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  1. Book ; Online: Baclofen in the Treatment of Alcohol Use Disorder

    Heydtmann, Mathis / Agabio, Roberta / de Beaurepaire, Renaud

    2019  

    Keywords Medicine ; Psychiatry ; Baclofen ; alcohol use disorder ; GABA-B receptor agonist ; Alcohol withdrawal syndrome ; Alcoholism ; Addiction ; Mental Health ; Liver disease
    Size 1 electronic resource (130 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021229834
    ISBN 9782889459674 ; 2889459675
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Thesis: Kartierung und Sequenzierung polymorpher Dra-I-Schnittstellen am Genort D 3 S 18 des kurzen Armes des Chromosoms Nr. 3 des Menschen

    Heydtmann, Mathis

    1993  

    Author's details vorgelegt von Mathis Heydtmann
    Language German
    Size 114 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Düsseldorf, Univ., Diss., 1993
    HBZ-ID HT007114504
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    96 E 787 order for loan Magazin

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  3. Article ; Online: Baclofen effect related to liver damage.

    Heydtmann, Mathis

    Alcoholism, clinical and experimental research

    2011  Volume 35, Issue 5, Page(s) 848

    MeSH term(s) Alcoholism/drug therapy ; Baclofen/therapeutic use ; Female ; GABA Agonists/therapeutic use ; Humans ; Male
    Chemical Substances GABA Agonists ; Baclofen (H789N3FKE8)
    Language English
    Publishing date 2011-05
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 428999-7
    ISSN 1530-0277 ; 0145-6008
    ISSN (online) 1530-0277
    ISSN 0145-6008
    DOI 10.1111/j.1530-0277.2010.01414.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Alcohol and hospital readmission.

    Heydtmann, Mathis

    Clinical medicine (London, England)

    2010  Volume 10, Issue 2, Page(s) 201; author reply 202–3

    MeSH term(s) Alcohol-Related Disorders/epidemiology ; Alcohol-Related Disorders/therapy ; Humans ; Length of Stay ; Liver Diseases, Alcoholic/epidemiology ; Liver Diseases, Alcoholic/therapy ; Patient Readmission/statistics & numerical data
    Language English
    Publishing date 2010-04-27
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 2048646-7
    ISSN 1473-4893 ; 1470-2118
    ISSN (online) 1473-4893
    ISSN 1470-2118
    DOI 10.7861/clinmedicine.10-2-201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Editorial: Baclofen in the Treatment of Alcohol Use Disorder.

    de Beaurepaire, Renaud / Heydtmann, Mathis / Agabio, Roberta

    Frontiers in psychiatry

    2019  Volume 10, Page(s) 338

    Language English
    Publishing date 2019-05-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2019.00338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Baclofen and the Alcohol Withdrawal Syndrome-A Short Review.

    Cooney, Gary / Heydtmann, Mathis / Smith, Iain D

    Frontiers in psychiatry

    2019  Volume 9, Page(s) 773

    Abstract: The Alcohol Withdrawal Syndrome (AWS), which may occur with or without delirium, is a frequent consequence of sudden alcohol cessation in patients with moderate to severe Alcohol Dependence Syndrome (ADS). Withdrawal as a result of habituation to alcohol ...

    Abstract The Alcohol Withdrawal Syndrome (AWS), which may occur with or without delirium, is a frequent consequence of sudden alcohol cessation in patients with moderate to severe Alcohol Dependence Syndrome (ADS). Withdrawal as a result of habituation to alcohol is part of the definition of the Alcohol Dependence Syndrome (ICD10). Since the recognition of Delirium Tremens, in the early nineteenth century, the management of the syndrome, an acute medical emergency, has proven controversial. The barbiturates, chlormethiazole, and recently the safer benzodiazepines transformed the management of these conditions. The benzodiazepines, particularly diazepam and chlordiazepoxide, are now the most used first line agents in the treatment of AWS. In addition, a number of other agents, including baclofen, a GABA-B receptor agonist, have the potential to suppress the alcohol withdrawal syndrome. In this review we review the potential use of baclofen in its role to treat AWS. We summarize initial case reports as well as more recent randomized trials of AWS treatment with baclofen. We conclude that currently there is not enough evidence to support the use of baclofen as a first line treatment for AWS. More research will be needed to determine where baclofen might have a role in second-line management of the Alcohol Withdrawal Syndrome on its own or in combination with benzodiazepines or other agents.
    Language English
    Publishing date 2019-01-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2018.00773
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Macrophages in hepatitis B and hepatitis C virus infections.

    Heydtmann, Mathis

    Journal of virology

    2008  Volume 83, Issue 7, Page(s) 2796–2802

    MeSH term(s) Hepatitis B/immunology ; Hepatitis C/immunology ; Humans ; Macrophages/immunology
    Language English
    Publishing date 2008-10-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00996-08
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The statistics of targets.

