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  1. Article ; Online: Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation-Reply.

    Deidda, Simona / Spolverato, Gaya / Restivo, Angelo

    JAMA surgery

    2022  Volume 157, Issue 6, Page(s) 550–551

    MeSH term(s) Chemoradiotherapy ; Humans ; Rectal Neoplasms/surgery
    Language English
    Publishing date 2022-02-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2021.7592
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  2. Article ; Online: Transpositions of the great arteries versus aortic dextropositions. A review of some embryogenetic and morphological aspects.

    Restivo, Angelo / di Gioia, Cira / Marino, Bruno / Putotto, Carolina

    Anatomical record (Hoboken, N.J. : 2007)

    2022  Volume 306, Issue 3, Page(s) 502–514

    Abstract: This review examines and discusses the morphology and embryology of two main groups of conotruncal cardiac malformations: (a) transposition of the great arteries (complete transposition and incomplete/partial transposition namely double outlet right ... ...

    Abstract This review examines and discusses the morphology and embryology of two main groups of conotruncal cardiac malformations: (a) transposition of the great arteries (complete transposition and incomplete/partial transposition namely double outlet right ventricle), and (b) aortic dextroposition defects (tetralogy of Fallot and Eisenmenger malformation). In both groups, persistent truncus arteriosus was included because maldevelopment of the neural crest cell supply to the outflow tract, contributing to the production of the persistent truncus arteriosus, is shared by both groups of malformations. The potentially important role of the proximal conal cushions in the rotatory sequence of the conotruncus is emphasized. Most importantly, this study emphasizes the differentiation between the double-outlet right ventricle, which is a partial or incomplete transposition of the great arteries, and the Eisenmenger malformation, which is an aortic dextroposition. Special emphasis is also given to the leftward shift of the conoventricular junction, which covers an important morphogenetic role in both aortic dextropositions and transposition defects as well as in normal development, and whose molecular genetic regulation seems to remain unclear at present. Emphasis is placed on the distinct and overlapping roles of Tbx1 and Pitx2 transcription factors in modulating the development of the cardiac outflow tract.
    MeSH term(s) Humans ; Transposition of Great Vessels ; Truncus Arteriosus, Persistent ; Heart Defects, Congenital ; Arteries
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2269667-2
    ISSN 1932-8494 ; 1932-8486
    ISSN (online) 1932-8494
    ISSN 1932-8486
    DOI 10.1002/ar.25129
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  3. Article: Barriers to and Facilitators for Accessing HPV Vaccination in Migrant and Refugee Populations: A Systematic Review.

    Graci, Davide / Piazza, Nicolò / Ardagna, Salvatore / Casuccio, Alessandra / Drobov, Anton / Geraci, Federica / Immordino, Angelo / Pirrello, Alessandra / Restivo, Vincenzo / Rumbo, Riccardo / Stefano, Rosalba / Virone, Roberta / Zarcone, Elena / Immordino, Palmira

    Vaccines

    2024  Volume 12, Issue 3

    Abstract: Human papillomavirus (HPV) is the most prevalent sexually transmitted virus globally and a primary cause of cervical cancer, which ranks fourth among tumors in both incidence and mortality. Despite the availability of effective vaccines worldwide, HPV ... ...

    Abstract Human papillomavirus (HPV) is the most prevalent sexually transmitted virus globally and a primary cause of cervical cancer, which ranks fourth among tumors in both incidence and mortality. Despite the availability of effective vaccines worldwide, HPV vaccination rates vary, especially among migrant and refugee populations. Indeed, migrant status may act as a determinant against accessing vaccinations, among many other factors. The objective of this paper is to evaluate barriers to and facilitators for accessing HPV vaccination in migrant and refugee populations. A systematic review of the existing peer-reviewed academic literature was conducted according to the PRISMA 2020 guidelines in which we examined thirty-four studies to evaluate HPV vaccination rates in these populations and identify factors acting as barriers or facilitators. Key determinants include socio-economic status and health literacy. Communication barriers, including language and cultural factors, also impact access to information and trust in the health workforce. Understanding and considering these factors is crucial for developing proper and inclusive vaccination strategies to ensure that no population is overlooked.
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12030256
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  4. Article ; Online: Schrödinger's Worker: Are They Positive or Negative for SARS-CoV-2?

    Meloni, Federico / Campagna, Marcello / Restivo, Angelo / Cocco, Pierluigi

    International journal of environmental research and public health

    2020  Volume 17, Issue 17

    Abstract: In these days of 2020, tests for the diagnosis of SARS-CoV-2, and their use in the context of health surveillance of workers, are becoming popular. Nevertheless, their sensitivity and specificity could vary on the basis of the type of test used and on ... ...

