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  1. Article ; Online: Twisting IL-1 signaling to kill CML stem cells.

    Stramucci, Lorenzo / Perrotti, Danilo

    Blood

    2016  Volume 128, Issue 23, Page(s) 2592–2593

    MeSH term(s) Humans ; Imatinib Mesylate ; Interleukin-1 ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Neoplastic Stem Cells ; Signal Transduction ; Stem Cells
    Chemical Substances Interleukin-1 ; Imatinib Mesylate (8A1O1M485B)
    Language English
    Publishing date 2016-12-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2016-10-741009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.140: Show issues Location:
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  2. Article ; Online: A "RANning" leap with "XPOrt" into TKI resistance.

    Rassool, Feyruz / Perrotti, Danilo

    Blood

    2015  Volume 125, Issue 11, Page(s) 1686–1688

    MeSH term(s) Active Transport, Cell Nucleus ; Fusion Proteins, bcr-abl/metabolism ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism ; RNA, Small Interfering/genetics
    Chemical Substances BCR-ABL1 fusion protein, human ; RNA, Small Interfering ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
    Language English
    Publishing date 2015-03-11
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-01-622217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Investigating the Susceptibility to Failure of a Rock Cliff by Integrating Structure-from-Motion Analysis and 3D Geomechanical Modelling

    Perrotti, Michele / Godone, Danilo / Allasia, Paolo / Baldo, Marco / Fazio, Nunzio Luciano / Lollino, Piernicola

    Remote Sensing. 2020 Dec. 06, v. 12, no. 23

    2020  

    Abstract: Multi-temporal UAV and digital photo surveys have been acquired between 2017 and 2020 on a coastal cliff in soft rocks in South-Eastern Italy for hazard assessment and the corresponding point clouds have been processed and compared. The multi-temporal ... ...

    Abstract Multi-temporal UAV and digital photo surveys have been acquired between 2017 and 2020 on a coastal cliff in soft rocks in South-Eastern Italy for hazard assessment and the corresponding point clouds have been processed and compared. The multi-temporal survey results provide indications of a progressive deepening process of erosion and detachment of blocks from the mid-height portion of the cliff, with the upper stiffer rock stratum working provisionally as a shelf against the risk of general collapse. Based on the DEM model obtained, a three-dimensional geomechanical finite element model has been created and analyzed in order to investigate the general stability of the cliff and to detect the rock portions which are more susceptible to failure. Concerning the evolving erosion process, active in the cliff, the photogrammetric analyses and the modeling simulations result in agreement and a proneness to both local and general instabilities has been achieved.
    Keywords data collection ; finite element analysis ; hazard characterization ; models ; photogrammetry ; remote sensing ; risk ; rocks ; surveys ; Italy
    Language English
    Dates of publication 2020-1206
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2513863-7
    ISSN 2072-4292
    ISSN 2072-4292
    DOI 10.3390/rs12233994
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: SETting OP449 into the PP2A-activating drug family.

    Neviani, Paolo / Perrotti, Danilo

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2014  Volume 20, Issue 8, Page(s) 2026–2028

    Abstract: The protein phosphatase 2A (PP2A) tumor suppressor is inactivated in different leukemias through the activity of its endogenous inhibitors (e.g., SET), which are aberrantly regulated by oncogenic tyrosine kinases. Like other effective and nontoxic PP2A- ... ...

    Abstract The protein phosphatase 2A (PP2A) tumor suppressor is inactivated in different leukemias through the activity of its endogenous inhibitors (e.g., SET), which are aberrantly regulated by oncogenic tyrosine kinases. Like other effective and nontoxic PP2A-activating drugs (PAD), OP449 inhibits SET and impairs leukemogenesis. This further supports the immediate use of PADs in patients with leukemia.
    MeSH term(s) Animals ; DNA-Binding Proteins ; Drug Resistance, Neoplasm/drug effects ; Histone Chaperones/antagonists & inhibitors ; Humans ; Leukemia, Myeloid/drug therapy ; Male ; Peptides/pharmacology ; Protein Kinase Inhibitors/pharmacology ; Transcription Factors/antagonists & inhibitors
    Chemical Substances DNA-Binding Proteins ; Histone Chaperones ; OP449 peptide ; Peptides ; Protein Kinase Inhibitors ; SET protein, human ; Transcription Factors
    Language English
    Publishing date 2014-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-14-0166
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
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  5. Article ; Online: Investigating the Susceptibility to Failure of a Rock Cliff by Integrating Structure-from-Motion Analysis and 3D Geomechanical Modelling

