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Article ; Online: Impact of Ag/ZnO Reinforcements on the Anticancer and Biological Performances of CA@Ag/ZnO Nanocomposite Materials.

Alahmadi, Nadiyah / Hussein, Mahmoud A

2023 Volume 28, Issue 3

Abstract: In this study, an unpretentious, non-toxic, and cost-effective dissolution casting method was utilized to synthesize a group of anticancer and biologically active hybrid nanocomposite materials containing biopolymer cellulose acetate. Pristine ZnO and ... ...

Abstract	In this study, an unpretentious, non-toxic, and cost-effective dissolution casting method was utilized to synthesize a group of anticancer and biologically active hybrid nanocomposite materials containing biopolymer cellulose acetate. Pristine ZnO and Ag
MeSH term(s)	Zinc Oxide/pharmacology ; Zinc Oxide/chemistry ; Nanocomposites/chemistry ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry
Chemical Substances	Zinc Oxide (SOI2LOH54Z) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-01-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28031290
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Article ; Online: Dataset for detecting and characterizing Arab computation propaganda on X.

Almotairy, Bodor Moheel / Abdullah, Manal / Alahmadi, Dimah Hussein

Data in brief

2024 Volume 53, Page(s) 110089

Abstract: Arab nations are greatly influenced by computational propaganda. Detecting Arab computational propaganda has become a trending topic in social media research. Despite all the efforts made, the definitive definition of a propagandistic characteristic is ... ...

Abstract	Arab nations are greatly influenced by computational propaganda. Detecting Arab computational propaganda has become a trending topic in social media research. Despite all the efforts made, the definitive definition of a propagandistic characteristic is still not clear. Additionally, the earlier datasets were acquired and labelled for a specific study but were neglected thereafter. As a result, researchers are unable to assess whether the proposed AI detectors can be generalized or not. There is a lack of real ground truth, either to characterize Arab propagandist behaviours or evaluate the new proposed detectors. The provided dataset aims to demonstrate the value of characterizing Arab computational propaganda on X (Twitter) to close the research gap. It is prepared using a scientific approach to guarantee data quality. To ensure the quality of the data, the propagandist users' data was requested from the X Transparency center. Although the data released by X relates to propagandist users, at their level, the tweets were not classified as propaganda or not. Usually, propagandists mix propaganda and non-propaganda tweets to hide their identities. Therefore, three journalist volunteers were employed to label 2100 tweets for either propaganda or not and then label the propagandist tweet according to the propaganda technique used. The dataset covers sports and banking issues. As a result, the dataset consists of 16,355,558 tweets with their meta data from propagandist users in 2019. Plus, 2100 propagandists labelled tweets. The propagandist's dataset helps the research community apply supervised and unsupervised machine learning and deep learning algorithms to classify the credibility of Arab tweets and users. On the other hand, this paper suggests looking at behaviour rather than content to distinguish propaganda communication. The datasets enable deep non-textual analysis to investigate the main characteristics of Arab computational propaganda on X.
Language	English
Publishing date	2024-01-23
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2024.110089
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Article ; Online: Impact of Ag/ZnO Reinforcements on the Anticancer and Biological Performances of CA@Ag/ZnO Nanocomposite Materials

