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  1. Article ; Online: Protective roles and protective mechanisms of neutralizing antibodies against SARS-CoV-2 infection and their potential clinical implications.

    Abebe, Endeshaw Chekol / Dejenie, Tadesse Asmamaw

    Frontiers in immunology

    2023  Volume 14, Page(s) 1055457

    Abstract: Neutralizing antibodies (NAbs) are central players in the humoral immunity that defends the body from SARS-CoV-2 infection by blocking viral entry into host cells and neutralizing their biological effects. Even though NAbs primarily work by neutralizing ... ...

    Abstract Neutralizing antibodies (NAbs) are central players in the humoral immunity that defends the body from SARS-CoV-2 infection by blocking viral entry into host cells and neutralizing their biological effects. Even though NAbs primarily work by neutralizing viral antigens, on some occasions, they may also combat the SARS-CoV-2 virus escaping neutralization by employing several effector mechanisms in collaboration with immune cells like natural killer (NK) cells and phagocytes. Besides their prophylactic and therapeutic roles, antibodies can be used for COVID-19 diagnosis, severity evaluation, and prognosis assessment in clinical practice. Furthermore, the measurement of NAbs could have key implications in determining individual or herd immunity against SARS-CoV-2, vaccine effectiveness, and duration of the humoral protective response, as well as aiding in the selection of suitable individuals who can donate convalescent plasma to treat infected people. Despite all these clinical applications of NAbs, using them in clinical settings can present some challenges. This review discusses the protective functions, possible protective mechanisms against SARS-CoV-2, and potential clinical applications of NAbs in COVID-19. This article also highlights the possible challenges and solutions associated with COVID-19 antibody-based prophylaxis, therapy, and vaccination.
    MeSH term(s) Humans ; Antibodies, Neutralizing ; COVID-19 ; SARS-CoV-2 ; COVID-19 Testing ; COVID-19 Serotherapy ; Antibodies, Viral
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1055457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Human immunodeficiency virus positive status disclosure among children in northwest Ethiopia: a cross-sectional study.

    Adella, Getachew Asmare / Yimer, Meklit Abie / Abebe, Endeshaw Chekol

    African health sciences

    2023  Volume 23, Issue 1, Page(s) 178–189

    Abstract: Background: Human Immunodeficiency Virus positive status disclosure is an essential component of pediatric care and longterm disease management. However, one of the greatest challenges that caregiver/mothers and health care workers face is the ... ...

    Abstract Background: Human Immunodeficiency Virus positive status disclosure is an essential component of pediatric care and longterm disease management. However, one of the greatest challenges that caregiver/mothers and health care workers face is the disclosure of HIV positive status to children living with the virus. Therefore, the objective of this study was to assess HIV positive status disclosure and associated factors among HIV positive children in northwest Ethiopia.
    Methods: Institutional based cross-sectional study was conducted among 417 sampled HIV positive children attending pediatric ART clinics of public health facilities from February 01 to March 30 2020 in northwest Ethiopia. Simple random sampling technique was used to select study participants. A structured interviewer administered questionnaire was used for data collection and the collected data entered into Epi data software. Binary logistic regression analysis was done and variables with P-value <0.05 was considered as a significant predictors of HIV positive status disclosure of HIV positive children.
    Result: From 417 sampled population, 390 were involved in this study making 93.5% response rate. The study revealed that 53.6% with 95% CI (0.486-0.586) of HIV positive children knew their HIV positive sero status. Caregiver/mothers who had greater than three family sizes (AOR=1.984, 95% CI=1.046-3.762), children whose ages greater than 10 years (AOR=6.679, 95% CI=3.372-13.227) and children on ART for more than 5 years (AOR=8.96, 95% CI=6.402-12.257) were predictors of HIV positive status disclosure.
    Conclusion: The HIV positive status disclosure was high in the study area relative to other studies. Family size, children age, and length of children on ART were predictors of HIV positive status disclosure for HIV positive children. Health care providers, especially those working at pediatrics ART clinics should keep these factors in mid while working with caregivers to encourage disclosure of HIV positive status.
    MeSH term(s) Female ; Humans ; Child ; Disclosure ; HIV Infections/epidemiology ; Cross-Sectional Studies ; Ethiopia/epidemiology ; HIV Seropositivity ; Ambulatory Care Facilities ; Surveys and Questionnaires ; HIV
    Language English
    Publishing date 2023-07-21
    Publishing country Uganda
    Document type Journal Article
    ZDB-ID 2240308-5
    ISSN 1729-0503 ; 1680-6905
    ISSN (online) 1729-0503
    ISSN 1680-6905
    DOI 10.4314/ahs.v23i1.20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Frequency and correlates of poor glycemic control in patients with type 2 diabetes at Jimma Medical Centre, Ethiopia: a cross-sectional study.

