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  1. Article ; Online: Chronic obstructive pulmonary disease and poverty: an association that respects no borders.

    Mannino, D M

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2020  Volume 24, Issue 2, Page(s) 149

    MeSH term(s) Humans ; Morocco ; Poverty ; Pulmonary Disease, Chronic Obstructive ; Respect ; Risk Factors
    Language English
    Publishing date 2020-01-28
    Publishing country France
    Document type Editorial ; Comment
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.19.0767
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    Zs.MO 261: Show issues

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  2. Article ; Online: Correction: Race-specific reference values and lung function impairment, breathlessness and prognosis: analysis of NHANES 2007-2012.

    Ekström, Magnus / Mannino, David

    Respiratory research

    2023  Volume 24, Issue 1, Page(s) 41

    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-023-02351-3
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  3. Article ; Online: The Race to Abandon Ethnicity in Interpreting Pulmonary Function: Further Evidence.

    Ekström, Magnus / Mannino, David

    Chest

    2023  Volume 164, Issue 6, Page(s) 1348–1349

    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.08.022
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    Zs.MO 349: Show issues

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  4. Article ; Online: Research race-specific reference values and lung function impairment, breathlessness and prognosis: Analysis of NHANES 2007-2012.

    Ekström, Magnus / Mannino, David

    Respiratory research

    2022  Volume 23, Issue 1, Page(s) 271

    Abstract: Background: Spirometry reference values differ by race/ethnicity, which is controversial. We evaluated the effect of race-specific references on prevalence of lung function impairment and its relation to breathlessness and mortality in the US population. ...

    Abstract Background: Spirometry reference values differ by race/ethnicity, which is controversial. We evaluated the effect of race-specific references on prevalence of lung function impairment and its relation to breathlessness and mortality in the US population.
    Methods: Population-based analysis of the National Health and Nutrition Examination Survey (NHANES) 2007-2012. Race/ethnicity was analyzed as black, white, or other. Reference values for forced expiratory volume in one second (FEV
    Results: We studied 14,123 people (50% female). Compared to those for white, black reference values identified markedly fewer cases of lung function impairment (FEV
    Conclusion: Compared to using a common reference (for white) across the population, race-specific spirometry references did not improve prediction of breathlessness and prognosis, and may misclassify lung function as normal despite worse outcomes in black people.
    MeSH term(s) Dyspnea/diagnosis ; Dyspnea/epidemiology ; Female ; Forced Expiratory Volume ; Humans ; Lung ; Male ; Nutrition Surveys ; Reference Values ; Spirometry ; Vital Capacity
    Language English
    Publishing date 2022-10-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-022-02194-4
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  5. Article ; Online: Addressing the origins and health effects of small lungs.

    Ekström, Magnus / Backman, Helena / Mannino, David

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 8, Page(s) e73

    MeSH term(s) Humans ; Lung
    Language English
    Publishing date 2023-06-21
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00185-6
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    Zs.A 7041: Show issues Location:
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  6. Article ; Online: Clinical Implications of the Global Lung Function Initiative Race-Neutral Spirometry Reference Equations in Terms of Breathlessness and Mortality.

    Ekström, Magnus / Backman, Helena / Mannino, David

    American journal of respiratory and critical care medicine

    2023  Volume 209, Issue 1, Page(s) 104–106

    MeSH term(s) Humans ; Spirometry ; Lung ; Dyspnea ; Reference Values ; Forced Expiratory Volume ; Vital Capacity
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202212-2229LE
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  7. Article: Displaced Posterior Cruciate Avulsion Fracture Fixation With Medial Collateral Ligament and Lateral Meniscus Injury Using Combined Open and Arthroscopic Methods.

    Kanakamedala, Ajay C / Mannino, Brian J / Kruckeberg, Bradley M / Cinque, Mark E / Haskel, Jonathan D / Alaia, Michael J / Godin, Jonathan A

    Arthroscopy techniques

    2024  Volume 13, Issue 3, Page(s) 102886

    Abstract: Tibial-sided posterior cruciate ligament avulsion fractures are challenging injuries that often occur concomitantly in the setting of multiligament knee and other soft-tissue injuries. There is no consensus on the optimal surgical approach or timing of ... ...

    Abstract Tibial-sided posterior cruciate ligament avulsion fractures are challenging injuries that often occur concomitantly in the setting of multiligament knee and other soft-tissue injuries. There is no consensus on the optimal surgical approach or timing of treatment for these injuries. This Technical Note describes the fixation of a displaced posterior cruciate ligament avulsion fracture with concomitant grade 3 medial collateral ligament injuries and bucket-handle lateral meniscus tears using open and arthroscopic techniques. This method allows the surgeon to address multiple pathologies in a single stage, although it requires strategic planning and rehabilitation considerations.
    Language English
    Publishing date 2024-01-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2653101-X
    ISSN 2212-6287
    ISSN 2212-6287
    DOI 10.1016/j.eats.2023.11.014
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  8. Article ; Online: Quality of life impact in patients with cutaneous toxicities caused by EGFR inhibitors and immunotherapy.

    Mannino, Maria / Sollena, Pietro / Di Stefani, Alessandro / Rossi, Ernesto / D'Argento, Ettore / Schinzari, Giovanni / Tortora, Giampaolo / Peris, Ketty

    Dermatology (Basel, Switzerland)

    2024  

    Abstract: Background: novel oncologic therapies, including epidermal growth factor receptor inhibitors (EGFR-Is) and immune checkpoint inhibitors (ICIs), are associated with a new spectrum of adverse reactions, with prominent cutaneous toxicities. The impact of ... ...