Nadiyah Alahmadi / Mahmoud A. Hussein

Molecules, Vol 28, Iss 1290, p

2023 Volume 1290

Abstract	In this study, an unpretentious, non-toxic, and cost-effective dissolution casting method was utilized to synthesize a group of anticancer and biologically active hybrid nanocomposite materials containing biopolymer cellulose acetate. Pristine ZnO and Ag (0.01, 0.05, 0.1) /ZnO hybrid nanofillers based on variable Ag NP loadings were prepared via green procedures in the presence of gum arabic (GA). The chemical structures and the morphological features of the designed nanocomposite materials were investigated by PXRD, TEM, SEM, FTIR, TGA, and XPS characterization techniques. The characterization techniques confirmed the formation of CA@Ag (0.01, 0.05, 0.1) /ZnO hybrid nanocomposite materials with an average crystallite size of 15 nm. All investigated materials showed two degradation steps. The thermal stability of the fabricated samples was ranked in the following order: CA/ZnO < CA@Ag (0.01) /ZnO < CA@Ag (0.05) /ZnO = CA@Ag (0.1) /ZnO. Hence, the higher Ag doping level slightly enhanced the thermal stability. The developed nanocomposites were tested against six pathogens and were used as the target material to reduce the number of cancer cells. The presence of Ag NPs had a positive impact on the biological and the anticancer activities of the CA-reinforced Ag/ZnO composite materials. The CA@Ag (0.1) /ZnO hybrid nanocomposite membrane had the highest antimicrobial activity in comparison to the other fabricated materials. Furthermore, the developed CA@Ag (0.1) /ZnO hybrid nanocomposite material effectively induced cell death in breast cancer.
Keywords	cellulose acetate ; Ag-doped ZnO ; nanocomposite materials ; green synthesis ; antibacterial activity ; anticancer activity ; Organic chemistry ; QD241-441
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Evaluation of Cellular Changes and Immunohistochemistry Expression of p53 and p16 in the Oral Mucosa Among Saudi Smokers.

Elmahdi, Faris M / Mostafa, Heba E / Eldib, Ali M / Youssef, Magda H / Alahmadi, Lama S / Alkurdi, Abdullah A / Hussein, Hend M

Cureus

2024 Volume 16, Issue 2, Page(s) e55027

Abstract: Background: Smoking is a well-known risk factor for various health problems, including oral cancer. P16 and P53 proteins are involved in cell cycle regulation and proliferation, and their expression levels can provide insights into cellular health.: ... ...

Abstract	Background: Smoking is a well-known risk factor for various health problems, including oral cancer. P16 and P53 proteins are involved in cell cycle regulation and proliferation, and their expression levels can provide insights into cellular health. Objective: This study aims to evaluate the cellular changes and immunohistochemistry expression of p53 and p16 in the oral mucosa among Saudi smokers. Method: In a cross-sectional study obtained by scraping the buccal mucosa, 1000 samples were collected from 2022 to 2023. All of the study's participants were Saudi citizens of both genders. Seven hundred cigarette smokers and 300 nonsmokers made up the controls, using two sampling techniques: initially purposive and then snowball sampling. The materials were subjected to immunohistochemical analysis for P16 and P53 protein overexpression. The samples were scored based on the percentage of positively stained cells and staining intensity. The data were analyzed using SPSS, and categorical variables were identified as frequencies and percentages using the chi-squared test; a value of (P<0.05) was considered significant. Result: Cigarette smokers demonstrate significantly higher rates of cytological inflammation, reverse cytological infection, atypia, and binucleated/multinucleated cells compared to nonsmokers, with an overall abnormal result rate of 46% versus 18.7%, respectively (P=0.024). The study found higher P53 and P16 expression among smokers (7.14% and 2.14%, respectively) compared to nonsmokers (0.1% and 0.33%) (P=0.038). No significant differences were observed in P53/P16 expression across age groups (P=0.72) or between male and female participants (P=0.25). Conclusion: These findings highlight the detrimental effects of smoking on cellular health and reinforce the importance of smoking cessation in reducing the risk of developing cytological abnormalities and associated diseases. These results highlight the association of smoking with increased biomarker expression, emphasizing its relevance in understanding oral health risks.
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.55027
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Article ; Online: Decision support system for handling control decisions and decision-maker related to supply chain

Dimah Hussein Alahmadi / Arwa A. Jamjoom

Journal of Big Data, Vol 9, Iss 1, Pp 1-

2022 Volume 14

Abstract: Abstract Background The present study presents a knowledge-based DSS framework for supporting the decision-maker and handling control decisions related to supply chains. Methods Two binary variables were adopted for denoting at which time point a given ... ...