    Mengstie, Misganaw Asmamaw / Abebe, Endeshaw Chekol / Dejenie, Tadesse Asmamaw / Seid, Mohammed Abdu / Teshome, Assefa Agegnehu

    The Pan African medical journal

    2024  Volume 47, Page(s) 7

    Abstract: Introduction: the majority of studies in Ethiopia determine the prevalence of glycemic control employed by fasting blood sugar (FBS), which is impacted by a variety of factors. Hence, the purpose of this study was to assess the status of glycemic ... ...

    Abstract Introduction: the majority of studies in Ethiopia determine the prevalence of glycemic control employed by fasting blood sugar (FBS), which is impacted by a variety of factors. Hence, the purpose of this study was to assess the status of glycemic control using HbA1c and its correlates in patients with type 2 diabetes in Southwest Ethiopia.
    Methods: a cross-sectional study was employed among 124 T2 diabetes mellitus (DM) patients at Jimma Medical Center (JMC), Southwest Ethiopia. HbA1c and FBS were estimated using the Cobas 6000 analyzer. The body mass index (BMI) and waist-to-hip ratio were calculated as the standard formula. Data were analyzed by SPSS version 25. Logistic regression analysis was employed to identify independent risk factors associated with poor glycemic control of DM patients.
    Results: males comprised 63.7% (n=79) of the total respondents. The mean age of aOR: 2.21, 95% CI 1.13, 4.34; p = 0.01f participants was 51.84 ± 11.6 years; 60.5% (n=75) of T2 DM patients were in poor glycemic control (HbA1c ≥ 7%). In multivariate logistic regression analysis, BMI of ≥ 30, (aOR: 2.21, 95% CI 1.13, 4.34) increased waist-to-hip ratio (aOR: 1.63, 95% CI 0.82, 2.18), high systolic blood pressure (aOR: 1.52, 95% CI 1.11, 6.23), high FBS (aOR: 1.61, 95% CI 1.00, 4.12), and longer duration of DM (aOR: 1.23, 95% CI 0.87, 1.88) were associated with poor glycemic control.
    Conclusion: the level of poor glycemic control in the study population is high. Obesity and/or overweight, central obesity, systolic hypertension, and fasting blood sugar levels were all associated with poor glycemic control in T2 DM patients.
    MeSH term(s) Male ; Humans ; Female ; Diabetes Mellitus, Type 2/complications ; Cross-Sectional Studies ; Blood Glucose ; Ethiopia/epidemiology ; Glycated Hemoglobin ; Glycemic Control ; Hyperglycemia/epidemiology ; Obesity/complications
    Chemical Substances Blood Glucose ; Glycated Hemoglobin
    Language English
    Publishing date 2024-01-08
    Publishing country Uganda
    Document type Journal Article
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    DOI 10.11604/pamj.2024.47.7.37452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Phytochemical Investigation and Determination of Antibacterial Activity of Solvent Leave Extracts of

    Ayalew Tiruneh, Tizezew / Ayalew Tiruneh, Gebrehiwot / Chekol Abebe, Endeshaw / Mengie Ayele, Teklie

    Infection and drug resistance

    2022  Volume 15, Page(s) 807–819

    Abstract: Background: Among many traditionally used medicinal plants, : Methods: In this study, 800 g of powdered leaves of : Results: The three extracts (methanol, ethyl acetate, and chloroform) of : Conclusion: Data obtained from this study ... ...

    Abstract Background: Among many traditionally used medicinal plants,
    Methods: In this study, 800 g of powdered leaves of
    Results: The three extracts (methanol, ethyl acetate, and chloroform) of
    Conclusion: Data obtained from this study collectively indicated that the three solvent extracts of
    Language English
    Publishing date 2022-03-04
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S352049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Investigation of Antibacterial and Anti-Diarrhoeal Activities of 80% Methanol Leaf and Fruit Extract of

    Mengie Ayele, Teklie / Chekol Abebe, Endeshaw / Bogale Kassie, Achenef

    publication RETRACTED

    Journal of experimental pharmacology

    2021  Volume 13, Page(s) 613–626

    Abstract: Background: Leonotis ocymifolia: Methods: The leaves and fruits of : Results: A significant (: Conclusion: Results from this study collectively indicated that 80% methanol leaf and fruit extracts ... ...