    Michele Perrotti / Danilo Godone / Paolo Allasia / Marco Baldo / Nunzio Luciano Fazio / Piernicola Lollino

    Remote Sensing, Vol 12, Iss 23, p

    2020  Volume 3994

    Abstract: Multi-temporal UAV and digital photo surveys have been acquired between 2017 and 2020 on a coastal cliff in soft rocks in South-Eastern Italy for hazard assessment and the corresponding point clouds have been processed and compared. The multi-temporal ... ...

    Abstract Multi-temporal UAV and digital photo surveys have been acquired between 2017 and 2020 on a coastal cliff in soft rocks in South-Eastern Italy for hazard assessment and the corresponding point clouds have been processed and compared. The multi-temporal survey results provide indications of a progressive deepening process of erosion and detachment of blocks from the mid-height portion of the cliff, with the upper stiffer rock stratum working provisionally as a shelf against the risk of general collapse. Based on the DEM model obtained, a three-dimensional geomechanical finite element model has been created and analyzed in order to investigate the general stability of the cliff and to detect the rock portions which are more susceptible to failure. Concerning the evolving erosion process, active in the cliff, the photogrammetric analyses and the modeling simulations result in agreement and a proneness to both local and general instabilities has been achieved.
    Keywords UAV ; photogrammetry ; point clouds ; image acquisition ; photographs matching ; TIN surface ; Science ; Q
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Protein phosphatase 2A: a target for anticancer therapy.

    Perrotti, Danilo / Neviani, Paolo

    The Lancet. Oncology

    2013  Volume 14, Issue 6, Page(s) e229–38

    Abstract: Protein phosphatase 2A (PP2A), one of the main serine-threonine phosphatases in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven intracellular signalling pathways. Unrestrained activation of oncogenic kinases ... ...

    Abstract Protein phosphatase 2A (PP2A), one of the main serine-threonine phosphatases in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven intracellular signalling pathways. Unrestrained activation of oncogenic kinases together with inhibition of tumour suppressors is often required for development of cancer. PP2A has been shown to be genetically altered or functionally inactivated in many solid cancers and leukaemias, and is therefore a tumour suppressor. For example, the phosphatase activity of PP2A is suppressed in chronic myeloid leukaemia and other malignancies characterised by aberrant activity of oncogenic kinases. Preclinical studies show that pharmacological restoration of PP2A tumour-suppressor activity by PP2A-activating drugs (eg, FTY720) effectively antagonises cancer development and progression. Here, we discuss PP2A as a druggable tumour suppressor in view of the possible introduction of PP2A-activating drugs into anticancer therapeutic protocols.
    MeSH term(s) Animals ; Antineoplastic Agents/therapeutic use ; Drug Design ; Enzyme Activation ; Enzyme Activators/therapeutic use ; Humans ; Molecular Targeted Therapy ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Neoplasms/pathology ; Protein Phosphatase 2/metabolism ; Signal Transduction/drug effects
    Chemical Substances Antineoplastic Agents ; Enzyme Activators ; Protein Phosphatase 2 (EC 3.1.3.16)
    Language English
    Publishing date 2013-04-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(12)70558-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
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    Zs.MO 460: Show issues

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  7. Article ; Online: Unfolding tyrosine kinase inhibitor sensitivity in chronic myeloid leukemia.

    Perrotti, Danilo / Neviani, Paolo

    Cell cycle (Georgetown, Tex.)

    2012  Volume 11, Issue 23, Page(s) 4300–4301

    MeSH term(s) Animals ; Antineoplastic Agents/toxicity ; Cell Survival/drug effects ; Eukaryotic Initiation Factor-2/metabolism ; Fusion Proteins, bcr-abl/metabolism ; Humans ; Piperazines/toxicity ; Pyrimidines/toxicity ; eIF-2 Kinase/metabolism
    Chemical Substances Antineoplastic Agents ; Eukaryotic Initiation Factor-2 ; Piperazines ; Pyrimidines ; Fusion Proteins, bcr-abl (EC 2.7.10.2) ; eIF-2 Kinase (EC 2.7.11.1)
    Language English
    Publishing date 2012-11-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.4161/cc.22808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5881: Show issues Location:
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  8. Article ; Online: Correlation between Implant Geometry, Bone Density, and the Insertion Torque/Depth Integral: A Study on Bovine Ribs.

