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Article ; Online: Wen-Shen-Tong-Luo-Zhi-Tong Decoction regulates bone-fat balance in osteoporosis by adipocyte-derived exosomes.

Wang, Lining / Pan, Yalan / Liu, Mengmig / Sun, Jie / Yun, Li / Tu, Pengcheng / Wu, Chengjie / Yu, Ziceng / Han, Zhitao / Li, Muzhe / Guo, Yang / Ma, Yong

Pharmaceutical biology

2023 Volume 61, Issue 1, Page(s) 568–580

Abstract: Context: Wen-Shen-Tong-Luo-Zhi-Tong (WSTLZT) Decoction is a Chinese prescription ...

Abstract	Context: Wen-Shen-Tong-Luo-Zhi-Tong (WSTLZT) Decoction is a Chinese prescription with antiosteoporosis effects, especially in patients with abnormal lipid metabolism. Objective: To explore the effect and mechanism of WSTLZT on osteoporosis (OP) through adipocyte-derived exosomes. Materials and methods: Adipocyte-derived exosomes with or without WSTLZT treated were identified by transmission electron microscopy, nanoparticle tracking analysis (NTA) and western blotting (WB). Co-culture experiments for bone marrow mesenchymal stem cells (BMSCs) and exosomes were performed to examine the uptake and effect of exosome in osteogenesis and adipogenic differentiation of BMSC. MicroRNA profiles, luciferase and IP were used for exploring specific mechanisms of exosome on BMSC. Results: ALP, Alizarin red and Oil red staining showed that WSTLZT-induced exosomes from adipocyte can regulate osteoblastic and adipogenic differentiation of BMSC. MicroRNA profiles observed that WSTLZT treatment resulted in 87 differentially expressed miRNAs ( Conclusions: WSTLZT can exert anti-OP effect through SPRY2 via the MAKP signalling by miR-122-5p carried by adipocyte-derived exosomes.
MeSH term(s)	Mice ; Animals ; Exosomes/genetics ; Exosomes/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Cell Differentiation ; Adipogenesis ; Osteogenesis ; Adipocytes
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-03-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2023.2190773
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Article ; Online: Multiomics profiling of the therapeutic effect of Dan-deng-tong-nao capsule on cerebral ischemia-reperfusion injury.

Shi, Yingying / Du, Qiuzheng / Li, Zhuolun / Xue, Lianping / Jia, Qingquan / Zheng, Tianyuan / Liu, Jiyun / Ren, Ruobing / Sun, Zhi

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 128, Page(s) 155335

Abstract: ... and metabolic disorders. Dan-deng-tong-nao capsule (DDTN) is a traditional Chinese medicine used ...

Abstract	Background: Stroke is a complex physiological process associated with intestinal flora dysbiosis and metabolic disorders. Dan-deng-tong-nao capsule (DDTN) is a traditional Chinese medicine used clinically to treat cerebral ischemia-reperfusion injury (CIRI) for many years. However, little is known about the effects of DDTN in the treatment of CIRI from the perspective of gut microbiota and metabolites. Purpose: This study aimed to investigate the regulatory roles of DDTN in endogenous metabolism and gut microbiota in CIRI rats, thus providing a basis for clinical rational drug use and discovering natural products with potential physiological activities in DDTN for the treatment of CIRI. Methods: The chemical composition of DDTN in vitro and in vivo was investigated using ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLCHRMS), followed by target prediction using reverse molecular docking. Secondly, a biological evaluation of DDTN ameliorating neural damage in CIRI was performed at the whole animal level. Then, an integrated omics approach based on UHPLCHRMS and 16S rRNA sequencing was proposed to reveal the anti-CIRI effect and possible mechanism of DDTN. Finally, exploring the intrinsic link between changes in metabolite profiles, changes in the intestinal flora, and targets of components to reveal DDTN for the treatment of CIRI. Results: A total of 112 chemical components of DDTN were identified in vitro and 10 absorbed constituents in vivo. The efficacy of DDTN in the treatment of CIRI was confirmed by alleviating cerebral infarction and neurological deficits. After the DDTN intervention, 21 and 26 metabolites were significantly altered in plasma and fecal, respectively. Based on the fecal microbiome, a total of 36 genera were enriched among the different groups. Finally, the results of the network integration analysis showed that the 10 potential active ingredients of DDTN could mediate the differential expression of 24 metabolites and 6 gut microbes by targeting 25 target proteins. Conclusion: This study was the first to outline the landscapes of metabolites as well as gut microbiota regulated by DDTN in CIRI rats using multi-omics data, and comprehensively revealed the systematic relationships among ingredients, targets, metabolites, and gut microbiota, thus providing new perspectives on the mechanism of DDTN in the treatment of CIRI.
MeSH term(s)	Animals ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/chemistry ; Reperfusion Injury/drug therapy ; Gastrointestinal Microbiome/drug effects ; Male ; Rats, Sprague-Dawley ; Rats ; Brain Ischemia/drug therapy ; Molecular Docking Simulation ; Chromatography, High Pressure Liquid ; RNA, Ribosomal, 16S ; Capsules ; Multiomics
Chemical Substances	Drugs, Chinese Herbal ; RNA, Ribosomal, 16S ; Capsules
Language	English
Publishing date	2024-01-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.155335
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Article ; Online: Radiographic and clinical outcomes of muenster and sugar tong splints for distal radius fractures: a comparative study.