    Abstract Background: Leonotis ocymifolia
    Methods: The leaves and fruits of
    Results: A significant (
    Conclusion: Results from this study collectively indicated that 80% methanol leaf and fruit extracts of
    Language English
    Publishing date 2021-06-29
    Publishing country New Zealand
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2587465-2
    ISSN 1179-1454
    ISSN 1179-1454
    DOI 10.2147/JEP.S319981
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  6. Article: Regulatory effects and potential therapeutic implications of alarin in depression, and arguments on its receptor.

    Abebe, Endeshaw Chekol / Mengstie, Misganaw Asmamaw / Seid, Mohammed Abdu / Dejenie, Tadesse Asmamaw

    Frontiers in psychiatry

    2022  Volume 13, Page(s) 1051235

    Abstract: Alarin is a pleiotropic peptide involved in a multitude of putative biological activities, notably, it has a regulatory effect on depression-like behaviors. Although further elucidating research is needed, animal-based cumulative evidence has shown the ... ...

    Abstract Alarin is a pleiotropic peptide involved in a multitude of putative biological activities, notably, it has a regulatory effect on depression-like behaviors. Although further elucidating research is needed, animal-based cumulative evidence has shown the antidepressant-like effects of alarin. In light of its regulatory role in depression, alarin could be used as a promising antidepressant in future treatment for depression. Nevertheless, the available information is still insufficient and the therapeutic relevance of alarin in depression is still of concern. Moreover, a plethora of studies have reported that the actions of alarin, including antidepressant activities, are mediated by a separate yet unidentified receptor, highlighting the need for more extensive research. This review focuses on the current understanding of the regulatory effects and future therapeutic relevance of alarin on depression, and the arguments on its receptors.
    Language English
    Publishing date 2022-11-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2022.1051235
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Incidence and predictors of early posttraumatic seizures among patients with moderate or severe traumatic brain injury in Northwest Ethiopia: an institution-based prospective study.

    Baye, Nega Dagnew / Baye, Fikadie Dagnew / Teshome, Assefa Agegnehu / Ayenew, Atalo Agimas / Mulu, Anmut Tilahun / Abebe, Endeshaw Chekol / Muche, Zelalem Tilahun

    BMC neurology

    2024  Volume 24, Issue 1, Page(s) 41

    Abstract: Background: Early posttraumatic seizure (PTS) is a well-known complication of traumatic brain injury (TBI) that can induce the development of secondary brain injuries, including increased intracranial pressure, brain death, and metabolic crisis which ... ...

    Abstract Background: Early posttraumatic seizure (PTS) is a well-known complication of traumatic brain injury (TBI) that can induce the development of secondary brain injuries, including increased intracranial pressure, brain death, and metabolic crisis which may result in worse outcomes. It is also a well-recognized risk factor for the development of late post-traumatic seizure and epilepsy. This study was aimed to assess the incidence and predictors of PTS among patients with moderate or severe TBI admitted to Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia.
    Methods and setting: An institutional-based prospective follow-up study was conducted on 402 patients with TBI admitted to the neurologic unit from June 1, 2022 to January 30, 2023. A systematic sampling technique was employed. The incidence rate of occurrence of early PTS was calculated. Both bivariable and multivariable Cox proportional hazard regression was performed. The strength of the association was measured using adjusted hazard ratios with a 95% confidence interval and p-values < 0.05.
    Results: The incidence rate of early PTS was 2.7 per 100 person-days observation. Early PTS was observed in 17.7% of TBI patients. Age 75 and above (AHR = 2.85, 95%CI: 1.58-5.39), severe TBI (AHR = 2.06, 95%CI: 1.03-3.71), epidural hematoma (AHR = 2.4, 95% CI: 1.28-4.57), brain contusion (AHR = 2.6, 95%CI: 1.07-4.09), surgical intervention (AHR = 1.7, 95%CI: 1.03-3.82), posttraumatic amnesia (AHR = 1.99, 95%CI: 1.08-3.48), history of comorbidities (AHR = 1.56, 95%CI: 1.08-3.86), and history of alcohol abuse (AHR = 3.1, 95%CI: 1.89-5.23) were potential predictors of early PTS.
    Conclusion: The incidence of early PTS was high. Since, early PTS can worsen secondary brain damage, knowing the predictors helps to provide an effective management plan for patients likely to develop early PTS and improve their outcome.
    MeSH term(s) Humans ; Aged ; Prospective Studies ; Incidence ; Ethiopia/epidemiology ; Follow-Up Studies ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/epidemiology ; Brain Injuries ; Brain Neoplasms ; Seizures
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-024-03536-z
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  8. Article ; Online: Ciltacabtagene autoleucel: The second anti-BCMA CAR T-cell therapeutic armamentarium of relapsed or refractory multiple myeloma.

