LIVIVO - Search results -

Search results

Result 1 - 10 of total 127

Search options

Article: Effect of remote ischaemic conditioning on left ventricular function in ST-segment elevation myocardial infarction patients: The CONDI-2 echocardiographic sub-study.

Wood, Gregory / Johnsen, Pia Hedegaard / Pedersen, Anders Lehmann Dahl / Frederiksen, Christian Alcaraz / Poulsen, Steen Hvitfeldt / Bøtker, Hans Erik / Kim, Won Yong

Frontiers in cardiovascular medicine

2023 Volume 9, Page(s) 1054142

Abstract: Background: Remote ischaemic conditioning (RIC) applied to the arm by inflation and deflation of a pneumatic cuff has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous ... ...

Abstract	Background: Remote ischaemic conditioning (RIC) applied to the arm by inflation and deflation of a pneumatic cuff has been shown to reduce myocardial infarct size in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PPCI). However, the effect of RIC on left ventricular ejection fraction (LVEF) following infarct healing remains unknown. Objective: To investigate whether RIC applied in the ambulance before PPCI can improve left ventricular (LV) function in STEMI patients 3 months following infarction. Methods: Echocardiography was performed in a total of 694 patients from the CONDI-2 study a median of 112 days (IQR 63) after the initial admission. LVEF and LV end-diastolic and end-systolic volumes were calculated using the modified Simpsons biplane method of disks. LV global longitudinal strain (GLS) was estimated using 2-dimensional cine-loops with a frame rate > 55 frames/second, measured in the three standard apical views. Results: There was no difference in the measured echocardiographic parameters in the RIC group as compared to the control group, including LV EF, LV GLS, tricuspid annular plane systolic excursion or left ventricular volumes. In the control group, 32% had an ejection fraction < 50% compared to 37% in the RIC group (p = 0.129). Conclusion: In this largest to date randomized imaging study of RIC, RIC as an adjunct to PPCI was not associated with a change in echocardiographic measures of cardiac function compared to standard PPCI alone.
Language	English
Publishing date	2023-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1054142
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Cortical somatosensory evoked potential amplitudes and clinical outcome after cardiac arrest: a retrospective multicenter study.

Aalberts, Noelle / Westhall, Erik / Johnsen, Birger / Hahn, Katrin / Kenda, Martin / Cronberg, Tobias / Friberg, Hans / Preuß, Sandra / Ploner, Christoph J / Storm, Christian / Nee, Jens / Leithner, Christoph / Endisch, Christian

Journal of neurology

2023 Volume 270, Issue 12, Page(s) 5999–6009

Abstract: Objective: Bilaterally absent cortical somatosensory evoked potentials (SSEPs) reliably predict poor outcome in comatose cardiac arrest (CA) patients. Cortical SSEP amplitudes are a recent prognostic extension; however, amplitude thresholds, inter- ... ...

