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  1. Article: Xpert Carba-R Assay on Flagged Blood Culture Samples: Clinical Utility in Intensive Care Unit Patients with Bacteremia Caused by

    Rajendran, Surendran / Gopalakrishnan, Ram / Tarigopula, Anil / Kumar, D Suresh / Nambi, P Senthur / Sethuraman, Nandini / Chandran, Chitra / Ramakrishnan, Nagarajan / Ramasubramanian, V

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2023  Volume 27, Issue 9, Page(s) 655–662

    Abstract: ... study of patients more than 18 years of age on whom Xpert Carba-R (FDA approved for rectal swab specimen ... intensive care unit between January 2015 and November 2018. We analyzed the performance of Xpert Carba-R in comparison ... Carba-R serves as a rapid diagnostic tool for predicting carbapenem resistance in intensive care unit ...

    Abstract Introduction and background: Rapid molecular diagnostics to predict carbapenem resistance well before the availability of routine drug sensitivity testing (DST) can serve as an antimicrobial stewardship tool in the context of high rates of Carbapenem-resistant
    Materials and methods: A retrospective observational study of patients more than 18 years of age on whom Xpert Carba-R (FDA approved for rectal swab specimen) was done on gram-negative bacteria (GNB) flagged blood culture samples, in an Indian intensive care unit between January 2015 and November 2018. We analyzed the performance of Xpert Carba-R in comparison with routine DST.
    Results: A total of 164 GNBs were isolated from 160 patients.
    Conclusion: Xpert Carba-R serves as a rapid diagnostic tool for predicting carbapenem resistance in intensive care unit patients with bacteremia caused by
    How to cite this article: Rajendran S, Gopalakrishnan R, Tarigopula A, Kumar DS, Nambi PS, Sethuraman N,
    Language English
    Publishing date 2023-09-14
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-24533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sesbanimide R, a Novel Cytotoxic Polyketide Produced by Magnetotactic Bacteria.

    Awal, Ram Prasad / Haack, Patrick A / Bader, Chantal D / Riese, Cornelius N / Schüler, Dirk / Müller, Rolf

    mBio

    2021  Volume 12, Issue 3

    Abstract: Genomic information from various magnetotactic bacteria suggested that besides their common ability to form magnetosomes, they potentially also represent a source of bioactive natural products. By using targeted deletion and transcriptional activation, ... ...

    Abstract Genomic information from various magnetotactic bacteria suggested that besides their common ability to form magnetosomes, they potentially also represent a source of bioactive natural products. By using targeted deletion and transcriptional activation, we connected a large biosynthetic gene cluster (BGC) of the
    MeSH term(s) Bacterial Proteins/biosynthesis ; Bacterial Proteins/classification ; Bacterial Proteins/metabolism ; Biological Products/metabolism ; Biosynthetic Pathways ; Magnetospirillum/metabolism ; Phylogeny ; Polyketides/metabolism ; Secondary Metabolism
    Chemical Substances Bacterial Proteins ; Biological Products ; Polyketides
    Language English
    Publishing date 2021-05-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mBio.00591-21
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  3. Article ; Online: Magnetic and Transport Anomalies and Large Magnetocaloric Effect in Cubic R 4 PtAl ( R = Ho and Er)

    Kartik K. Iyer / Sudhindra Rayaprol / Ram Kumar / Shidaling Matteppanavar / Suneel Dodamani / Kalobaran Maiti / Echur V. Sampathkumaran

    Magnetochemistry, Vol 9, Iss 85, p

    2023  Volume 85

    Abstract: We report the electronic properties of R 4 PtAl ( R = Ho, and Er), which contains three sites for R ...

