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  1. Article ; Online: Correction to: Programmed death-ligand 1 and tumor-infiltrating lymphocytes (TILs) - low TIL density may predict poorer long-term prognosis in T1 laryngeal cancer.

    Pakkanen, Pihla / Ilmarinen, Taru / Halme, Elina / Irjala, Heikki / Koivunen, Petri / Pukkila, Matti / Ventelä, Sami / Almangush, Alhadi / Birkman, Eva-Maria / Lindgren, Outi / Pohjolainen, Virva / Sjöblom, Nelli / Haglund, Caj / Hagström, Jaana / Aaltonen, Leena-Maija

    Virchows Archiv : an international journal of pathology

    2023  

    Language English
    Publishing date 2023-08-09
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-023-03618-2
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  2. Article ; Online: Outcomes of intraocular lens scleral fixation with the friction knot technique.

    Aaltonen, Petri / Oskala, Pertti / Immonen, Ilkka

    Acta ophthalmologica

    2018  Volume 97, Issue 4, Page(s) e506–e513

    Abstract: Purpose: To examine the clinical outcomes of intraocular lens (IOL) scleral fixation with the friction knot technique.: Methods: Retrospective case series of 152 eyes of 152 patients with inadequate capsular bag support operated with the friction ... ...

    Abstract Purpose: To examine the clinical outcomes of intraocular lens (IOL) scleral fixation with the friction knot technique.
    Methods: Retrospective case series of 152 eyes of 152 patients with inadequate capsular bag support operated with the friction knot IOL scleral fixation technique by a single surgeon. The fixated IOLs were one-piece or three-piece models all with open loop haptics. Main outcome measures were change in corrected distance visual acuity (CDVA) and postoperative complications.
    Results: The mean follow-up time was 11.7 months (median 4.9, range 0.7-64.8). The mean logarithm of the minimum angle of resolution CDVA improved from preoperative 0.77 ± 0.73 (Snellen 20/118 ± 7.3 lines) to 0.44 ± 0.56 (Snellen 20/55 ± 5.6 lines) at the final visit (p < 0.001). The main postoperative complications were ocular hypertension (30.3%), uveitis-glaucoma-hyphaema syndrome (12.5%; UGHS), vitreous haemorrhage (11.2%) and retinal detachment (8.6%). Two (1.3%) cases of suture breakage were seen. In multivariate Cox regression analysis, age under 60 years [hazard ratio (HR) = 5.41; 95% confidence interval (CI) 1.95-15.01] and scleral fixated one-piece IOL (HR = 4.23; 95% CI 1.44-12.44) were found as significant independent risk factors for developing new UGHS.
    Conclusion: The friction knot technique provides a firm scleral fixation. Scleral fixation may successfully be utilized in dislocated three-piece IOLs with loop haptics. We recommend avoiding scleral fixation of one-piece IOLs in young patients due to a high risk of UGHS.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Artificial Lens Implant Migration/prevention & control ; Cataract Extraction ; Female ; Follow-Up Studies ; Friction ; Humans ; Lens Capsule, Crystalline/surgery ; Lens Implantation, Intraocular/methods ; Lenses, Intraocular ; Male ; Middle Aged ; Prosthesis Design ; Retrospective Studies ; Sclera/surgery ; Suture Techniques/instrumentation ; Sutures ; Treatment Outcome ; Visual Acuity ; Young Adult
    Language English
    Publishing date 2018-10-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.13931
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  3. Article ; Online: Programmed death-ligand 1 and tumor-infiltrating lymphocytes (TILs) - low TIL density may predict poorer long-term prognosis in T1 laryngeal cancer.

    Pakkanen, Pihla / Ilmarinen, Taru / Halme, Elina / Irjala, Heikki / Koivunen, Petri / Pukkila, Matti / Ventelä, Sami / Almangush, Alhadi / Birkman, Eva-Maria / Lindgren, Outi / Pohjolainen, Virva / Sjöblom, Nelli / Haglund, Caj / Hagström, Jaana / Aaltonen, Leena-Maija

    Virchows Archiv : an international journal of pathology

    2023  

    Abstract: We evaluated the prognostic role of programmed death-ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in T1 glottic laryngeal squamous cell carcinoma (LSCC). T1 glottic LSCC patients (n = 174) treated at five Finnish university hospitals ... ...

