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  1. Article ; Online: QnAs with Ben Barres.

    Barres, Ben / Nair, Prashant

    Proceedings of the National Academy of Sciences of the United States of America

    2015  Volume 112, Issue 33, Page(s) 10074–10075

    MeSH term(s) Animals ; Axons/physiology ; Gene Expression Regulation ; Humans ; Nerve Tissue Proteins/metabolism ; Wallerian Degeneration/metabolism
    Chemical Substances Nerve Tissue Proteins ; Wld protein, rat
    Language English
    Publishing date 2015-08-18
    Publishing country United States
    Document type Comment ; Interview ; Portraits
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1512539112
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  2. Article ; Online: Stop blocking postdocs' paths to success.

    Barres, Ben A

    Nature

    2017  Volume 548, Issue 7669, Page(s) 517–519

    MeSH term(s) Health Personnel ; Humans ; Research Personnel
    Language English
    Publishing date 2017--30
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/548517a
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  3. Article ; Online: Assembling a Cellular User Manual for the Brain.

    Sloan, Steven A / Barres, Ben A

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2018  Volume 38, Issue 13, Page(s) 3149–3153

    Abstract: ... by these data.Following a lengthy battle with pancreatic cancer, Ben Barres passed away during the writing ... of these enormous gene lists to memory, Ben could oftentimes be spotted at meetings buried in his cell phone ... of this Progression piece. Among Ben's innumerable contributions to the greater scientific community, his addition ...

    Abstract For many years, efforts to decipher the various cellular components that comprise the CNS were stymied by a lack of technical strategies for isolating and profiling the brain's resident cell types. The advent of transcriptional profiling, combined with powerful new purification schemes, changed this reality and transformed our understanding of the macroglial populations within the brain. Here, we chronicle the historical context and scientific setting for our efforts to transcriptionally profile neurons, astrocytes, and oligodendrocytes, and highlight some of the profound discoveries that were cultivated by these data.Following a lengthy battle with pancreatic cancer, Ben Barres passed away during the writing of this Progression piece. Among Ben's innumerable contributions to the greater scientific community, his addition of publicly available transcriptome databases of CNS cell types will forever remain a relic of his generous spirit and boundless scientific curiosity. Although he had impressively committed a majority of these enormous gene lists to memory, Ben could oftentimes be spotted at meetings buried in his cell phone on the Barres RNAseq database. Perhaps the only thing he enjoyed more than exploring these data himself, was knowing how useful these contributions had been (and will hopefully continue to be) to his scientific peers.
    MeSH term(s) Animals ; Brain/cytology ; Brain/metabolism ; Databases, Genetic ; Gene Expression Profiling/methods ; Humans ; Transcriptome
    Language English
    Publishing date 2018-01-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.2479-17.2018
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  4. Article ; Online: Designing and troubleshooting immunopanning protocols for purifying neural cells.

    Barres, Ben A

    Cold Spring Harbor protocols

    2014  Volume 2014, Issue 12, Page(s) 1342–1347

    Abstract: Purifying and culturing cells from the central nervous system (CNS) has proved to be an incredibly powerful tool for dissecting fundamental neuron and glial properties, and especially powerful in understanding neuronal-glial interactions. In a series of ... ...

    Abstract Purifying and culturing cells from the central nervous system (CNS) has proved to be an incredibly powerful tool for dissecting fundamental neuron and glial properties, and especially powerful in understanding neuronal-glial interactions. In a series of detailed protocols, we have provided step-by-step instructions for purifying and culturing specific types of neurons, glia, and vascular cells from the CNS by immunopanning. This article discusses common pitfalls and errors as well as important design considerations for the immunopanning procedure.
    MeSH term(s) Animals ; Antibodies/metabolism ; Cell Separation/methods ; Culture Media ; Immunologic Techniques/methods ; Neurons/cytology
    Chemical Substances Antibodies ; Culture Media
    Language English
    Publishing date 2014-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 1559-6095
    ISSN (online) 1559-6095
    DOI 10.1101/pdb.ip073999
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  5. Article ; Online: A genetically distinct microglial subset promotes myelination.

    Bennett, Mariko L / Barres, Ben A

    The EMBO journal

    2017  Volume 36, Issue 22, Page(s) 3269–3271

    MeSH term(s) Humans ; Microglia ; Myelin Sheath ; Organogenesis
    Language English
    Publishing date 2017-11-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.201798389
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  6. Article ; Online: How to pick a graduate advisor.

    Barres, Ben A

    Neuron

    2013  Volume 80, Issue 2, Page(s) 275–279

    Abstract: In this NeuroView, I provide a guide for young scientists on how to select a graduate advisor or postdoctoral advisor. Good mentorship is not only pivotal for career success, but it is pivotal for driving innovation and for the health of our universities. ...