    Abstract In these days of 2020, tests for the diagnosis of SARS-CoV-2, and their use in the context of health surveillance of workers, are becoming popular. Nevertheless, their sensitivity and specificity could vary on the basis of the type of test used and on the moment of infection of the subject tested. The aim of this viewpoint paper is to make employers, workers, occupational physicians, and public health specialists think about the limits of diagnostic tests currently available, and the possible implication related to the erroneous and incautious assignment of "immunity passports" or "risk-free certificates" to workers during screening campaigns in workplaces.
    MeSH term(s) Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/standards ; Coronavirus Infections/diagnosis ; Humans ; Occupational Health ; Pandemics ; Pneumonia, Viral/diagnosis ; SARS-CoV-2 ; Sensitivity and Specificity ; Workplace
    Keywords covid19
    Language English
    Publishing date 2020-08-31
    Publishing country Switzerland
    Document type Journal Article
    ISSN 1660-4601
    ISSN (online) 1660-4601
    DOI 10.3390/ijerph17176316
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  5. Article ; Online: Schrödinger’s Worker

    Federico Meloni / Marcello Campagna / Angelo Restivo / Pierluigi Cocco

    International Journal of Environmental Research and Public Health, Vol 17, Iss 6316, p

    Are They Positive or Negative for SARS-CoV-2?

    2020  Volume 6316

    Abstract: In these days of 2020, tests for the diagnosis of SARS-CoV-2, and their use in the context of health surveillance of workers, are becoming popular. Nevertheless, their sensitivity and specificity could vary on the basis of the type of test used and on ... ...

    Abstract In these days of 2020, tests for the diagnosis of SARS-CoV-2, and their use in the context of health surveillance of workers, are becoming popular. Nevertheless, their sensitivity and specificity could vary on the basis of the type of test used and on the moment of infection of the subject tested. The aim of this viewpoint paper is to make employers, workers, occupational physicians, and public health specialists think about the limits of diagnostic tests currently available, and the possible implication related to the erroneous and incautious assignment of “immunity passports” or “risk-free certificates” to workers during screening campaigns in workplaces.
    Keywords SARS-CoV-2 ; COVID-19 ; serologic tests ; reverse transcriptase polymerase chain reaction ; sensitivity and specificity ; Predictive value of tests ; Medicine ; R ; covid19
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: COVID-19 free pathways decrease postoperative complications in patients undergoing elective colorectal surgery.

    Deidda, Simona / Bao, Quoc Riccardo / Capelli, Giulia / Pucciarelli, Salvatore / Zorcolo, Luigi / Spolverato, Gaya / Restivo, Angelo

    Surgery in practice and science

    2022  Volume 11, Page(s) 100125

    Abstract: Background: To reduce the exposition risk to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in surgical patients more prone to develop serious forms of Coronavirus disease 2019, a reorganization that previewed the creation "COVID-19-free" ... ...

    Abstract Background: To reduce the exposition risk to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in surgical patients more prone to develop serious forms of Coronavirus disease 2019, a reorganization that previewed the creation "COVID-19-free" hospitals or units was pursued. The aim of this study was to quantify the effect of clear pathways to reduce the risk of SARS-Cov-2 transmission, on postoperative complications.
    Methods: Data of all consecutive patients undergoing surgical procedure for colorectal diseases, between November 2019 and July 2020 in two Italian referral centers, were retrospectively analyzed. Patients were divided into two groups: the ones underwent surgical procedures during the period before the pandemic from November 2019 to March 2020 (Group 1) (before-COVID), and those who underwent surgical procedure from April to July 2020 during the pandemic (Group 2) (during-COVID pandemic).
    Results: Overall, 264 patients were collected, 168 (63.4%) in Group 1 and 96 (36.4%) Group 2. Preoperative characteristics were similar between groups; during the pandemic there was a higher proportion of patients who underwent surgical procedures for malignancy compared with the period before the pandemic (92.7% vs 72%;
    Conclusion: In this cohort study COVID-19-free pathways were significantly associated with low rate of postoperative morbidity in patients undergoing colorectal elective surgery.
    Language English
    Publishing date 2022-09-01
    Publishing country England
    Document type Journal Article
    ISSN 2666-2620
    ISSN (online) 2666-2620
    DOI 10.1016/j.sipas.2022.100125
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  7. Article: The paradox of Zeno in bariatric surgery weight loss: Superobese patients run faster than morbidly obese patients, but can't overtake them.