    Abstract We report the electronic properties of R 4 PtAl ( R = Ho, and Er), which contains three sites for R, by the measurements of magnetization (ac and dc), heat-capacity, transport, and magnetoresistance (MR). Dc magnetization data reveal antiferromagnetic order below 19 K and 12 K in Ho and Er compounds, respectively. Additional features observed at lower temperatures (12 K for Ho 4 PtAl and 5 K for Er 4 PtAl) are akin to the cluster spin-glass phase. Resistivity data exhibit a weak minimum at a temperature marginally higher than their respective Néel temperature ( T N ), which is unusual for such rare-earths with well-localized 4 f states. Isothermal magnetization and magnetoresistance data well below T N exhibit signatures of a subtle field-induced magnetic transition for a small magnetic field (<10 kOe). Notably, the isothermal entropy change at T N has the largest peak value within this rare-earth family; for a field change from zero to 50 kOe, the entropy change is ~14.5 J/kg K (Ho4PtAl) and ~21.5 J/kg K (Er 4 PtAl) suggesting a role of anisotropy of 4 f orbital in determining this large value. The results provide some clues for the advancement of the field of magnetocaloric effect. The magnetocaloric property of Er 4 PtAl is nonhysteretic, meeting a challenge to find materials with reversible magnetocaloric effect.
    Keywords rare earth intermetallics ; magnetocaloric effect ; antiferromagnetism ; Chemistry ; QD1-999
    Subject code 290
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: Magnetic and transport anomalies and large magnetocaloric effect in cubic R4PtAl (R = Ho and Er)

    Iyer, Kartik K. / Rayaprol, Sudhindra / Kumar, Ram / Matteppanavar, Shidaling / Dodamani, Suneel / Maiti, Kalobaran / Sampathkumaran, Echur V.

    2023  

    Abstract: We report the electronic properties of R4PtAl (R = Ho, and Er), which contains 3 sites for R ...

    Abstract We report the electronic properties of R4PtAl (R = Ho, and Er), which contains 3 sites for R, by the measurements of magnetization (ac and dc), heat-capacity, transport, and magnetoresistance (MR). Dc magnetization data reveal antiferromagnetic order below 19 K and 12 K in Ho and Er compounds, respectively. Additional features observed at lower temperatures (12 K for Ho4PtAl and 5 K for Er4PtAl) are akin to cluster spin-glass phase. Resistivity data exhibit a weak minimum at a temperature marginally higher than their respective N\'eel temperature (T_N) which is unusual for such rare-earths with well localized 4f states. Isothermal magnetization and magnetoresistance data well below T_N exhibit signatures of a subtle field-induced magnetic transition for a small magnetic field (less than 10 kOe). Notably, the isothermal entropy change at T_N has the largest peak value within this rare-earth family; for a field change from zero to 50 kOe, the entropy change is about 14.5 J/kg K (Ho4PtAl) and 21.5 J/kg K (Er4PtAl) suggesting a role of anisotropy of 4f orbital in determining this large value. The results provide some clues for the advancement of the field of magnetocaloric effect. The magnetocaloric property of Er4PtAl is nonhysteretic meeting a challenge to find materials with reversible magnetocaloric effect.
    Keywords Condensed Matter - Strongly Correlated Electrons ; Condensed Matter - Materials Science
    Subject code 530
    Publishing date 2023-04-20
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: On the Temporal Analysis of COVID-19 Pandemic and Prediction of R 0

    Patil, Kshitij / Murali, Anirudh / Ganguli, Piyali / Nandi, Sutanu / Sarkar, RamRup

    SSRN Electronic Journal ; ISSN 1556-5068

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3633240
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: GnRH-R-Targeted Lytic Peptide Sensitizes

    Ma, Shaolin / Pradeep, Sunila / Villar-Prados, Alejandro / Wen, Yunfei / Bayraktar, Emine / Mangala, Lingegowda S / Kim, Mark Seungwook / Wu, Sherry Y / Hu, Wei / Rodriguez-Aguayo, Cristian / Leuschner, Carola / Liang, Xiaoyan / Ram, Prahlad T / Schlacher, Katharina / Coleman, Robert L / Sood, Anil K

    Molecular cancer therapeutics

    2019  Volume 18, Issue 5, Page(s) 969–979

    Abstract: EP-100 is a synthetic lytic peptide that specifically targets the gonadotropin-releasing hormone receptor on cancer cells. To extend the utility of EP-100, we aimed to identify effective combination therapies with EP-100 for ovarian cancer and explore ... ...

