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  1. Article: Evaluating the impact of loneliness and social isolation on health literacy and health-related factors in young adults.

    Vasan, Shradha / Eikelis, Nina / Lim, Michelle H / Lambert, Elisabeth

    Frontiers in psychology

    2023  Volume 14, Page(s) 996611

    Abstract: Objectives: In current study, we aim to extend previous research by investigating the unique impact of loneliness on health literacy and health-related factors of young adults, after controlling for social isolation, depressive symptomology, and social ... ...

    Abstract Objectives: In current study, we aim to extend previous research by investigating the unique impact of loneliness on health literacy and health-related factors of young adults, after controlling for social isolation, depressive symptomology, and social anxiety, as well as evaluate how social isolation and loneliness differ in their impact on health literacy, and health-related factors among young adults, after accounting for abovementioned concomitant variables.
    Methods: Using a cross-sectional study design, 521 young adults completed an online survey in 2020, where they self-reported their loneliness, social isolation, health-related factors, and health literacy data.
    Results: Increased loneliness was associated with decrease in several health literacy domains (e.g., poorer social support for health, lower appraisal of health information, among others) and increase in some health-related factors (e.g., higher perceived stress, higher negative affect), among young adults, even after controlling for social anxiety, depressive symptomology, and social isolation. Contrastingly, increase in social isolation was associated with changes in some health-related factors - more somatic health complaints, higher alcohol use, poorer cognitive and physical functioning, and lower scores for only one health literacy domain (i.e., social support for health) among young adults, after adjusting for the influence of social anxiety, depressive symptomology, and loneliness.
    Conclusion: Even after accounting for the influence of several co-occurring social and mental health symptoms, higher loneliness was associated poorer health literacy and health-related factors in young adults. We also found loneliness and social isolation may differ in the mechanisms through which they impact health literacy and health-related factors in young adults.
    Language English
    Publishing date 2023-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.996611
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  2. Article: Effect of elexacaftor-tezacaftor-ivacaftor on nasal potential difference and lung function in Phe508del rats.

    Reyne, Nicole / Cmielewski, Patricia / McCarron, Alexandra / Smith, Ronan / Eikelis, Nina / Pirakalathanan, Piraveen / Parsons, David / Donnelley, Martin

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1362325

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1362325
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  3. Article ; Online: Impact of loneliness on health-related factors in Australia during the COVID-19 pandemic: A retrospective study.

    Vasan, Shradha / Lambert, Elisabeth / Eikelis, Nina / Lim, Michelle H

    Health & social care in the community

    2022  Volume 30, Issue 6, Page(s) e5293–e5304

    Abstract: COVID-19 pandemic and its associated social and physical distancing restrictions may have had a severe impact on health. In the present study, we investigate the changes in physical, social and mental health, as well as the health literacy of Australians ...

    Abstract COVID-19 pandemic and its associated social and physical distancing restrictions may have had a severe impact on health. In the present study, we investigate the changes in physical, social and mental health, as well as the health literacy of Australians subsequent to the onset of COVID-19 pandemic, and examine the influence of loneliness on these health-related factors. Using a retrospective cross-sectional study design, 607 Australian adults completed a self-report online survey which assessed their health-related factors before and after onset of the COVID-19 pandemic (data collected between June 2020 to November 2020). Australians reported statistically significant increase in a number of (poorer) health-related factors (e.g., weight gain, sleeping difficulties, poor somatic health, higher loneliness, more issues navigating the healthcare system) post onset of COVID-19 pandemic. Further, after adjusting for covariates, higher loneliness during pandemic predicted poorer health-related outcomes (e.g., more somatic health complaints, poorer quality of diet, poorer social support for health). The COVID-19 pandemic and its associated social and physical distancing restrictions may have contributed towards poorer health-related factors among Australian adults. Further, increased loneliness during the pandemic may have further worsened physical health and health literacy outcomes among Australians.
    MeSH term(s) Adult ; Humans ; Loneliness ; Pandemics ; COVID-19/epidemiology ; Retrospective Studies ; Cross-Sectional Studies ; Australia/epidemiology
    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1155902-0
    ISSN 1365-2524 ; 0966-0410
    ISSN (online) 1365-2524
    ISSN 0966-0410
    DOI 10.1111/hsc.13948
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    Zs.A 3728: Show issues Location:
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  4. Article: Autonomic Nervous System Function in Anorexia Nervosa: A Systematic Review.

    Jenkins, Zoe M / Eikelis, Nina / Phillipou, Andrea / Castle, David J / Wilding, Helen E / Lambert, Elisabeth A

    Frontiers in neuroscience

    2021  Volume 15, Page(s) 682208

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-06-28
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2021.682208
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  5. Article ; Online: Association of x-ray velocimetry (XV) ventilation analysis compared to spirometry.

    Kirkness, Jason P / Dusting, Jonathan / Eikelis, Nina / Pirakalathanan, Piraveen / DeMarco, John / Shiao, Stephen L / Fouras, Andreas

    Frontiers in medical technology

    2023  Volume 5, Page(s) 1148310

    Abstract: Introduction: X-ray Velocimetry (XV) ventilation analysis is a 4-dimensional imaging-based method for quantifying regional ventilation, aiding in the assessment of lung function. We examined the performance characteristics of XV ventilation analysis by ... ...

    Abstract Introduction: X-ray Velocimetry (XV) ventilation analysis is a 4-dimensional imaging-based method for quantifying regional ventilation, aiding in the assessment of lung function. We examined the performance characteristics of XV ventilation analysis by examining correlation to spirometry and measurement repeatability.
    Methods: XV analysis was assessed in 27 patients receiving thoracic radiotherapy for non-lung cancer malignancies. Measurements were obtained pre-treatment and at 4 and 12-months post-treatment. XV metrics such as ventilation defect percent (VDP) and regional ventilation heterogeneity (VH) were compared to spirometry at each time point, using correlation analysis. Repeatability was assessed between multiple runs of the analysis algorithm, as well as between multiple breaths in the same patient. Change in VH and VDP in a case series over 12 months was used to determine effect size and estimate sample sizes for future studies.
    Results: VDP and VH were found to significantly correlate with FEV
    Conclusions: The performance and safety of XV analysis make it ideal for both clinical and research applications across most lung indications. Our results support continued research and provide a basis for powering future studies using XV as an endpoint to examine lung health and determine therapeutic efficacy.
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3129
    ISSN (online) 2673-3129
    DOI 10.3389/fmedt.2023.1148310
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  6. Article ; Online: Renalase - a potential biomarker for risk of atrial fibrillation?

    Schlaich, Markus P / Lambert, Gavin W / Eikelis, Nina

    Kardiologia polska

    2018  Volume 76, Issue 8, Page(s) 1201–1202

    MeSH term(s) Atrial Fibrillation ; Biomarkers ; Humans ; Monoamine Oxidase ; Risk
    Chemical Substances Biomarkers ; Monoamine Oxidase (EC 1.4.3.4) ; renalase (EC 1.4.3.4.)
    Language English
    Publishing date 2018-08-17
    Publishing country Poland
    Document type Journal Article ; Comment
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.5603/KP.2018.0163
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 598: Show issues Location:
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  7. Article ; Online: Arterial stiffness in underweight and weight-restored anorexia nervosa.

    Jenkins, Zoe M / Phillipou, Andrea / Castle, David J / Eikelis, Nina / Lambert, Elisabeth A

    Psychophysiology

    2021  Volume 58, Issue 11, Page(s) e13913

    Abstract: Cardiovascular complications have been demonstrated in patients with anorexia nervosa (AN) in both the state of starvation and during weight restoration, however, the underlying mechanisms remain unclear. The current study aimed to assess arterial ... ...

    Abstract Cardiovascular complications have been demonstrated in patients with anorexia nervosa (AN) in both the state of starvation and during weight restoration, however, the underlying mechanisms remain unclear. The current study aimed to assess arterial stiffness via carotid-femoral pulse wave velocity (cfPWV) in the acute and weight-restored states of AN. The study also aimed to determine the association between psychological distress and cfPWV. The sample included 37 participants; 10 participants with AN, 17 who were weight-restored (AN-WR; minimum body mass index >18.5 for at least 12 months) and 10 healthy controls (HCs). cfPWV via applanation tonometry was conducted to assess arterial stiffness. Psychological distress was assessed using the depression anxiety stress scale (DASS-21) and the state-trait anxiety inventory (STAI). Between-group comparisons were performed to determine differences between groups, a two-stage hierarchical regression model was performed to determine the contribution of physiological and psychological variables on cfPWV and correlation analyses were also performed. Vascular stiffness was significantly increased in the AN and AN-WR groups, relative to HCs. The total DASS score was the only significant predictor of cfPWV across the sample. There were positive associations between cfPWV and depression, anxiety and stress, as assessed by the DASS. Furthermore, cfPWV was positively associated with STAI trait anxiety. Arterial stiffness was increased in individuals in the acute and weight-restored states of AN, demonstrating early signs of the development of arteriosclerotic cardiovascular disease. Increased arterial stiffness was associated with increased psychological distress, which may be a contributing mechanism to the increased cardiovascular risk in AN.
    MeSH term(s) Adult ; Anorexia Nervosa/physiopathology ; Anxiety/physiopathology ; Depression/physiopathology ; Female ; Humans ; Psychological Distress ; Pulse Wave Analysis ; Stress, Psychological/physiopathology ; Thinness/physiopathology ; Vascular Stiffness/physiology ; Young Adult
    Language English
    Publishing date 2021-07-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209486-1
    ISSN 1540-5958 ; 0048-5772
    ISSN (online) 1540-5958
    ISSN 0048-5772
    DOI 10.1111/psyp.13913
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 502: Show issues Location:
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  8. Article ; Online: Autonomic nervous system function in women with anorexia nervosa.

    Jenkins, Zoe M / Castle, David J / Eikelis, Nina / Phillipou, Andrea / Lambert, Gavin W / Lambert, Elisabeth A

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2021  Volume 32, Issue 1, Page(s) 29–42

    Abstract: Purpose: Abnormalities in autonomic function have been observed in people with anorexia nervosa. However, the majority of investigations have utilised heart rate variability as the sole assessment of autonomic activity. The current study utilised a ... ...

    Abstract Purpose: Abnormalities in autonomic function have been observed in people with anorexia nervosa. However, the majority of investigations have utilised heart rate variability as the sole assessment of autonomic activity. The current study utilised a variety of methodologies to assess autonomic nervous system function in women with a current diagnosis of anorexia, a past diagnosis of anorexia who were weight-restored, and healthy controls.
    Methods: The sample included 37 participants: 10 participants with anorexia, 17 weight-restored participants (minimum body mass index > 18.5 for minimum of 12 months) and 10 controls. Assessments of autonomic function included muscle sympathetic nerve activity (MSNA) using microneurography, heart rate variability, baroreflex sensitivity, blood pressure variability, head-up tilt table test, sudomotor function and assessment of plasma catecholamines.
    Results: MSNA (bursts/min) was significantly decreased in both anorexia (10.22 ± 6.24) and weight-restored (17.58 ± 1.68) groups, as compared to controls (23.62 ± 1.01, p < 0.001 and p = 0.033, respectively). Participants with anorexia had a significantly lower standard deviation in heart rate, lower blood pressure variability and decreased sudomotor function as compared to controls. Weight-restored participants demonstrated decreased baroreflex sensitivity in response to head-up tilt as compared to controls.
    Conclusion: Women with a current or previous diagnosis of anorexia have significantly decreased sympathetic activity, which may reflect a physiological response to decreased energy intake. During the state of starvation, women with anorexia also displayed decreased sudomotor function. The consequences of a sustained decrease in MSNA are unknown, and future studies should investigate autonomic function in long-term weight-restored participants to determine whether activity returns to normal.
    MeSH term(s) Anorexia ; Anorexia Nervosa ; Autonomic Nervous System/physiology ; Baroreflex/physiology ; Blood Pressure ; Female ; Heart Rate/physiology ; Humans ; Sympathetic Nervous System
    Language English
    Publishing date 2021-11-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-021-00836-z
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    Zs.A 3270: Show issues Location:
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  9. Article ; Online: Sympathetic activity in obesity: a brief review of methods and supportive data.

    Lambert, Gavin W / Schlaich, Markus P / Eikelis, Nina / Lambert, Elisabeth A

    Annals of the New York Academy of Sciences

    2019  Volume 1454, Issue 1, Page(s) 56–67

    Abstract: The increase in the prevalence of obesity and the concomitant rise in obesity-related illness have led to substantial pressure on health care systems throughout the world. While the combination of reduced exercise, increased sedentary time, poor diet, ... ...

    Abstract The increase in the prevalence of obesity and the concomitant rise in obesity-related illness have led to substantial pressure on health care systems throughout the world. While the combination of reduced exercise, increased sedentary time, poor diet, and genetic predisposition is undoubtedly pivotal in generating obesity and increasing disease risk, a large body of work indicates that the sympathetic nervous system (SNS) contributes to obesity-related disease development and progression. In obesity, sympathetic nervous activity is regionalized, with activity in some outflows being particularly sensitive to the obese state, whereas other outflows, or responses to stimuli, may be blunted, thereby making the assessment of sympathetic nervous activation in the clinical setting difficult. Isotope dilution methods and direct nerve recording techniques have been developed and utilized in clinical research, demonstrating that in obesity there is preferential activation of the muscle vasoconstrictor and renal sympathetic outflows. With weight loss, sympathetic activity is reduced. Importantly, sympathetic nervous activity is associated with end-organ dysfunction and changes in sympathetic activation that accompany weight loss are often reflected in an improvement of end-organ function. Whether targeting the SNS directly improves obesity-related illness remains unknown, but merits further attention.
    MeSH term(s) Humans ; Obesity/physiopathology ; Sympathetic Nervous System/physiopathology
    Language English
    Publishing date 2019-07-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/nyas.14140
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    Se 110: Show issues Location:
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  10. Article: Functional imaging for assessing regional lung ventilation in preclinical and clinical research.

    Karmali, Dipan / Sowho, Mudiaga / Bose, Sonali / Pearce, Jackson / Tejwani, Vickram / Diamant, Zuzana / Yarlagadda, Keerthi / Ponce, Erick / Eikelis, Nina / Otvos, Tamas / Khan, Akram / Lester, Michael / Fouras, Andreas / Kirkness, Jason / Siddharthan, Trishul

    Frontiers in medicine

    2023  Volume 10, Page(s) 1160292

    Abstract: Dynamic heterogeneity in lung ventilation is an important measure of pulmonary function and may be characteristic of early pulmonary disease. While standard indices like spirometry, body plethysmography, and blood gases have been utilized to assess lung ... ...

    Abstract Dynamic heterogeneity in lung ventilation is an important measure of pulmonary function and may be characteristic of early pulmonary disease. While standard indices like spirometry, body plethysmography, and blood gases have been utilized to assess lung function, they do not provide adequate information on regional ventilatory distribution nor function assessments of ventilation during the respiratory cycle. Emerging technologies such as xenon CT, volumetric CT, functional MRI and X-ray velocimetry can assess regional ventilation using non-invasive radiographic methods that may complement current methods of assessing lung function. As a supplement to current modalities of pulmonary function assessment, functional lung imaging has the potential to identify respiratory disease phenotypes with distinct natural histories. Moreover, these novel technologies may offer an optimal strategy to evaluate the effectiveness of novel therapies and therapies targeting localized small airways disease in preclinical and clinical research. In this review, we aim to discuss the features of functional lung imaging, as well as its potential application and limitations to adoption in research.
    Language English
    Publishing date 2023-05-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1160292
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