    Chekol Abebe, Endeshaw / Yibeltal Shiferaw, Mestet / Tadele Admasu, Fitalew / Asmamaw Dejenie, Tadesse

    Frontiers in immunology

    2022  Volume 13, Page(s) 991092

    Abstract: Ciltacabtagene autoleucel (also known as cilta-cel) is a chimeric antigen receptor (CAR) T-cell therapy that targets B-cell maturation antigen (BCMA) on the surface of cancer cells in B cell malignancies, such as multiple myeloma (MM). It is a second- ... ...

    Abstract Ciltacabtagene autoleucel (also known as cilta-cel) is a chimeric antigen receptor (CAR) T-cell therapy that targets B-cell maturation antigen (BCMA) on the surface of cancer cells in B cell malignancies, such as multiple myeloma (MM). It is a second-generation CAR that is outfitted with an ectodomain comprising two BCMA-binding single chain variable fragment (ScFv) domains, a transmembrane domain, and an endodomain possessing CD3ζ and 4-1BB. Cilta-cel is an autologous, gene-edited CAR T-cell that is prepared by collecting and modifying the recipient's T-cells to create a patient personalized treatment in the laboratory to be infused back. This CAR T-cell product exceptionally entails CARs with two BCMA-targeting single-domain antibodies that detect two epitopes of BCMA expressed on the malignant cells of MM. Cilta-cel is the current addition to the treatment armamentarium of relapsed or refractory (r/r) MM after its approval by the FDA on February 28, 2022, based on the results of the Phase 1b/2 CARTITUDE-1 study. It was the second approved anti-BCMA CAR T-cell product after idecabtagene vicleucel (ide-cel) to treat myeloma patients. It induces early, deep, and long-lasting responses with a tolerable safety profile in r/r MM. Cilta-cel-treated myeloma patients may potentially experience adverse effects ranging from mild to life-threatening, but they are mostly manageable toxicities. Besides, it has a consistent safety profile upon a longer follow-up of patients. Cilta-cel generally outperforms ide cel in terms of efficacy in MM, but shows comparable adverse events. This review highlights the current updates on cilta-cel efficacy, adverse events, comparison with ide-cel, and its future direction in the treatment of MM.
    MeSH term(s) B-Cell Maturation Antigen ; Clinical Trials, Phase I as Topic ; Clinical Trials, Phase II as Topic ; Epitopes/metabolism ; Humans ; Multiple Myeloma ; Receptors, Chimeric Antigen ; Single-Chain Antibodies/genetics ; Single-Chain Antibodies/metabolism ; Single-Domain Antibodies/metabolism ; T-Lymphocytes
    Chemical Substances B-Cell Maturation Antigen ; Epitopes ; Receptors, Chimeric Antigen ; Single-Chain Antibodies ; Single-Domain Antibodies ; idecabtagene vicleucel (8PX1X7UG4D)
    Language English
    Publishing date 2022-09-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.991092
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  9. Article: Undernutrition and associated factors among internally displaced lactating mothers in Sekota camps, northern Ethiopia: A cross-sectional study.

    Mengstie, Misganaw Asmamaw / Worke, Mulugeta Dile / Belay, Yalemshet / Chekol Abebe, Endeshaw / Asmamaw Dejenie, Tadesse / Abdu Seid, Mohammed / Azezew, Muluken Teshome

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1108233

    Abstract: Background: Undernutrition is the term used to describe when a person consumes insufficient amounts of nutrients and energy to meet their needs for maintaining health. Despite substantial progress, undernutrition remains a serious public health concern ... ...

