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  1. Article: Case report: Severe pneumonia and pneumomediastinum in a previously robust adolescent caused by Omicron BA.5.2.

    Xiang, Tianxin / Fang, Jianhua / Cheng, Tao / Li, Zhongmin / Wu, Daxian / Zhang, Shouhua / Ge, Shanfei / Zhang, Wei

    Frontiers in medicine

    2023  Volume 10, Page(s) 1132630

    Abstract: The manifestation of severe pneumonia is only occasional, and pneumomediastinum is a condition that occurs rarely in Coronavirus disease 2019 (COVID-19) patients, especially in those patients who are infected with the Omicron variant. In addition, ... ...

    Abstract The manifestation of severe pneumonia is only occasional, and pneumomediastinum is a condition that occurs rarely in Coronavirus disease 2019 (COVID-19) patients, especially in those patients who are infected with the Omicron variant. In addition, whether severe pneumonia or pneumomediastinum often occurs in patients in older age, in poor physical condition, or with underlying diseases remains to be ascertained. To date, severe pneumonia and pneumomediastinum due to Omicron infection had not been reported in a young patient with an excellent physical condition. In this study, we report such a case with the aforementioned manifestations in a robust adolescent infected with Omicron BA.5.2.
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1132630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Designing Low Tortuosity Electrodes through Pattern Optimization for Fast-Charging.

    Wang, Ying / Zhang, Yuxuan / Cao, Daxian / Ji, Tongtai / Ren, Haoze / Wang, Guanyi / Wu, Qingliu / Zhu, Hongli

    Small methods

    2023  Volume 7, Issue 4, Page(s) e2201344

    Abstract: The development of fast-charging technologies is crucial for expediting the progress and promotion of electric vehicles. In addition to innovative material exploration, reduction in the tortuosity of electrodes is a favored strategy to enhance the fast- ... ...

    Abstract The development of fast-charging technologies is crucial for expediting the progress and promotion of electric vehicles. In addition to innovative material exploration, reduction in the tortuosity of electrodes is a favored strategy to enhance the fast-charging capability of lithium-ion batteries by optimizing the ion-transfer kinetics. To realize the industrialization of low-tortuosity electrodes, a facile, cost-effective, highly controlled, and high-output continuous additive manufacturing roll-to-roll screen printing technology is proposed to render customized vertical channels within electrodes. Extremely precise vertical channels are fabricated by applying the as-developed inks, using LiNi
    Language English
    Publishing date 2023-02-20
    Publishing country Germany
    Document type Journal Article
    ISSN 2366-9608
    ISSN (online) 2366-9608
    DOI 10.1002/smtd.202201344
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The natural course of COVID-19 patients without clinical intervention.

    Wu, Daxian / Rao, Qunfang / Zhang, Wenfeng

    Journal of medical virology

    2021  Volume 93, Issue 9, Page(s) 5527–5537

    Abstract: The natural course of coronavirus disease 2019 (COVID-19) patients without clinical intervention has not yet been documented. One hundred and fifty-eight patients from two hospitals were enrolled to identify the indicators of severe COVID-19 and observe ... ...