    Abstract EP-100 is a synthetic lytic peptide that specifically targets the gonadotropin-releasing hormone receptor on cancer cells. To extend the utility of EP-100, we aimed to identify effective combination therapies with EP-100 for ovarian cancer and explore potential mechanisms of this combination. A series of
    MeSH term(s) Animals ; BRCA1 Protein/genetics ; Cell Proliferation/drug effects ; Cisplatin/pharmacology ; DNA Damage/drug effects ; Doxorubicin/pharmacology ; Drug Resistance, Neoplasm/genetics ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Mice ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Paclitaxel/pharmacology ; Peptides/chemical synthesis ; Peptides/pharmacology ; Phthalazines/pharmacology ; Piperazines/pharmacology ; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology ; Receptors, LHRH/antagonists & inhibitors ; Receptors, LHRH/genetics ; Xenograft Model Antitumor Assays
    Chemical Substances BRCA1 Protein ; Peptides ; Phthalazines ; Piperazines ; Poly(ADP-ribose) Polymerase Inhibitors ; Receptors, LHRH ; Doxorubicin (80168379AG) ; Paclitaxel (P88XT4IS4D) ; Cisplatin (Q20Q21Q62J) ; olaparib (WOH1JD9AR8)
    Language English
    Publishing date 2019-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2063563-1
    ISSN 1538-8514 ; 1535-7163
    ISSN (online) 1538-8514
    ISSN 1535-7163
    DOI 10.1158/1535-7163.MCT-18-0770
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5750: Show issues Location:
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  7. Article ; Online: R.I.R.S. (RENAL STONE DENSITY, INFERIOR POLE STONE, RENAL INFUNDIBULAR LENGTH, STONE BURDEN) SCORING SYSTEM FOR PREDICTING STONE FREE RATE FOLLOWING RETROGRADE INTRARENAL SURGERY

    Vishnuvardan Reddy N / Charan Kumar G.V. / Devaraj Rahul / DHEERAJ SSS / Ram Reddy Ch

    Basrah Journal of Surgery, Vol 29, Iss 2, Pp 123-

    2023  Volume 133

    Abstract: Background: This study evaluated the accuracy of the R.I.R.S scoring system (kidney stone density ... p = 0.001) and 0.837 (p = 0.028) respectively. AUROC) for R.I.R.S. Score predicting Complications ... was 0.8 (p = 0.002) statistically significant. Conclusion: R.I.R.S. scoring system was statistically ...

    Abstract Background: This study evaluated the accuracy of the R.I.R.S scoring system (kidney stone density, inferior pole stones, stone burden, and renal infundibular length) in predicting the stone-free rate (SFR) post RIRS. Methods: This retrospective study was conducted in 50 patients aged 18-65 years undergoing RIRS for kidney stones in a tertiary institute hospital from February 2022 to June 2023. Medical records were analysed to obtain the the pre-operative investigations, intra-operative findings and post-operative complications and follow up data. The RIRS parameters were also measured to predict stone free rate post RIRS. Results: 38% patients had mild RIRS score (4-5), 60% patients had moderate RIRS score (6-8) and 2% patients had severe RIRS score (9-10). 46 patients (92%) had stone free (SF) status while remaining 4 patients (8%) had residual stone fragments. 22% patients had complications such as fever (18% patients) and urosepsis (4% patients). AUROC for stone burden (mm) and stone density (HU) predicting SF status was 0.989 (p = 0.001) and 0.837 (p = 0.028) respectively. AUROC) for R.I.R.S. Score predicting Complications was 0.8 (p = 0.002) statistically significant. Conclusion: R.I.R.S. scoring system was statistically significant in assessing stone free rate and complications. The higher R.I.R.S. score was associated with more residual stone fragments, lower stone clearance and higher postop complications. Hence R.I.R.S is a reliable and accurate preoperative tool for estimating the probability of stone-free state and complications after RIRS surgery.
    Keywords scoring system ; urolithiasis ; stone ; surgery ; postoperative complications ; Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher university of basrah
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: tsfeaturex: An R Package for Automating Time Series Feature Extraction.

