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  1. Book ; Thesis: Zelltypspezifische Charakterisierung des humanen G-Protein-gekoppelten Rezeptors 182 (GPR182)

    Schmid, Christian David / Goerdt, Sergij

    2020  

    Institution Universität Heidelberg
    Author's details vorgelegt von Christian David Schmid ; Referent: Herr Prof. Dr. med. Sergij Goerdt
    Language German
    Size vi, 77 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2020
    HBZ-ID HT020613947
    Database Catalogue ZB MED Medicine, Health

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  2. Book ; Thesis: Angiokrine Liganden des Wnt Signalwegs kontrollieren die Lebergröße und die metabolische Zonierung der Hepatozyten in Mäusen

    Leibing, Thomas / Goerdt, Sergij

    2019  

    Institution Universität Heidelberg
    Author's details vorgelegt von Thomas Leibing ; Referent: Prof. Dr. med. Sergij Goerdt
    Language German
    Size 96 Blätter, Diagramme, Illustrationen
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2020
    HBZ-ID HT020545012
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Online ; Thesis: Tau- und S-100b-Protein in der Differenzialdiagnose der bakteriellen Meningitis

    Goerdt, Christoph Michael

    2012  

    Abstract: ... Tau-Protein und S-100b-Protein als Marker für neuronalen beziehungsweise glialen Zelluntergang ... weisen darauf hin, dass S-100b-Protein ein guter Parameter in der Diagnostik der bakteriellen Meningitis ...

    Author's details vorgelegt von Christoph Michael Goerdt
    Abstract Trotz intensiver Bemühungen um eine verbesserte Diagnostik und Therapie stellt die bakterielle Meningitis nach wie vor ein ernst zu nehmendes Krankheitsbild dar, welches für die betroffenen Patienten nicht selten mit Folgeschäden oder tödlich endet. Unter diesem Gesichtspunkt wird die Indikation zur frühzeitigen Therapie mit Antibiotika, die oftmals kombiniert werden, großzügig gestellt. Folglich werden viele Patienten, die an einer oft harmlosen Virusmeningitis erkrankt sind, über einen langen Zeitraum antibiotisch behandelt. Dies zieht zum einen die Möglichkeit folgenschwerer Nebenwirkungen und zum anderen erhebliche Kosten im Gesundheitssystem nach sich. Da unter Berücksichtigung der klinischen Untersuchungsergebnisse und der laborchemischen Analysen einschließlich der Liquordiagnostik in vielen Fällen keine eindeutige Aussage zur Genese der Erkrankung gemacht werden kann, war das Ziel dieser Studie, die Parameter Tau-Protein und S-100b-Protein als Marker für neuronalen beziehungsweise glialen Zelluntergang bei bakterieller Meningitis im Hinblick auf ihren diagnostischen Wert hin zu überprüfen. Die hier vorliegenden Ergebnisse weisen darauf hin, dass S-100b-Protein ein guter Parameter in der Diagnostik der bakteriellen Meningitis ist. In Bezug auf Sensitivität und Spezifität schneidet es im Vergleich mit den Routineparametern der Liquordiagnostik teils besser und teils schlechter ab. In jedem Fall kann durch die zusätzliche Bestimmung dieses Parameters mehr diagnostische Sicherheit insofern erlangt werden, als durch die hohe ermittelte Spezifität bei akzeptabler Sensitivität die Diagnose sicher bestätigt werden kann ...
    Language German
    Size Online-Ressource (PDF-Datei: 84 S., 4.573 KB), Ill., graph. Darst
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Göttingen, 2012
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book ; Online ; Thesis: Tau- und S-100b-Protein in der Differenzialdiagnose der bakteriellen Meningitis

    Goerdt, Christoph Verfasser] / Schmidt, Holger [Akademischer Betreuer] / [Eiffert, Helmut [Akademischer Betreuer] / Virsik-köpp, Patricia [Akademischer Betreuer]

    2012  

    Author's details Christoph Goerdt. Gutachter: Holger Schmidt ; Helmut Eiffert ; Patricia Virsik-Köpp. Betreuer: Holger Schmidt
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Niedersächsische Staats- und Universitätsbibliothek Göttingen
    Publishing place Göttingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article: Jessner’s Lymphocytic Infiltration of the Skin: A CD8+ Polyclonal Reactive Skin Condition

    Poenitz, N. / Dippel, E. / Klemke, C.-D. / Qadoumi, M. / Goerdt, S.