    Di Stefano, Danilo Alessio / Arosio, Paolo / Perrotti, Vittoria / Iezzi, Giovanna / Scarano, Antonio / Piattelli, Adriano

    Dentistry journal

    2019  Volume 7, Issue 1

    Abstract: During insertion of dental implants, measurement of dynamic parameters such as the torque-depth curve integral or insertion energy might convey more information about primary stability than traditional static parameters such as the insertion or removal ... ...

    Abstract During insertion of dental implants, measurement of dynamic parameters such as the torque-depth curve integral or insertion energy might convey more information about primary stability than traditional static parameters such as the insertion or removal torque. However, the relationship between these dynamic parameters, bone density, and implant geometry is not well understood. The aim of this investigation was to compare static and dynamic implant stability measurements concerning three different implant designs when implants were inserted into bovine bone ribs and dynamic parameters were collected using an instantaneous torque measuring implant motor. Standard implant osteotomies were created in segments of bovine ribs. After measuring the bone density using the implant motor, 10 cylindrical, 10 hybrid tapered-cylindrical, and 10 modified cylindrical implants were placed, and their primary stability was assessed by measuring the torque⁻depth curve integral, along with insertion and removal torque. The relationship between these quantities, bone density, and implant geometry was investigated by means of regression and covariance analysis. The regression lines describing the relationship between the torque⁻depth integral and bone density differed significantly from those describing the relationship between insertion torque, removal torque, and bone density for all three designs. The torque⁻depth curve integral provides different information about immediate primary stability than insertion and removal torque and in certain clinical conditions might be more reliable than these static parameters for assessing implant primary stability. Further research should be carried out to investigate the findings of the present study.
    Language English
    Publishing date 2019-03-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681351-8
    ISSN 2304-6767 ; 2304-6767
    ISSN (online) 2304-6767
    ISSN 2304-6767
    DOI 10.3390/dj7010025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The new role of microRNAs in cancer.

    Perrotti, Danilo / Eiring, Anna M

    Future oncology (London, England)

    2010  Volume 6, Issue 8, Page(s) 1203–1206

    MeSH term(s) Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/physiology ; Neoplasms/genetics ; Neoplasms/therapy
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2010-10-18
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon.10.78
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: From the Biology of PP2A to the PADs for Therapy of Hematologic Malignancies.

    Ciccone, Maria / Calin, George A / Perrotti, Danilo

    Frontiers in oncology

    2015  Volume 5, Page(s) 21

    Abstract: Over the past decades, an emerging role of phosphatases in the pathogenesis of hematologic malignancies and solid tumors has been established. The tumor-suppressor protein phosphatase 2A (PP2A) belongs to the serine-threonine phosphatases family and ... ...

    Abstract Over the past decades, an emerging role of phosphatases in the pathogenesis of hematologic malignancies and solid tumors has been established. The tumor-suppressor protein phosphatase 2A (PP2A) belongs to the serine-threonine phosphatases family and accounts for the majority of serine-threonine phosphatase activity in eukaryotic cells. Numerous studies have shown that inhibition of PP2A expression and/or function may contribute to leukemogenesis in several hematological malignancies. Likewise, overexpression or aberrant expression of physiologic PP2A inhibitory molecules (e.g., SET and its associated SETBP1 and CIP2A) may turn off PP2A function and participate to leukemic progression. The discovery of PP2A as tumor suppressor has prompted the evaluation of the safety and the efficacy of new compounds, which can restore PP2A activity in leukemic cells. Although further studies are needed to better understand how PP2A acts in the intricate phosphatases/kinases cancer network, the results reviewed herein strongly support the development on new PP2A-activating drugs and the immediate introduction of those available into clinical protocols for leukemia patients refractory or resistant to current available therapies.
    Language English
    Publishing date 2015-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2015.00021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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