    Abstract Background: Undernutrition is the term used to describe when a person consumes insufficient amounts of nutrients and energy to meet their needs for maintaining health. Despite substantial progress, undernutrition remains a serious public health concern in many low and middle-income nations, including Ethiopia. Women and children are, in reality, the most nutritionally vulnerable individuals, particularly in times of crisis. In Ethiopia, 27 percent of lactating women are thin or malnourished, and 38% of children are stunted. Although the issue of undernutrition may worsen in times of emergency, like war, there are limited studies available in Ethiopia that show the nutritional status of lactating mothers in humanitarian settings.
    Objectives: The main aim of this study was to determine the prevalence and investigate the factors associated with undernutrition among internally displaced lactating mothers in Sekota camps, in northern Ethiopia.
    Methods: A cross-sectional study through a simple random sampling technique was conducted among 420 randomly selected lactating mothers in Sekota Internally Displaced Persons (IDP) camps. Data were collected using a structured questionnaire and anthropometric measurements. Logistic regression analysis was employed to identify independent factors associated with maternal undernutrition.
    Results: Using a cut-off mid-upper arm circumference <23 cm, the prevalence of undernutrition among internally displaced lactating mothers was 54.8%. Large family size [adjusted odds ratio (AOR) = 4.35; 95% CI: 1.32, 10.22], short birth interval (AOR = 4.85; 95% CI: 1.24, 10.00), low maternal daily meal frequency (AOR = 2.54; 95% CI: 1.12, 5.75), and low dietary diversity score (AOR = 1.79; 95% CI: 1.03, 3.10) were all significantly associated with undernutrition.
    Conclusion: The prevalence of undernutrition among internally displaced lactating mothers is relatively high. Governments and other concerned organizations involved in providing care and support to Sekota IDP camps should increase their efforts to improve the nutritional status of lactating mothers.
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1108233
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  10. Article ; Online: Blood glucose level and serum lipid profiles among people living with HIV on dolutegravir-based versus efavirenz-based cART; a comparative cross-sectional study.

    Jemal, Mohammed / Shibabaw Molla, Tewodros / Tiruneh G Medhin, Markeshaw / Chekol Abebe, Endeshaw / Asmamaw Dejenie, Tadesse

    Annals of medicine

    2023  Volume 55, Issue 2, Page(s) 2295435

    Abstract: Background: Antiretroviral therapy-linked metabolic abnormalities have become a growing concern among people living with HIV. There is limited data regarding the effects of dolutegravir-based treatment on blood glucose levels and serum lipid profiles in ...

    Abstract Background: Antiretroviral therapy-linked metabolic abnormalities have become a growing concern among people living with HIV. There is limited data regarding the effects of dolutegravir-based treatment on blood glucose levels and serum lipid profiles in people living with HIV in Ethiopia. Thus, this study aimed to assess blood glucose levels and serum lipid profiles among people living with HIV on dolutegravir-based versus efavirenz-based therapy.
    Method and materials: An institutional-based comparative cross-sectional study was conducted from 30 June 2021 to 30 August 2021. A total of 128 participants (64 in the dolutegravir-based group and 64 in the efavirenz-based group) were enrolled in the study. The Chi-square, independent
    Result: The prevalence of hyperglycemia and dyslipidemia were 17.2% (11/64) and 79.7% (51/64) in the dolutegravir group, and 9.4% (6/64) and 75% (48/64) in the efavirenz group, respectively. The efavirenz group had significantly higher mean values of total cholesterol (190.73 ± 44.13 vs. 175.27 ± 37.67 mg/dl,
    Conclusion: Efavirenz-based therapy resulted in higher mean values of total cholesterol and high-density lipoprotein as compared with dolutegravir-based therapy. It is important to consider and evaluate high-density lipoprotein levels in HIV patients on dolutegravir-based therapy, and total cholesterol levels in people living with HIV on efavirenz-based therapy.
    MeSH term(s) Humans ; Male ; Female ; HIV Infections/drug therapy ; Blood Glucose ; Cross-Sectional Studies ; Benzoxazines/therapeutic use ; Heterocyclic Compounds, 3-Ring/adverse effects ; Hyperglycemia ; Lipids ; Cholesterol ; Lipoproteins, HDL/therapeutic use ; Dyslipidemias/chemically induced ; Dyslipidemias/epidemiology ; Anti-HIV Agents/adverse effects
    Chemical Substances efavirenz (JE6H2O27P8) ; dolutegravir (DKO1W9H7M1) ; Blood Glucose ; Benzoxazines ; Heterocyclic Compounds, 3-Ring ; Lipids ; Cholesterol (97C5T2UQ7J) ; Lipoproteins, HDL ; Anti-HIV Agents
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2023.2295435
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