    Dermatology

    2003  Volume 207, Issue 3, Page(s) 276–284

    Abstract: Background: Jessner’s lymphocytic infiltration of the skin (JLIS) is a clinically and ...

    Institution Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht Karl University of Heidelberg, Mannheim, and Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Berlin, Germany
    Abstract Background: Jessner’s lymphocytic infiltration of the skin (JLIS) is a clinically and histologically distinct disease entity. Conflicting results have been reported concerning its differentiation from cutaneous lupus erythematosus and polymorphous light eruption, its relationship to palpable migratory arciform erythema and its classification as a B-cell or a CD4+ T-cell lymphoproliferative disease. Objective: Our study was performed in order to re-evaluate JLIS clinically and by immunohistochemical and molecular analyses. Methods: Stringent inclusion/exclusion criteria were used to collect a cohort of 34 patients with JLIS that did not overlap with lupus erythematosus or polymorphous light eruption. Clinical data were analysed, and immunohistochemical and molecular studies were performed including TCR-γ PCR GeneScan software analysis of tissue and peripheral blood samples. Results: In the majority of the patients, the lesions consisted only of papules and plaques while in 12% annular lesions were also seen. The lesions were found on the face (38%), on the trunk and arms (50%) or at both sites (12%). Immunohistochemical analyses revealed a clear predominance of T cells in all patients, and of CD8+ T cells in 77% of the patients. As judged by TCR-γ PCR GeneScan analysis, 98 and 79% of the tissue and peripheral blood samples, respectively, showed a polyclonal T-cell population; identical T-cell clones were not detected concomitantly in both the skin and the peripheral blood of the same patient. Conclusions: JLIS occurs at 2 major predilection sites, that is the face and trunk. Therefore introduction of palpable migratory arciform erythema as a separate entity is not justified. The lymphoid infiltrates are dominated immunohistochemically by CD8+ T cells that do not show clonality on molecular analysis. Thus, JLIS represents a characteristic CD8+ polyclonal reactive skin condition.
    Keywords GeneScan software ; Jessner’s lymphocytic infiltration of the skin ; Pseudo-T-cell lymphoma ; T-cell receptor rearrangement
    Language English
    Publishing date 2003-10-17
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Clinical and Laboratory Investigations
    ZDB-ID 1099692-8
    ISSN 1421-9832 ; 1018-8665
    ISSN (online) 1421-9832
    ISSN 1018-8665
    DOI 10.1159/000073090
    Database Karger publisher's database

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  6. Article: Deficiency of Stabilin-1 in the Context of Hepatic Melanoma Metastasis.

    Wohlfeil, Sebastian A / Olsavszky, Ana / Irkens, Anna Lena / Häfele, Verena / Dietsch, Bianca / Straub, Niklas / Goerdt, Sergij / Géraud, Cyrill

    Cancers

    2024  Volume 16, Issue 2

    Abstract: Background: This study analyzed the role of Stabilin-1 on hepatic melanoma metastasis in preclinical mouse models.: Methods: In : Results: While hepatic metastasis of B16F10 : Conclusions: Hepatic melanoma metastases show resistance to Stabilin- ...

    Abstract Background: This study analyzed the role of Stabilin-1 on hepatic melanoma metastasis in preclinical mouse models.
    Methods: In
    Results: While hepatic metastasis of B16F10
    Conclusions: Hepatic melanoma metastases show resistance to Stabilin-1 targeting approaches. This suggests that anti-Stab1 therapies should be considered with respect to the tumor entity or target organs.
    Language English
    Publishing date 2024-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16020441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Serum of Patients with Behçet’s Disease Induces Classical (Pro-Inflammatory) Activation of Human Macrophages in vitro

    Alpsoy, E. / Kodelja, V. / Goerdt, S. / Orfanos, C.E. / Zouboulis, Ch.C.