Abstract	Abstract Background The present study presents a knowledge-based DSS framework for supporting the decision-maker and handling control decisions related to supply chains. Methods Two binary variables were adopted for denoting at which time point a given task $$i$$ i starts and finishes. The scheduling issues are represented through the ontological model and appropriately interpreted using the Java environment. Regarding primary data, digital form of administration using google form platform took precedence over physical administration. Results The findings might not be exact replication of the findings from previous studies that are limited to the influence of information and material flow on the performance of supply chain as there are concerns of what factors constitute information and material flow that need to be identified and considered. However, with the finding of associating factors of information and material flow may need to consider this in managing the flow and the supply chain. Associating factors such as information quality, information visibility, material cost, fund shortage and so on, play a role in information and material flow and the decisions made in an organization. Conclusions Factors associating with information and material flow need to be considered in decision making as well, as the cost in any of the elements affects the flow and this would impede supply chain performance of the organization.
Keywords	Decision support system ; Continuous process improvement ; Data analytics ; Supply chains ; Computer engineering. Computer hardware ; TK7885-7895 ; Information technology ; T58.5-58.64 ; Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Immunomodulatory effect of Myrtenol on benzo (a) pyrene-induced lung cancer in Swiss albino mice via modulation of tumor markers, cytokines and inhibition of PCNA expression.

Zhang, Haoliang / Ramamoorthy, Anuradha / Rengarajan, Thamaraiselvan / Iyappan, Petchi / Alahmadi, Tahani A / Wainwright, Milton / Hussein-Al-Ali, Samer Hasan

Journal of biochemical and molecular toxicology

2023 Volume 38, Issue 1, Page(s) e23578

Abstract: Lung cancer is one of the most common cancers in men. Although many diagnostic and treatment regimens have been followed in the treatment for lung cancer, increasing mortality rate due to lung cancer is depressing and hence requires alternative plant ... ...

Abstract	Lung cancer is one of the most common cancers in men. Although many diagnostic and treatment regimens have been followed in the treatment for lung cancer, increasing mortality rate due to lung cancer is depressing and hence requires alternative plant based therapeutics with with less side-effects. Myrtenol exhibits anti-inflammatory and antioxidant properties. Hence we intended to study the effect of Myrtenol on B(a)P-induced lung cancer. Our study showed that B(a)P lowered hematological count, decreased phagocyte and avidity indices, nitroblue tetrazolium (NBT) reduction, levels of immunoglubulins, antioxidant levels, whereas Myrtenol treatment restored them back to normal levels. On the other hand, xenobiotic and liver dysfunction marker enzymes and pro-inflammatory cytokines were elevated on B(a)P exposure, which retuned back to normal by Myrtenol. This study thus describes the immunomodulatory and antioxidant effects of Myrtenol on B[a]P-induced immune destruction.
MeSH term(s)	Humans ; Male ; Mice ; Animals ; Lung Neoplasms/chemically induced ; Lung Neoplasms/drug therapy ; Cytokines/metabolism ; Benzo(a)pyrene/toxicity ; Antioxidants/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Biomarkers, Tumor/metabolism ; Lung/metabolism ; Bicyclic Monoterpenes
Chemical Substances	Cytokines ; Benzo(a)pyrene (3417WMA06D) ; myrtenol (S1B8392IQY) ; Antioxidants ; Proliferating Cell Nuclear Antigen ; Biomarkers, Tumor ; Bicyclic Monoterpenes
Language	English
Publishing date	2023-11-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1410020-4
ISSN	1099-0461 ; 1095-6670
ISSN (online)	1099-0461
ISSN	1095-6670
DOI	10.1002/jbt.23578
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Article ; Online: Testosterone with Silymarin Improves Diabetes-obesity Comorbidity Complications by Modulating Inflammatory Responses and CYP7A1/ACC Gene Expressions in Rats.

Zhu, Dongli / Du, Yuanyuan / Zhou, Lili / Alahmadi, Tahani Awad / Hussein-Al-Ali, Samer Hasan / Wang, Qinhu

Combinatorial chemistry & high throughput screening

2023

Abstract: Background: The co-morbidity of DMOB has become increasingly problematic among the world's population because of a high-calorie diet and sedentary lifestyle. DMOB is associated with lower testosterone (TN) levels, the male sex hormone. The phytochemical ...