Abstract	Objective: Bilaterally absent cortical somatosensory evoked potentials (SSEPs) reliably predict poor outcome in comatose cardiac arrest (CA) patients. Cortical SSEP amplitudes are a recent prognostic extension; however, amplitude thresholds, inter-recording, and inter-rater agreement remain uncertain. Methods: In a retrospective multicenter cohort study, we determined cortical SSEP amplitudes of comatose CA patients using a standardized evaluation pathway. We studied inter-recording agreement in repeated SSEPs and inter-rater agreement by four raters independently determining 100 cortical SSEP amplitudes. Primary outcome was assessed using the cerebral performance category (CPC) upon intensive care unit discharge dichotomized into good (CPC 1-3) and poor outcome (CPC 4-5). Results: Of 706 patients with SSEPs with median 3 days after CA, 277 (39.2%) had good and 429 (60.8%) poor outcome. Of patients with bilaterally absent cortical SSEPs, one (0.8%) survived with CPC 3 and 130 (99.2%) had poor outcome. Otherwise, the lowest cortical SSEP amplitude in good outcome patients was 0.5 µV. 184 (42.9%) of 429 poor outcome patients had lower cortical SSEP amplitudes. In 106 repeated SSEPs, there were 6 (5.7%) with prognostication-relevant changes in SSEP categories. Following a standardized evaluation pathway, inter-rater agreement was almost perfect with a Fleiss' kappa of 0.88. Interpretation: Bilaterally absent and cortical SSEP amplitudes below 0.5 µV predicted poor outcome with high specificity. A standardized evaluation pathway provided high inter-rater and inter-recording agreement. Regain of consciousness in patients with bilaterally absent cortical SSEPs rarely occurs. High-amplitude cortical SSEP amplitudes likely indicate the absence of severe brain injury.
MeSH term(s)	Humans ; Cohort Studies ; Coma/diagnosis ; Coma/etiology ; Heart Arrest/complications ; Retrospective Studies ; Evoked Potentials, Somatosensory/physiology ; Prognosis
Language	English
Publishing date	2023-08-28
Publishing country	Germany
Document type	Multicenter Study ; Journal Article
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-023-11951-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui II Zs.40: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Migraine-Associated Mutation in the Na,K-ATPase Leads to Disturbances in Cardiac Metabolism and Reduced Cardiac Function.

Staehr, Christian / Rohde, Palle Duun / Krarup, Nikolaj Thure / Ringgaard, Steffen / Laustsen, Christoffer / Johnsen, Jacob / Nielsen, Rikke / Beck, Hans Christian / Morth, Jens Preben / Lykke-Hartmann, Karin / Jespersen, Nichlas Riise / Abramochkin, Denis / Nyegaard, Mette / Bøtker, Hans Erik / Aalkjaer, Christian / Matchkov, Vladimir

Journal of the American Heart Association

2022 Volume 11, Issue 7, Page(s) e021814

Abstract: Background Mutations ... ...

Abstract	Background Mutations in
MeSH term(s)	Animals ; Heart/physiopathology ; Heterozygote ; Mice ; Migraine Disorders ; Migraine with Aura/metabolism ; Mutation ; Myocardium/metabolism ; Sodium-Potassium-Exchanging ATPase/genetics
Chemical Substances	Atp1a2 protein, mouse (EC 3.6.1.-) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
Language	English
Publishing date	2022-03-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.021814
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Myocardial subcellular glycogen distribution and sarcoplasmic reticulum Ca

Nielsen, Joachim / Johnsen, Jacob / Pryds, Kasper / Ørtenblad, Niels / Bøtker, Hans Erik

Journal of muscle research and cell motility

2019 Volume 42, Issue 1, Page(s) 17–31

Abstract: Ischaemic preconditioning (IPC) protects against myocardial ischaemia-reperfusion injury. The metabolic and ionic effects of IPC remain to be clarified in detail. We aimed to investigate the effect of IPC (2 times 5 min ischaemia) on the subcellular ... ...

Abstract	Ischaemic preconditioning (IPC) protects against myocardial ischaemia-reperfusion injury. The metabolic and ionic effects of IPC remain to be clarified in detail. We aimed to investigate the effect of IPC (2 times 5 min ischaemia) on the subcellular distribution of glycogen and Ca
MeSH term(s)	Animals ; Glycogen/metabolism ; Ischemic Preconditioning/methods ; Male ; Myocardial Reperfusion Injury/physiopathology ; Rats ; Sarcoplasmic Reticulum/metabolism
Chemical Substances	Glycogen (9005-79-2)
Language	English
Publishing date	2019-10-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	283053-x
ISSN	1573-2657 ; 0142-4319
ISSN (online)	1573-2657
ISSN	0142-4319
DOI	10.1007/s10974-019-09557-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.B 2376: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 298: Show issues

Order via subito

Details ▾

Article ; Online: Clinical Outcomes Associated With Left Atrial Appendage Occlusion Versus Direct Oral Anticoagulation in Atrial Fibrillation.