    Medas, Fabio / Moroni, Enrico / Deidda, Simona / Zorcolo, Luigi / Restivo, Angelo / Canu, Gian Luigi / Cappellacci, Federico / Calò, Pietro Giorgio / Pintus, Stefano / Fantola, Giovanni

    Frontiers in surgery

    2023  Volume 10, Page(s) 1100483

    Abstract: Introduction: Superobesity (SO) is defined as a BMI > 50 Kg/m: Methods: In this retrospective study we aimed to compare the outcomes of SO patients compared to morbidly obese (MO) patients.: Results: We included in this study 154 MO patients, with ...

    Abstract Introduction: Superobesity (SO) is defined as a BMI > 50 Kg/m
    Methods: In this retrospective study we aimed to compare the outcomes of SO patients compared to morbidly obese (MO) patients.
    Results: We included in this study 154 MO patients, with a median preoperative BMI of 40.8 kg/m
    Discussion: Our study confirms that, although SO patients tend to gain a greater weight loss than MO patients, they less frequently achieve the desired BMI target. In this setting, it should be necessary to re-consider malabsorptive procedures as first choice.
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1100483
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  8. Article: Schrödinger's Worker: Are They Positive or Negative for SARS-CoV-2?

    Meloni, Federico / Campagna, Marcello / Restivo, Angelo / Cocco, Pierluigi

    Int. j. environ. res. public health (Online)

    Abstract: In these days of 2020, tests for the diagnosis of SARS-CoV-2, and their use in the context of health surveillance of workers, are becoming popular. Nevertheless, their sensitivity and specificity could vary on the basis of the type of test used and on ... ...

    Abstract In these days of 2020, tests for the diagnosis of SARS-CoV-2, and their use in the context of health surveillance of workers, are becoming popular. Nevertheless, their sensitivity and specificity could vary on the basis of the type of test used and on the moment of infection of the subject tested. The aim of this viewpoint paper is to make employers, workers, occupational physicians, and public health specialists think about the limits of diagnostic tests currently available, and the possible implication related to the erroneous and incautious assignment of "immunity passports" or "risk-free certificates" to workers during screening campaigns in workplaces.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #736691
    Database COVID19

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  9. Article ; Online: Limits of Clinical Restaging in Detecting Responders After Neoadjuvant Therapies for Rectal Cancer.

    Deidda, Simona / Spolverato, Gaya / Capelli, Giulia / Bao, Riccardo Quoc / Bettoni, Lorenzo / Crimì, Filippo / Zorcolo, Luigi / Pucciarelli, Salvatore / Restivo, Angelo

    Diseases of the colon and rectum

    2022  Volume 66, Issue 7, Page(s) 957–964

    Abstract: Background: Accurate clinical restaging is required to select patients who respond to neoadjuvant chemoradiotherapy for locally advanced rectal cancer and who may benefit from an organ preservation strategy.: Objective: The purpose of this study was ... ...

