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  1. Article ; Online: A timely, user-friendly analysis of the mouse DNA methylome.

    Esteller, Manel

    Cell genomics

    2022  Volume 2, Issue 7, Page(s) 100153

    Abstract: Mouse models are widely used in biomedical sciences and in epigenetic studies, yet a simple way to interrogate the mouse DNA methylation was lacking. In this issue ... ...

    Abstract Mouse models are widely used in biomedical sciences and in epigenetic studies, yet a simple way to interrogate the mouse DNA methylation was lacking. In this issue of
    Language English
    Publishing date 2022-07-13
    Publishing country United States
    Document type News
    ISSN 2666-979X
    ISSN (online) 2666-979X
    DOI 10.1016/j.xgen.2022.100153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Epigenetics in biology and medicine

    Esteller, Manel

    2009  

    Author's details ed. by Manel Esteller
    Keywords Epigenesis, Genetic
    Language English
    Size XII, 297 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    Note Hier auch später erschienene, unveränderte Nachdrucke
    HBZ-ID HT015505960
    ISBN 978-0-8493-7289-6 ; 978-0-367-40349-2 ; 0-8493-7289-5 ; 0-367-40349-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 5050 order for loan Magazin

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  3. Article ; Online: DNA methylation in cancer: From mouse to human and back again.

    Esteller, Manel

    EBioMedicine

    2021  Volume 68, Page(s) 103393

    MeSH term(s) Animals ; DNA Methylation ; Disease Models, Animal ; Epigenesis, Genetic ; Humans ; Mice ; Neoplasms/genetics ; Promoter Regions, Genetic ; Sequence Analysis, DNA/methods
    Language English
    Publishing date 2021-05-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7090: Show issues Location:
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  4. Book: DNA methylation

    Esteller, Manel

    approaches, methods, and applications

    2005  

    Author's details ed. by Manel Esteller
    Keywords DNA/Methylation
    Subject code 572.86
    Language English
    Size 223 S. : Ill., graph. Darst.
    Publisher CRC Press
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014022682
    ISBN 0-8493-2050-X ; 978-0-8493-2050-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 4545 order for loan Magazin

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  5. Book: DNA methylation, epigenetics and metastasis

    Esteller, Manel

    (Cancer metastasis - biology and treatment ; 7)

    2005  

    Author's details ed. by Manel Esteller
    Series title Cancer metastasis - biology and treatment ; 7
    Collection
    Keywords DNS ; Methylierung ; Epigenese ; Metastase
    Subject Metastasierung ; Desoxyribonucleinsäure ; DNA ; DNA-Molekül ; Desoxyribonukleinsäure
    Language English
    Size XI, 310 S. : Ill.
    Publisher Springer
    Publishing place Dordrecht u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT014339274
    ISBN 1-4020-3641-8 ; 978-1-4020-3641-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2005 A 2750 order for loan Magazin

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  6. Article ; Online: Single-cell analysis of the epitranscriptome: RNA modifications under the microscope.

    Crespo-García, Eva / Bueno-Costa, Alberto / Esteller, Manel

    RNA biology

    2024  Volume 21, Issue 1, Page(s) 1–8

    Abstract: The identification of mechanisms capable of modifying genetic information by the addition of covalent RNA modifications distinguishes a level of complexity in gene expression which challenges key long-standing concepts of RNA biology. One of the current ... ...

    Abstract The identification of mechanisms capable of modifying genetic information by the addition of covalent RNA modifications distinguishes a level of complexity in gene expression which challenges key long-standing concepts of RNA biology. One of the current challenges of molecular biology is to properly understand the molecular functions of these RNA modifications, with more than 170 different ones having been identified so far. However, it has not been possible to map specific RNA modifications at a single-cell resolution until very recently. This review will highlight the technological advances in single-cell methodologies aimed at assessing and testing the biological function of certain RNA modifications, focusing on m
    MeSH term(s) RNA/genetics ; RNA/metabolism ; Molecular Biology ; Single-Cell Analysis ; RNA Processing, Post-Transcriptional ; Transcriptome
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2024-02-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2159587-2
    ISSN 1555-8584 ; 1555-8584
    ISSN (online) 1555-8584
    ISSN 1555-8584
    DOI 10.1080/15476286.2024.2315385
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  7. Article ; Online: Global Shift in Alternative Splicing and Therapeutic Susceptibilities in Leukemia Driven by METTL3 Overexpression.