    Dermatology

    2003  Volume 206, Issue 3, Page(s) 225–232

    Abstract: Background: Although several immunological abnormalities have been demonstrated in Behçet’s disease ... that serum factor(s) may be responsible for inflammatory changes in BD. ...

    Institution Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany Department of Dermatology, University School of Medicine, Antalya, Turkey
    Abstract Background: Although several immunological abnormalities have been demonstrated in Behçet’s disease (BD), the exact mechanism of the inflammatory changes occurring is still unknown. Antigen-presenting cells, such as mononuclear phagocytes, play a major role in the regulation of immune-mediated as well as of non-specific inflammation. Objective: To investigate the serum activity of patients with BD on antigen and chemokine expression of human macrophages in vitro. Methods: Serum of 15 patients (8 women, 7 men; mean age 33 ± 10 years) with BD was incubated with cultured macrophages isolated from peripheral blood of healthy volunteers. Macrophages maintained in patients’ serum, fetal calf serum with/without dexamethasone and interleukin (IL)-4 or γ-interferon were investigated for alternative macrophage-activation-associated CC-chemokine 1 (AMAC-1) and IL-8 mRNA expression by Northern blotting. In addition, cytocentrifuge macrophage preparations were stained with monoclonal antibodies against proteins indicating alternative (anti-inflammatory) macrophage activation, such as MS-1 high-molecular-weight protein (MS-1-HMWP), RM3/1 antigen (CD163) and 25F9, as well as classical (pro-inflammatory) macrophage activation, such as CD11c, class I receptor binding the Fc part of IgG (FcγRI: CD64) and class III receptor binding the Fc part of IgG (FcγRIII: CD16). Results: Macrophages treated with patients’ serum showed neither AMAC-1 expression nor staining with monoclonal antibodies for MS-1-HMWP, CD163 or 25F9. Concomitant treatment with IL-4/dexamethasone up-regulated significantly the expression of CD163. In contrast, IL-8 mRNA expression and staining for CD11c and CD64 were strongly positive after treatment with serum of patients with BD. CD64 positivity and IL-8 mRNA expression were more prominent in patients with active BD than in patients with inactive disease. Conclusion: Taken together, our results indicate that serum of patients with BD induces classical (pro-inflammatory) activation of human peripheral blood macrophages in vitro. Our findings suggest that serum factor(s) may be responsible for inflammatory changes in BD.
    Keywords Interleukin 8 ; CD64 ; Behçet’s disease ; Serum ; Macrophages ; AMAC-1
    Language English
    Publishing date 2003-04-17
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Clinical and Laboratory Investigations
    ZDB-ID 1099692-8
    ISSN 1421-9832 ; 1018-8665
    ISSN (online) 1421-9832
    ISSN 1018-8665
    DOI 10.1159/000068888
    Database Karger publisher's database

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  8. Book ; Thesis: Untersuchungen zur entzündlich-aktivierten Endothelzelle in vivo und in vitro

    Goerdt, Sergij

    1986  

    Size 74 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Münster, Univ., Diss., 1987
    HBZ-ID HT002948681
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  9. Article ; Online: Angiodiversity and organotypic functions of sinusoidal endothelial cells.

    Koch, Philipp-Sebastian / Lee, Ki Hong / Goerdt, Sergij / Augustin, Hellmut G

    Angiogenesis

    2021  Volume 24, Issue 2, Page(s) 289–310

    Abstract: Angiodiversity' refers to the structural and functional heterogeneity of endothelial cells (EC) along the segments of the vascular tree and especially within the microvascular beds of different organs. Organotypically differentiated EC ranging from ... ...

