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  1. Book ; Online: Genere, disabilità, linguaggio : Progetti e prospettive a Milano

    Brambilla, Marina / D'Amico, Marilisa / Crestani, Valentina / Nardocci, Costanza

    2021  

    Keywords Gender studies, gender groups ; Disability: social aspects ; Gender ; Disability ; German, Italian ; Language ; Non-Discrimination ; Diversity ; Inclusiveness
    Size 1 electronic resource (226 pages)
    Publisher FrancoAngeli
    Publishing place Milan
    Document type Book ; Online
    Note Italian ; Open Access
    HBZ-ID HT021291903
    ISBN 9788835133421 ; 8835133424
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Nine-Year Nationwide Environmental Surveillance of Hepatitis E Virus in Urban Wastewaters in Italy (2011-2019).

    Iaconelli, Marcello / Bonanno Ferraro, Giusy / Mancini, Pamela / Suffredini, Elisabetta / Veneri, Carolina / Ciccaglione, Anna Rita / Bruni, Roberto / Della Libera, Simonetta / Bignami, Francesco / Brambilla, Massimo / De Medici, Dario / Brandtner, David / Schembri, Pietro / D'Amato, Stefania / La Rosa, Giuseppina

    International journal of environmental research and public health

    2020  Volume 17, Issue 6

    Abstract: Hepatitis E virus (HEV) is an emerging causative agent of acute hepatitis worldwide. To provide ...

    Abstract Hepatitis E virus (HEV) is an emerging causative agent of acute hepatitis worldwide. To provide insights into the epidemiology of HEV in Italy, a large-scale investigation was conducted into urban sewage over nine years (2011-2019), collecting 1374 sewage samples from 48 wastewater treatment plants located in all the 20 regions of Italy. Broadly reactive primers targeting the ORF1 and ORF2 regions were used for the detection and typing of HEV, followed by Sanger and next generation sequencing (NGS). Real-time RT-qPCR was also used to attempt quantification of positive samples. HEV RNA detection occurred in 74 urban sewage samples (5.4%), with a statistically significant higher frequency (7.1%) in central Italy. Fifty-six samples were characterized as G3 strains and 18 as G1. While the detection of G3 strains occurred in all the surveillance period, G1 strains were mainly detected in 2011-2012, and never in 2017-2019. Typing was achieved in 2 samples (3f subtype). Viral concentrations in quantifiable samples ranged from 1.2 × 10
    MeSH term(s) Environmental Monitoring ; Hepatitis E ; Hepatitis E virus ; Humans ; Italy ; Phylogeny ; RNA, Viral ; Wastewater/virology
    Chemical Substances RNA, Viral ; Waste Water
    Language English
    Publishing date 2020-03-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph17062059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer.

    Sabatini, Maria Elisa / Compagnoni, Micaela / Maffini, Fausto / Miccolo, Claudia / Pagni, Fabio / Lombardi, Mariano / Brambilla, Virginia / Lepanto, Daniela / Tagliabue, Marta / Ansarin, Mohssen / Citro, Simona / Chiocca, Susanna

    Frontiers in molecular biosciences

    2022  Volume 9, Page(s) 940449

    Abstract: Functional loss of E-cadherin is frequent during tumor progression and occurs through a variety ... of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more ... in hampering the HPV-mediated E-cadherin cleavage in HNC. ...

    Abstract Functional loss of E-cadherin is frequent during tumor progression and occurs through a variety of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more malignant phenotype promoting Epithelial to Mesenchymal Transition (EMT). The UBC9/SUMO pathway has been also shown to be involved in the regulation of EMT in different cancers. Here we found an increased expression of UBC9 in the progression of Head and Neck Cancer (HNC) and uncovered a role for UBC9/SUMO in hampering the HPV-mediated E-cadherin cleavage in HNC.
    Language English
    Publishing date 2022-08-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2022.940449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Algoritmo de detección e Interfaz gráfica de usuario diseñados en Python para autocolimador digital

    Guillermo Juan Bergues / Clemar Schürrer / Nancy Brambilla

    Tecnología y Ciencia, Iss 41, Pp 75-

    2021  Volume 90

    Abstract: En este trabajo se presenta la interfaz gráfica de usuario y se explica el modelo de detección de líneas diseñado en Python para la misma. Luego de los resultados de la calibración del instrumento electrónico se procedió a crear la interfaz gráfica de ... ...

