LIVIVO - Search results -

Search results

Result 1 - 10 of total 99

Search options

Article ; Online: Prognostic value of peripheral blood neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, pan-immune-inflammation value and systemic immune-inflammation index for the efficacy of immunotherapy in patients with advanced gastric cancer.

Fu, Maodong / Zhang, Xiuping / Shen, Feng / Ma, Jun / Li, Zhiyong

2024

Abstract: Aim: ...

Abstract	Aim:
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2024-0031
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Study on the predictive value of pretreatment peripheral blood inflammatory markers regarding immunotherapy in patients with inoperable advanced or locally advanced oesophageal squamous cell carcinoma.

Fu, Maodong / Li, Zhiyong / Ma, Jun / Shen, Feng / Zhang, Xiuping

Scandinavian journal of gastroenterology

2024 , Page(s) 1–8

Abstract: Objective: To explore the effects of pretreatment peripheral blood panimmune-inflammation value (PIV), systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) on the efficacy and prognostic ... ...

Abstract	Objective: To explore the effects of pretreatment peripheral blood panimmune-inflammation value (PIV), systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) on the efficacy and prognostic value of immunotherapy in patients with inoperable advanced or locally advanced oesophageal squamous cell carcinoma (ESCC). Methods: Clinical data of 107 inoperable advanced or locally advanced ESCC patients were retrospectively analysed between May 2019 and August 2023, the receiver operating characteristic curves (ROCs) of PIV, SII, NLR, and PLR in patients prior to immunotherapy were plotted, and their optimal cutoff values were determined. The risk factors were determined by univariate and multivariate analyses in groups based on the optimal cut-off values. Results: Peripheral blood PIV, SII and PLR before immunotherapy had predictive value for the optimal efficacy of immunotherapy in patients with inoperable advanced or locally advanced ESCC; patients with PIV ≥415.885, SII ≥834.295 and NLR ≥3.740 had a low objective response rate (ORR), disease control rate (DCR), a short progression-free survival (PFS) and overall survival (OS) after immunotherapy ( Conclusion: In patients with inoperable advanced or locally advanced ESCC, peripheral blood PIV, SII, and NLR have predictive value for immunotherapy outcome, SII is an independent risk factor affecting the survival prognosis, and SII ≥834.295 suggests a poor prognosis from immunotherapy.
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.1080/00365521.2024.2319319
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 567: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cuproptosis-related risk score based on machine learning algorithm predicts prognosis and characterizes tumor microenvironment in head and neck squamous carcinomas.

Ye, Maodong / Zhang, Guangping / Lu, Yongjian / Ren, Shuai / Ji, Yingchang

Scientific reports

2023 Volume 13, Issue 1, Page(s) 11870

Abstract: Cuproptosis is a recently discovered type of programmed cell death that shows significant potential in the diagnosis and treatment of cancer. It has important significance in the prognosis of HSNC. This study aims to construct a cuproptosis-related ... ...

Abstract	Cuproptosis is a recently discovered type of programmed cell death that shows significant potential in the diagnosis and treatment of cancer. It has important significance in the prognosis of HSNC. This study aims to construct a cuproptosis-related prognostic model and risk score through new data analysis methods such as machine learning algorithms for the prognosis analysis of HSNC. Protein-protein interaction network and machine learning methods were employed to identify hub genes that were used to construct a TreeGradientBoosting model for predicting overall survival. The relationship between the risk scores obtained from the model and features such as tumor microenvironment (TME) and tumor immunity was explored. The C-indexes of the TreeGradientBoosting model in the training and validation cohorts were 0.776 and 0.848, respectively. The nomogram based on risk scores and clinical features showed good performance, and distinguished the TME and immunity between high-risk and low-risk groups. The cuproptosis-associated risk score can be used to predict prognoses, TME, and tumor immunity of HNSC patients.
MeSH term(s)	Humans ; Algorithms ; Head and Neck Neoplasms ; Machine Learning ; Prognosis ; Risk Factors ; Squamous Cell Carcinoma of Head and Neck ; Tumor Microenvironment ; Copper ; Apoptosis
Chemical Substances	Copper (789U1901C5)
Language	English
Publishing date	2023-07-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-38060-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Equine small intestinal angiomatosis.