    Janin, Maxime / Esteller, Manel

    Blood cancer discovery

    2023  Volume 4, Issue 3, Page(s) 176–179

    Abstract: Summary: Mutations in splicing factors are commonly observed in chronic lymphocytic leukemia (CLL); however, other mechanisms can also contribute to the dysregulation of alternative splicing. One example is the overexpression of the m6A RNA ... ...

    Abstract Summary: Mutations in splicing factors are commonly observed in chronic lymphocytic leukemia (CLL); however, other mechanisms can also contribute to the dysregulation of alternative splicing. One example is the overexpression of the m6A RNA methyltransferase METTL3, that by depositing the epitranscriptomic mark in spliceosome transcripts leads to aberrant splicing, but at the same time creates vulnerability to METTL3 inhibitors. See related article by Wu et al., p. 228 (8) .
    MeSH term(s) Humans ; Alternative Splicing/genetics ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; RNA Splicing ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Methyltransferases/therapeutic use ; RNA Splicing Factors/genetics
    Chemical Substances Methyltransferases (EC 2.1.1.-) ; RNA Splicing Factors ; METTL3 protein, human (EC 2.1.1.62)
    Language English
    Publishing date 2023-04-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3028898-8
    ISSN 2643-3249 ; 2643-3230
    ISSN (online) 2643-3249
    ISSN 2643-3230
    DOI 10.1158/2643-3230.BCD-23-0035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Response to Kang et al.

    Garcia-Prieto, Carlos A / Davalos, Veronica / Esteller, Manel

    Journal of the National Cancer Institute

    2023  Volume 115, Issue 10, Page(s) 1234–1235

    Language English
    Publishing date 2023-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djad166
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  9. Article: Experimental and Bioinformatic Approaches to Studying DNA Methylation in Cancer.

    Merkel, Angelika / Esteller, Manel

    Cancers

    2022  Volume 14, Issue 2

    Abstract: DNA methylation is an essential epigenetic mark. Alterations of normal DNA methylation are a defining feature of cancer. Here, we review experimental and bioinformatic approaches to showcase the breadth and depth of information that this epigenetic mark ... ...

    Abstract DNA methylation is an essential epigenetic mark. Alterations of normal DNA methylation are a defining feature of cancer. Here, we review experimental and bioinformatic approaches to showcase the breadth and depth of information that this epigenetic mark provides for cancer research. First, we describe classical approaches for interrogating bulk DNA from cell populations as well as more recently developed approaches for single cells and multi-Omics. Second, we focus on the computational analysis from primary data processing to the identification of unique methylation signatures. Additionally, we discuss challenges such as sparse data and cellular heterogeneity.
    Language English
    Publishing date 2022-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14020349
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  10. Article ; Online: PRC2 Loss and DNMT Inhibition Boost Viral Mimicry in Cancer.

    Guil, Sonia / Esteller, Manel

    Cancer discovery

    2022  Volume 12, Issue 9, Page(s) 2020–2022

    Abstract: Summary: In this issue of Cancer Discovery, Patel and colleagues explore the synergistic lethality of PRC2 inactivation and DNMT inhibition in malignant peripheral nerve sheath tumor cells. Reactivation of retrotransposons under this dual control ... ...

    Abstract Summary: In this issue of Cancer Discovery, Patel and colleagues explore the synergistic lethality of PRC2 inactivation and DNMT inhibition in malignant peripheral nerve sheath tumor cells. Reactivation of retrotransposons under this dual control suggests that the viral mimicry response contributes to enhanced cytotoxicity with potential clinical implications. See related article by Patel et al., p. 2120 (5).
    MeSH term(s) Humans ; Mutation ; Neurofibrosarcoma/genetics
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-22-0733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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