    Abstract Background: novel oncologic therapies, including epidermal growth factor receptor inhibitors (EGFR-Is) and immune checkpoint inhibitors (ICIs), are associated with a new spectrum of adverse reactions, with prominent cutaneous toxicities. The impact of cutaneous adverse events (cAEs) on patients' quality of life (QoL) represents an unmet clinical need.
    Objectives: 1) to assess whether cutaneous toxicities directed therapies are effective in reducing the QoL burden via the submission of two patient reported outcome measures (PROMs); 2) to investigate whether class of oncologic therapy, type of cAE and toxicity severity differently impact on patients' QoL.
    Methods: a prospective observational study was conducted at the Dermatology department of the Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, from October 2018 to October 2019. Patients aged ≥ 18 years, under therapy with EGFR-Is or ICIs and experiencing a treatment-related cAE were eligible for the study. Dermatology Life Quality Index (DLQI) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire- Core 30 version 3.0 (EORTC QLQ-C30) were administered to patients at first clinical visit (T0), at 1-month (T1), and at 3-month (T2) dermatological follow-up.
    Results: Sixty cAEs of 51 patients have been recorded. A significant difference in the mean score for both DLQI and EORTC QLQ-C30 was found along the 3-months dermatological follow-up (p <0.0001). A similar QoL improvement was reported for PROMs stratified by class of therapy and toxicity severity (p <0.0001). No difference was reported for patients with pyogenic granuloma-like lesions and psoriasiform eruption as per DLQI. Class of therapy and toxicity severity did not differently impact on patients' QoL at selected timepoints; we reported a higher EORTC QLQ-C30 score at T2 for patients developing psoriasiform eruption compared to other types of cAEs.
    Conclusions: Early patients' referral to dermatologists and tailored management could result in better QoL.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1099692-8
    ISSN 1421-9832 ; 1018-8665
    ISSN (online) 1421-9832
    ISSN 1018-8665
    DOI 10.1159/000536332
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    Ui VI Zs.35: Show issues Location:
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  9. Article ; Online: Patient and Clinical Demographics of New Users to Single-Inhaler Triple Therapy in Patients with Chronic Obstructive Pulmonary Disease.

    Wu, Benjamin / Mannino, David / Mu, George / Stiegler, Marjorie / Bogart, Michael

    Pulmonary therapy

    2022  Volume 8, Issue 2, Page(s) 195–208

    Abstract: Introduction: Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) triple therapy was approved by the United States Food and Drug Administration in 2017 as a maintenance therapy for chronic obstructive pulmonary disease (COPD). ... ...

    Abstract Introduction: Single-inhaler fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) triple therapy was approved by the United States Food and Drug Administration in 2017 as a maintenance therapy for chronic obstructive pulmonary disease (COPD). Patient characteristics and treatment patterns prior to initiating FF/UMEC/VI are currently unknown. This study assessed patient characteristics, exacerbation, and medication history in patients with COPD before the initiation of FF/UMEC/VI or multiple-inhaler triple therapy (MITT).
    Methods: This was a retrospective study using the Optum Clinformatics
    Results: The study population included 3933 FF/UMEC/VI users and 18,244 MITT users. Mean (standard deviation) patient age was 72.2 (8.6) years in FF/UMEC/VI users and 70.7 (9.7) years in MITT users. Prior to initiating triple therapy, the majority of FF/UMEC/VI (89.1%) and MITT (93.8%) users experienced a moderate or severe exacerbation or used a COPD maintenance therapy during the baseline period. In addition, 41.2% of FF/UMEC/VI users received overlapping ICS/LAMA/LABA, 20.3% received ICS/LABA, and 9.7% received LAMA/LABA.
    Conclusion: In this population of COPD patients, triple therapy was frequently initiated after previous maintenance medication use or an exacerbation, in line with treatment guideline recommendations.
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article
    ISSN 2364-1746
    ISSN (online) 2364-1746
    DOI 10.1007/s41030-022-00189-6
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  10. Article ; Online: Investigational systemic drugs for moderate to severe plaque psoriasis: What's new?

    Calabrese, Laura / Malvaso, Dalma / Antonelli, Flaminia / Mannino, Maria / Peris, Ketty / Chiricozzi, Andrea

    Expert opinion on investigational drugs

    2023  Volume 32, Issue 3, Page(s) 229–243

    Abstract: Introduction: The therapeutic armamentarium for the treatment of psoriasis, a chronic inflammatory skin disease, is now reasonably broad and structured, with several therapeutic agents that demonstrated a successful long-term control of this condition. ... ...

    Abstract Introduction: The therapeutic armamentarium for the treatment of psoriasis, a chronic inflammatory skin disease, is now reasonably broad and structured, with several therapeutic agents that demonstrated a successful long-term control of this condition. However, there are still unfulfilled gaps resulting from the inherent limitations of existing therapies, which have paved the way for the identification of new therapeutic strategies or the improvement of the existing ones.
    Areas covered: The aim of this review is to thoroughly explore new therapeutic strategies and novel drugs that are currently in the pipeline for the treatment of psoriasis, focusing primarily on agents that are currently in phase I/II of clinical development. Some of which retrace already existing therapeutic approaches, such as the IL23/Th17 pathway inhibition, while others unveil new and yet unexplored ones.
    Expert opinion: Since the therapeutic landscape of psoriasis is wide, it is not yet clear whether novel agents will fill the remaining gaps in the context of a broader and more diversified set of oral and biologic therapies. Nevertheless, with the development of precision medicine approaches, the development of innovative targeted drugs will still have a therapeutic rationale in psoriasis.
    MeSH term(s) Humans ; Antibodies, Monoclonal/pharmacology ; Drugs, Investigational/pharmacology ; Drugs, Investigational/therapeutic use ; Psoriasis/drug therapy
    Chemical Substances Antibodies, Monoclonal ; Drugs, Investigational
    Language English
    Publishing date 2023-03-03
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2023.2184684
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