Zhang, Maodong / Dickinson, Ryan M

The Canadian veterinary journal = La revue veterinaire canadienne

2020 Volume 61, Issue 11, Page(s) 1159–1161

Abstract: Multiple red, raised nodules multifocally distributed along the serosal surface of the normal and the nonviable jejunum were identified in a 24-year-old neutered male horse undergoing surgery for removal of the strangulating lipoma around the jejunum. ... ...

Abstract	Multiple red, raised nodules multifocally distributed along the serosal surface of the normal and the nonviable jejunum were identified in a 24-year-old neutered male horse undergoing surgery for removal of the strangulating lipoma around the jejunum. Histologically, these nodules consisted of many significantly and variably dilated, blood-filled vascular channels lined by a single layer of flattened, well-differentiated endothelial cells with occasional thrombi within a mildly thickened fibrous stroma. A diagnosis of intestinal angiomatosis was proposed. To the best of the authors' knowledge, this is the second report of small intestinal angiomatosis in a horse.
MeSH term(s)	Angiomatosis/diagnosis ; Angiomatosis/surgery ; Angiomatosis/veterinary ; Animals ; Endothelial Cells ; Horse Diseases/diagnosis ; Horse Diseases/surgery ; Horses ; Intestines ; Jejunum ; Lipoma/veterinary ; Male
Language	English
Publishing date	2020-11-04
Publishing country	Canada
Document type	Case Reports
ZDB-ID	41603-4
ISSN	0008-5286
ISSN	0008-5286
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 572: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Body temperature responsive capsules templated from Pickering emulsion for thermally triggered release of β-carotene.

Xia, Chunmiao / Xu, Zihui / Xu, Maodong / Zhang, Cuige / Xu, Bo / Liu, Benhai / Yan, Xin / Zheng, Zhenan / Zhang, Rongli

International journal of biological macromolecules

2024 Volume 266, Issue Pt 1, Page(s) 130940

Abstract: In recent years, functional foods with lipophilic nutraceutical ingredients are gaining more and more attention because of its potential healthy and commercial value, and developing of various bioderived food-grade particles for use in fabrication of ... ...

Abstract	In recent years, functional foods with lipophilic nutraceutical ingredients are gaining more and more attention because of its potential healthy and commercial value, and developing of various bioderived food-grade particles for use in fabrication of Pickering emulsion has attracted great attentions. Herein, the bio-originated sodium caseinate-lysozyme (Cas-Lyz) complex particles were firstly designed to be used as a novel interfacial emulsifier for Pickering emulsions. Pickering emulsions of various food oils were all successfully stabilized by the Cas-Lyz particles without addition of any synthetic surfactants, while the fluorescence microscopy and SEM characterizations clearly evidenced Cas-Lyz particles were attached on the surface of emulsion droplets. Additionally, the Cas-Lyz particles stabilized emulsion can also be used to encapsulate the β-carotene-loaded soybean oil, suggestion a potential method to carry lipophilic bioactive ingredients in an aqueous formulation for food, cosmetic and medical industry. At last, we present a Pickering emulsion strategy that utilizes biocompatible, edible and body temperature-responsive lard oil as the core material in microcapsules, which can achieve hermetic sealing and physiological temperature-triggered release of model nutraceutical ingredient (β-carotene).
Language	English
Publishing date	2024-03-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.130940
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 2374: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Ferritinophagy-mediated ferroptosis facilitates methotrexate-induced hepatotoxicity by high-mobility group box 1 (HMGB1).

Wang, Chengbo / Leng, Maodong / Ding, Cong / Zhu, Xiangzhan / Zhang, Yaodong / Sun, Chenchen / Lou, Pu

Liver international : official journal of the International Association for the Study of the Liver

2023 Volume 44, Issue 3, Page(s) 691–705

Abstract: Background and aim: Hepatotoxicity is a well-defined reaction to methotrexate (MTX), a drug commonly used for the treatment of rheumatoid arthritis and various tumours. We sought to elucidate the mechanism underlying MTX-induced hepatotoxicity and ... ...