    Heydtmann, M

    Gut

    2006  Volume 55, Issue 11, Page(s) 1672–1673

    MeSH term(s) Clinical Competence/statistics & numerical data ; Colonoscopy/standards ; Education, Medical, Graduate/statistics & numerical data ; Goals ; Humans ; Statistics as Topic
    Language English
    Publishing date 2006-11
    Publishing country England
    Document type Letter
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gut.2006.103903
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Genome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders.

    Li, Wenqianglong / Zhou, Hang / Thygesen, Johan H / Heydtmann, Mathis / Smith, Iain / Degenhardt, Franziska / Nöthen, Markus / Morgan, Marsha Y / Kranzler, Henry R / Gelernter, Joel / Bass, Nicholas / McQuillin, Andrew

    Psychiatric genetics

    2023  Volume 33, Issue 6, Page(s) 233–242

    Abstract: Introduction: While progress has been made in determining the genetic basis of antisocial behaviour, little progress has been made for antisocial personality disorder (ASPD), a condition that often co-occurs with other psychiatric conditions including ... ...

    Abstract Introduction: While progress has been made in determining the genetic basis of antisocial behaviour, little progress has been made for antisocial personality disorder (ASPD), a condition that often co-occurs with other psychiatric conditions including substance use disorders, attention deficit hyperactivity disorder (ADHD), and anxiety disorders. This study aims to improve the understanding of the genetic risk for ASPD and its relationship with other disorders and traits.
    Methods: We conducted a genome-wide association study (GWAS) of the number of ASPD diagnostic criteria data from 3217 alcohol-dependent participants recruited in the UK (UCL, N = 644) and the USA (Yale-Penn, N = 2573).
    Results: We identified rs9806493, a chromosome 15 variant, that showed a genome-wide significant association ( Z -score = -5.501, P = 3.77 × 10 -8 ) with ASPD criteria. rs9806493 is an eQTL for SLCO3A1 (Solute Carrier Organic Anion Transporter Family Member 3A1), a ubiquitously expressed gene with strong expression in brain regions that include the anterior cingulate and frontal cortices. Polygenic risk score analysis identified positive correlations between ASPD and smoking, ADHD, depression traits, and posttraumatic stress disorder. Negative correlations were observed between ASPD PRS and alcohol intake frequency, reproductive traits, and level of educational attainment.
    Conclusion: This study provides evidence for an association between ASPD risk and SLCO3A1 and provides insight into the genetic architecture and pleiotropic associations of ASPD.
    MeSH term(s) Humans ; Antisocial Personality Disorder/diagnosis ; Antisocial Personality Disorder/genetics ; Genome-Wide Association Study ; Anxiety Disorders ; Risk Factors
    Chemical Substances 4-aminospiroperidol (114442-96-5)
    Language English
    Publishing date 2023-09-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1067837-2
    ISSN 1473-5873 ; 0955-8829
    ISSN (online) 1473-5873
    ISSN 0955-8829
    DOI 10.1097/YPG.0000000000000352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Audit of medical (non-targeted) liver biopsy specimen quality, pathology reporting and effect on patient management.

    Seth, Sidhant / Forrest, Ewan H / Morris, Judith M / Heydtmann, Mathis / Konanahalli, Prakash / Kohnen, Gabriele / Oien, Karin A

    Journal of clinical pathology

    2021  Volume 75, Issue 7, Page(s) 498–502

    Abstract: Aims: To evaluate our medical liver pathology practice and its influence on patient management, using audit templates published by the UK Royal College of Pathologists (RCPath).: Methods: We audited medical liver biopsies reported in our centre in ... ...

    Abstract Aims: To evaluate our medical liver pathology practice and its influence on patient management, using audit templates published by the UK Royal College of Pathologists (RCPath).
    Methods: We audited medical liver biopsies reported in our centre in 2019 using RCPath proformas. Data were collected from pathology reports and corresponding electronic patient record.
    Results: 60 cases were selected for audit from 135 eligible biopsies reported in 2019. 58/60 cases were core biopsies and 2/60 were laparoscopic wedge biopsies. 53/57 (93%) core biopsies with available data met RCPath adequacy criteria (length >15 mm and/or ≥6 portal tracts). Most reports (57/60; 95%) were judged to have helped patient management. 25/60 (42%) biopsy reports helped to clarify the clinical diagnosis and 48/60 (80%) led to altered management.
    Conclusions: We demonstrate the utility of the RCPath audit templates, highlighting the clinical value of medical liver biopsies in the diagnostic work-up and management of patients with liver disease.
    MeSH term(s) Biopsy ; Biopsy, Large-Core Needle ; Humans ; Liver/pathology ; Liver Diseases/diagnosis ; Liver Diseases/pathology ; Liver Diseases/therapy ; Medical Audit ; Pathologists
    Language English
    Publishing date 2021-05-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 80261-x
    ISSN 1472-4146 ; 0021-9746
    ISSN (online) 1472-4146
    ISSN 0021-9746
    DOI 10.1136/jclinpath-2020-207366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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