Abstract: The fifth edition of the World Health Organization Classification of Haematolymphoid Tumours (WHO-HAEM5) is the product of an evidence-based evolution of the revised fourth edition with wide multidisciplinary consultation. Nonetheless, while every ... ...

Abstract	The fifth edition of the World Health Organization Classification of Haematolymphoid Tumours (WHO-HAEM5) is the product of an evidence-based evolution of the revised fourth edition with wide multidisciplinary consultation. Nonetheless, while every classification incorporates scientific advances and aims to improve upon the prior version, medical knowledge remains incomplete and individual neoplasms may not be easily subclassified in a given scheme. Thus, optimal classification requires ongoing study, and there are certain aspects of some entities and subtypes that require further refinements. In this review, we highlight a selection of these challenging areas to prompt more research investigations. These include (1) a 'placeholder term' of splenic B-cell lymphoma/leukaemia with prominent nucleoli (SBLPN) to accommodate many of the splenic lymphomas previously classified as hairy cell leukaemia variant and B-prolymphocytic leukaemia, a clear new start to define their pathobiology; (2) how best to classify BCL2 rearrangement negative follicular lymphoma including those with BCL6 rearrangement, integrating the emerging new knowledge on various germinal centre B-cell subsets; (3) what is the spectrum of non-IG gene partners of MYC translocation in diffuse large B-cell lymphoma/high-grade B-cell lymphoma and how they impact MYC expression and clinical outcome; how best to investigate this in a routine clinical setting; and (4) how best to define high-grade B-cell lymphoma not otherwise specified and high-grade B-cell lymphoma with 11q aberrations to distinguish them from their mimics and characterise their molecular pathogenetic mechanism. Addressing these questions would provide more robust evidence to better define these entities/subtypes, improve their diagnosis and/or prognostic stratification, leading to better patient care. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
MeSH term(s)	Humans ; Lymphoma, Large B-Cell, Diffuse/classification ; Lymphoma, Large B-Cell, Diffuse/genetics ; Lymphoma, Large B-Cell, Diffuse/pathology ; Prognosis ; Proto-Oncogene Proteins c-bcl-2/genetics ; Translocation, Genetic ; United Kingdom ; World Health Organization
Chemical Substances	Proto-Oncogene Proteins c-bcl-2
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	3119-7
ISSN	1096-9896 ; 0022-3417
ISSN (online)	1096-9896
ISSN	0022-3417
DOI	10.1002/path.6246
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Article ; Online: Uniform or Sex-Specific Cardiac Troponin Thresholds to Rule-out Myocardial Infarction at Presentation.

Li, Ziwen / Wereski, Ryan / Anand, Atul / Lowry, Matthew Th / Doudesis, Dimitrios / McDermott, Michael / Ferry, Amy V / Tuck, Chris / Chapman, Andrew R / Lee, Kuan Ken / Shah, Anoop Sv / Mills, Nicholas L / Kimenai, Dorien M

Journal of the American College of Cardiology

2024

Abstract: Background: Myocardial infarction can be ruled out in patients with a single cardiac troponin measurement. Whether use of a uniform rule-out threshold has resulted in sex-differences in care remains unclear.: Objectives: To evaluate implementation of ...

Abstract	Background: Myocardial infarction can be ruled out in patients with a single cardiac troponin measurement. Whether use of a uniform rule-out threshold has resulted in sex-differences in care remains unclear. Objectives: To evaluate implementation of a uniform rule-out threshold in females and males with possible myocardial infarction, and to derive and validate sex-specific thresholds. Methods: The implementation of a uniform rule-out threshold (<5 ng/L) with a high-sensitivity cardiac troponin I assay was evaluated in consecutive patients presenting with possible myocardial infarction. The proportion of low-risk patients discharged from Emergency Department (ED) and incidence of myocardial infarction or cardiac death at 30 days were determined. Sex-specific thresholds were derived and validated, and proportion of female and male patients stratified as low-risk compared with uniform threshold RESULTS: In 16,792 patients (58±17 years, 46% female) care was guided using a uniform threshold. This identified more female than male patients as low-risk (73% versus 62%), but a similar proportion of low-risk patients were discharged from ED (81% for both) with fewer than 5 (<0.1%) patients having a subsequent myocardial infarction or cardiac death at 30 days. Compared to uniform threshold of <5 ng/L, use of sex-specific thresholds would increase the proportion of female (61.8% versus 65.9%) and reduce the proportion of male (54.8% versus 47.8%) patients identified as low-risk. Conclusions: Implementation of a uniform rule-out threshold for myocardial infarction was safe and effective in both sexes. Sex-specific rule-out thresholds should be considered, but their impact on effectiveness and safety may be limited.
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	605507-2
ISSN	1558-3597 ; 0735-1097
ISSN (online)	1558-3597
ISSN	0735-1097
DOI	10.1016/j.jacc.2024.03.365
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Zs.A 1846: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Multimorbidity among persons aged 25-64 years: a population-based study of social determinants and all-cause mortality.

Ferry, F R / Rosato, M G / Curran, E J / O'Reilly, D / Leavey, G

Journal of public health (Oxford, England)

2020 Volume 44, Issue 1, Page(s) e59–e67

Abstract: Background: Despite increasing multimorbidity across the lifespan, little is known about the co-occurrence of conditions and risk factors among younger adults. This population-based study examines multimorbidity, social determinants and associated ... ...

Abstract	Background: Despite increasing multimorbidity across the lifespan, little is known about the co-occurrence of conditions and risk factors among younger adults. This population-based study examines multimorbidity, social determinants and associated mortality among younger and middle-age adults. Method: Analysis was based on the Northern Ireland population aged 25-64 years enumerated in the 2011 Census (n = 878 345), with all-cause mortality follow-up to 2014 (8659 deaths). Logistic regression was used to examine social determinants and Cox proportional hazards models in the analysis of associated mortality. Results: Prevalence of multimorbidity was 13.7% in females and 12.7% in males. There was a strong association between multimorbidity that included mental/cognitive illness and deprivation. Among those never married, multimorbid physical conditions were less likely [relative risk ratios (RRR) = 0.92: 95% confidence interval (CI) = 0.88, 0.95 for males; and RRR = 0.90: 0.87, 0.94 for females]. Rurality was associated with lower physical multimorbidity (RRR = 0.92: 0.89, 0.95) but higher mental/cognitive multimorbidity (RRR = 1.35: 1.12, 1.64) among females. All multimorbid categories were associated with elevated risk of mortality. Conclusion: The health and economic challenges created by multimorbidity should be addressed further 'upstream'. Future multimorbidity research should include younger adults to inform the development of preventative interventions and align health and social care services more closely with patients' needs.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Mental Disorders/epidemiology ; Middle Aged ; Multimorbidity ; Prevalence ; Risk Factors ; Social Determinants of Health
Language	English
Publishing date	2020-12-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2142082-8
ISSN	1741-3850 ; 1741-3842
ISSN (online)	1741-3850
ISSN	1741-3842
DOI	10.1093/pubmed/fdaa209
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Article ; Online: Daptomycin pharmacokinetic/pharmacodynamic target in staphylococcal infections.

Garreau, Romain / Pham, Truong-Thanh / Bourguignon, Laurent / Millet, Aurélien / Parant, François / Bussy, David / Desevre, Marine / Franchi, Victor / Ferry, Tristan / Goutelle, Sylvain

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae018
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