Abstract	Background and aim: Hepatotoxicity is a well-defined reaction to methotrexate (MTX), a drug commonly used for the treatment of rheumatoid arthritis and various tumours. We sought to elucidate the mechanism underlying MTX-induced hepatotoxicity and establish a potentially effective intervention strategy. Methods: We administered MTX to liver cells and mice and assessed hepatotoxicity by cell viability assay and hepatic pathological changes. We determined ferroptosis and ferritinophagy by detecting ferroptosis-related markers and autophagic degradation of ferritin heavy chain 1 (FTH1). Results: We have shown that hepatocytes treated with MTX undergo ferroptosis, and this process can be attenuated by ferroptosis inhibitors. Interestingly, NCOA4-mediated ferritinophagy was found to be involved in MTX-induced ferroptosis, which was demonstrated by the relief of ferroptosis through the inhibition of autophagy or knockdown of Ncoa4. Furthermore, MTX treatment resulted in the elevation of high-mobility group box 1 (HMGB1) expression. The depletion of Hmgb1 in hepatocytes considerably alleviated MTX-induced hepatotoxicity by limiting autophagy and the subsequent autophagy-dependent ferroptosis. It is noteworthy that glycyrrhizic acid (GA), a precise inhibitor of HMGB1, effectively suppressed autophagy, ferroptosis and hepatotoxicity caused by MTX. Conclusion: Our study shows the significant roles of autophagy-dependent ferroptosis and HMGB1 in MTX-induced hepatotoxicity. It emphasizes that the inhibition of ferritinophagy and HMGB1 may have potential as a therapeutic approach for preventing and treating MTX-induced liver injury.
MeSH term(s)	Animals ; Mice ; Autophagy ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/drug therapy ; Ferroptosis ; HMGB1 Protein ; Methotrexate/toxicity ; Methotrexate/therapeutic use
Chemical Substances	HMGB1 Protein ; Methotrexate (YL5FZ2Y5U1) ; HMGB1 protein, mouse
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/liv.15811
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1632: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Dendrobium officinale

Wang, Mengmeng / Zhang, Erwei / Yu, Chenrui / Liu, Dandan / Zhao, Shiguang / Xu, Maodong / Zhao, Xiaofeng / Yue, Wenjin / Nie, Guangjun

Polymers

2022 Volume 14, Issue 10

Abstract: Hydrogels have been widespreadly used in various fields. But weak toughness has limited their further applications. In this study, ...

Abstract	Hydrogels have been widespreadly used in various fields. But weak toughness has limited their further applications. In this study,
Language	English
Publishing date	2022-05-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym14102070
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The Guiding Significance of Fractional Flow Reserve (FFR) for Coronary Heart Disease Revascularization.

Yang, Maodong / Zhang, Li / Tang, Han / Zheng, Dechang / Wu, Jian

Discovery medicine

2021 Volume 31, Issue 162, Page(s) 31–35

Abstract: Coronary angiography is an important diagnostic tool for coronary heart disease. While it can identify anatomical coronary stenosis, its ability to identify hemodynamic changes is limited. The Fractional Flow Reserve (FFR) technique, combined with ... ...

Abstract	Coronary angiography is an important diagnostic tool for coronary heart disease. While it can identify anatomical coronary stenosis, its ability to identify hemodynamic changes is limited. The Fractional Flow Reserve (FFR) technique, combined with coronary angiography, facilitates both the functional and anatomical assessment of heart disease. New studies have shown that FFR has unique advantages in guiding percutaneous coronary intervention (PCI), and it is currently being used in coronary artery bypass graft (CABG) as well as for assessing the prognosis of patients after surgery. It may also play a significant role in assessing the patency of a graft. However, some studies have shown that in considering the cardioprotective benefits of CABG, applying FFR guidelines to CABG may reduce or impair its "surgical collateralization" effect and increase the rate of incomplete revascularization. We compared the advantages and disadvantages of FFR to guide PCI and CABG, which will provide health practitioners with useful resources to determine the best diagnosis and treatment for patients.
MeSH term(s)	Coronary Angiography ; Coronary Artery Bypass ; Coronary Artery Disease ; Coronary Stenosis/diagnosis ; Coronary Stenosis/surgery ; Fractional Flow Reserve, Myocardial ; Humans ; Percutaneous Coronary Intervention ; Treatment Outcome
Language	English
Publishing date	2021-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2415544-5
ISSN	1944-7930 ; 1944-7930
ISSN (online)	1944-7930
ISSN	1944-7930
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Surgical Treatment of Lutembacher Syndrome with a Huge Right Atrium: A Case Report.

Yang, Maodong / Zhang, Li / Tang, Han / Liu, Linsong / Wu, Jian

The heart surgery forum

2021 Volume 24, Issue 2, Page(s) E359–E362

Abstract: Background: Lutembacher's syndrome (LS) is a rare cardiovascular anomaly that is defined as any combination of congenital or iatrogenic atrial septal defect (ASD) with congenital or acquired mitral stenosis (MS). The clinical features and hemodynamic ... ...