Nielsen-Kudsk, Jens Erik / Korsholm, Kasper / Damgaard, Dorte / Valentin, Jan Brink / Diener, Hans-Christoph / Camm, Alan John / Johnsen, Soren Paaske

JACC. Cardiovascular interventions

2021 Volume 14, Issue 1, Page(s) 69–78

Abstract: Objectives: This study sought to investigate clinical outcomes associated with left atrial appendage occlusion (LAAO) versus direct oral anticoagulants (DOACs) in patients with high-risk atrial fibrillation (AF).: Background: LAAO has been shown to ... ...

Abstract	Objectives: This study sought to investigate clinical outcomes associated with left atrial appendage occlusion (LAAO) versus direct oral anticoagulants (DOACs) in patients with high-risk atrial fibrillation (AF). Background: LAAO has been shown to be noninferior to warfarin for stroke prevention in AF. However, anticoagulation with DOACs is now preferred over warfarin as thromboprophylaxis in AF. Methods: Patients with AF enrolled in the Amulet Observational Registry (n = 1,088) who had successful LAAO with the Amplatzer Amulet device (n = 1,078) were compared with a propensity score-matched control cohort of incident AF patients (n = 1,184) treated by DOACs identified from Danish national patient registries. Propensity score matching was based on the covariates of the CHA Results: AF patients treated with LAAO had a significantly lower risk of the primary composite outcome as compared with patients treated with DOACs (hazard ratio [HR]: 0.57; 95% confidence interval [CI]: 0.49 to 0.67). Total events and event rates per 100 patient-years were (LAAO vs. DOACs) 256 vs. 461 and 14.5 vs. 25.7, respectively. The risk of ischemic stroke was comparable between groups (HR: 1.11; 95% CI: 0.71 to 1.75), while risk of major bleeding (HR: 0.62; 95% CI: 0.49 to 0.79) and all-cause mortality (HR: 0.53; 95% CI: 0.43 to 0.64) were significantly lower in patients treated with LAAO. Conclusions: Among high-risk AF patients, LAAO in comparison with DOACs may have similar stroke prevention efficacy but lower risk of major bleeding and mortality.
Language	English
Publishing date	2021-01-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2020.09.051
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6669: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Clinical outcomes of left atrial appendage occlusion versus direct oral anticoagulation in patients with atrial fibrillation and prior ischemic stroke: A propensity-score matched study.

Korsholm, Kasper / Valentin, Jan Brink / Damgaard, Dorte / Diener, Hans-Christoph / Camm, Alan John / Landmesser, Ulf / Hildick-Smith, David / Johnsen, Søren Paaske / Nielsen-Kudsk, Jens Erik

International journal of cardiology

2022 Volume 363, Page(s) 56–63

Abstract: Background: This propensity-score matched study investigated clinical outcomes associated with left atrial appendage occlusion (LAAO) versus direct oral anticoagulation (DOAC) in patients with AF and prior ischemic stroke.: Methods: AF patients ... ...

Abstract	Background: This propensity-score matched study investigated clinical outcomes associated with left atrial appendage occlusion (LAAO) versus direct oral anticoagulation (DOAC) in patients with AF and prior ischemic stroke. Methods: AF patients enrolled in the Amulet Observational Study with a history of ischemic stroke and successful LAAO (n = 299) were compared with a propensity-score matched cohort of incident AF patients with prior ischemic stroke and treated by DOAC (n = 301). The control cohort was identified through the Danish National Patient Registries. Propensity score matching was based on covariates of the CHA Results: Mean (SD) CHA Conclusion: This study indicated significantly lower risk of the composite outcome of stroke, major bleeding and all-cause mortality with LAAO therapy compared to DOAC, in patients with AF and prior stroke. The stroke prevention effectiveness appeared similar, with a significantly lower risk of major bleeding events with LAAO. The suggested clinical benefit of LAAO over DOAC require confirmation in the ongoing randomized OCCLUSION-AF trial.
MeSH term(s)	Anticoagulants ; Atrial Appendage/surgery ; Atrial Fibrillation/complications ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/drug therapy ; Hemorrhage/chemically induced ; Humans ; Ischemic Stroke ; Propensity Score ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/etiology ; Treatment Outcome
Chemical Substances	Anticoagulants
Language	English
Publishing date	2022-06-30
Publishing country	Netherlands
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2022.06.065
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1673: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Round robin using the depth of penetration test method on an armour grade alumina

Erik P. Carton / Bernt B. Johnsen / Dennis-Bo Rahbek / Hans Broos / Almar Snippe

Defence Technology, Vol 15, Iss 6, Pp 829-

2019 Volume 836

Abstract: The depth of penetration (DOP) method is a well-known ballistic test method for characterisation and ranking of ceramic armour materials. The ceramic tile is bonded to a backing material of semi-infinite thickness, and the penetration depth of the ... ...

Abstract	The depth of penetration (DOP) method is a well-known ballistic test method for characterisation and ranking of ceramic armour materials. The ceramic tile is bonded to a backing material of semi-infinite thickness, and the penetration depth of the projectile gives a measure of the performance of the ceramic. There is, however, an inherent variability in the results from this test method. In this work, the accuracy and the variability of the DOP method has been investigated in a round robin exercise. Six ballistic test centres took part in the exercise. A test protocol was developed, in which the threat type (projectile and impact conditions) and a procedure on how to prepare the targets were specified. The targets consisted of alumina tiles of two different thicknesses that were bonded to polycarbonate backing cubes. Two different 7.62 mm armour piercing projectiles were employed; one with a hard steel core and one with a tungsten carbide core. The projectiles and the other materials all came from single material batches in order to avoid batch-to-batch variations in material properties. These materials were distributed between the ballistic test centres. The test results of the different ballistic test facilities were collected and compared. There was not a lot of variation between the average DOP values obtained at each laboratory, but the variation in penetration depth between shots was high. The consequence of this variation may be less confidence in the test results, and a statistical method was used to evaluate the required number of tests that are sufficient to obtain an average result with high confidence. In most cases, the required number of tests is much higher than what is practically feasible. This work was conducted as part of the European Defence Agency-project CERAMBALL. Keywords: Ballistics, Depth of penetration, Test method, Armour, Ceramic, Statistics
Keywords	Military Science ; U
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition.

Hansen, Jan / Johnsen, Jacob / Nielsen, Jan Møller / Sørensen, Charlotte Brandt / Elkjær, Casper Carlsen / Jespersen, Nichlas Riise / Bøtker, Hans Erik

Drug design, development and therapy

2020 Volume 14, Page(s) 2549–2560

Abstract: Purpose: The mechanism of cardioprotection by Kv7.1-5 (KCNQ1-5) channels inhibition by XE991 is unclear. We examined the impact of administration time on the cardioprotective efficacy of XE991, the involvement of key pro-survival kinases, and the ... ...

Abstract	Purpose: The mechanism of cardioprotection by Kv7.1-5 (KCNQ1-5) channels inhibition by XE991 is unclear. We examined the impact of administration time on the cardioprotective efficacy of XE991, the involvement of key pro-survival kinases, and the importance of the Kv7 subchannels. Methods: Isolated perfused rat hearts were divided into five groups: 1) vehicle, 2) pre-, 3) post- or 4) pre- and post-ischemic administration of XE991 or 5) chromanol 293B (Kv7.1 inhibitor) followed by infarct size quantification. HL-1 cells undergoing simulated ischemia/reperfusion were exposed to either a) vehicle, b) pre-, c) per-, d) post-ischemic administration of XE991 or pre-, per- and post-ischemic administration of e) XE991, f) Chromanol 293B or g) HMR1556 (Kv7.1 inhibitor). HL-1 cell injury was evaluated by propidium iodide/Hoechst staining. Pro-survival kinase activation of Akt, Erk and STAT3 in XE991-mediated HL-1 cell protection was evaluated using phosphokinase inhibitors. Kv7 subtype expression was examined by RT-PCR and qPCR. Results: XE991, but not Chromanol 293B, reduced infarct size and improved hemodynamic recovery in all isolated heart groups. XE991 protected HL-1 cells when administered during simulated ischemia. Minor activation of the survival kinases was observed in cells exposed to XE991 but pharmacological inhibition of kinase activation did not reduce XE991-mediated protection. Kv7 subchannels 1-5 were all present in rat hearts but predominately Kv7.1 and Kv7.4 were present in HL-1 cells and selective Kv7.1 did not reduce ischemia/reperfusion injury. Conclusion: The cardioprotective efficacy of XE991 seems to depend on its presence during ischemia and early reperfusion and do not rely on RISK (p-Akt and p-Erk) and SAFE (p-STAT3) pathway activation. The protective effect of XE991 seems mainly mediated through the Kv7.4 subchannel.
MeSH term(s)	Animals ; Chromans/administration & dosage ; Chromans/pharmacology ; KCNQ1 Potassium Channel/antagonists & inhibitors ; Male ; Potassium Channel Blockers/administration & dosage ; Potassium Channel Blockers/pharmacology ; Protective Agents/administration & dosage ; Protective Agents/pharmacology ; Rats ; Rats, Wistar ; Sulfonamides/administration & dosage ; Sulfonamides/pharmacology ; Time Factors
Chemical Substances	Chromans ; HMR 1556 ; KCNQ1 Potassium Channel ; Potassium Channel Blockers ; Protective Agents ; Sulfonamides ; 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane (163163-23-3)
Language	English
Publishing date	2020-07-02
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S226406
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Effect of paroxetine on left ventricular remodeling in an in vivo rat model of myocardial infarction.

Lassen, Thomas Ravn / Nielsen, Jan Møller / Johnsen, Jacob / Ringgaard, Steffen / Bøtker, Hans Erik / Kristiansen, Steen Buus

Basic research in cardiology

2017 Volume 112, Issue 3, Page(s) 26

Abstract: Left ventricular (LV) remodeling following a myocardial infarction (MI) involves formation of reactive oxygen species (ROS). Paroxetine, a selective serotonin reuptake inhibitor, has an antioxidant effect in the vascular wall. We investigated whether ... ...

Abstract	Left ventricular (LV) remodeling following a myocardial infarction (MI) involves formation of reactive oxygen species (ROS). Paroxetine, a selective serotonin reuptake inhibitor, has an antioxidant effect in the vascular wall. We investigated whether paroxetine reduces myocardial ROS formation and LV remodeling following a MI. In a total of 32 Wistar rats, MI was induced by a 30-min ligation of the left anterior descending artery followed by 7- or 28-day reperfusion. During the 28 days of reperfusion, LV remodeling was evaluated by magnetic resonance imaging (MRI) and echocardiography (n = 20). After 28 days of reperfusion, the susceptibility to ventricular tachycardia was evaluated prior to sacrifice and histological assessment of myocyte cross-sectional area, fibrosis, and presence of myofibroblasts. Myocardial ROS formation was measured with dihydroethidium after 7 days of reperfusion in separate groups (n = 12). Diastolic LV volume, evaluated by MRI (417 ± 60 vs. 511 ± 64 µL, p < 0.05), and echocardiography (515 ± 80 vs. 596 ± 83 µL, p < 0.05) as well as diastolic LV internal diameter evaluated with echocardiography (7.2 ± 0.6 vs. 8.1 ± 0.7 mm, p < 0.05) were lower in the paroxetine group than in controls. Furthermore, myocyte cross-sectional area was reduced in the paroxetine group compared with controls (277 ± 26 vs. 354 ± 23 mm
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Echocardiography ; Magnetic Resonance Imaging ; Male ; Myocardial Infarction/pathology ; Paroxetine/pharmacology ; Rats ; Rats, Wistar ; Reactive Oxygen Species ; Serotonin Uptake Inhibitors/pharmacology ; Ventricular Remodeling/drug effects
Chemical Substances	Antioxidants ; Reactive Oxygen Species ; Serotonin Uptake Inhibitors ; Paroxetine (41VRH5220H)
Keywords	covid19
Language	English
Publishing date	2017-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	189755-x
ISSN	1435-1803 ; 0300-8428 ; 0175-9418
ISSN (online)	1435-1803
ISSN	0300-8428 ; 0175-9418
DOI	10.1007/s00395-017-0614-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ui IV Zs.30: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus.