Jo, Young-Hoon / Lee, Myoung Keun / Lee, Young Seok / Choi, Wan-Sun / Kim, Joo-Hak / Kim, Jiwhan / Lee, Chang-Hun

BMC musculoskeletal disorders

2024 Volume 25, Issue 1, Page(s) 261

Abstract: ... radius fractures. Conservative treatments such as Sugar tong splints (STs) and Muenster splints (MUs) are commonly ...

Abstract	Background: Non-operative management is typically indicated for extra-articular distal radius fractures. Conservative treatments such as Sugar tong splints (STs) and Muenster splints (MUs) are commonly used. However, there is limited research and outcome data comparing the two splint types. Therefore, this study aimed to investigate and compare the radiographic and clinical outcomes of treatment using STs and MUs. Methods: In this retrospective comparative study, we aimed to evaluate and compare the radiographic and clinical outcomes of STs and MUs for the treatment of distal radius fractures. The study included 64 patients who underwent closed reduction (CR) in the emergency room and were treated with either STs or MUs splints (STs group: n = 38, MUs group: n = 26). Initial X-rays, post-CR X-rays, and last outpatient follow-up X-rays were evaluated. Radial height (RH), ulnar variance (UV), radial inclination (RI), and volar tilt (VT) were measured by a blinded investigator. The Quick DASH form was applied to measure patients' satisfaction after treatments. Results: There were no significant differences in baseline characteristics, initial radiographic measurements, or radiographic measurements immediately after CR between the two groups. However, the overall radiological values deteriorated to some degree in both groups compared to the post-CR images. Furthermore, using a paired test, the STs group showed significant differences in RH and RI, and the MUs group showed significant differences in RH and UV between the last follow-up and post-CR images. Conclusions: The study concluded that there was no difference in clinical outcomes between the two splint types. However, both STs and MUs groups showed reduced radiographic parameters, and the MUs group showed a significant reduction of RH and UV in the treatment of distal radius fractures. Level of evidence: Level IV; Retrospective Comparison; Treatment Study.
MeSH term(s)	Humans ; Treatment Outcome ; Retrospective Studies ; Splints ; Sugars ; Wrist Fractures ; Radius Fractures/therapy ; Radius Fractures/surgery ; Range of Motion, Articular ; Bone Plates ; Fracture Fixation, Internal/methods
Chemical Substances	Sugars
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-024-07362-9
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Article ; Online: Rapid and comprehensive identification of chemical constituents in Mai-Luo-Shu-Tong pill by UHPLC-Q-Orbitrap HRMS combined with a data mining strategy.

Zhang, Xiangyu / Chu, Yaojuan / Wang, Mengli / Shi, Yingying / Zuo, Lihua / Li, Zhuolun / Liu, Jiyun / Kang, Jian / Du, Shuzhang / Li, Bing / Sun, Zhi / Zhang, Xiaojian

Analytical methods : advancing methods and applications

2022 Volume 14, Issue 47, Page(s) 4990–5000

Abstract: Mai-Luo-Shu-Tong pill is an effective traditional Chinese medicine formula for the treatment ... spectral data of Mai-Luo-Shu-Tong pill were acquired by ultra-high performance liquid chromatography ... Shu-Tong pill by constructing a database of precursor ions and summarizing the mass spectral ...