Abstract	Background: Lutembacher's syndrome (LS) is a rare cardiovascular anomaly that is defined as any combination of congenital or iatrogenic atrial septal defect (ASD) with congenital or acquired mitral stenosis (MS). The clinical features and hemodynamic effects of LS depend on the balance between ASD and MS. Case report: In this case report, we describe a rare case of LS with a huge right atrium in a 39-year-old male patient who was admitted to the hospital with worsening fatigue and breathlessness on exertion. Clinical examination revealed central cyanosis, raised jugular venous pressure bilaterally, clear breath sounds bilaterally with no dry and wet rales, hyperdynamic apex beat, and dull heart sounds. His vital signs on admission included blood pressure of 90/60 mmHg, irregular pulse of 76 beats/min, and oxygen saturation of 90.4%. Echocardiography revealed moderate to severe MS with ASD (ostium secundum). The patient's condition deteriorated after initial medical management, and he underwent open heart surgery for mitral valve replacement, ASD repair, tricuspid annuloplasty, and right atrial volume reduction. Conclusions: This case report describes the successful surgical management of this rare condition.
MeSH term(s)	Adult ; Cardiac Surgical Procedures/methods ; Echocardiography ; Heart Atria/diagnostic imaging ; Heart Atria/surgery ; Hemodynamics/physiology ; Humans ; Lutembacher Syndrome/diagnosis ; Lutembacher Syndrome/physiopathology ; Lutembacher Syndrome/surgery ; Male ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Rare Diseases
Language	English
Publishing date	2021-04-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2069188-9
ISSN	1522-6662 ; 1098-3511
ISSN (online)	1522-6662
ISSN	1098-3511
DOI	10.1532/hsf.3641
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5745: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Characterization of the interactome of the porcine reproductive and respiratory syndrome virus glycoprotein-5.

Zhang, Maodong / Zakhartchouk, Alexander

Archives of virology

2018 Volume 163, Issue 6, Page(s) 1595–1605

Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry, causing reproductive failure in sows and respiratory disorders in piglets. Glycosylated protein 5 (GP5) is a major envelope protein ... ...

Abstract	Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry, causing reproductive failure in sows and respiratory disorders in piglets. Glycosylated protein 5 (GP5) is a major envelope protein of the virus. It is essential for virus particle assembly and involved in viral pathogenesis. In the present study, we identified the host cellular proteins that interact with GP5 by performing immunoprecipitation in MARC-145 cells infected by a recombinant PRRSV containing a FLAG-tag insertion in GP5. In total, 122 cellular proteins were identified by LC-MS/MS. Gene Ontology and KEGG databases were used to map these proteins to different cellular processes, locations and functions. Interestingly, 10.24% of identified cellular proteins were involved in the process of translation. Follow up experiments demonstrated that expression of GP5 in transfected cells led to inhibition of translation of reporter genes. Interaction between GP5 and ATP synthase subunit alpha (ATP5A) was further confirmed by co-immunoprecipitation suggesting a possible role of GP5 in regulation of ATP production in cells. These data contribute to a better understanding of GP5's role in viral pathogenesis and virus-host interactions.
MeSH term(s)	Adenosine Triphosphate/biosynthesis ; Animals ; Cell Line, Transformed ; Epithelial Cells/metabolism ; Epithelial Cells/virology ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Ontology ; Host-Pathogen Interactions ; Mitochondrial Proton-Translocating ATPases/genetics ; Mitochondrial Proton-Translocating ATPases/metabolism ; Molecular Sequence Annotation ; Porcine respiratory and reproductive syndrome virus/genetics ; Porcine respiratory and reproductive syndrome virus/growth & development ; Porcine respiratory and reproductive syndrome virus/metabolism ; Protein Interaction Mapping ; Signal Transduction ; Swine ; Viral Envelope Proteins/genetics ; Viral Envelope Proteins/metabolism
Chemical Substances	Viral Envelope Proteins ; Adenosine Triphosphate (8L70Q75FXE) ; Mitochondrial Proton-Translocating ATPases (EC 3.6.3.-)
Language	English
Publishing date	2018-06
Publishing country	Austria
Document type	Journal Article
ZDB-ID	7491-3
ISSN	1432-8798 ; 0304-8608
ISSN (online)	1432-8798
ISSN	0304-8608
DOI	10.1007/s00705-018-3787-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Ud II Zs.110: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito