Article: Structure and Function of the Blood-Brain Barrier (BBB).
Handbook of experimental pharmacology
2020 Volume 273, Page(s) 3–31
Abstract: The blood-brain barrier (BBB) protects the vertebrate central nervous system from harmful blood-borne, endogenous and exogenous substances to ensure proper neuronal function. The BBB describes a function that is established by endothelial cells of CNS ... ...
| Abstract | The blood-brain barrier (BBB) protects the vertebrate central nervous system from harmful blood-borne, endogenous and exogenous substances to ensure proper neuronal function. The BBB describes a function that is established by endothelial cells of CNS vessels in conjunction with pericytes, astrocytes, neurons and microglia, together forming the neurovascular unit (NVU). Endothelial barrier function is crucially induced and maintained by the Wnt/β-catenin pathway and requires intact NVU for proper functionality. The BBB and the NVU are characterized by a specialized assortment of molecular specializations, providing the basis for tightening, transport and immune response functionality.The present chapter introduces state-of-the-art knowledge of BBB structure and function and highlights current research topics, aiming to understanding in more depth the cellular and molecular interactions at the NVU, determining functionality of the BBB in health and disease, and providing novel potential targets for therapeutic BBB modulation. Moreover, we highlight recent advances in understanding BBB and NVU heterogeneity within the CNS as well as their contribution to CNS physiology, such as neurovascular coupling, and pathophysiology, is discussed. Finally, we give an outlook onto new avenues of BBB research. |
|---|---|
| MeSH term(s) | Astrocytes ; Biological Transport ; Blood-Brain Barrier/metabolism ; Endothelial Cells/metabolism ; Humans ; Pericytes/metabolism |
| Language | English |
| Publishing date | 2020-11-30 |
| Publishing country | Germany |
| Document type | Journal Article |
| ISSN | 0171-2004 |
| ISSN | 0171-2004 |
| DOI | 10.1007/164_2020_404 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Sign. bis Bd. 125 (1997): 1982 A 2146: Show issues | ||||
| danach: Sign. bei den Einzelbänden: Show issues |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.