Abstract	Mai-Luo-Shu-Tong pill is an effective traditional Chinese medicine formula for the treatment of superficial thrombophlebitis, but it was insufficiently chemically scrutinized. In this study, the mass spectral data of Mai-Luo-Shu-Tong pill were acquired by ultra-high performance liquid chromatography coupled with Q Exactive hybrid Quadrupole-Orbitrap high resolution mass spectrometry. Then, a data mining strategy combining multiple data processing methods was used to identify chemical constituents in Mai-Luo-Shu-Tong pill by constructing a database of precursor ions and summarizing the mass spectral fragmentation behaviors. As a result, a total of 211 compounds including 70 flavonoids, 56 terpenoids, 37 phenolic acids and 48 others were identified in positive and negative ion modes. Among them, 66 compounds have passed comparison verification with reference standards, 145 compounds were identified based on the data mining strategy combining the characteristic cleavage behaviour of homologous compounds and fragment ions and 4 compounds were potentially new compounds. This study provides a database for quality evaluation and further study of Mai-Luo-Shu-Tong pill
MeSH term(s)	Medicine, Chinese Traditional ; Data Mining
Language	English
Publishing date	2022-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/d2ay01453j
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Article ; Online: Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway.

Zhang, Xing / Su, Jie / Lin, Jiacheng / Liu, Lujiong / Wu, Jiamin / Yuan, Wenli / Zhang, Yibao / Chen, Qi / Su, Zi Jian / Xu, Guihua / Sun, Meng / Zhang, Yile / Chen, Xuan / Zhang, Wei

Journal of ethnopharmacology

2023 Volume 314, Page(s) 116633

Abstract: Ethnopharmacological relevance: Fu-Zheng-Tong-Luo (FZTL) formula is a Chinese herbal prescription ...

Abstract	Ethnopharmacological relevance: Fu-Zheng-Tong-Luo (FZTL) formula is a Chinese herbal prescription which is used to treat idiopathic pulmonary fibrosis (IPF). We previously reported that the FZTL formula could improve IPF injury in rats; however, the mechanism remains unelucidated. Aim of the study: To elucidate the effects and mechanisms of the FZTL formula on IPF. Materials and methods: The bleomycin-induced pulmonary fibrosis rat model and transforming growth factor-β-induced lung fibroblast model were used. Histological changes and fibrosis formation were detected in the rat model after treatment with the FZTL formula. Furthermore, the effects of the FZTL formula on autophagy and lung fibroblast activation were determined. Moreover, the mechanism of FZTL was explored using transcriptomics analysis. Results: We observed that FZTL alleviated IPF injury in rats and inhibited inflammatory responses and fibrosis formation in rats. Moreover, it promoted autophagy and inhibited lung fibroblast activation in vitro. Transcriptomics analysis revealed that FZTL regulates the Janus kinase 2 (JAK)/signal transducer and activator of the transcription 3 (STAT) signaling pathway. The JAK2/STAT3 signaling activator interleukin 6 inhibited the anti-fibroblast activation effect of the FZTL formula. Combined treatment with the JAK2 inhibitor (AZD1480) and autophagy inhibitor (3-methyladenine) did not enhance the antifibrotic effect of FZTL. Conclusions: The FZTL formula can inhibit IPF injury and lung fibroblast activation. Its effects are mediated via the JAK2/STAT3 signaling pathway. The FZTL formula may be a potential complementary therapy for pulmonary fibrosis.
MeSH term(s)	Rats ; Animals ; Janus Kinase 2/metabolism ; STAT3 Transcription Factor/metabolism ; Idiopathic Pulmonary Fibrosis/chemically induced ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/pathology ; Signal Transduction ; Fibrosis ; Bleomycin ; Fluorouracil/pharmacology
Chemical Substances	Janus Kinase 2 (EC 2.7.10.2) ; STAT3 Transcription Factor ; Bleomycin (11056-06-7) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2023-05-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116633
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Shen-Hong-Tong-Luo Formula Attenuates Macrophage Inflammation and Lipid Accumulation through the Activation of the PPAR-

Zhang, Zepeng / Zhai, Lu / Lu, Jing / Sun, Sanmiao / Wang, Dandan / Zhao, Daqing / Sun, Liwei / Zhao, Weimin / Li, Xiangyan / Chen, Ying

Oxidative medicine and cellular longevity

2020 Volume 2020, Page(s) 3426925

Abstract: ... by oxidized lipoproteins that attack macrophages in the endarterium. The Shen-Hong-Tong-Luo (SHTL) formula has ...

Abstract	Atherosclerosis (AS) is the killer of human health and longevity, which is majorly caused by oxidized lipoproteins that attack macrophages in the endarterium. The Shen-Hong-Tong-Luo (SHTL) formula has shown great clinical efficacy and vascular protective effect for over 30 years in China, to attenuate AS progression. However, its pharmacological mechanism needs more investigation. In this study, we first investigated the chemical composition of SHTL by fingerprint analysis using high-performance liquid chromatography. In primary mouse peritoneal macrophages induced by lipopolysaccharide (LPS), we found that SHTL pretreatment suppressed reactive oxygen species accumulation and reversed the increases of the inflammatory factors, TNF-
MeSH term(s)	ATP Binding Cassette Transporter 1/metabolism ; Animals ; Cell Survival/drug effects ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Lipid Metabolism/drug effects ; Lipopolysaccharides/pharmacology ; Lipoproteins, LDL/pharmacology ; Liver X Receptors/metabolism ; Macrophages, Peritoneal/cytology ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/metabolism ; Mice ; Mice, Knockout ; PPAR gamma/metabolism ; Plaque, Atherosclerotic/drug therapy ; Plaque, Atherosclerotic/pathology ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; Signal Transduction/drug effects
Chemical Substances	ABCA1 protein, mouse ; ATP Binding Cassette Transporter 1 ; Drugs, Chinese Herbal ; Lipopolysaccharides ; Lipoproteins, LDL ; Liver X Receptors ; Nr1h3 protein, mouse ; PPAR gamma ; Protective Agents ; oxidized low density lipoprotein
Language	English
Publishing date	2020-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2020/3426925
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Medical Morphology Training Using the Xuexi Tong Platform During the COVID-19 Pandemic: Development and Validation of a Web-Based Teaching Approach.

Liu, Qinlai / Sun, Wenping / Du, Changqing / Yang, Leiying / Yuan, Na / Cui, Haiqing / Song, Wengang / Ge, Li

JMIR medical informatics

2021 Volume 9, Issue 3, Page(s) e24497

Abstract: ... the Xuexi Tong platform as the major platform to realize a new "seven-in-one" teaching method (ie, videos ... of knowledge of the students.: Results: Using the Xuexi Tong platform as the major platform to conduct ...

Abstract	Background: Histology and Embryology and Pathology are two important basic medical morphology courses for studying human histological structures under healthy and pathological conditions, respectively. There is a natural succession between the two courses. At the beginning of 2020, the COVID-19 pandemic suddenly swept the world. During this unusual period, to ensure that medical students would understand and master basic medical knowledge and to lay a solid foundation for future medical bridge courses and professional courses, a web-based medical morphology teaching team, mainly including teachers of courses in Histology and Embryology and Pathology, was established. Objective: This study aimed to explore a new teaching mode of Histology and Embryology and Pathology courses during the COVID-19 pandemic and to illustrate its feasibility and acceptability. Methods: From March to July 2020, our team selected clinical medicine undergraduate students who started their studies in 2018 and 2019 as recipients of web-based teaching. Meanwhile, nursing undergraduate students who started their studies in 2019 and 2020 were selected for traditional offline teaching as the control group. For the web-based teaching, our team used the Xuexi Tong platform as the major platform to realize a new "seven-in-one" teaching method (ie, videos, materials, chapter tests, interactions, homework, live broadcasts, and case analysis/discussion). This new teaching mode involved diverse web-based teaching methods and contents, including flipped classroom, screen-to-screen experimental teaching, a drawing competition, and a writing activity on the theme of "What I Know About COVID-19." When the teaching was about to end, a questionnaire was administered to obtain feedback regarding the teaching performance. In the meantime, the final written pathology examination results of the web-based teaching and traditional offline teaching groups were compared to examine the mastery of knowledge of the students. Results: Using the Xuexi Tong platform as the major platform to conduct "seven-in-one" teaching is feasible and acceptable. With regard to the teaching performance of this new web-based teaching mode, students demonstrated a high degree of satisfaction, and the questionnaire showed that 71.3% or more of the students in different groups reported a greater degree of satisfaction or being very satisfied. In fact, more students achieved high scores (90-100) in the web-based learning group than in the offline learning control group (P=.02). Especially, the number of students with objective scores >60 in the web-based learning group was greater than that in the offline learning control group (P=.045). Conclusions: This study showed that the web-based teaching mode was not inferior to the traditional offline teaching mode for medical morphology courses, proving the feasibility and acceptability of web-based teaching during the COVID-19 pandemic. Our findings lay a solid theoretical foundation for follow-up studies of medical students.
Language	English
Publishing date	2021-03-15
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2798261-0
ISSN	2291-9694
ISSN	2291-9694
DOI	10.2196/24497
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Article: Genetic effects of FTO gene insertion/deletion (InDel) on fat-tail measurements and growth traits in Tong sheep

Wang, Shuhui / Liu, Shirong / Yuan, Tingting / Sun, Xiuzhu

Animal biotechnology. 2021 Apr. 1, v. 32, no. 2

2021

Abstract: Tong sheep is a kind of famous fat-tailed sheep in China, which no longer meets market demands ... on fat-tail measurements and growth traits, 166 healthy individuals from Tong sheep were identified and ... analyzed. Herein, 10 novel InDel polymorphisms were founded in the Tong sheep FTO gene, which displayed ...

Abstract	Tong sheep is a kind of famous fat-tailed sheep in China, which no longer meets market demands because of the large amount of fat deposition in tail. Fat mass and obesity associated (FTO) gene regulates fatty acid transport and fat metabolism to affect obesity and is also reported to regulate phenotypic traits in healthy animals. To identify the insertion/deletion (InDel) variations of the FTO gene and evaluate their effects on fat-tail measurements and growth traits, 166 healthy individuals from Tong sheep were identified and analyzed. Herein, 10 novel InDel polymorphisms were founded in the Tong sheep FTO gene, which displayed intermediate polymorphism (0.25 < PIC < 0.5) and were in Hardy–Weinberg equilibrium (p > .05). Correlation analysis of 78 Tong sheep phenotypic traits data and InDel polymorphisms showed that eight InDel loci were significantly associated with partial growth traits (p < .05), four InDel loci were significantly correlated with fat-tail measurements (p < .05). In particular, individuals with genotype DD showed better phenotypic traits than individuals with other genotypes at male sheep InDel 5 and InDel 8 loci, which had small tail-fat dimensions while having good growth traits. These results confirmed potential usefulness of FTO gene in marker-assisted selection programs of Tong sheep breeding.
Keywords	biotechnology ; fatty acids ; genes ; genotype ; lipid metabolism ; males ; marker-assisted selection ; markets ; obesity ; phenotype ; sheep ; tail ; China
Language	English
Dates of publication	2021-0401
Size	p. 229-239.
Publishing place	Taylor & Francis
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2043243-4
ISSN	1532-2378 ; 1049-5398
ISSN (online)	1532-2378
ISSN	1049-5398
DOI	10.1080/10495398.2019.1680379
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway

Zhang, Xing / Su, Jie / Lin, Jiacheng / Liu, Lujiong / Wu, Jiamin / Yuan, Wenli / Zhang, Yibao / Chen, Qi / Su, Zi jian / Xu, Guihua / Sun, Meng / Zhang, Yile / Chen, Xuan / Zhang, Wei

Journal of Ethnopharmacology. 2023 Oct., v. 314 p.116633-

2023

Abstract: Fu-Zheng-Tong-Luo (FZTL) formula is a Chinese herbal prescription which is used to treat ...

Abstract	Fu-Zheng-Tong-Luo (FZTL) formula is a Chinese herbal prescription which is used to treat idiopathic pulmonary fibrosis (IPF). We previously reported that the FZTL formula could improve IPF injury in rats; however, the mechanism remains unelucidated. To elucidate the effects and mechanisms of the FZTL formula on IPF. The bleomycin-induced pulmonary fibrosis rat model and transforming growth factor-β-induced lung fibroblast model were used. Histological changes and fibrosis formation were detected in the rat model after treatment with the FZTL formula. Furthermore, the effects of the FZTL formula on autophagy and lung fibroblast activation were determined. Moreover, the mechanism of FZTL was explored using transcriptomics analysis. We observed that FZTL alleviated IPF injury in rats and inhibited inflammatory responses and fibrosis formation in rats. Moreover, it promoted autophagy and inhibited lung fibroblast activation in vitro. Transcriptomics analysis revealed that FZTL regulates the Janus kinase 2 (JAK)/signal transducer and activator of the transcription 3 (STAT) signaling pathway. The JAK2/STAT3 signaling activator interleukin 6 inhibited the anti-fibroblast activation effect of the FZTL formula. Combined treatment with the JAK2 inhibitor (AZD1480) and autophagy inhibitor (3-methyladenine) did not enhance the antifibrotic effect of FZTL. The FZTL formula can inhibit IPF injury and lung fibroblast activation. Its effects are mediated via the JAK2/STAT3 signaling pathway. The FZTL formula may be a potential complementary therapy for pulmonary fibrosis.
Keywords	animal models ; autophagy ; fibroblasts ; fibrosis ; histology ; interleukin-6 ; lungs ; non-specific protein-tyrosine kinase ; pulmonary fibrosis ; therapeutics ; traditional medicine ; transactivators ; transcriptomics ; Traditional Chinese medicine ; Fu-zheng-Tong-Luo formula ; Idiopathic pulmonary fibrosis ; Janus kinase 2/signal transducer and activator of transcription 3
Language	English
Dates of publication	2023-10
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116633
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Medical Morphology Training Using the Xuexi Tong Platform During the COVID-19 Pandemic

Liu, Qinlai / Sun, Wenping / Du, Changqing / Yang, Leiying / Yuan, Na / Cui, Haiqing / Song, Wengang / Ge, Li

JMIR Medical Informatics, Vol 9, Iss 3, p e

Development and Validation of a Web-Based Teaching Approach

2021 Volume 24497

Abstract: ... as the control group. For the web-based teaching, our team used the Xuexi Tong platform as the major platform ... Tong platform as the ... ...

Abstract	BackgroundHistology and Embryology and Pathology are two important basic medical morphology courses for studying human histological structures under healthy and pathological conditions, respectively. There is a natural succession between the two courses. At the beginning of 2020, the COVID-19 pandemic suddenly swept the world. During this unusual period, to ensure that medical students would understand and master basic medical knowledge and to lay a solid foundation for future medical bridge courses and professional courses, a web-based medical morphology teaching team, mainly including teachers of courses in Histology and Embryology and Pathology, was established. ObjectiveThis study aimed to explore a new teaching mode of Histology and Embryology and Pathology courses during the COVID-19 pandemic and to illustrate its feasibility and acceptability. MethodsFrom March to July 2020, our team selected clinical medicine undergraduate students who started their studies in 2018 and 2019 as recipients of web-based teaching. Meanwhile, nursing undergraduate students who started their studies in 2019 and 2020 were selected for traditional offline teaching as the control group. For the web-based teaching, our team used the Xuexi Tong platform as the major platform to realize a new “seven-in-one” teaching method (ie, videos, materials, chapter tests, interactions, homework, live broadcasts, and case analysis/discussion). This new teaching mode involved diverse web-based teaching methods and contents, including flipped classroom, screen-to-screen experimental teaching, a drawing competition, and a writing activity on the theme of “What I Know About COVID-19.” When the teaching was about to end, a questionnaire was administered to obtain feedback regarding the teaching performance. In the meantime, the final written pathology examination results of the web-based teaching and traditional offline teaching groups were compared to examine the mastery of knowledge of the students. ResultsUsing the Xuexi Tong platform as the ...
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	370
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	JMIR Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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