    Abstract En este trabajo se presenta la interfaz gráfica de usuario y se explica el modelo de detección de líneas diseñado en Python para la misma. Luego de los resultados de la calibración del instrumento electrónico se procedió a crear la interfaz gráfica de usuario en python en base al prototipo de la GUI construida en Matlab para lo cual se tuvo que escribir el algoritmo de detección en el mismo lenguaje. El instrumento electrónico está construido con un autocolimador analógico comercial, Nikon 6D, y una interfaz visual ad hoc.
    Keywords autocolimador electrónico ; python ; detección de líneas ; interfaz visual ; gui ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Science (General) ; Q1-390
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Universidad Tecnologica Nacional
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The UBC9/SUMO pathway affects E-cadherin cleavage in HPV-positive head and neck cancer

    Maria Elisa Sabatini / Micaela Compagnoni / Fausto Maffini / Claudia Miccolo / Fabio Pagni / Mariano Lombardi / Virginia Brambilla / Daniela Lepanto / Marta Tagliabue / Mohssen Ansarin / Simona Citro / Susanna Chiocca

    Frontiers in Molecular Biosciences, Vol

    2022  Volume 9

    Abstract: Functional loss of E-cadherin is frequent during tumor progression and occurs through a variety ... of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more ... in hampering the HPV-mediated E-cadherin cleavage in HNC. ...

    Abstract Functional loss of E-cadherin is frequent during tumor progression and occurs through a variety of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more malignant phenotype promoting Epithelial to Mesenchymal Transition (EMT). The UBC9/SUMO pathway has been also shown to be involved in the regulation of EMT in different cancers. Here we found an increased expression of UBC9 in the progression of Head and Neck Cancer (HNC) and uncovered a role for UBC9/SUMO in hampering the HPV-mediated E-cadherin cleavage in HNC.
    Keywords head and neck cancer ; head and neck squamous cell carcinoma ; HPV ; SUMO ; Ubc9 ; E-cadherin ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: La citta e i chierici.

    Brambilla, E

    Societa e storia

    2001  Volume 24, Issue 92, Page(s) 339–343

    Title translation The city and clerics.
    MeSH term(s) Cities/economics ; Cities/ethnology ; Cities/history ; Cities/legislation & jurisprudence ; Clergy/economics ; Clergy/history ; Clergy/legislation & jurisprudence ; Clergy/psychology ; Culture ; Europe/ethnology ; Fund Raising/economics ; Fund Raising/history ; Fund Raising/legislation & jurisprudence ; Hierarchy, Social ; History, 16th Century ; History, 17th Century ; Religion/history ; Secularism/history ; Social Class ; Urban Health/history ; Urban Population/history ; Urban Renewal/economics ; Urban Renewal/education ; Urban Renewal/history ; Urban Renewal/legislation & jurisprudence ; Volunteers/education ; Volunteers/history ; Volunteers/legislation & jurisprudence ; Volunteers/psychology
    Language Italian
    Publishing date 2001
    Publishing country Italy
    Document type Historical Article ; Journal Article
    ISSN 0391-6987
    ISSN 0391-6987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Computational Analysis of Dengue Virus Envelope Protein (E) Reveals an Epitope with Flavivirus Immunodiagnostic Potential in Peptide Microarrays.

    Bergamaschi, Greta / Fassi, Enrico M A / Romanato, Alessandro / D'Annessa, Ilda / Odinolfi, Maria Teresa / Brambilla, Dario / Damin, Francesco / Chiari, Marcella / Gori, Alessandro / Colombo, Giorgio / Cretich, Marina

    International journal of molecular sciences

    2019  Volume 20, Issue 8

    Abstract: ... we focused on the Dengue viral envelope protein (E); computational analyses ranging from extensive ...