    Abstract 'Angiodiversity' refers to the structural and functional heterogeneity of endothelial cells (EC) along the segments of the vascular tree and especially within the microvascular beds of different organs. Organotypically differentiated EC ranging from continuous, barrier-forming endothelium to discontinuous, fenestrated endothelium perform organ-specific functions such as the maintenance of the tightly sealed blood-brain barrier or the clearance of macromolecular waste products from the peripheral blood by liver EC-expressed scavenger receptors. The microvascular bed of the liver, composed of discontinuous, fenestrated liver sinusoidal endothelial cells (LSEC), is a prime example of organ-specific angiodiversity. Anatomy and development of LSEC have been extensively studied by electron microscopy as well as linage-tracing experiments. Recent advances in cell isolation and bulk transcriptomics or single-cell RNA sequencing techniques allowed the identification of distinct LSEC molecular programs and have led to the identification of LSEC subpopulations. LSEC execute homeostatic functions such as fine tuning the vascular tone, clearing noxious substances from the circulation, and modulating immunoregulatory mechanisms. In recent years, the identification and functional analysis of LSEC-derived angiocrine signals, which control liver homeostasis and disease pathogenesis in an instructive manner, marks a major change of paradigm in the understanding of liver function in health and disease. This review summarizes recent advances in the understanding of liver vascular angiodiversity and the functional consequences resulting thereof.
    MeSH term(s) Animals ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Humans ; Liver/metabolism ; Liver/pathology ; Liver Diseases/genetics ; Liver Diseases/metabolism ; Liver Diseases/pathology ; Organ Specificity/genetics ; RNA-Seq ; Single-Cell Analysis
    Language English
    Publishing date 2021-03-21
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1484717-6
    ISSN 1573-7209 ; 0969-6970
    ISSN (online) 1573-7209
    ISSN 0969-6970
    DOI 10.1007/s10456-021-09780-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Relative Ellipsoid Zone Reflectivity in Macular Telangiectasia Type 2.

    Goerdt, Lukas / Weinhold, Leonie / Isselmann, Ben / Garcia, Jose Luis Rodriguez / Künzel, Sandrine H / Schmid, Matthias / Holz, Frank G / Tzaridis, Simone / Thiele, Sarah

    Investigative ophthalmology & visual science

    2023  Volume 64, Issue 10, Page(s) 21

    Abstract: Purpose: The relative ellipsoid zone reflectivity (rEZR) has been proposed as an innovative biomarker for photoreceptor integrity. This study evaluates the rEZR in macular telangiectasia type 2 (MacTel) eyes of different disease stages.: Methods: The ...

    Abstract Purpose: The relative ellipsoid zone reflectivity (rEZR) has been proposed as an innovative biomarker for photoreceptor integrity. This study evaluates the rEZR in macular telangiectasia type 2 (MacTel) eyes of different disease stages.
    Methods: The mean rEZR (ratio ellipsoid zone [EZ]/external limiting membrane [ELM] reflectivity [arbitrary units {AUs}], grey level range = 0-1) was analyzed for an entire spectral domain optical coherence tomography volume scan (global) and for each subfield of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid (topographic) in patients with MacTel and controls. MacTel disease severity was classified according to Gass and Blodi.
    Results: Linear mixed-model analysis of 145 eyes of 74 patients and 50 eyes of 25 controls revealed globally lower, yet not statistically significant, rEZR values in MacTel eyes. Topographically, most pronounced decreases were found in stages 3 and 4/5 for the temporal inner (coefficient estimates [CEs] = -25.4 [-38.2; -12.6] and -34.1 [-48.7; -19.6] AU, both: P < 0.001), the inferior inner (-29.9 [-44.6; -15.6] and -35.3 [-52.1; -18.5] AU, both: P < 0.001), the nasal inner (-21.5 [-35.52; -7.4] and -31.6 [-47.6; -15.6] AU, P = 0,003 and P < 0.001), and in the superior inner subfield of stage 4/5 (-25.0 [-42.0; -7.9] AU, P = 0.004).
    Conclusions: The rEZR showed association with disease severity and the predilection area of MacTel. Given the current understanding of the pathophysiological concept of MacTel, these findings underscore the value of the rEZR as a potential novel biomarker for outer retinal integrity. Longitudinal studies are demanded to better characterize its value as a biomarker for early photoreceptor alterations and disease progression in MacTel.
    MeSH term(s) Humans ; Retinal Telangiectasis/diagnosis ; Fundus Oculi ; Biomarkers ; Tomography, Optical Coherence/methods ; Diabetes Mellitus, Type 2 ; Fluorescein Angiography/methods ; Retrospective Studies
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.64.10.21
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