    Roque, Nelson A / Ram, Nilam

    Journal of open source software

    2019  Volume 4, Issue 37

    Language English
    Publishing date 2019-05-31
    Publishing country United States
    Document type Journal Article
    ISSN 2475-9066
    ISSN 2475-9066
    DOI 10.21105/joss.01279
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  9. Article ; Online: (with research data) Reproductive isolation in alpine gingers: How do coexisting Roscoea (R. purpurea and R. tumjensis) conserve species integrity?

    Paudel, Babu Ram / Burd, Martin / Shrestha, Mani / Dyer, Adrian G / Li, Qing-Jun

    Evolution; international journal of organic evolution

    2018  Volume 72, Issue 9, Page(s) 1840–1850

    Abstract: ... gingers, Roscoea purpurea and R. tumjensis, occur sympatrically in central Nepal and have such similar ... by a combination of phenological displacement of flowering, earlier for R. tumjensis and later for R. purpurea, and ... complete fidelity of visitation by different pollinator species, bumblebees for R. tumjensis and a long ...

    Abstract Multiple barriers may contribute to reproductive isolation between closely related species. Understanding the relative strength of these barriers can illuminate the ecological factors that currently maintain species integrity and how these factors originally promoted speciation. Two Himalayan alpine gingers, Roscoea purpurea and R. tumjensis, occur sympatrically in central Nepal and have such similar morphology that it is not clear whether or how they maintain a distinct identity. Our quantitative measurements of the components of reproductive isolation show that they are, in fact, completely isolated by a combination of phenological displacement of flowering, earlier for R. tumjensis and later for R. purpurea, and complete fidelity of visitation by different pollinator species, bumblebees for R. tumjensis and a long-tongued fly for R. purpurea. Furthermore, the nectar of R. tumjensis flowers is available to the shorter tongued bumblebees while R. purpurea nectar is less accessible, requiring deep probing from long-tongued flies. Although flowering phenology is a strong current barrier that seemingly obviates any need for pollinator discrimination, this current pattern need not reflect selective forces occurring at the initial divergence of R. tumjensis. There has been considerable pollinator switching during the radiation of the Himalayan Roscoea, and the association of flowering time with type of pollinator in these sympatric species may have originated among the earliest or latest flowering individuals or populations of an ancestor to exploit either bumblebee activity early in the breeding season or long-tongued fly abundance later in the season. These two sympatric Roscoea species add to accumulating evidence of the primacy of prezygotic pollination traits in speciation among angiosperms even in the absence of postzygotic incompatibility.
    MeSH term(s) Animals ; Coleoptera/physiology ; Flowers/physiology ; Pollination ; Quantitative Trait, Heritable ; Reproductive Isolation ; Species Specificity ; Zingiberaceae/classification ; Zingiberaceae/physiology
    Language English
    Publishing date 2018-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2036375-8
    ISSN 1558-5646 ; 0014-3820
    ISSN (online) 1558-5646
    ISSN 0014-3820
    DOI 10.1111/evo.13546
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  10. Article ; Online: Activation of dsRNA-Dependent Protein Kinase R by MicroRNA-378 Sustains Metabolic Inflammation in Hepatic Insulin Resistance.

    Wang, Hao / Song, Yongyan / Wu, Yuxin / Kumar, Virender / Mahato, Ram I / Su, Qiaozhu

    Diabetes

    2021  

    Abstract: ... miR-378a can directly bind to and activate the dsRNA-dependent protein kinase R (PKR) to sustain ...

    Abstract MicroRNAs (miRNAs) are noncoding small RNAs that regulate various pathophysiological cellular processes. Here we reported that expression of the miR-378 family was significantly induced by metabolic inflammatory inducers, a high-fructose diet, and inflammatory cytokine TNFα. Hepatic miRNA profiling revealed that expression of miR-378a was highly upregulated which, in turn, targeted the 3'-UTR of PPARα mRNA, impaired mitochondrial fatty acid β-oxidation and induced mitochondrial and ER stress. More importantly, the upregulated miR-378a can directly bind to and activate the dsRNA-dependent protein kinase R (PKR) to sustain the metabolic stress.
    Language English
    Publishing date 2021-01-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/20-0181
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    Uh III Zs.175: Show issues Location:
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