Abstract	Background: The co-morbidity of DMOB has become increasingly problematic among the world's population because of a high-calorie diet and sedentary lifestyle. DMOB is associated with lower testosterone (TN) levels, the male sex hormone. The phytochemical compound silymarin (SN) exerts antidiabetic activity by modifying β-cells and anti-obesity activity by inhibiting adipogenesis by methylxanthine. Aim: The goal of this study was to find out how well testosterone (TN) with silymarin (SN) protects against oxidative stress and inflammation in the liver of the experimental rats with type 2 diabetes (T2D) and obesity (DMOB). Objectives: The present study evaluates the efficacy of TN and SN combination (TNSN) on the levels of the potential parameters, such as body mass, serum marker enzymes, fasting glucose levels, HbA1c levels, lipid profile, enzymatic and non-enzymatic antioxidants, proinflammatory cytokines, gene expression pathways, and histopathology in a DMOB comorbidity rat model. Methods: Male Sprague-Dawley (SD) rats were fed a high-fat diet (HFD) for 20 weeks with an administration of a single dose of streptozotocin (STZ) i.p. injection (30 mg/kg) on the 9th week of the study. The procedure was to develop the DMOB co-morbidity model in the experimental animals. Co-treatment of TN and SN administration were followed throughout the experiment. Rats were sacrificed after overnight fasting to collect serum and liver tissue samples. Samples were analyzed using a clinical chemistry automated analyzer, spectrophotometry, and quantitative real-time PCR (qPCR) methods and protocols. Results: Analyses of body mass changes, serum marker enzymes, fasting glucose levels, HbA1c levels, lipid profiles, enzymatic and non-enzymatic antioxidants, TNF-α, IL-6, adiponectin, CYP7A1, ACC expression pathways, and histopathology showed significant abnormal levels (P ≤ 0.05) in the pathological group. These were efficiently treated to normal by the administration of TNSN. Conclusion: These results concluded that TNSN exerted protective efficacy against the liver abnormalities in the co-morbidity of the DMOB rat model.
Language	English
Publishing date	2023-11-08
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/0113862073272401231108054024
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Article ; Online: A Suggested Proposal for the Requirements of Developing Secondary-Grade NaturalScience Curricula in the Light of the Strategic Aims of Saudi Arabia Vision 2030 According to Science-Teaching Specialists

Ali Hasan Hussein Alahmadi

Journal of Educational Sciences, Vol 30, Iss 3, Pp 479-

2018 Volume 508

Abstract: The main intent of the present study was to determine the requirements for developing natural-science curricula in the light of the strategic aims of Saudi Arabia vision 2030 according to natural-science-teaching specialists, and to set a supposed ... ...

Abstract	The main intent of the present study was to determine the requirements for developing natural-science curricula in the light of the strategic aims of Saudi Arabia vision 2030 according to natural-science-teaching specialists, and to set a supposed prospect for development in the light of such requirements. In order to render such a purpose, the researcher employed the descriptive approach to conduct a five-section questionnaire related to components of natural-science curricula (aims, content, teaching strategies, activities and evaluation). The questionnaire contained 105 items related to the requirements for developing natural-science curricula in the light of 2030 vision. The questionnaire was administered to 92 natural-science teaching specialists. Statistical analyses of the available data proved the participants' consensus as per the proposed development requirements. Mean scores of agreement among participants ranged between 4.43 and 4.56. No statistically significant differences were detected in the rate of agreement due variables of gender or employment. Consequently the researcher designed the proposed development prospect including all major components of natural-Science curricula in the backdrop of strategic aims of the 2030 vision. The study recommended the necessity of conducting curricula-development prospects particularly in natural sciences in the light of 2030 vision, benefitting from the present proposal, revising and evaluating it by a committee of specialists in order to make the utmost use of it.
Keywords	science teaching ; science curriculum components ; curricula development ; national transformation program 2020 ; Education ; L
Subject code	910
Language	Arabic
Publishing date	2018-09-01T00:00:00Z
Publisher	King Saud University
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Performance Evaluation of Cementitious Composites Incorporating Nano Graphite Platelets as Additive Carbon Material.

