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Article ; Online: T-cell receptor sequencing specifies psoriasis as a systemic and atopic dermatitis as a skin-focused, allergen-driven disease.

Roesner, Lennart M / Farag, Ahmed K / Pospich, Rebecca / Traidl, Stephan / Werfel, Thomas

2022 Volume 77, Issue 9, Page(s) 2737–2747

Abstract: ... skin diseases in developed countries. A hallmark of both diseases is T-cell infiltration into the skin ... However, it is still not clarified to what extent these infiltrating T cells are antigen-specific skin-homing ... T cells or unspecific heterogeneous bystander cells.: Methods: To elucidate this, T cells from lesional ...

Abstract	Background: Atopic dermatitis (AD) and psoriasis represent two of the most common inflammatory skin diseases in developed countries. A hallmark of both diseases is T-cell infiltration into the skin. However, it is still not clarified to what extent these infiltrating T cells are antigen-specific skin-homing T cells or unspecific heterogeneous bystander cells. Methods: To elucidate this, T cells from lesional skin and from blood of 9 AD and 10 psoriasis patients were compared by receptor (TCR) sequencing. Therefore, peripheral blood mononuclear cells (PBMC) were cell-sorted according to expression of the cutaneous leukocyte antigen (CLA) into skin-homing (CLA Results: Intra-individual comparison of TCRB CDR3 regions revealed that clonally expanded T cells in skin lesions of both AD and psoriasis patients corresponded to skin-homing circulating T cells. However, in psoriasis patients, these T-cell clones were also detectable to a larger extent among CLA Conclusions: Our data show that in line with the systemic nature of psoriasis, T-cell clones that infiltrate psoriatic skin lesions do not exclusively possess skin-homing ability and are therefore most probably specific to antigens that are not exclusively expressed or located in the skin. T cells driving AD skin inflammation appear to home nearly exclusively to the skin and are, to a certain extent, specific to aeroallergens.
MeSH term(s)	Allergens ; Antigens, Differentiation, T-Lymphocyte ; Antigens, Neoplasm ; Dermatitis, Atopic ; Humans ; Leukocytes, Mononuclear/metabolism ; Membrane Glycoproteins ; Psoriasis ; Receptors, Antigen, T-Cell/genetics ; Receptors, Lymphocyte Homing
Chemical Substances	Allergens ; Antigens, Differentiation, T-Lymphocyte ; Antigens, Neoplasm ; Membrane Glycoproteins ; Receptors, Antigen, T-Cell ; Receptors, Lymphocyte Homing
Language	English
Publishing date	2022-03-14
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15272
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Article ; Online: Addition of PEG-interferon to long-term nucleos(t)ide analogue therapy enhances HBsAg decline and clearance in HBeAg-negative chronic hepatitis B: Multicentre Randomized Trial (PAS Study).

Farag, Mina S / van Campenhout, Margo J H / Sonneveld, M J / Fung, Scott / van Erpecum, Karel J / Wong, David K / Verhey, Elke / de Man, Robert / De Knegt, Robert J / Brouwer, Johannes T / Baak, Hubertus C / Feld, Jordan J / Liem, Kin Seng / Boonstra, André / Hansen, Bettina E / Janssen, Harry L A

Journal of viral hepatitis

2024 Volume 31, Issue 4, Page(s) 197–207

Abstract: We studied whether 48 weeks of PEG-IFN alfa-2a add-on increases HBsAg-decline and clearance in HBeAg-negative patients on long-term nucleo(s)tide analogue (NA) therapy. In this investigator-initiated, randomized, controlled trial conducted in Europe and ... ...

Abstract	We studied whether 48 weeks of PEG-IFN alfa-2a add-on increases HBsAg-decline and clearance in HBeAg-negative patients on long-term nucleo(s)tide analogue (NA) therapy. In this investigator-initiated, randomized, controlled trial conducted in Europe and Canada, HBeAg-negative patients treated with NA > 12 months, with HBVDNA < 200 IU/mL, were enrolled. Patients were randomized 2:1 to 48 weeks of PEG-IFN alfa-2a add-on (180 μg per week) or continued NA-monotherapy with subsequent follow-up to Week 72. Endpoints were HBsAg decline (≥1 log
MeSH term(s)	Humans ; Antiviral Agents/therapeutic use ; Hepatitis B Surface Antigens ; Hepatitis B e Antigens ; Hepatitis B, Chronic/drug therapy ; Drug Therapy, Combination ; Polyethylene Glycols/therapeutic use ; Recombinant Proteins/therapeutic use ; Treatment Outcome ; DNA, Viral
Chemical Substances	Antiviral Agents ; Hepatitis B Surface Antigens ; Hepatitis B e Antigens ; Polyethylene Glycols (3WJQ0SDW1A) ; Recombinant Proteins ; DNA, Viral
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212497-7
ISSN	1365-2893 ; 1352-0504
ISSN (online)	1365-2893
ISSN	1352-0504
DOI	10.1111/jvh.13918
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Article ; Online: A comparison of myocardial magnetic resonance extracellular volume mapping at 3 T against histology of tissue collagen in severe aortic valve stenosis and obstructive hypertrophic cardiomyopathy.