    Abstract In this NeuroView, I provide a guide for young scientists on how to select a graduate advisor or postdoctoral advisor. Good mentorship is not only pivotal for career success, but it is pivotal for driving innovation and for the health of our universities. Universities need to do much more to teach faculty how to mentor and to ensure mentoring quality. I propose an M-index to measure mentoring quality. I also call here for better studies of what great mentorship entails, better reward for great mentors, and more consideration of mentoring quality when awarding prizes and grants.
    MeSH term(s) Education, Graduate ; Mentors/psychology ; Research Personnel/education
    Language English
    Publishing date 2013-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2013.10.005
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  7. Article ; Online: Reactive Astrocytes: Production, Function, and Therapeutic Potential.

    Liddelow, Shane A / Barres, Ben A

    Immunity

    2017  Volume 46, Issue 6, Page(s) 957–967

    Abstract: Astrocytes constitute approximately 30% of the cells in the mammalian central nervous system (CNS). They are integral to brain and spinal-cord physiology and perform many functions important for normal neuronal development, synapse formation, and proper ... ...

    Abstract Astrocytes constitute approximately 30% of the cells in the mammalian central nervous system (CNS). They are integral to brain and spinal-cord physiology and perform many functions important for normal neuronal development, synapse formation, and proper propagation of action potentials. We still know very little, however, about how these functions change in response to immune attack, chronic neurodegenerative disease, or acute trauma. In this review, we summarize recent studies that demonstrate that different initiating CNS injuries can elicit at least two types of "reactive" astrocytes with strikingly different properties, one type being helpful and the other harmful. We will also discuss new methods for purifying and investigating reactive-astrocyte functions and provide an overview of new markers for delineating these different states of reactive astrocytes. The discovery that astrocytes have different types of reactive states has important implications for the development of new therapies for CNS injury and diseases.
    MeSH term(s) Animals ; Astrocytes/physiology ; Biological Therapy/trends ; Brain/immunology ; Central Nervous System/immunology ; Humans ; Neurodegenerative Diseases/immunology ; Neurodegenerative Diseases/therapy ; Neurons/physiology
    Language English
    Publishing date 2017-06-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2017.06.006
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  8. Article ; Online: Microglia and macrophages in brain homeostasis and disease.

    Li, Qingyun / Barres, Ben A

    Nature reviews. Immunology

    2017  Volume 18, Issue 4, Page(s) 225–242

    Abstract: Microglia and non-parenchymal macrophages in the brain are mononuclear phagocytes that are increasingly recognized to be essential players in the development, homeostasis and diseases of the central nervous system. With the availability of new genetic, ... ...

    Abstract Microglia and non-parenchymal macrophages in the brain are mononuclear phagocytes that are increasingly recognized to be essential players in the development, homeostasis and diseases of the central nervous system. With the availability of new genetic, molecular and pharmacological tools, considerable advances have been made towards our understanding of the embryonic origins, developmental programmes and functions of these cells. These exciting discoveries, some of which are still controversial, also raise many new questions, which makes brain macrophage biology a fast-growing field at the intersection of neuroscience and immunology. Here, we review the current knowledge of how and where brain macrophages are generated, with a focus on parenchymal microglia. We also discuss their normal functions during development and homeostasis, the disturbance of which may lead to various neurodegenerative and neuropsychiatric diseases.
    MeSH term(s) Animals ; Brain/cytology ; Brain/embryology ; Brain/immunology ; Brain Diseases/etiology ; Brain Diseases/immunology ; Brain Diseases/pathology ; Cell Differentiation ; Homeostasis/immunology ; Humans ; Macrophages/cytology ; Macrophages/immunology ; Microglia/cytology ; Microglia/immunology ; Models, Immunological ; Models, Neurological
    Language English
    Publishing date 2017-11-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/nri.2017.125
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  9. Article ; Online: Regeneration: Not everything is scary about a glial scar.

    Liddelow, Shane A / Barres, Ben A

    Nature

    2016  Volume 532, Issue 7598, Page(s) 182–183

    MeSH term(s) Animals ; Astrocytes/pathology ; Axons/physiology ; Central Nervous System/pathology ; Central Nervous System/physiology ; Cicatrix/pathology ; Female ; Models, Biological ; Nerve Regeneration
    Language English
    Publishing date 2016-04-14
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature17318
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  10. Article ; Online: Glia Get Neurons in Shape.

    Sun, Lu O / Barres, Ben A

    Cell

    2016  Volume 165, Issue 4, Page(s) 775–776

    Abstract: Glial cells are essential components of the nervous system. In this issue, Singhvi et al. uncover cellular and molecular mechanisms through which C. elegans glia shape sensory neuron terminals and thus control animal thermosensing behaviors. ...

    Abstract Glial cells are essential components of the nervous system. In this issue, Singhvi et al. uncover cellular and molecular mechanisms through which C. elegans glia shape sensory neuron terminals and thus control animal thermosensing behaviors.
    MeSH term(s) Animals ; Caenorhabditis elegans ; Neuroglia ; Neurons ; Sensory Receptor Cells
    Language English
    Publishing date 2016-05-05
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2016.04.052
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