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Article ; Online: Filling gaps in experiences religious understanding of people living with cancer in palliative care: a phenomenological qualitative study.

Silva, Hellen Luiza Meireles / Valério, Pedro Henrique Martins / Barreira, Cristiano Roque Antunes / Peria, Fernanda Maris

BMC palliative care

2023 Volume 22, Issue 1, Page(s) 127

Abstract: Background: According to a phenomenology of contemporary religion, the analysis of religious experiences finds that they are part of an individual's search for something powerful that overcomes him seeking not only a need, but the meaning of all ... ...

Abstract	Background: According to a phenomenology of contemporary religion, the analysis of religious experiences finds that they are part of an individual's search for something powerful that overcomes him seeking not only a need, but the meaning of all existence. The present study aims to contribute to a deeper understanding of the religious experiences of people living with cancer in palliative care (PC) and fill gaps in access to experience, with regard to how it was properly lived. Methods: A qualitative, phenomenological, cross-sectional study was conducted with 14 people living with cancer undergoing PC at two outpatient clinics of a public hospital. The experiences were accessed through in-depth interviews and the results were analysed according to the principles of classical phenomenology. Results: The patients confidently surrendered to the divine, attributing to it the power of continuity of life or not, which sustained them and launched them into horizons of hope, directing them to possibilities of achieving meaning in life, which it fed back their faith and to continue living, opening them up to an intense perception of the value of life. Conclusions: The religious positions of confident surrender to the divine, to his will and a belief in his intervention, regardless of the outcome, opened possibilities to patients for the belief in the continuity of life by the power of faith. This position allowed the patients in this study to visualize achievements in the present and in the future, opening a horizon of hope, meaning and value of living. This study showed how this elements are presented and sustained, providing subsidies to health professionals seeking to provide more holistic care.
MeSH term(s)	Male ; Humans ; Palliative Care ; Cross-Sectional Studies ; Hospice and Palliative Care Nursing ; Neoplasms/therapy ; Ambulatory Care Facilities
Language	English
Publishing date	2023-09-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2091556-1
ISSN	1472-684X ; 1472-684X
ISSN (online)	1472-684X
ISSN	1472-684X
DOI	10.1186/s12904-023-01254-w
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Article ; Online: Colorimetric detection of Pseudomonas aeruginosa by aptamer-functionalized gold nanoparticles.

Schmitz, Fernanda Raquel Wust / Cesca, Karina / Valério, Alexsandra / de Oliveira, Débora / Hotza, Dachamir

Applied microbiology and biotechnology

2022

Abstract: Novel rapid methodologies for the detection of bacteria have been recently investigated and applied. In hospital environments, infections by pathogens are very common and can cause serious health problems. Pseudomonas aeruginosa is one of the most common ...

Abstract	Novel rapid methodologies for the detection of bacteria have been recently investigated and applied. In hospital environments, infections by pathogens are very common and can cause serious health problems. Pseudomonas aeruginosa is one of the most common bacteria, which can grow in hospital equipment such as catheters and respirators. Even at low concentrations, it can cause severe infections as it is resistant to antibiotics and other treatments. Based on this subject's relevance, this work aimed to develop a colorimetric biosensor using aptamer-functionalized gold nanoparticles for identifying P. aeruginosa. The detection mechanism is based on the color change of gold nanoparticles (AuNPs) from red to blue-purple through NaCl induction after bacteria incubation and aptamer-target binding. First, AuNPs were synthesized and characterized. The influence of aptamer and sodium chloride concentration on the agglomeration of AuNPs was investigated. Optimization of aptamer concentration and salt addition were performed. The best condition for detection was 5 µM aptamers and 200 mM of NaCl. In this case, P. aeruginosa was detected after 5 h for concentrations from 10
Language	English
Publishing date	2022-11-24
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-022-12283-5
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Article ; Online: Amyloid-beta-related angiitis: a treatable rapidly progressive dementia.

Nasir, Memoona / Nortey, Donald / Malek, Naveed / Valerio, Fernanda / Chaudhuri, Abhijit

Practical neurology

2022 Volume 22, Issue 3, Page(s) 228–230

Abstract: A 73-year-old woman developed cognitive decline over 1 year. MR scan of the brain showed a focal asymmetrical leukoencephalopathy involving the right frontal, temporal, parietal and occipital lobes. Extensive laboratory investigations found no cause but ... ...

Abstract	A 73-year-old woman developed cognitive decline over 1 year. MR scan of the brain showed a focal asymmetrical leukoencephalopathy involving the right frontal, temporal, parietal and occipital lobes. Extensive laboratory investigations found no cause but brain biopsy identified amyloid-beta-related angiitis (ABRA), a potentially treatable cause of rapid-onset dementia. We gave intravenous methylprednisolone and then two courses of intravenous cyclophosphamide, after which her cognitive skills gradually but significantly improved over several months.
MeSH term(s)	Aged ; Amyloid beta-Peptides/metabolism ; Biopsy ; Brain/pathology ; Dementia/complications ; Dementia/diagnostic imaging ; Dementia/drug therapy ; Female ; Humans ; Vasculitis/pathology
Chemical Substances	Amyloid beta-Peptides
Language	English
Publishing date	2022-03-09
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2170881-2
ISSN	1474-7766 ; 1474-7758
ISSN (online)	1474-7766
ISSN	1474-7758
DOI	10.1136/practneurol-2021-003263
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Article ; Online: Colorimetric detection of Pseudomonas aeruginosa by aptamer-functionalized gold nanoparticles

Schmitz, Fernanda Raquel Wust / Cesca, Karina / Valério, Alexsandra / de Oliveira, Débora / Hotza, Dachamir

Appl Microbiol Biotechnol. 2023 Jan., v. 107, no. 1 p.71-80

2023

Abstract	Novel rapid methodologies for the detection of bacteria have been recently investigated and applied. In hospital environments, infections by pathogens are very common and can cause serious health problems. Pseudomonas aeruginosa is one of the most common bacteria, which can grow in hospital equipment such as catheters and respirators. Even at low concentrations, it can cause severe infections as it is resistant to antibiotics and other treatments. Based on this subject’s relevance, this work aimed to develop a colorimetric biosensor using aptamer-functionalized gold nanoparticles for identifying P. aeruginosa. The detection mechanism is based on the color change of gold nanoparticles (AuNPs) from red to blue-purple through NaCl induction after bacteria incubation and aptamer-target binding. First, AuNPs were synthesized and characterized. The influence of aptamer and sodium chloride concentration on the agglomeration of AuNPs was investigated. Optimization of aptamer concentration and salt addition were performed. The best condition for detection was 5 µM aptamers and 200 mM of NaCl. In this case, P. aeruginosa was detected after 5 h for concentrations from 10⁸ to 10⁵ CFU mL⁻¹, being 10⁵ and 10⁴ CFU mL⁻¹ the detection limit for color change by the naked eye and UV–Vis spectrometry, respectively. In addition, other bacteria such as E. coli, S. typhimurium, and Enterobacteriaceae bacterium were also detected with color changing from red to gray. Finally, it was confirmed that the salt incubation time can be 2 h, and that the ideal aptamer concentration is 5 µM. Thus, the colorimetric analysis can be a simple and fast detection method for P. aeruginosa in the range of 10⁸ to 10⁵ CFU mL⁻¹ to the naked eye. KEY POINTS: • A new method for rapid detection of Pseudomonas aeruginosa • Aptamers conjugated with gold nanoparticles allow pathogen detection by colorimetry • No need for previous surface modification of nanoparticles
Keywords	Escherichia coli ; Pseudomonas aeruginosa ; bacteria ; biosensors ; color ; colorimetry ; detection limit ; hospitals ; microbial detection ; nanogold ; nanoparticles ; oligonucleotides ; rapid methods ; sodium chloride ; ultraviolet-visible spectroscopy
Language	English
Dates of publication	2023-01
Size	p. 71-80.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-022-12283-5
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Article ; Online: Social isolation leads to mild social recognition impairment and losses in brain cellularity.

Guimarães, Daniel Menezes / Valério-Gomes, Bruna / Vianna-Barbosa, Rodrigo Jorge / Oliveira, Washington / Neves, Gilda Ângela / Tovar-Moll, Fernanda / Lent, Roberto

Brain structure & function

2023 Volume 228, Issue 9, Page(s) 2051–2066

Abstract: Chronic social stress is a significant risk factor for several neuropsychiatric disorders, mainly major depressive disorder (MDD). In this way, patients with clinical depression may display many symptoms, including disrupted social behavior and anxiety. ... ...

Abstract	Chronic social stress is a significant risk factor for several neuropsychiatric disorders, mainly major depressive disorder (MDD). In this way, patients with clinical depression may display many symptoms, including disrupted social behavior and anxiety. However, like many other psychiatric diseases, MDD has a very complex etiology and pathophysiology. Because social isolation is one of the multiple depression-inducing factors in humans, this study aims to understand better the link between social stress and MDD using an animal model based on social isolation after weaning, which is known to produce social stress in mice. We focused on cellular composition and white matter integrity to establish possible links with the abnormal social behavior that rodents isolated after weaning displayed in the three-chamber social approach and recognition tests. We used the isotropic fractionator method to assess brain cellularity, which allows us to robustly estimate the number of oligodendrocytes and neurons in dissected brain regions. In addition, diffusion tensor imaging (DTI) was employed to analyze white matter microstructure. Results have shown that post-weaning social isolation impairs social recognition and reduces the number of neurons and oligodendrocytes in important brain regions involved in social behavior, such as the anterior neocortex and the olfactory bulb. Despite the limitations of animal models of psychological traits, evidence suggests that behavioral impairments observed in patients might have similar biological underpinnings.
MeSH term(s)	Humans ; Mice ; Animals ; Depressive Disorder, Major ; Diffusion Tensor Imaging/methods ; Brain ; White Matter ; Social Isolation
Language	English
Publishing date	2023-09-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2273162-3
ISSN	1863-2661 ; 1863-2653
ISSN (online)	1863-2661
ISSN	1863-2653
DOI	10.1007/s00429-023-02705-z
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Article ; Online: Personal positioning of oncology patients in palliative care: a mixed-methods study.

Silva, Hellen Luiza Meireles / Valério, Pedro Henrique Martins / Barreira, Cristiano Roque Antunes / Peria, Fernanda Maris

BMC palliative care

2022 Volume 21, Issue 1, Page(s) 34

Abstract: Background: Advanced oncological disease requires comprehensive health care, although attention is predominantly paid to the physical dimension of care. The consideration of personal positioning encompasses other dimensions of patients' management of ... ...

Abstract	Background: Advanced oncological disease requires comprehensive health care, although attention is predominantly paid to the physical dimension of care. The consideration of personal positioning encompasses other dimensions of patients' management of their illness, such as existential management and expanding forms of care. The objective of this study was to understand the personal positioning of cancer patients in palliative care. Methods: This was a cross-sectional study using the mixed convergent parallel method. The sample consisted of 71 cancer patients in palliative care, of whom 14 participated in the qualitative and quantitative portions and 57 participated in only the quantitative portion. Phenomenological interviews were performed, and qualitative and quantitative methods were used to collect meaning of life (PIL-Test), quality of life (EORTC QLQ C-30), anxiety and depression (HADS) and sociodemographic data. The interview results were analysed according to the principles of classical phenomenology, and the quantitative data were analysed using the generalized structural equations model. Results: The results showed that the patients turned to living, focusing on their possibilities and distancing themselves from the impact of the illness and the factuality of death, which the patients themselves associated with not succumbing to depression, a condition whose signs were exhibited by 21% of the sample. Sustaining this positioning required a tenacious fight, which feeds on sensitivity to life. Linked to this position was the belief in the continuation of life through religious faith, together with the patients' realization of the meaning of their lives. In this same direction, there was a direct association between awareness of the meaning of life and increased scores on the functional scales (p < 0.01) and decreased scores for symptoms (p < 0.01), anxiety (p = 0.02) and depression (p < 0.01). The last element that emerged and structured this experience was the intense will to live and a sense of the value of life. Conclusions: Through the use of mixed methods, the present study recognized the existential positioning of cancer patients in palliative care. This understanding can aid in the realization of more comprehensive and meaningful treatment plans and can contribute to the goal of achieving humanization in this area of treatment.
MeSH term(s)	Cross-Sectional Studies ; Humans ; Neoplasms/therapy ; Palliative Care ; Patient Positioning/methods ; Qualitative Research
Language	English
Publishing date	2022-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2091556-1
ISSN	1472-684X ; 1472-684X
ISSN (online)	1472-684X
ISSN	1472-684X
DOI	10.1186/s12904-022-00916-5
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Article ; Online: Avaliação das concentrações de nutrientes e sólidos na bacia hidrográfica do Igarapé Belmont, Porto Velho/RO

Fernanda Bay Hurtado / Lídia Bruna Teles Gonzaga / Valério Magalhães Lopes

Diversitas Journal, Vol 6, Iss

2021 Volume 4

Abstract: As atividades antrópicas alteram os processos naturais dos recursos hídricos, gerando modificações na quantidade e qualidade das águas, principalmente em bacias hidrográficas urbanas. Neste contexto, o objetivo deste trabalho foi avaliar a qualidade da ... ...

Abstract	As atividades antrópicas alteram os processos naturais dos recursos hídricos, gerando modificações na quantidade e qualidade das águas, principalmente em bacias hidrográficas urbanas. Neste contexto, o objetivo deste trabalho foi avaliar a qualidade da água em área antropizada e em uma floresta urbana, mediante análise de parâmetros físico-químicos na bacia do Igarapé Belmont, situado no município de Porto Velho (RO), afluente do Rio Madeira. O monitoramento foi realizado em seis pontos, a montante, a jusante e no interior da unidade de conservação, Parque Natural Municipal de Porto Velho, com frequência trimestral, nas estações chuvosa e seca, entre março a dezembro/2019. Os parâmetros analisados foram o nitrogênio (nitrito, nitrato e nitrogênio amoniacal), fósforo total e sólido total. Foram realizados o tratamento estatístico dos dados, de forma descritiva e com a aplicação da correlação de Pearson. Verificou-se forte influência temporal e espacial na qualidade das águas, com maiores concentrações no período de seca (nitrogênio amoniacal e fósforo total), no ponto de coleta inserido em área antropizada, ficaram acima do estabelecido pela resolução do CONAMA nº 357/2005. Pode-se afirmar, também, segundo o coeficiente de Pearson, que existiu forte correlação entre os sólidos totais e os demais parâmetros analisados. Com base na análise dos dados obtidos nesta pesquisa alguns nutrientes têm o aumento na concentração devido á área de influência urbana contida na bacia hidrográfica e devido ao período sazonal.
Keywords	Education ; L ; Science ; Q ; Social Sciences ; H
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Universidade Estadual de Alagoas
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An overview and future prospects on aptamers for food safety.

Schmitz, Fernanda Raquel Wust / Valério, Alexsandra / de Oliveira, Débora / Hotza, Dachamir

Applied microbiology and biotechnology

2020 Volume 104, Issue 16, Page(s) 6929–6939

Abstract: Introduction: Many bacteria are responsible for infections in humans and plants, being found in vegetables, water, and medical devices. Most bacterial detection methods are time-consuming and take days to give the result. Aptamers are a promising ... ...

Abstract	Introduction: Many bacteria are responsible for infections in humans and plants, being found in vegetables, water, and medical devices. Most bacterial detection methods are time-consuming and take days to give the result. Aptamers are a promising alternative for a quick and reliable measurement technique to detect bacteria present in food products. Selected aptamers are DNA or RNA oligonucleotides that can bind with bacteria or other molecules with affinity and specificity for the target cells by the SELEX or cell-SELEX technique. This method is based on some rounds to remove the non-ligand oligonucleotides, leaving the aptamers specific to bind to the selected bacteria. Compared with conventional methodologies, the detection approach using aptamers is a rapid, low-cost form of analysis. Objective: This review summarizes obtention methods and applications of aptamers in the food industry and biotechnology. Besides, different techniques with aptamers are presented, which enable more effective target detection. Conclusion: Applications of aptamers as biosensors, or the association of aptamers with nanomaterials, may be employed in analyses by colorimetric, fluorescence, or electrical devices. Additionally, more efficient ways of sample preparation are presented, which can support food safety to provide human health, with a low-cost method for contaminant detection. Key points • Aptamers are promising for detecting contaminants outbreaks. • Studies are needed to identify aptamers for different targets.
MeSH term(s)	Aptamers, Nucleotide ; Bacteria/genetics ; Bacteria/isolation & purification ; Biosensing Techniques/methods ; Colorimetry/methods ; DNA/metabolism ; Fluorescence ; Food Safety/methods ; RNA/metabolism ; SELEX Aptamer Technique/economics ; SELEX Aptamer Technique/methods ; SELEX Aptamer Technique/trends
Chemical Substances	Aptamers, Nucleotide ; RNA (63231-63-0) ; DNA (9007-49-2)
Keywords	covid19
Language	English
Publishing date	2020-06-25
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-020-10747-0
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Article ; Online: Unveiling empathy: Transforming child neurodisability in the Brazilian context of poverty and violence.

Dos Santos, Gleidna Nascimento / Lima-Costa, Ariela Raissa / Otoni, Fernanda / Veiga, Heila Magali da Silva / Peres, Rodrigo Sanches / Azevedo, Adriano Valério / Antunes, Maria Cristina / Bonfá-Araujo, Bruno / Cortez, Pedro Afonso

Developmental medicine and child neurology

2023 Volume 66, Issue 4, Page(s) 541–542

MeSH term(s)	Child ; Humans ; Empathy ; Brazil ; Violence ; Disabled Persons ; Poverty
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Letter
ZDB-ID	80369-8
ISSN	1469-8749 ; 0012-1622
ISSN (online)	1469-8749
ISSN	0012-1622
DOI	10.1111/dmcn.15784
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Article ; Online: Desvendando a empatia: Transformando a neurodeficiência infantil no contexto brasileiro de vulnerabilidade psicossocial.

Dos Santos, Gleidna Nascimento / Lima-Costa, Ariela Raissa / Otoni, Fernanda / da Veiga, Heila Magali da Silva / Peres, Rodrigo Sanches / Azevedo, Adriano Valério / Antunes, Maria Cristina / Bonfá-Araujo, Bruno / Cortez, Pedro Afonso

Developmental medicine and child neurology

2023 Volume 66, Issue 4, Page(s) e55–e56

Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Letter
ZDB-ID	80369-8
ISSN	1469-8749 ; 0012-1622
ISSN (online)	1469-8749
ISSN	0012-1622
DOI	10.1111/dmcn.15786
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