    Abstract The natural course of coronavirus disease 2019 (COVID-19) patients without clinical intervention has not yet been documented. One hundred and fifty-eight patients from two hospitals were enrolled to identify the indicators of severe COVID-19 and observe the natural course of COVID-19 patients without clinical intervention. The total computed tomography (CT) score, a quantitative score based on assessment of the number, quadrant, and area of the lesions in CT, tended to perform better than assessment based only on the number or area of the lesions (p = 0.0004 and p = 0.0887, respectively). Multivariate logistic regression showed that the total CT score, chest tightness, lymphocyte, and lactate dehydrogenase (LDH) were independent factors for severe COVID-19. For patients admitted in 2 weeks from onset to hospitalization, the frequency of severe COVID-19 was gradually increased with the delayed hospitalization. The symptoms of fatigue, dry cough, sputum production, chest tightness, and polypnea were gradually more frequent. The levels of C-reactive protein, alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, γ-glutamyl transpeptidase, LDH, and d-dimer were also gradually increased, as well as the scores based on CT. Conversely, the lymphocyte count and the albumin level were gradually decreased with the delayed hospitalization. Detail turning points of the above alterations were observed after 10-14 days from onset to hospitalization. Total CT score was a simple and feasible score for identifying severe COVID-19. COVID-19 patients without clinical intervention deteriorated gradually during the initial 10-14 days but gradually improved thereafter.
    MeSH term(s) Adult ; Aged ; COVID-19/diagnostic imaging ; COVID-19/physiopathology ; China ; Diagnostic Tests, Routine ; Female ; Hospitalization ; Humans ; Logistic Models ; Lymphocyte Count ; Male ; Middle Aged ; Multivariate Analysis ; SARS-CoV-2 ; Severity of Illness Index ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-05-19
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Case report

    Tianxin Xiang / Jianhua Fang / Tao Cheng / Zhongmin Li / Daxian Wu / Shouhua Zhang / Shanfei Ge / Wei Zhang

    Frontiers in Medicine, Vol

    Severe pneumonia and pneumomediastinum in a previously robust adolescent caused by Omicron BA.5.2

    2023  Volume 10

    Abstract: The manifestation of severe pneumonia is only occasional, and pneumomediastinum is a condition that occurs rarely in Coronavirus disease 2019 (COVID-19) patients, especially in those patients who are infected with the Omicron variant. In addition, ... ...

    Abstract The manifestation of severe pneumonia is only occasional, and pneumomediastinum is a condition that occurs rarely in Coronavirus disease 2019 (COVID-19) patients, especially in those patients who are infected with the Omicron variant. In addition, whether severe pneumonia or pneumomediastinum often occurs in patients in older age, in poor physical condition, or with underlying diseases remains to be ascertained. To date, severe pneumonia and pneumomediastinum due to Omicron infection had not been reported in a young patient with an excellent physical condition. In this study, we report such a case with the aforementioned manifestations in a robust adolescent infected with Omicron BA.5.2.
    Keywords COVID-19 ; Omicron ; mediastinal emphysema ; severe pneumonia ; adolescent ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Weighted thyroid-stimulating hormone disturbance in prognosis of hepatitis B virus-related acute-on-chronic liver failure.

    Tu, Yasi / Ji, Feiyang / Yang, Jing / Rao, Qunfang / Wu, Haiquan / Xie, Zhongyang / Zhang, Sainan / Hou, Zhouhua / Wu, Daxian

    Hepatology research : the official journal of the Japan Society of Hepatology

    2023  Volume 54, Issue 2, Page(s) 151–161

    Abstract: Aim: To weight the prognostic value of thyroid hormones in catastrophic acute-on-chronic liver failure (ACLF).: Methods: A retrospective cohort (n = 635) and two prospective cohorts (n = 353, and 198) were enrolled in this study. The performance of a ...

    Abstract Aim: To weight the prognostic value of thyroid hormones in catastrophic acute-on-chronic liver failure (ACLF).
    Methods: A retrospective cohort (n = 635) and two prospective cohorts (n = 353, and 198) were enrolled in this study. The performance of a novel developed prognostic score was assessed from aspects of reliability, discrimination, and clinical net benefit.
    Results: Thyroid-stimulating hormone (TSH) was identified to have the most potential as a prognostic predictor for hepatitis B virus-related ACLF among thyroid hormones. The novel score (modified chronic liver failure-organ failure score [mCLIF-OFs]) was developed with weighted TSH and other scored organs in the CLIF-OFs using the retrospective cohort (n = 635). The predicted risk and observed probabilities of death were comparable across the deciles of mCLIF-OFs (Hosmer-Lemeshow χ
    Conclusion: Weighted TSH portended the outcome of ACLF patients, which could be treated as a "damaged organ" of the hypothalamic-pituitary-thyroid axis. The novel mCLIF-OFs is a reliable prognostic score with better discrimination power and clinical net benefit than CLIF-OFs, CLIF-SOFAs, CLIF-C ACLFs, MELD, and Child-Pugh.
    Language English
    Publishing date 2023-10-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1387041-5
    ISSN 1386-6346 ; 0928-4346
    ISSN 1386-6346 ; 0928-4346
    DOI 10.1111/hepr.13970
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3826: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Hemorrhagic fever with renal syndrome presenting as leukemoid reaction and hemophagocytic lymphohistiocytosis.

