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Book ; Online ; E-Book: HIV and psychiatry

Joska, John A. / Stein, Dan J. / Grant, Igor

(WPA series in evidence and experience in psychiatry ; Current science and clinical practice series)

2014

Title variant	HIV/AIDS and psychiatry
Author's details	edited by John A. Joska, Dan J. Stein, Igor Grant
Series title	WPA series in evidence and experience in psychiatry Current science and clinical practice series
Keywords	HIV Infections / psychology ; HIV Infections / physiopathology ; HIV-positive persons / Psychology / Electronic books ; Aids ; Psychiatrie
Subject	Seelenheilkunde ; Acquired immune deficiency syndrome ; Erworbenes Immundefektsyndrom
Language	English
Size	1 Online-Ressource (xvi, 269 Seiten), Illustrationen
Publisher	Wiley Blackwell
Publishing place	Chichester, West Sussex, UK
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Note	Includes bibliographical references and index ; Abweichender Titel gemäß Bild auf der Verlagsseite: HIV/AIDS and psychiatry
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT019509657
ISBN	978-1-118-33950-3 ; 978-111-833-950-3 ; 111-833-950-9 ; 1-118-33950-9 ; 978-1-118-33953-4 ; 978-111-833-953-4 ; 111-833-953-3 ; 1-118-33953-3 ; 978-1-118-33952-7 ; 978-111-833-952-7 ; 111-833-952-5 ; 1-118-33952-5 ; 9781118339541 ; 1118339541
DOI	10.1002/9781118339503
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Mental and cognitive healthcare training targeting primary healthcare workers providing HIV services in Africa: a scoping review.

Munsami, Adele / Dreyer, Anna J / Sibeko, Goodman / Gouse, Hetta / Nightingale, Sam / Joska, John A

AIDS care

2022 Volume 35, Issue 2, Page(s) 280–288

Abstract: Mental health and neurocognitive functioning remain a concern among people living with HIV. Symptomatic neurocognitive impairment (NCI) and mental illness can cause difficulties in daily functioning, including problems adhering to treatment. However, ... ...

Abstract	Mental health and neurocognitive functioning remain a concern among people living with HIV. Symptomatic neurocognitive impairment (NCI) and mental illness can cause difficulties in daily functioning, including problems adhering to treatment. However, many healthcare workers in resource-limited settings have limited knowledge about the relationship between HIV and NCI. A synthesis of available literature on mental health and NCI training provided to healthcare workers delivering HIV services in Africa, is lacking. We conducted a scoping review of published literature to identify training interventions which targeted healthcare workers providing careto people with HIV in Africa. Ten studies met the inclusion criteria. One study focused on NCI, two studies mentioned HIV-associated dementia and seven studies were centred on common mental health disorders. Most studies used a multi-method training approach, with pre-and post-testing as the main evaluation technique. This review highlights the gap in training interventions addressing NCI in Africa. Although there is some commitment to building capacity for mental health and NCI assessment among healthcare workers in this setting, this review suggests that there is a need for research to develop and evaluate training interventions for healthcare workers delivering HIV services in Africa.
MeSH term(s)	Humans ; HIV Infections/therapy ; Africa ; Delivery of Health Care ; Health Personnel/psychology ; Cognition
Language	English
Publishing date	2022-07-17
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1012651-x
ISSN	1360-0451 ; 0954-0121
ISSN (online)	1360-0451
ISSN	0954-0121
DOI	10.1080/09540121.2022.2099512
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Article ; Online: A new approach to cognitive impairment in people with HIV.

Nightingale, Sam / Cinque, Paola / Joska, John A / Price, Richard W / Underwood, Jonathan

The lancet. HIV

2022 Volume 9, Issue 12, Page(s) e815–e817

MeSH term(s)	Humans ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/psychology ; Cognitive Dysfunction/etiology ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology
Language	English
Publishing date	2022-09-20
Publishing country	Netherlands
Document type	Journal Article
ISSN	2352-3018
ISSN (online)	2352-3018
DOI	10.1016/S2352-3018(22)00267-3
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Article: Analysis of the Mechanical Properties of 3D-Printed Plastic Samples Subjected to Selected Degradation Effects.