    Abstract We evaluated the prognostic role of programmed death-ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs) in T1 glottic laryngeal squamous cell carcinoma (LSCC). T1 glottic LSCC patients (n = 174) treated at five Finnish university hospitals between 2003 and 2013 were included. Tissue microarray (TMA) blocks were used for PD-L1 immunohistochemistry. TILs were scored from intratumoral and stromal regions in whole tissue sections. Of 174 patients, 92 (53%) had negative, 66 (38%) intermediate, and 16 (9%) high PD-L1 levels. Of 80 patients whose TILs were analyzed, 50 (63%) had low and 30 (38%) high stromal TIL density. Patients with a local recurrence or a new primary tumor of the larynx had lower TIL density than had other patients (p = 0.047). High PD-L1 expression with low stromal TIL density was associated with inferior 5-year disease-specific survival (85% vs. 100%, p = 0.02). In conclusion, in patients treated for T1 glottic LSCC, low stromal TIL density was associated with local recurrences and new primary tumors of the larynx. High PD-L1 expression with low stromal TIL density may be associated with worse survival in T1 glottic LSCC.
    Language English
    Publishing date 2023-07-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-023-03586-7
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  4. Article ; Online: T1 glottic laryngeal cancer: the role of routine follow-up visits in detecting local recurrence.

    Pakkanen, Pihla / Ilmarinen, Taru / Halme, Elina / Irjala, Heikki / Koivunen, Petri / Pukkila, Matti / Ventelä, Sami / Hagström, Jaana / Aaltonen, Leena-Maija

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2021  Volume 278, Issue 12, Page(s) 4863–4869

    Abstract: Purpose: We assessed the treatment outcome and the benefits of routine follow-up visits in T1 glottic laryngeal squamous cell carcinoma (LSCC).: Methods: Medical records of patients diagnosed with stage T1 glottic LSCC (N = 303) in five Finnish ... ...

    Abstract Purpose: We assessed the treatment outcome and the benefits of routine follow-up visits in T1 glottic laryngeal squamous cell carcinoma (LSCC).
    Methods: Medical records of patients diagnosed with stage T1 glottic LSCC (N = 303) in five Finnish university hospitals between 2003 and 2015 were reviewed. Moreover, data from the Finnish Cancer Registry and the Population Register Center were collected.
    Results: Of all 38 recurrences, 26 (68%) were detected during a routine follow-up visit, and over half (21 of 38, 55%) presented without new symptoms. Primary treatment method (surgery vs. radiotherapy) was not connected with 5-year disease-specific survival (DSS) or laryngeal preservation rate.
    Conclusion: The majority of recurrences were detected on a routine follow-up visit, and local recurrences often presented without new symptoms. Routine post-treatment follow-up of T1 glottic LSCC seems beneficial.
    Trial registration: Trial registration number and date of registration HUS/356/2017 11.12.2017.
    MeSH term(s) Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/therapy ; Follow-Up Studies ; Glottis/pathology ; Head and Neck Neoplasms ; Humans ; Laryngeal Neoplasms/diagnosis ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/therapy ; Neoplasm Recurrence, Local/epidemiology ; Neoplasm Recurrence, Local/pathology ; Neoplasm Staging ; Retrospective Studies
    Language English
    Publishing date 2021-08-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-021-06983-3
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  5. Article: The nephrin-based slit diaphragm: new insight into the signalling platform identifies targets for therapy.

    Aaltonen, Petri / Holthöfer, Harry

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2007  Volume 22, Issue 12, Page(s) 3408–3410

    MeSH term(s) Animals ; Humans ; Kidney Diseases/drug therapy ; Kidney Diseases/etiology ; Membrane Proteins/drug effects ; Membrane Proteins/physiology ; Molecular Biology ; Podocytes/physiology ; Signal Transduction
    Chemical Substances Membrane Proteins ; nephrin
    Language English
    Publishing date 2007-12
    Publishing country England
    Document type Editorial ; Review
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfm403
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    Zs.A 2198: Show issues Location:
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    Zs.MO 329: Show issues

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  6. Article ; Online: Psychoactive substance use in specialized psychiatric care patients.