    Abstract Background: Accurate clinical restaging is required to select patients who respond to neoadjuvant chemoradiotherapy for locally advanced rectal cancer and who may benefit from an organ preservation strategy.
    Objective: The purpose of this study was to review our experience with the clinical restaging of rectal cancer after neoadjuvant therapy to assess its accuracy in detecting major and pathological complete response to treatment.
    Design: This was a retrospective cohort study.
    Setting: This study was conducted at 2 high-volume Italian centers for Colorectal Surgery.
    Patients: Data were included from all consecutive patients who underwent neoadjuvant therapy and surgery for locally advanced rectal cancer from January 2012 to July 2020. Criteria to define clinical response were no palpable mass, a superficial ulcer <2 cm (major response), or no mucosal abnormality (complete response) at endoscopy and no metastatic nodes at MRI.
    Main outcome measures: The main outcome measures were sensitivity, specificity, positive predictive values, and negative predictive values of clinical restaging in detecting pathological complete response (ypT0) or major pathological response (ypT0-1) after neoadjuvant therapy.
    Results: A total of 333 patients were included; 81 (24.3%) had a complete response whereas 115 (34.5%) had a pathological major response. Accuracy for clinical complete response was 80.8% and for major clinical response was 72.9%. Sensitivity was low for both clinical complete response (37.5%) in detecting ypT0 and clinical major response (59.3%) in detecting ypT0-1. Positive predictive value was 68.2% for ypT0 and 60.4% for ypT0-1.
    Limitations: The main limitation of the study its retrospective nature.
    Conclusion: Accuracy of actual clinical criteria to define pathological complete response or pathological major response is poor. Failure to achieve good sensitivity and precision is a major limiting factor in the clinical setting. Current clinical assessments need to be revised to account for indications for rectal preservation after neoadjuvant chemoradiotherapy. See Video Abstract at http://links.lww.com/DCR/C63 .
    Lmites de la reestadificacin clnica en la deteccin de respondedores despus de terapias neoadyuvantes para el cncer de recto: ANTECEDENTES:Se requiere una nueva reestadificación clínica precisa para seleccionar pacientes que respondan a la quimiorradioterapia neoadyuvante para el cáncer de recto localmente avanzado y que puedan beneficiarse de una estrategia de preservación de órganos.OBJETIVO:El propósito de este estudio fue revisar nuestra experiencia con la reestadificación clínica del cáncer de recto después de la terapia neoadyuvante para evaluar su precisión en la detección de una respuesta patológica importante y completa al tratamiento.DISEÑO:Estudio de cohorte retrospectivo.AJUSTE:Este estudio se realizó en dos centros italianos de alto volumen para cirugía colorrectal.PACIENTES:Incluimos datos de todos los pacientes consecutivos que se sometieron a terapia neoadyuvante y cirugía por cáncer de recto localmente avanzado desde enero de 2012 hasta julio de 2020. Los criterios para definir la respuesta clínica fueron ausencia de masa palpable, úlcera superficial <2 cm (respuesta mayor) o ausencia de anomalías en la mucosa. (respuesta completa) en la endoscopia, y sin ganglios metastásicos en la resonancia magnética.PRINCIPALES MEDIDAS DE RESULTADO:Exploramos la sensibilidad, la especificidad, los valores predictivos positivos y negativos de la reestadificación clínica para detectar una respuesta patológica completa (ypT0) o mayor (ypT0-1) después de la terapia neoadyuvante.RESULTADOS:Se incluyeron 333 pacientes; 81 (24,3%) tuvieron una respuesta completa mientras que 115 (34,5%) tuvieron una respuesta patológica mayor. La precisión de la respuesta clínica completa y la respuesta clínica importante fue del 80,8 % y el 72,9 %, respectivamente. La sensibilidad fue baja tanto para la respuesta clínica completa (37,5 %) en la detección de ypT0 como para la respuesta clínica mayor (59,3 %) en la detección de ypT0-1. El valor predictivo positivo fue del 68,2 % para ypT0 y del 60,4 % para ypT0-1.LIMITACIONES:Nuestro estudio tiene como principal limitación su carácter retrospectivo.CONCLUSIÓNES:La precisión de los criterios clínicos reales para definir una respuesta patológica completa o mayor es pobre. El hecho de no lograr una buena sensibilidad y precisión es un factor limitante importante en el entorno clínico. La indicación para la preservación rectal después de la quimiorradioterapia neoadyuvante necesita una mejora de la evaluación clínica actual. Consulte Video Resumen en http://links.lww.com/DCR/C63 . (Traducción-Dr. Mauricio Santamaria ).
    MeSH term(s) Humans ; Neoadjuvant Therapy ; Retrospective Studies ; Chemoradiotherapy ; Treatment Outcome ; Neoplasm Staging ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/therapy
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Video-Audio Media ; Journal Article
    ZDB-ID 212581-x
    ISSN 1530-0358 ; 0012-3706
    ISSN (online) 1530-0358
    ISSN 0012-3706
    DOI 10.1097/DCR.0000000000002450
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  10. Article: Extranodal Biphenotypic Non-Hodgkin Lymphoma of the Popliteal Cavity: A Case Report and Review of Literature.

    Restivo, Giulia A / Mussolin, Lara / D'Angelo, Paolo / Zin, Angelica / Pigazzi, Martina / Carraro, Elisa / D'Amore, Emanuele S G / Pillon, Marta / Farruggia, Piero

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 7

    Abstract: Primary soft-tissue lymphoma (PSTL) is a rare extranodal non-Hodgkin lymphoma, characterized by a mass growing within soft-tissue, which is connective tissue, adipose tissue, and skeletal muscle. Here, we describe a case of biphenotypic lymphoblastic ... ...

    Abstract Primary soft-tissue lymphoma (PSTL) is a rare extranodal non-Hodgkin lymphoma, characterized by a mass growing within soft-tissue, which is connective tissue, adipose tissue, and skeletal muscle. Here, we describe a case of biphenotypic lymphoblastic lymphoma arising from soft tissue of the popliteal fossa in an 11-year-old boy. A pediatric review about PSTL revealed that anaplastic large cell lymphoma is the most common histological type and a biphenotypic lymphoblastic lymphoma has not yet been reported in childhood. Lymphoma should always be considered in patients presenting with a soft-tissue mass, and a comprehensive immunohistochemical evaluation, including B-cell, T-cell, and myeloid markers, is needed to make a correct diagnosis and establish the most suitable treatment.
    Language English
    Publishing date 2022-07-07
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12071649
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