Ahmad, Farhan / Jamal, Arshad / Iqbal, Mudassir / Alqurashi, Muwaffaq / Almoshaogeh, Meshal / Al-Ahmadi, Hassan M / E Hussein, Enas

Materials (Basel, Switzerland)

2021 Volume 15, Issue 1

Abstract: Nano graphite platelets (NGPs) belong to the carbon family and have a huge impact on the construction industry. NGPs are used as multi-functional fillers and have the potential to develop reinforcing within cementitious composites. In this paper, NGPs ... ...

Abstract	Nano graphite platelets (NGPs) belong to the carbon family and have a huge impact on the construction industry. NGPs are used as multi-functional fillers and have the potential to develop reinforcing within cementitious composites. In this paper, NGPs were incorporated in cementitious composites to investigate the effects of NGPs on the fresh, mechanical, durability, and microstructural properties of concrete. Five mixes were prepared with intrusion of NGPs (0%, 0.5%, 1.5%, 3%, and 5% by weight of cement). The properties studied involved workability, air content, hardened density, compressive strength, tensile strength, flexural strength, sorptivity, ultrasonic pulse velocity (UPV), water absorption, and external sulfate attack. The workability and percent air content decrease by 22.5% and 33.8%, respectively, for concrete with 5% NGPs compared to the control mix. The specimens containing 5% of NGPs revealed the hardened density, compressive, tensile, and flexural strength to increase by 11.4%, 38.5%, 31.6%, and 44.34%, respectively, compared to the control mix. The results revealed that the incorporation of 5%NGPs in cementitious composites reduces the sorptivity and water absorption by 32.2% and 73.9%, respectively, whereas, it increases the UPV value by 7.5% compared to the control mix. Furthermore, the incorporation of NGPs provided better resistance against external sulfate attacks. SEM-EDX spectroscopy was carried out to investigate its microstructural analysis.
Language	English
Publishing date	2021-12-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15010290
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Article ; Online: Numerical Study of Natural Convection of Biological Nanofluid Flow Prepared from Tea Leaves under the Effect of Magnetic Field

Yacine Khetib / Ahmad Alahmadi / Ali Alzaed / Hussein A. Saleem / Mohsen Sharifpur / Goshtasp Cheraghian

Processes, Vol 9, Iss 1824, p

2021 Volume 1824

Abstract: The heat transfer of a biological nanofluid ( N/F ) in a rectangular cavity with two hot triangular blades is examined in this work. The properties used for nanoparticles ( N/Ps ) are derived from a N / P prepared naturally from tea leaves. Silver N/Ps ... ...

Abstract	The heat transfer of a biological nanofluid ( N/F ) in a rectangular cavity with two hot triangular blades is examined in this work. The properties used for nanoparticles ( N/Ps ) are derived from a N / P prepared naturally from tea leaves. Silver N/Ps are distributed in a 50–50 water/ethylene glycol solution. The cavity’s bottom wall is extremely hot, while the upper wall is extremely cold. The side walls are insulated, and the enclosure is surrounded by a horizontal magnetic field ( M/F ). The equations are solved using the control volume technique and the SIMPLE algorithm. Finally, the Nu is determined by changing the dimensions of the blade, the Rayleigh number ( Ra ), and the Hartmann number ( Ha ). Finally, a correlation is expressed for the Nu in the range of parameter changes. The results demonstrate that an increment in the Ra from 10 3 to 10 5 enhances the Nu more than 2.5 times in the absence of an M/F . An enhancement in the strength of the M/F , especially at the Ra of 105, leads to a dramatic reduction in the Nu . An increase in the height of the triangular blade intensifies the amount of Nu in weak and strong convection. The enlargement of the base of the triangular blade first enhances and then decreases as the Nu . The addition of 5% silver biological N/Ps to the fluid enhances the Nu by 13.7% in the absence of an M/F for high Ras.
Keywords	triangular blade ; natural convection ; magnetic field ; biological nanofluid ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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