    Karpov, Boris / Joffe, Grigori / Aaltonen, Kari / Suvisaari, Jaana / Baryshnikov, Ilya / Koivisto, Maaria / Melartin, Tarja / Suominen, Kirsi / Näätänen, Petri / Heikkinen, Martti / Oksanen, Jorma / Isometsä, Erkki

    International journal of psychiatry in medicine

    2017  Volume 52, Issue 4-6, Page(s) 399–415

    Abstract: Objective Life expectancy of psychiatric patients is markedly shorter compared to the general population, likely partly due to smoking or misuse of other substances. We investigated prevalence and correlates of substance use among psychiatric patients. ... ...

    Abstract Objective Life expectancy of psychiatric patients is markedly shorter compared to the general population, likely partly due to smoking or misuse of other substances. We investigated prevalence and correlates of substance use among psychiatric patients. Methods Within the Helsinki University Psychiatric Consortium Study, data were collected on substance use (alcohol, smoking, and illicit drugs) among patients with schizophrenia or schizoaffective disorder (n = 113), bipolar (n = 99), or depressive disorder (n = 188). Clinical diagnoses of substance use were recorded, and information on smoking, hazardous alcohol use, or misuse of other substances was obtained using questionnaires. Results One-fourth (27.7%) of the patients had clinical diagnoses of substance use disorders. In addition, in the Alcohol Use Disorders Identification Test, 43.1% had hazardous alcohol use and 38.4% were daily smokers. All substance use was more common in men than in women. Bipolar patients had the highest prevalence of alcohol use disorders and hazardous use, whereas those with schizophrenia or schizoaffective disorder were more often daily smokers. In regression analyses, self-reported alcohol consumption was associated with symptoms of anxiety and borderline personality disorder and low conscientiousness. No associations emerged for smoking. Conclusions The vast majority of psychiatric care patients have a diagnosed substance use disorder, hazardous alcohol use, or smoke daily, males more often than females. Bipolar patients have the highest rates of alcohol misuse, schizophrenia or schizoaffective disorder patients of smoking. Alcohol use may associate with symptoms of anxiety, borderline personality disorder, and low conscientiousness. Preventive and treatment efforts specifically targeted at harmful substance use among psychiatric patients are necessary.
    MeSH term(s) Adolescent ; Adult ; Depressive Disorder/complications ; Depressive Disorder/psychology ; Female ; Humans ; Male ; Mental Health Services ; Middle Aged ; Prevalence ; Psychotic Disorders/complications ; Psychotic Disorders/psychology ; Schizophrenia/complications ; Street Drugs ; Substance-Related Disorders/complications ; Substance-Related Disorders/psychology ; Surveys and Questionnaires ; Young Adult
    Chemical Substances Street Drugs
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 220669-9
    ISSN 1541-3527 ; 0091-2174
    ISSN (online) 1541-3527
    ISSN 0091-2174
    DOI 10.1177/0091217417738937
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  7. Article ; Online: Enhanced tuberculosis outbreak investigation using whole genome sequencing and IGRA.

    Smit, Pieter W / Vasankari, Tuula / Aaltonen, Hanna / Haanperä, Marjo / Casali, Nicola / Marttila, Harri / Marttila, Jane / Ojanen, Päivi / Ruohola, Aino / Ruutu, Petri / Drobniewski, Francis / Lyytikäinen, Outi / Soini, Hanna

    The European respiratory journal

    2015  Volume 45, Issue 1, Page(s) 276–279

    MeSH term(s) Adolescent ; Adult ; Contact Tracing ; Disease Outbreaks ; Female ; Finland/epidemiology ; Genome, Bacterial ; Genotype ; Humans ; Male ; Sequence Analysis, DNA/methods ; Tuberculosis/epidemiology ; Tuberculosis/genetics ; Tuberculosis/therapy ; Young Adult
    Language English
    Publishing date 2015-01
    Publishing country England
    Document type Letter
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/09031936.00125914
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    Zs.MO 292: Show issues

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  8. Article ; Online: Laryngeal cancer in Finland: A 5-year follow-up study of 366 patients.