    Rao, Qunfang / Luo, Lin / Gao, Li / Xiong, Wanyin / Nie, Qinqin / Wu, Daxian

    Journal of medical virology

    2021  Volume 94, Issue 2, Page(s) 433–435

    MeSH term(s) Bone Marrow/pathology ; Hantaan virus/pathogenicity ; Hemorrhagic Fever with Renal Syndrome/complications ; Hemorrhagic Fever with Renal Syndrome/diagnosis ; Humans ; Leukemoid Reaction/complications ; Leukemoid Reaction/virology ; Lymphohistiocytosis, Hemophagocytic/complications ; Lymphohistiocytosis, Hemophagocytic/virology ; Male ; Middle Aged
    Language English
    Publishing date 2021-09-15
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Low Growth Hormone Levels Predict Poor Outcome of Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.

    Wu, Daxian / Zhang, Lingjian / Ma, Shanshan / Zhao, Yalei / Chen, Ronggao / Zhang, Fen / Liu, Qiuhong / Xu, Xiaowei / Xie, Zhongyang

    Frontiers in medicine

    2021  Volume 8, Page(s) 655863

    Abstract: Background and Aims: ...

    Abstract Background and Aims:
    Language English
    Publishing date 2021-07-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.655863
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  8. Article ; Online: Overexpression of microRNA-381-3p ameliorates hypoxia/ischemia-induced neuronal damage and microglial inflammation via regulating the C-C chemokine receptor type 2 /nuclear transcription factor-kappa B axis.

    Che, Yuanmei / He, Jianglong / Li, Xiaopeng / Wu, Daxian / Zhang, Yi / Yuan, Guicai

    Bioengineered

    2022  Volume 13, Issue 3, Page(s) 6839–6855

    Abstract: microRNAs, as small endogenous RNAs, influence umpteen sophisticated cellular biological functions regarding neurodegenerative and cerebrovascular diseases. Here, we interrogated miR-381-3p's influence on BV2 activation and neurotoxicity in ischemic and ... ...

    Abstract microRNAs, as small endogenous RNAs, influence umpteen sophisticated cellular biological functions regarding neurodegenerative and cerebrovascular diseases. Here, we interrogated miR-381-3p's influence on BV2 activation and neurotoxicity in ischemic and hypoxic environment. Oxygen-glucose deprivation (OGD) was adopted to induce microglial activation and HT-22 neuron damage. Quantitative polymerase chain reaction (qRT-PCR) was taken to check miR-381-3p expression in OGD-elicited BV2 cells and HT-22 neurons. It transpired that miR-381-3p expression was lowered in BV2 cells and HT-22 cells elicited by OGD. miR-381-3p up-regulation remarkably hampered inflammatory mediator expression in BV2 cells induced by OGD and weakened HT22 neuron apoptosis.
    MeSH term(s) Animals ; Apoptosis/genetics ; Glucose/metabolism ; Glucose/toxicity ; Hypoxia/metabolism ; Hypoxia/pathology ; Inflammation/metabolism ; Ischemia/metabolism ; Ischemia/pathology ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Microglia/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Neurons/metabolism ; Oxygen ; Rats ; Receptors, Chemokine/metabolism
    Chemical Substances MIRN381 microRNA, rat ; MicroRNAs ; NF-kappa B ; Receptors, Chemokine ; Glucose (IY9XDZ35W2) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2737830-5
    ISSN 2165-5987 ; 2165-5979
    ISSN (online) 2165-5987
    ISSN 2165-5979
    DOI 10.1080/21655979.2022.2038448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Lymphocyte subset alterations with disease severity, imaging manifestation, and delayed hospitalization in COVID-19 patients.

    Wu, Daxian / Wu, Xiaoping / Huang, Jiansheng / Rao, Qunfang / Zhang, Qi / Zhang, Wenfeng

    BMC infectious diseases

    2021  Volume 21, Issue 1, Page(s) 631

    Abstract: Background: COVID-19 continuously threated public health heavily. Present study aimed to investigate the lymphocyte subset alterations with disease severity, imaging manifestation, and delayed hospitalization in COVID-19 patients.: Methods: ... ...

    Abstract Background: COVID-19 continuously threated public health heavily. Present study aimed to investigate the lymphocyte subset alterations with disease severity, imaging manifestation, and delayed hospitalization in COVID-19 patients.
    Methods: Lymphocyte subsets was classified using flow cytometry with peripheral blood collected from 106 patients.
    Results: Multivariate logistic regression showed that chest tightness, lymphocyte count, and γ-glutamyl transpeptidase were the independent predictors for severe COVID-19. The T cell, CD4
    Conclusion: T lymphocyte and its subset negatively correlated with disease severity, CT manifestation and delayed hospitalization. The counts of lymphocyte subset were changed more profound than their proportions.
    MeSH term(s) Adult ; B-Lymphocytes ; COVID-19/diagnostic imaging ; COVID-19/pathology ; Diagnostic Tests, Routine ; Flow Cytometry ; Hospitalization ; Humans ; Killer Cells, Natural ; Logistic Models ; Lymphocyte Count ; Lymphocyte Subsets ; Male ; Middle Aged ; SARS-CoV-2 ; Severity of Illness Index
    Language English
    Publishing date 2021-07-01
    Publishing country England
    Document type Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-021-06354-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Modulating autophagy in mesenchymal stem cells effectively protects against hypoxia- or ischemia-induced injury

    Chenxia Hu / Lingfei Zhao / Daxian Wu / Lanjuan Li

    Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-

    2019  Volume 13

    Abstract: Abstract In mammals, a basal level of autophagy, a self-eating cellular process, degrades cytosolic proteins and subcellular organelles in lysosomes to provide energy, recycles the cytoplasmic components, and regenerates cellular building blocks; thus, ... ...

    Abstract Abstract In mammals, a basal level of autophagy, a self-eating cellular process, degrades cytosolic proteins and subcellular organelles in lysosomes to provide energy, recycles the cytoplasmic components, and regenerates cellular building blocks; thus, autophagy maintains cellular and tissue homeostasis in all eukaryotic cells. In general, adaptive autophagy increases when cells confront stressful conditions to improve the survival rate of the cells, while destructive autophagy is activated when the cellular stress is not manageable and elicits the regenerative capacity. Hypoxia-reoxygenation (H/R) injury and ischemia-reperfusion (I/R) injury initiate excessive autophagy and endoplasmic reticulum (ER) stress and consequently induce a string of damage in mammalian tissues or organs. Mesenchymal stem cell (MSC)-based therapy has yielded promising results in repairing H/R- or I/R-induced injury in various tissues. However, MSC transplantation in vivo must overcome the barriers including the low survival rate of transplanted stem cells, limited targeting capacity, and low grafting potency; therefore, much effort is needed to increase the survival and activity of MSCs in vivo. Modulating autophagy regulates the stemness and the anti-oxidative stress, anti-apoptosis, and pro-survival capacity of MSCs and can be applied to MSC-based therapy for repairing H/R- or I/R-induced cellular or tissue injury.
    Keywords Medicine (General) ; R5-920 ; Biochemistry ; QD415-436
    Subject code 610
    Language English
    Publishing date 2019-04-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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