Bakermans, Adrianus J / Kouwenhoven, Merel / de Vos, Judith / de Vries, Dylan K / Reckman, Yolan J / Farag, Emile S / Koolbergen, David R / Kluin, Jolanda / Nederveen, Aart J / Strijkers, Gustav J / Boekholdt, S Matthijs

Magma (New York, N.Y.)

2023 Volume 36, Issue 5, Page(s) 701–709

Abstract: ... hypertrophic cardiomyopathy.: Materials and methods: Sixteen patients underwent MRI examination at 3 T to acquire native T ... with myocardial collagen content. Myocardial native T: Discussion: We compared myocardial ECV mapping at 3 T ...

Abstract	Objective: Quantitative extracellular volume fraction (ECV) mapping with MRI is commonly used to investigate in vivo diffuse myocardial fibrosis. This study aimed to validate ECV measurements against ex vivo histology of myocardial tissue samples from patients with aortic valve stenosis or hypertrophic cardiomyopathy. Materials and methods: Sixteen patients underwent MRI examination at 3 T to acquire native T Results: Septal ECV was 30.3% ± 4.6% and correlated strongly (n = 16, r = 0.70; p = 0.003) with myocardial collagen content. Myocardial native T Discussion: We compared myocardial ECV mapping at 3 T against ex vivo histology of myocardial collagen content, adding evidence to the notion that ECV mapping is a surrogate marker for in vivo diffuse myocardial fibrosis.
MeSH term(s)	Humans ; Magnetic Resonance Imaging, Cine ; Predictive Value of Tests ; Biopsy ; Reproducibility of Results ; Myocardium/pathology ; Cardiomyopathy, Hypertrophic/diagnostic imaging ; Cardiomyopathy, Hypertrophic/pathology ; Magnetic Resonance Imaging ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/pathology ; Cardiomyopathies ; Collagen ; Fibrosis ; Magnetic Resonance Spectroscopy ; Contrast Media
Chemical Substances	Collagen (9007-34-5) ; Contrast Media
Language	English
Publishing date	2023-02-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1160826-2
ISSN	1352-8661 ; 0968-5243
ISSN (online)	1352-8661
ISSN	0968-5243
DOI	10.1007/s10334-023-01070-6
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Article: Exploiting Signal Joint T Cell Receptor Excision Circle to Investigate the Impact of COVID-19 and Autoimmune Diseases on Age Prediction and Immunosenescence.

Farag, Amina A / Kharboush, Taghrid G / Ibrahim, Noha H / Darwish, Mohamed / Fawzy, Iman M / Bayomy, Hanaa El-Sayed / Abdelmotaleb, Dina Saad / Abdul Basset, Shaza Abdul Basset / Abdel-Kareim, Amal M / Al Mohaini, Mohammed / Ahmed, Inas A / Fakher, Haidy M

Biomedicines

2022 Volume 10, Issue 12

Abstract: Signal joint T cell receptor excision circles ( ...

Abstract	Signal joint T cell receptor excision circles (
Language	English
Publishing date	2022-12-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10123193
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Article ; Online: Specific T cells targeting Staphylococcus aureus fibronectin-binding protein 1 induce a type 2/type 1 inflammatory response in sensitized atopic dermatitis patients.

Farag, Ahmed K / Roesner, Lennart M / Wieschowski, Susanne / Heratizadeh, Annice / Eiz-Vesper, Britta / Kwok, William W / Valenta, Rudolf / Werfel, Thomas

Allergy

2021 Volume 77, Issue 4, Page(s) 1245–1253

Abstract: ... characterize FBP1-specific T cells as possible trigger factors in AD.: Methods: Immunodominant T-cell ... epitopes were mapped by proliferation testing of patient-derived FBP1-specific T-cell lines after ... stained T helper cells in 8 out of 8 HLA-matched, IgE-sensitized AD patients.: Results: Cytokine ...