    Haapaniemi, Aaro / Koivunen, Petri / Saarilahti, Kauko / Kinnunen, Ilpo / Laranne, Jussi / Aaltonen, Leena-Maija / Närkiö, Mervi / Lindholm, Paula / Grénman, Reidar / Mäkitie, Antti / Atula, Timo

    Head & neck

    2016  Volume 38, Issue 1, Page(s) 36–43

    Abstract: Background: The purpose of this study was to acquire nationwide data on the management and outcome of laryngeal squamous cell carcinoma (SCC) in Finnish university hospitals over a 5-year posttreatment follow-up.: Methods: All records of patients ... ...

    Abstract Background: The purpose of this study was to acquire nationwide data on the management and outcome of laryngeal squamous cell carcinoma (SCC) in Finnish university hospitals over a 5-year posttreatment follow-up.
    Methods: All records of patients diagnosed and treated for primary laryngeal SCC during 2001 to 2005 were reviewed.
    Results: Three hundred sixty-six patients with laryngeal cancer were identified, 360 of whom had laryngeal SCC. Three hundred forty-two patients with laryngeal SCC (95%) were treated with curative intent. Five-year disease-specific survival (DSS) for T1a, T1b, T2, T3, and T4 glottic SCC was 100%, 95%, 78%, 79%, and 53%, respectively. The corresponding figures for T1 to T4 supraglottic SCC were 68%, 54%, 72%, and 59%.
    Conclusion: Results of this nationwide study give a general overview of the outcome of unselected patients treated with unified guidelines. Patients with T2 tumors, usually treated with radiotherapy (RT), had a worse prognosis than expected. This patient group warrants further investigation and possibly treatment intensification.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Carcinoma/mortality ; Carcinoma/pathology ; Carcinoma/therapy ; Disease-Free Survival ; Female ; Finland ; Follow-Up Studies ; Hospitals, University ; Humans ; Kaplan-Meier Estimate ; Laryngeal Neoplasms/mortality ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/therapy ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2016-01
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.23834
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    Zs.A 1493: Show issues Location:
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  9. Article ; Online: Differences and similarities of risk factors for suicidal ideation and attempts among patients with depressive or bipolar disorders.

    Aaltonen, Kari / Näätänen, Petri / Heikkinen, Martti / Koivisto, Maaria / Baryshnikov, Ilya / Karpov, Boris / Oksanen, Jorma / Melartin, Tarja / Suominen, Kirsi / Joffe, Grigori / Paunio, Tiina / Isometsä, Erkki

    Journal of affective disorders

    2016  Volume 193, Page(s) 318–330

    Abstract: Background: Substantial literature exists on risk factors for suicidal behaviour. However, their comparative strength, independence and specificity for either suicidal ideation or suicide attempt(s) remain unclear.: Methods: The Helsinki University ... ...

    Abstract Background: Substantial literature exists on risk factors for suicidal behaviour. However, their comparative strength, independence and specificity for either suicidal ideation or suicide attempt(s) remain unclear.
    Methods: The Helsinki University Psychiatric Consortium (HUPC) Study surveyed 287 psychiatric care patients with ICD-10-DCR depressive or bipolar disorders about lifetime suicidal behaviour, developmental history and attachment style, personality and psychological traits, current and lifetime symptom profiles, and life events. Psychiatric records were used to confirm diagnosis and complement information on suicide attempts. Multinomial regression models predicting lifetime suicidal ideation and single or repeated suicide attempts were generated.
    Results: Overall, 21.6% patients had no lifetime suicidal behaviour, 33.8% had lifetime suicide ideation without attempts, and 17.1% had a single and 27.5% repeated suicide attempts. In univariate analyses, lifetime suicidal behaviour was associated with numerous factors. In multivariate models, suicidal ideation was independently predicted by younger age, severe depressive disorder, bipolar disorder type II/nos, hopelessness, and childhood physical abuse. Repeated suicide attempts were independently predicted by younger age, female sex, severe depressive disorder with or without psychotic symptoms, bipolar disorder type II/nos, alcohol use disorder, borderline personality disorder traits, and childhood physical abuse.
    Limitations: Cross-sectional and retrospective study design, utilization of clinical diagnoses, and relatively low response rate.
    Conclusions: Risk factors for suicidal ideation and attempts may diverge both qualitatively and in terms of dose response. When effects of risk factors from multiple domains are concurrently examined, proximal clinical characteristics remain the most robust. All risk factors cluster into the group of repeated attempters.
    MeSH term(s) Adult ; Bipolar Disorder/diagnosis ; Bipolar Disorder/psychology ; Cross-Sectional Studies ; Depressive Disorder/diagnosis ; Depressive Disorder/psychology ; Female ; Finland ; Health Surveys ; Humans ; International Classification of Diseases ; Male ; Middle Aged ; Regression Analysis ; Retrospective Studies ; Risk Factors ; Suicidal Ideation ; Suicide, Attempted/psychology ; Suicide, Attempted/statistics & numerical data ; Young Adult
    Language English
    Publishing date 2016-03-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2015.12.033
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  10. Article ; Online: Relationships between self-reported childhood traumatic experiences, attachment style, neuroticism and features of borderline personality disorders in patients with mood disorders.

    Baryshnikov, Ilya / Joffe, Grigori / Koivisto, Maaria / Melartin, Tarja / Aaltonen, Kari / Suominen, Kirsi / Rosenström, Tom / Näätänen, Petri / Karpov, Boris / Heikkinen, Martti / Isometsä, Erkki

    Journal of affective disorders

    2016  Volume 210, Page(s) 82–89

    Abstract: Background: Co-occurring borderline personality disorder (BPD) features have a marked impact on treatment of patients with mood disorders. Overall, high neuroticism, childhood traumatic experiences (TEs) and insecure attachment are plausible ... ...

    Abstract Background: Co-occurring borderline personality disorder (BPD) features have a marked impact on treatment of patients with mood disorders. Overall, high neuroticism, childhood traumatic experiences (TEs) and insecure attachment are plausible aetiological factors for BPD. However, their relationship with BPD features specifically among patients with mood disorders remains unclear. We investigated these relationships among unipolar and bipolar mood disorder patients.
    Methods: As part of the Helsinki University Psychiatric Consortium study, the McLean Screening Instrument (MSI), the Experiences in Close Relationships-Revised (ECR-R), the Short Five (S5) and the Trauma and Distress Scale (TADS) were filled in by patients with mood disorders (n=282) in psychiatric care. Correlation coefficients between total scores of scales and their dimensions were estimated, and multivariate regression (MRA) and mediation analyses were conducted.
    Results: Spearman's correlations were strong (rho=0.58; p<0.001) between total scores of MSI and S5 Neuroticism and moderate (rho=0.42; p<0.001) between MSI and TADS as well as between MSI and ECR-R Attachment Anxiety. In MRA, young age, S5 Neuroticism and TADS predicted scores of MSI (p<0.001). ECR-R Attachment Anxiety mediated 33% (CI=17-53%) of the relationships between TADS and MSI.
    Limitations: Cross-sectional questionnaire study.
    Conclusions: We found moderately strong correlations between self-reported BPD features and concurrent high neuroticism, reported childhood traumatic experiences and Attachment Anxiety also among patients with mood disorders. Independent predictors for BPD features include young age, frequency of childhood traumatic experiences and high neuroticism. Insecure attachment may partially mediate the relationship between childhood traumatic experiences and borderline features among mood disorder patients.
    MeSH term(s) Adolescent ; Adult ; Bipolar Disorder/etiology ; Bipolar Disorder/psychology ; Borderline Personality Disorder/etiology ; Borderline Personality Disorder/psychology ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Mood Disorders/etiology ; Mood Disorders/psychology ; Neuropsychological Tests ; Neuroticism ; Object Attachment ; Self Report ; Surveys and Questionnaires ; Wounds and Injuries/complications ; Wounds and Injuries/psychology
    Language English
    Publishing date 2016-12-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2016.12.004
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