Jespersen, Nichlas Riise / Hjortbak, Marie Vognstoft / Lassen, Thomas Ravn / Støttrup, Nicolaj Brejnholt / Johnsen, Jacob / Tonnesen, Pernille Tilma / Larsen, Steen / Kimose, Hans-Henrik / Bøtker, Hans Erik

Scientific reports

2020 Volume 10, Issue 1, Page(s) 10344

Abstract: Ischemia reperfusion (IR) injury may be attenuated through succinate dehydrogenase (SDH) inhibition by dimethyl malonate (DiMAL). Whether SDH inhibition yields protection in diabetic individuals and translates into human cardiac tissue remain unknown. In ...

Abstract	Ischemia reperfusion (IR) injury may be attenuated through succinate dehydrogenase (SDH) inhibition by dimethyl malonate (DiMAL). Whether SDH inhibition yields protection in diabetic individuals and translates into human cardiac tissue remain unknown. In isolated perfused hearts from 24 weeks old male Zucker diabetic fatty (ZDF) and age matched non-diabetic control rats and atrial trabeculae from patients with and without diabetes, we compared infarct size, contractile force recovery and mitochondrial function. The cardioprotective effect of a 10 minutes DiMAL administration prior to global ischemia and ischemic preconditioning (IPC) was evaluated. In non-diabetic hearts exposed to IR, DiMAL 0.1 mM reduced infarct size compared to IR (55 ± 7% vs. 69 ± 6%, p < 0.05). Mitochondrial respiration was reduced by DiMAL 0.6 mM compared to sham and DiMAL 0.1 mM (p < 0.05). In diabetic hearts an increased concentration of DiMAL (0.6 mM) was required for protection compared to IR (64 ± 13% vs. 79 ± 8%, p < 0.05). Mitochondrial function remained unchanged. In trabeculae from humans without diabetes, IPC and DiMAL improved contractile force recovery compared to IR (43 ± 12% and 43 ± 13% vs. 23 ± 13%, p < 0.05) but in patients with diabetes only IPC provided protection compared to IR (51 ± 15% vs. 21 ± 8%, p < 0.05). Neither IPC nor DiMAL modulated mitochondrial respiration in patients. Cardioprotection by SDH inhibition is possible in human tissue, but depends on diabetes status. The narrow therapeutic range and discrepancy in respiration between experimental and human studies may limit clinical translation.
MeSH term(s)	Aged ; Animals ; Cardiotonic Agents/pharmacology ; Cardiotonic Agents/therapeutic use ; Diabetes Mellitus, Type 2/complications ; Female ; Heart/diagnostic imaging ; Heart/drug effects ; Humans ; Ischemic Preconditioning, Myocardial/methods ; Isolated Heart Preparation ; Male ; Malonates/pharmacology ; Malonates/therapeutic use ; Middle Aged ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Myocardial Contraction/drug effects ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis ; Myocardial Infarction/therapy ; Myocardial Reperfusion Injury/diagnosis ; Myocardial Reperfusion Injury/etiology ; Myocardial Reperfusion Injury/prevention & control ; Myocardium/cytology ; Myocardium/pathology ; Rats ; Rats, Zucker ; Succinate Dehydrogenase/antagonists & inhibitors ; Succinate Dehydrogenase/metabolism ; Treatment Outcome
Chemical Substances	Cardiotonic Agents ; Malonates ; SDHD protein, human ; Succinate Dehydrogenase (EC 1.3.99.1) ; methyl malonate (EM8Y79998C)
Language	English
Publishing date	2020-06-25
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-67247-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito