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  1. Article ; Online: Commentary: The A-B-C's of H-I-T.

    Moran, Hellmuth R Muller / Arora, Rakesh C / Manji, Rizwan A

    Seminars in thoracic and cardiovascular surgery

    2021  Volume 34, Issue 2, Page(s) 581–582

    Language English
    Publishing date 2021-06-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 1038278-1
    ISSN 1532-9488 ; 1043-0679
    ISSN (online) 1532-9488
    ISSN 1043-0679
    DOI 10.1053/j.semtcvs.2021.05.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2747: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: SEAMARK: phase II study of first-line encorafenib and cetuximab plus pembrolizumab for MSI-H/dMMR

    Elez, Elena / Kopetz, Scott / Tabernero, Josep / Bekaii-Saab, Tanios / Taieb, Julien / Yoshino, Takayuki / Manji, Gulam / Fernandez, Kathrine / Abbattista, Antonello / Zhang, Xiaosong / Morris, Van K

    Future oncology (London, England)

    2023  Volume 20, Issue 11, Page(s) 653–663

    Abstract: Patients with ... ...

    Abstract Patients with both
    MeSH term(s) Humans ; Cetuximab/therapeutic use ; Proto-Oncogene Proteins B-raf/genetics ; Mutation ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Colonic Neoplasms ; Clinical Trials, Phase II as Topic ; Randomized Controlled Trials as Topic ; Antibodies, Monoclonal, Humanized ; Neoplastic Syndromes, Hereditary ; Sulfonamides ; Brain Neoplasms ; Carbamates
    Chemical Substances Cetuximab (PQX0D8J21J) ; pembrolizumab (DPT0O3T46P) ; encorafenib (8L7891MRB6) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Antibodies, Monoclonal, Humanized ; Sulfonamides ; Carbamates
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article ; Clinical Trial Protocol
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2022-1249
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6478: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: In Vitro Anticoccidial Activities of the Extract and Fractions of Garcinia kola (Heckel h.) Against Eimeria tenella Oocyst.

    Shetshak, Manji A / Jatau, Isa D / Suleiman, Muhammed M / Ameh, Matthew P / Gabriel, Ada / Akefe, Isaac O

    Recent patents on biotechnology

    2021  Volume 15, Issue 1, Page(s) 76–84

    Abstract: Background: Commercial poultry farming is expanding every day and contributing to the provision of affordable and high-quality protein. However, this sector is confronted with many diseases of which coccidiosis is among the most important. There are ... ...

    Abstract Background: Commercial poultry farming is expanding every day and contributing to the provision of affordable and high-quality protein. However, this sector is confronted with many diseases of which coccidiosis is among the most important. There are many registered patents affirming the health benefits of Garcinia kola in poultry.
    Objective: Evaluation of in vitro anticoccidial activities of the extracts and fractions of Garcinia kola against Eimeria tenella oocyst was carried out.
    Methods: Fresh seeds of G. kola were collected, dried under shade at room temperature, and pulverized using a mortar and a pestle. The powder was exhaustively extracted with a soxhlet apparatus using 70% methanol, and the crude methanol extract (CME) was concentrated to dryness using a rotary evaporator. The CME was further partitioned using butanol, ethylacetate, and n-hexane. The CME, butanol fraction (BTF), ethylacetate fraction (EAF), and hexane fraction (HXF) were concentrated in vacuo and tested for the presence of phytochemical constituents using standard procedures. Similarly, the CME, butanol, ethyl acetate, and hexane fractions were evaluated in vitro for oocyst sporulation inhibition.
    Results: Phytochemical analysis revealed the presence of cardiac glycosides, saponins, carbohydrates, steroids/triterpenes, tannins, flavonoids, and alkaloids in the CME and BTF. The EAF contains all the metabolites mentioned except saponins. Similarly, HXF contains only cardiac glycosides, tannins, and steroids/ triterpenes. The CME and BTF caused a concentration-dependent increase in the inhibition of sporulation of unsporulated oocysts of E. tenella. In the acute toxicity studies, the CME did not produce any toxic effect or mortality at doses between 10 and 5000 mg/kg. The CME was then considered safe, and the LD50 was assumed to be >5000 mg/kg.
    Conclusion: The data obtained in this study suggested that the crude methanol extract (CME) of G. kola could be an appreciable beneficial effect as an anticoccidial agent against Eimeria tenella oocyst.
    MeSH term(s) Animals ; Chickens ; Eimeria tenella ; Garcinia kola ; Oocysts ; Patents as Topic ; Plant Extracts/pharmacology
    Chemical Substances Plant Extracts
    Language English
    Publishing date 2021-01-29
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 2212-4012
    ISSN (online) 2212-4012
    DOI 10.2174/1872208315666210129095213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Influence of peripheral magnetic stimulation of soleus muscle on H and M waves.

    Matsuda, Tadamitsu / Kurayama, Taichi / Tagami, Miki / Fujino, Yuji / Manji, Atsushi / Kusumoto, Yasuaki / Amimoto, Kazu

    Journal of physical therapy science

    2018  Volume 30, Issue 5, Page(s) 716–718

    Abstract: ... peripheral magnetic stimulation for 10 min. Pre-and post-stimulation latencies and amplitudes of H- and M ... 35.8 ± 1.3 vs. 35.8 ± 1.1 mV, respectively) of H-waves were similar. Pre-stimulation latencies of M ... stimulation on the amplitude and latency of the H-reflex suggests that magnetic stimulation did not activate ...

    Abstract [Purpose] This study evaluated the effects of repetitive peripheral magnetic stimulation of the soleus muscle on spinal cord and peripheral motor nerve excitability. [Subjects and Methods] Twelve healthy adults (mean age 22 years) who provided written informed consent were administered repetitive peripheral magnetic stimulation for 10 min. Pre-and post-stimulation latencies and amplitudes of H- and M-waves of the soleus muscle were measured using electromyography and compared using paired t-tests. [Results] Pre- and post-stimulation latencies (28.3 ± 3.3 vs. 29.1 ± 1.3 ms, respectively) and amplitudes (35.8 ± 1.3 vs. 35.8 ± 1.1 mV, respectively) of H-waves were similar. Pre-stimulation latencies of M-waves were significantly higher than post-stimulation latencies (6.1 ± 2.2 vs. 5.0 ± 0.9 ms, respectively), although pre- and post-stimulation amplitudes were similar (12.2 ± 1.4 vs. 12.2 ± 1.3 mV, respectively). Motor neuron excitability, based on the excitability of motor nerves and peripheral nerve action, was increased by M-waves following magnetic stimulation. [Conclusion] The lack of effect of magnetic stimulation on the amplitude and latency of the H-reflex suggests that magnetic stimulation did not activate sensory nerve synapses of α motor neurons in the spinal cord. However, because motor nerves were stimulated together with sensory nerves, the increased H-wave amplitude may have reflected changes in peripheral rather than in α motor nerves.
    Language English
    Publishing date 2018-05-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.30.716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Toxic neuropathies.

    Rossor, Alexander M / Manji, Hadi

    Current opinion in neurology

    2023  Volume 36, Issue 5, Page(s) 402–409

    Abstract: Purpose of review: Immunotherapy has had a significant impact on the treatment of an increasing number of cancers as well as in inflammatory, rheumatological and gastroenterological conditions.Recreational nitrous oxide use is now a global epidemic. ... ...

    Abstract Purpose of review: Immunotherapy has had a significant impact on the treatment of an increasing number of cancers as well as in inflammatory, rheumatological and gastroenterological conditions.Recreational nitrous oxide use is now a global epidemic. Linezolid is now recommended for the treatment of drug-resistant tuberculosis (TB); neuropathy is a significant cause of morbidity.Global warming will result in increasing toxin exposure, such as ciguatera, in previously unaffected areas.
    Recent findings: With increasing experience, the pathophysiology underlying the neuropathic complications of these drugs has become clear with guidelines now available, for the complications of immune check-point inhibitors and nitrous oxide toxicity. The optimum dose and duration of treatment for resistant TB with regimens, including linezolid, has been ascertained.
    Summary: Although neuropathic complications with immunotherapy are relatively rare, it is essential that they are recognized and treated early. Nitrous oxide toxicity should be in the differential diagnosis for all patients, particularly those of younger age, presenting with a neuropathy or myleo-neuropathy. Ciguatera toxicity is under recognized and its geographical spread will increase due to global warming. Further research is necessary on the mechanisms and treatment of both acute and chronic effects, which at present, are only symptomatic.
    MeSH term(s) Humans ; Ciguatera Poisoning ; Linezolid ; Nitrous Oxide/toxicity ; Polyneuropathies ; Immunotherapy
    Chemical Substances Linezolid (ISQ9I6J12J) ; Nitrous Oxide (K50XQU1029)
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000001193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2524: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Neonatal herpes simplex virus encephalitis with intracranial bleeding in a newborn baby with concurrent rhesus incompatibility.

    Clemence, Pascal / Mariki, Haika / Mkony, Martha / Manji, Karim Premji

    BMJ case reports

    2024  Volume 17, Issue 3

    Abstract: We report a baby with neonatal herpes simplex virus (HSV) encephalitis concurrent with Rrhesus (Rh) incompatibility. He was delivered by a Ggravida 2 mother with a history of miscarriage in her previous pregnancy at a gestation age of 4 months. She had ... ...

    Abstract We report a baby with neonatal herpes simplex virus (HSV) encephalitis concurrent with Rrhesus (Rh) incompatibility. He was delivered by a Ggravida 2 mother with a history of miscarriage in her previous pregnancy at a gestation age of 4 months. She had Bblood group 0 and Rrhesus negative. The baby was noticed to have jaundice on day one1 of life accompanied by generalised petechiae on the face and upper chest. A full blood picture revealed severe anaemia and severe thrombocytopaenia and HSV 1/2 IgM was positive. MRI of the brain showed multiple extensive haemorrhagic lesions on the frontal-temporal regions.
    MeSH term(s) Male ; Infant, Newborn ; Infant ; Pregnancy ; Female ; Humans ; Herpes Simplex/complications ; Herpes Simplex/diagnosis ; Herpes Simplex/drug therapy ; Encephalitis, Herpes Simplex/complications ; Pregnancy Complications, Infectious/diagnosis ; Simplexvirus
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-255822
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Thesis: Investigation of indicators of mechanical stress in cardiac fibrosis

    Lam, Jennifer Manji / Pfannkuche, Kurt Paul / Rosenkranz, Stephan

    2019  

    Institution Institut für Neurophysiologie
    Author's details vorgelegt von Jennifer Manji Lam ; 1. Berichterstatter: Privatdozent Dr. rer. medic. K. Pfannkuche, 2. Berichterstatter: Professor Dr. med. S.H. Rosenkranz ; aus dem Zentrum Physiologie und Pathophysiologie der Universität zu Köln, Institut frü Neurophysiologie
    Subject code 610
    Language English
    Size 81 Seiten, Illustrationen, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2019
    HBZ-ID HT020062369
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 D 582 order for loan Magazin

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  8. Article ; Online: Neurocristic cutaneous hamartoma of the scalp with disseminated melanocytic nevi.

    Mariki, Haika / Mwamanenge, Naomi / Mkony, Martha / Manji, Karim Premji

    BMJ case reports

    2023  Volume 16, Issue 2

    Abstract: We report a newborn with neurocristic cutaneous hamartoma of the scalp. He was delivered at term via caesarean section due to a previous scar and presented at the neonatal unit on the fifth day with giant congenital nevi on the scalp and disseminated ... ...

    Abstract We report a newborn with neurocristic cutaneous hamartoma of the scalp. He was delivered at term via caesarean section due to a previous scar and presented at the neonatal unit on the fifth day with giant congenital nevi on the scalp and disseminated melanocytic nevi throughout the body. The MRI scan of the brain showed a defect at the occipital region with herniation of the occipital lobes and ventricles through the defect, with infratentorial brain parenchyma exhibiting normal signal return and intact cerebellum. The initial diagnosis was a giant haemangioma, which has ruptured, and possible cytomegalovirus infection, causing 'blueberry muffin' syndrome. On follow-up, the hamartoma/haemangioma-like mass regressed, and a large well-demarcated melanotic patch on scalp and large encephalocele were seen. This infant is now being scheduled for neurosurgical intervention.
    MeSH term(s) Pregnancy ; Male ; Infant ; Infant, Newborn ; Humans ; Female ; Scalp ; Cesarean Section ; Nevus, Pigmented/diagnostic imaging ; Nevus, Pigmented/congenital ; Skin Diseases/congenital ; Skin Neoplasms/diagnosis ; Hamartoma/diagnostic imaging
    Language English
    Publishing date 2023-02-14
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-253156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Osteogenesis imperfecta type VIII: highlighting the need for genetic testing.

    Mariki, Haika / Muze, Kandi / Mussa, Fatima / Manji, Karim Premji

    BMJ case reports

    2023  Volume 16, Issue 7

    Abstract: We report a severe form of osteogenesis imperfecta (OI) type VIII from a lower-middle income country. This is the first case report of this type in Tanzania. The term neonate was delivered normally via spontaneous vaginal delivery and presented at the ... ...

    Abstract We report a severe form of osteogenesis imperfecta (OI) type VIII from a lower-middle income country. This is the first case report of this type in Tanzania. The term neonate was delivered normally via spontaneous vaginal delivery and presented at the neonatal unit with features of shortened limb girdles and macrocephaly. The long bones had multiple fractures. He was diagnosed clinically to have OI or a type of metaphysial dysplasia. A plain X-ray showed multiple fractures of the long bones. The eyes did not have blue sclerae. Clinically, the generic diagnosis of OI was made.Genetic testing revealed typical prolyl 3-hydroxylase 1 (
    MeSH term(s) Male ; Infant, Newborn ; Female ; Humans ; Osteogenesis Imperfecta/diagnosis ; Osteogenesis Imperfecta/genetics ; Fractures, Multiple ; Genetic Testing ; Osteochondrodysplasias ; Mutation
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-253155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Caudal regression syndrome without maternal diabetes mellitus.

    Mwamanenge, Naomi / Mariki, Haika / Mkony, Martha / Manji, Karim Premji

    BMJ case reports

    2023  Volume 16, Issue 3

    Abstract: Caudal regression is a rare complex disorder impacting the formation of the caudal segment of the spine and spinal cord. We report a preterm newborn baby who was referred to us due to respiratory distress syndrome and bilateral knee contracture. A ... ...

    Abstract Caudal regression is a rare complex disorder impacting the formation of the caudal segment of the spine and spinal cord. We report a preterm newborn baby who was referred to us due to respiratory distress syndrome and bilateral knee contracture. A clinical examination and a radiographic skeletal survey revealed a short spinal cord with complete agenesis of the lumbar, sacrum and coccygeal spine, and hypoplastic iliac bones with bilateral knee contractures. The mother did not have diabetes. The long-term outcome is not well-known in our set-up.
    MeSH term(s) Pregnancy ; Infant, Newborn ; Female ; Humans ; Sacrum/diagnostic imaging ; Spinal Cord ; Abnormalities, Multiple ; Spinal Diseases ; Diabetes, Gestational ; Nervous System Malformations
    Language English
    Publishing date 2023-03-23
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-253136
    Database MEDical Literature Analysis and Retrieval System OnLINE

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