Sedlak, Josef / Joska, Zdenek / Jansky, Jiri / Zouhar, Jan / Kolomy, Stepan / Slany, Martin / Svasta, Adam / Jirousek, Jan

Materials (Basel, Switzerland)

2023 Volume 16, Issue 8

Abstract: The Fused Filament Fabrication (FFF) method is an additive technology that is used for the creation of prototypes within Rapid Prototyping (RP) as well as for the creation of final components in piece or small-series production. The possibility of using ... ...

Abstract	The Fused Filament Fabrication (FFF) method is an additive technology that is used for the creation of prototypes within Rapid Prototyping (RP) as well as for the creation of final components in piece or small-series production. The possibility of using FFF technology in the creation of final products requires knowledge of the properties of the material and, at the same time, how these properties change due to degradation effects. In this study, the mechanical properties of the selected materials (PLA, PETG, ABS, and ASA) were tested in their non-degenerate state and after exposure of the samples to the selected degradation factors. For the analysis, which was carried out by the tensile test and the Shore D hardness test, samples of normalized shape were prepared. The effects of UV radiation, high temperature environments, high humidity environments, temperature cycles, and exposure to weather conditions were monitored. The parameters obtained from the tests (tensile strength and Shore D hardness) were statistically evaluated, and the influence of degradation factors on the properties of individual materials was assessed. The results showed that even between individual manufacturers of the same filament there are differences, both in the mechanical properties and in the behavior of the material after exposure to degradation effects.
Language	English
Publishing date	2023-04-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16083268
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Article ; Online: A Supervision Framework for Task-Shared Mental Health Workers: Implications for Clinical Trials and Beyond.

Rabie, Stephan / Poudyal, Anubhuti / King, Aisha / Ndwandwa, Esona-Sethu / Marais, Adele / Andersen, Lena / Joska, John / Sikkema, Kathleen

Global health, science and practice

2023 Volume 11, Issue 6

Abstract: The rise in task-shared interventions that address the mental health treatment gap in low- and middle-income countries (LMICs) has highlighted the need for additional support and supervision of nonspecialist mental health workers (NHWs). The supervision ... ...

Abstract	The rise in task-shared interventions that address the mental health treatment gap in low- and middle-income countries (LMICs) has highlighted the need for additional support and supervision of nonspecialist mental health workers (NHWs). The supervision of NHWs in most resource-limited settings is still primarily disorganized, without clear guidelines that provide the necessary structure for supervision. The need for supervision is even greater for NHWs working in the context of trauma, not only to provide training and ensure adequate delivery of care but also to provide support to minimize the psychological impact of their work. In South Africa, women face intersecting epidemics of HIV, intimate partner violence, and sexual trauma. This syndemic highlights the importance of integrating mental health treatment in HIV care, especially in settings like South Africa, where mental health services are limited. In this context, our group developed and is evaluating the effectiveness of ImpACT+, a task-shared coping intervention to improve clinical and mental health outcomes among HIV-infected women with sexual trauma in South Africa. We describe the ImpACT+ supervision model that is currently being implemented in the context of a hybrid effectiveness-implementation clinical trial. Combining experiences from clinical psychology, task-shared interventions, and trauma-informed care, the supervision model integrates formal elements of clinical supervision into categories that are suitable for use in task-shared trauma interventions in low-resource settings. To the best of our knowledge, such a trauma-informed supervision approach has not been widely documented in the literature, particularly in task-shared interventions in LMICs. In this article, we describe the ImpACT+ intervention, provide an overview of the supervision model, and provide illustrative examples of how the supervision model has been implemented.
MeSH term(s)	Humans ; Female ; Mental Health ; Mental Health Services ; Health Personnel ; South Africa ; HIV Infections/therapy
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2710875-2
ISSN	2169-575X ; 2169-575X
ISSN (online)	2169-575X
ISSN	2169-575X
DOI	10.9745/GHSP-D-23-00092
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Article ; Online: Blood and cerebrospinal fluid biomarker changes in patients with HIV-associated neurocognitive impairment treated with lithium: analysis from a randomised placebo-controlled trial.

Thela, Lindokuhle / Decloedt, Eric / Zetterberg, Henrik / Gisslén, Magnus / Lesosky, Maia / Gleich, Melanie / Koutsilieri, Eleni / Scheller, Carsten / Hye, Abdul / Joska, John

Journal of neurovirology

2023 Volume 29, Issue 2, Page(s) 156–166

Abstract: HIV-associated neurocognitive disorders (HAND) persist in the era of antiretroviral therapy (ART). Thus, ART does not completely halt or reverse the pathological processes behind HAND. Adjuvant mitigating treatments are, therefore, prudent. Lithium ... ...

Abstract	HIV-associated neurocognitive disorders (HAND) persist in the era of antiretroviral therapy (ART). Thus, ART does not completely halt or reverse the pathological processes behind HAND. Adjuvant mitigating treatments are, therefore, prudent. Lithium treatment is known to promote neuronal brain-derived neurotrophic factors (BDNF). Lithium is also an inhibitor of glycogen synthase kinase-3 beta (GSK-3-β). We analyzed biomarkers obtained from participants in a randomized placebo-controlled trial of lithium in ART-treated individuals with moderate or severe HAND. We assayed markers at baseline and 24 weeks across several pathways hypothesized to be affected by HIV, inflammation, or degeneration. Investigated biomarkers included dopamine, BDNF, neurofilament light chain, and CD8 + lymphocyte activation (CD38 + HLADR +). Alzheimer's Disease (AD) biomarkers included soluble amyloid precursor protein alpha and beta (sAPPα/β), Aβ38, 40, 42, and ten other biomarkers validated as predictors of mild cognitive impairment and progression in previous studies. These include apolipoprotein C3, pre-albumin, α1-acid glycoprotein, α1-antitrypsin, PEDF, CC4, ICAM-1, RANTES, clusterin, and cystatin c. We recruited 61 participants (placebo = 31; lithium = 30). The age baseline mean was 40 (± 8.35) years and the median CD4 + T-cell count was 498 (IQR: 389-651) cells/μL. Biomarker concentrations between groups did not differ at baseline. However, both groups' blood dopamine levels decreased significantly after 24 weeks (adj. p < 002). No other marker was significantly different between groups, and we concluded that lithium did not confer neuroprotection following 24 weeks of treatment. However, the study was limited in duration and sample size.
MeSH term(s)	Humans ; Adult ; Middle Aged ; HIV ; Lithium/therapeutic use ; Brain-Derived Neurotrophic Factor ; Dopamine ; Glycogen Synthase Kinase 3/therapeutic use ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/psychology ; Biomarkers
Chemical Substances	Lithium (9FN79X2M3F) ; Brain-Derived Neurotrophic Factor ; Dopamine (VTD58H1Z2X) ; Glycogen Synthase Kinase 3 (EC 2.7.11.26) ; Biomarkers
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1283265-0
ISSN	1538-2443 ; 1355-0284
ISSN (online)	1538-2443
ISSN	1355-0284
DOI	10.1007/s13365-023-01116-4
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Article ; Online: Response to: Asymptomatic neurocognitive impairment is a risk for symptomatic decline over a 3-year study period.

Nightingale, Sam / Dreyer, Anna J / Gisslén, Magnus / Winston, Alan / Joska, John A

AIDS (London, England)

2021 Volume 35, Issue 7, Page(s) 1152–1153

MeSH term(s)	AIDS Dementia Complex ; HIV Infections ; Humans ; Neuropsychological Tests
Language	English
Publishing date	2021-05-04
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000002848
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Article ; Online: Reply to 'Cognitive criteria in HIV: greater consensus is needed'.

Nightingale, Sam / Cinque, Paola / Dravid, Ameet / Dreyer, Anna J / Gisslén, Magnus / Joska, John A / Kwasa, Judith / Meyer, Ana-Claire / Mpongo, Nombeko / Nakasujja, Noeline / Pebody, Roger / Pozniak, Anton / Price, Richard W / Saylor, Deanna / Thomas, Kevin G F / Underwood, Jonathan / Vera, Jaime H / Winston, Alan

Nature reviews. Neurology

2024 Volume 20, Issue 2, Page(s) 129–130

MeSH term(s)	Humans ; Consensus ; Cognition ; HIV Infections/complications ; HIV Infections/diagnosis
Language	English
Publishing date	2024-01-15
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2491514-2
ISSN	1759-4766 ; 1759-4758
ISSN (online)	1759-4766
ISSN	1759-4758
DOI	10.1038/s41582-024-00928-0
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Article ; Online: Cerebrospinal fluid immune markers and HIV-associated neurocognitive impairments: A systematic review.

Williams, Monray E / Stein, Dan J / Joska, John A / Naudé, Petrus J W

Journal of neuroimmunology

2021 Volume 358, Page(s) 577649

Abstract: HIV-1 is responsible for the development of a spectrum of cognitive impairments known as HIV-associated neurocognitive disorder (HAND). In the era of antiretroviral therapy (ART), HAND remains prevalent in people living with HIV (PLWH), despite low or ... ...

Abstract	HIV-1 is responsible for the development of a spectrum of cognitive impairments known as HIV-associated neurocognitive disorder (HAND). In the era of antiretroviral therapy (ART), HAND remains prevalent in people living with HIV (PLWH), despite low or undetectable viral loads. Persistent neuroinflammation likely plays an important role in the contributing biological mechanisms. Multiple cerebrospinal fluid (CSF) immune markers have been studied but it is unclear which markers most consistently correlate with neurocognitive impairment. We therefore conducted a systematic review of studies of the association of CSF immune markers with neurocognitive performance in ART-experienced PLWH. We aimed to synthesize the published data to determine consistent findings and to indicate the most noteworthy CSF markers of HAND. Twenty-nine studies were included, with 20 cross-sectional studies and 9 longitudinal studies. From the group of markers most often assayed, specific monocyte activation (higher levels of Neopterin, sCD163, sCD14) and neuroinflammatory markers (higher levels of IFN-γ, IL-1α, IL-7, IL-8, sTNFR-II and lower levels of IL-6) showed a consistent direction in association with HIV-associated neurocognitive impairment. Furthermore, significant differences exist in CSF immune markers between HIV-positive people with and without neurocognitive impairment, regardless of viral load and nadir/current CD4
MeSH term(s)	AIDS Dementia Complex/cerebrospinal fluid ; AIDS Dementia Complex/diagnosis ; AIDS Dementia Complex/immunology ; Biomarkers/cerebrospinal fluid ; HIV Infections/cerebrospinal fluid ; HIV Infections/diagnosis ; HIV Infections/immunology ; HIV-1/immunology ; Humans ; Inflammation Mediators/cerebrospinal fluid ; Inflammation Mediators/immunology ; Viral Load/methods
Chemical Substances	Biomarkers ; Inflammation Mediators
Language	English
Publishing date	2021-06-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	8335-5
ISSN	1872-8421 ; 0165-5728
ISSN (online)	1872-8421
ISSN	0165-5728
DOI	10.1016/j.jneuroim.2021.577649
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Article ; Online: Moving on From HAND: Why We Need New Criteria for Cognitive Impairment in Persons Living With Human Immunodeficiency Virus and a Proposed Way Forward.

Nightingale, Sam / Dreyer, Anna J / Saylor, Deanna / Gisslén, Magnus / Winston, Alan / Joska, John A

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2021 Volume 73, Issue 6, Page(s) 1113–1118

Abstract: Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) criteria are frequently used to describe cognitive impairment in persons living with HIV (PLWH) across diverse populations globally. These criteria typically find 20-60% of ... ...

Abstract	Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) criteria are frequently used to describe cognitive impairment in persons living with HIV (PLWH) across diverse populations globally. These criteria typically find 20-60% of PLWH meet criteria for HAND, which does not tally with clinical observations in the modern era that cognitive disorders present relatively infrequently. Most with HAND have asymptomatic neurocognitive impairment; however, the significance of low cognitive test performance without symptoms is uncertain. Methods underlying HAND criteria carry a false-positive rate that can exceed 20%. Comorbidities, education, and complex socioeconomic factors can influence cognitive test performance, further increasing the potential for misclassification. We propose a new framework to characterize cognitive impairment in PLWH that requires a clinical history and acknowledges the multifactorial nature of low cognitive test performance. This framework is intended to be applicable across diverse populations globally, be more aligned with clinical observations, and more closely represent HIV brain pathology.
MeSH term(s)	Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/etiology ; HIV ; HIV Infections/complications ; Humans ; Neurocognitive Disorders/diagnosis ; Neurocognitive Disorders/epidemiology ; Neurocognitive Disorders/etiology ; Neuropsychological Tests
Language	English
Publishing date	2021-05-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciab366
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