    Abstract The mosquito-borne viral disease caused by the Dengue virus is an expanding global threat. Diagnosis in low-resource-settings and epidemiological surveillance urgently requires new immunoprobes for serological tests. Structure-based epitope prediction is an efficient method to design diagnostic peptidic probes able to reveal specific antibodies elicited in response to infections in patients' sera. In this study, we focused on the Dengue viral envelope protein (E); computational analyses ranging from extensive Molecular Dynamics (MD) simulations and energy-decomposition-based prediction of potentially immunoreactive regions identified putative epitope sequences. Interestingly, one such epitope showed internal dynamic and energetic properties markedly different from those of other predicted sequences. The epitope was thus synthesized as a linear peptide, modified for chemoselective immobilization on microarrays and used in a serological assay to discriminate Dengue-infected individuals from healthy controls. The synthetic epitope probe showed a diagnostic performance comparable to that of the full antigen in terms of specificity and sensitivity. Given the high level of sequence identity among different flaviviruses, the epitope was immune-reactive towards Zika-infected sera as well. The results are discussed in the context of the quest for new possible structure-dynamics-based rules for the prediction of the immunoreactivity of selected antigenic regions with potential pan-flavivirus immunodiagnostic capacity.
    MeSH term(s) Antibodies, Viral ; Computational Biology ; Cross Reactions/immunology ; Dengue/blood ; Dengue/immunology ; Dengue/virology ; Dengue Virus/immunology ; Dengue Virus/pathogenicity ; Epitope Mapping ; Epitopes/immunology ; Humans ; Molecular Dynamics Simulation ; Peptides/immunology ; Viral Envelope Proteins/immunology ; Zika Virus/immunology ; Zika Virus/pathogenicity ; Zika Virus Infection/blood ; Zika Virus Infection/immunology ; Zika Virus Infection/virology
    Chemical Substances Antibodies, Viral ; Epitopes ; Peptides ; Viral Envelope Proteins
    Language English
    Publishing date 2019-04-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms20081921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Increased Total Serum Immunoglobulin E in Children Developing Mycoplasma pneumoniae-related Extra-pulmonary Diseases.

    Poddighe, Dimitri / Comi, Elena Virginia / Brambilla, Ilaria / Licari, Amelia / Bruni, Paola / Marseglia, Gian Luigi

    Iranian journal of allergy, asthma, and immunology

    2018  Volume 17, Issue 5, Page(s) 490–496

    Abstract: ... of serum Immunoglobulin E (IgE) in a small group of these children. Here, we assessed total serum IgE ...

    Abstract Mycoplasma pneumoniae has been recognized to be involved in several extra-pulmonary diseases, but the underlying immunologic mechanisms are still largely unknown. Recently, we observed a significant elevation of serum Immunoglobulin E (IgE) in a small group of these children. Here, we assessed total serum IgE levels in children affected with Mycoplasma pneumoniae-related extra-pulmonary diseases. We prospectively collected the data of 162 children admitted to the hospital (because of respiratory infections or extra-pulmonary diseases) who were evaluated for Mycoplasma pneumoniae serology and total serum IgE levels, concomitantly. Based upon clinical and serology aspects, 3 groups of children were identified: I) with non-mycoplasma respiratory disease; II) with mycoplasma-related respiratory diseases; III) with extra-pulmonary diseases related to concomitant/recent Mycoplasma pneumoniae infection. Interestingly, children with Mycoplasma pneumoniae-related extra-pulmonary diseases showed a significant elevation of total serum IgE. In particular, patients developing Mycoplasma pneumoniae-related extra-pulmonary diseases (group III) showed significantly higher level of IgE than both previous groups (p<0.001 vs. group I; p<0.01 vs. group II). In conclusion, hospitalized children diagnosed with Mycoplasma pneumoniae-related extra-pulmonary diseases resulted to have significantly increased serum IgE compared to children developing respiratory illnesses only.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Immunoglobulin E/blood ; Infant ; Male ; Mycoplasma pneumoniae/physiology ; Myocarditis ; Pneumonia, Mycoplasma/immunology ; Prospective Studies ; Up-Regulation ; Urticaria ; Vasculitis
    Chemical Substances Immunoglobulin E (37341-29-0)
    Language English
    Publishing date 2018-10-09
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2488724-9
    ISSN 1735-1502
    ISSN 1735-1502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6806: Show issues Location:
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  9. Article: Il percorsi terapeutico del bambino e dell' adolescente con obesità grave.

    Valerio, G / Licenziati, M R / Tanas, R / Morino, G / Ambruzzi, A M / Balsamo, A / Brambilla, P / Bruzzi, P / Calcaterra, V / Crinò, A / De Falco, R / Franzese, A / Giordano, U / Grugni, G / Iaccarino Idelson, P / Iughetti, L / Maffeis, C / Manco, M / Miraglia Del Giudice, E /
    Mozzillo, E / Zito, E / Bernasconi, S

    Minerva pediatrica

    2012  Volume 64, Issue 4, Page(s) 413–431

    Abstract: Obesity is a complex public health issue. Recent data indicate the increasing prevalence and severity of obesity in children. Severe obesity is a real chronic condition for the difficulties of long-term clinical treatment, the high drop-out rate, the ... ...

    Title translation Management of children and adolescents with severe obesity.
    Abstract Obesity is a complex public health issue. Recent data indicate the increasing prevalence and severity of obesity in children. Severe obesity is a real chronic condition for the difficulties of long-term clinical treatment, the high drop-out rate, the large burden of health and psychological problems and the high probability of persistence in adulthood. A staged approach for weight management is recommended. The establishment of permanent healthy lifestyle habits aimed at healthy eating, increasing physical activity and reducing sedentary behavior is the first outcome, because of the long-term health benefits of these behaviors. Improvement in medical conditions is also an important sign of long-term health benefits. Rapid weight loss is not pursued, for the implications on growth ad pubertal development and the risk of inducing eating disorders. Children and adolescents with severe obesity should be referred to a pediatric weight management center that has access to a multidisciplinary team with expertise in childhood obesity. This article provides pediatricians a comprehensive and evidence based update on treatment recommendations of severe obesity in children and adolescents.
    MeSH term(s) Adolescent ; Behavior Therapy/methods ; Body Mass Index ; Child ; Diet, Reducing ; Evidence-Based Medicine ; Exercise ; Humans ; Italy/epidemiology ; Life Style ; Obesity, Morbid/diagnosis ; Obesity, Morbid/epidemiology ; Obesity, Morbid/therapy ; Prevalence ; Severity of Illness Index ; Treatment Outcome ; Weight Loss
    Language Italian
    Publishing date 2012-08
    Publishing country Italy
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 123571-0
    ISSN 1827-1715 ; 0026-4946
    ISSN (online) 1827-1715
    ISSN 0026-4946
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Il medico del Lavoro Competente e la Sorveglianza Sanitaria in Agricoltura.

    Colosio, C / Ariano, E / Somaruga, C / Rabozzi, G / Vellere, F / Brambilla, G / Colombi, A

    Giornale italiano di medicina del lavoro ed ergonomia

    2010  Volume 32, Issue 4 Suppl, Page(s) 413–417

    Abstract: Despite the underreporting of occupational diseases in agriculture, available data clearly show a significant health risk, and therefore the need of health surveillance at the workplace. The implementation of health surveillance programs for agricultural ...

    Title translation The occupational health physician and the health surveillance in agriculture.
    Abstract Despite the underreporting of occupational diseases in agriculture, available data clearly show a significant health risk, and therefore the need of health surveillance at the workplace. The implementation of health surveillance programs for agricultural workers relies on the possibility of creating a system able to reach the workers at their workplaces, with the collaboration of employers' associations, able to support enterprises in several issues, including risk assessment and management. The health surveillance program can be organized in a component common for all workers, based on physical examination, chemistry, electrocardiography, hearing and lung functions examinations, and on tests addressing specific risks, if present: vibration, physical overload, chemicals, biological agents, allergens. The frequency of examinations must be decided based on risk assessment and health surveillance outcomes.
    MeSH term(s) Adolescent ; Adult ; Aged ; Agriculture ; Humans ; Middle Aged ; Occupational Diseases/prevention & control ; Occupational Health ; Occupational Medicine ; Population Surveillance ; Young Adult
    Language Italian
    Publishing date 2010-10
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 603103-1
    ISSN 1592-7830 ; 0391-9889
    ISSN 1592-7830 ; 0391-9889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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