Abstract	Background: Atopic dermatitis (AD) is one of the most common inflammatory skin diseases worldwide and Staphylococcus aureus colonization and secondary infections occur in the majority of AD patients. Allergic sensitizations against microbial antigens have been discussed as possible trigger factors of AD. Recently, we reported IgE sensitization against fibronectin-binding protein 1 (FBP1), an essential virulence component in S. aureus, in a subgroup of patients suffering from AD. To expand these findings by investigating delayed-type immune reactions, the objective of this study was to detect and phenotypically characterize FBP1-specific T cells as possible trigger factors in AD. Methods: Immunodominant T-cell epitopes were mapped by proliferation testing of patient-derived FBP1-specific T-cell lines after stimulation with single 15mer peptides, which were derived from different functional domains of the FBP1 sequence. Major histocompatibility complex class II tetramers carrying immunodominant epitopes successfully stained T helper cells in 8 out of 8 HLA-matched, IgE-sensitized AD patients. Results: Cytokine profiling of multimer-sorted cells revealed that predominantly the type 2 cytokines IL-13 and IL-4 were secreted by these cells. In contrast, IL-17, the marker cytokine for response to extracellular pathogens, was scarcely detectable. Conclusions: We demonstrate that FBP1 contains immunodominant peptides that induce a specific pro-inflammatory T helper cell response with increased Th2 levels that can drive an allergic inflammation in sensitized AD patients.
MeSH term(s)	Carrier Proteins/metabolism ; Cytokines/metabolism ; Dermatitis, Atopic ; Fibronectins/metabolism ; Humans ; Immunoglobulin E ; Skin ; Staphylococcal Infections/metabolism ; Staphylococcus aureus
Chemical Substances	Carrier Proteins ; Cytokines ; Fibronectins ; Immunoglobulin E (37341-29-0)
Language	English
Publishing date	2021-10-22
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15120
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Article ; Online: Alveolar process changes associated with administration of nucleos(t)ide analogue (sofosbuvir) in rat model.

Farag, Dina Badawy Elsayed / El-Baz, Dalia Abdel-Hameed / Salem, Zeinab Amin

Dental and medical problems

2018 Volume 55, Issue 1, Page(s) 11–16

Abstract: ... of oral nucleos(t)ide analogues.: Objectives: Investigating sofosbuvir-induced alterations in the rat ...

Abstract	Background: Sofosbuvir is a nucleotide compound that has proved to be among the most potent orally available antiviral treatments. Infrequent but serious adverse events have been reported with the use of oral nucleos(t)ide analogues. Objectives: Investigating sofosbuvir-induced alterations in the rat mandibular alveolar process. Material and methods: In the study, 30 adult male albino rats were used and divided randomly into following groups: group 1, group 2 and group 3 (10 rats per group). Group 1 served as a control, group 2 received sofosbuvir through oral gavage at a dose of 40 mg/kg/day for 6 weeks, and group 3 was similar to group 2 but received sofosbuvir for 12 weeks. The animals were sacrificed at the end of the experiment. The mandibles were dissected and examined histologically as well as by scanning electron microscope (SEM) and energy dispersive X-ray unit (EDX). Results: Histologically, group 1 showed normal alveolar process. In group 2, histopathological changes occurred as bone trabeculae demonstrated obvious Howship's lacuna of osteoclasts. In group 3, bone trabeculae exhibited multiple degenerated areas as well as apparent vacuolization. Scanning electron microscopic examination revealed smooth alveolar bone architecture in group 1. On the other hand, groups 2 and 3 demonstrated irregular bone architecture with formation of multiple pores. EDX analysis demonstrated the highest calcium concentration in the control group, while the lowest was found in group 3. Statistical analysis of the EDX results revealed a statistically significant difference among the studied groups as the p-value was <0.01. Conclusions: It has been concluded that sofosbuvir induced apparent alterations in the rats' alveolar bone. This effect was exaggerated in a longer period of drug administration. The sofosbuvir-induced alterations might be attributed mainly to mitochondrial toxicity. The effect had been clearly shown histologically and morphologically as well as in bone mineral (calcium) content.
MeSH term(s)	Alveolar Process/metabolism ; Alveolar Process/pathology ; Animals ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Calcium/metabolism ; Cancellous Bone/pathology ; Drug Administration Schedule ; Mandible/metabolism ; Mandible/pathology ; Microscopy, Electron, Scanning ; Models, Animal ; Rats ; Sofosbuvir/administration & dosage ; Sofosbuvir/adverse effects ; Spectrometry, X-Ray Emission
Chemical Substances	Antiviral Agents ; Calcium (SY7Q814VUP) ; Sofosbuvir (WJ6CA3ZU8B)
Language	English
Publishing date	2018-08-27
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2592057-1
ISSN	2300-9020 ; 1644-387X
ISSN (online)	2300-9020
ISSN	1644-387X
DOI	10.17219/dmp/81592
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Article: HBVsvp-Pulsed Dendritic Cell Immunotherapy Induces Th1 Polarization and Hepatitis B Virus-Specific Cytotoxic T Lymphocytes Production.

Farag, Mohamed M S / Suef, Reda A / Al-Toukhy, Ghada M / Selim, Mohamed A / Elbahnasawy, Mostafa A / El Sharkawy, Nahla / Ezzat, Sameera / Shebl, Nashwa / Mansour, Mohamed T M

Infection and drug resistance

2020 Volume 13, Page(s) 2699–2709

Abstract: Background: In chronic hepatitis B virus (CHB) patients, both dendritic cells (DCs) and T ... particles (HBVsvp) can polarize Th1 cells to induce HBV-specific cytotoxic T-lymphocytes (CTL) responses ... donors, were differentiated into MoDCs and T cells. PBMCs-derived MoDCs were first pulsed with HBVsvp and ...

Abstract	Background: In chronic hepatitis B virus (CHB) patients, both dendritic cells (DCs) and T cells are functionally impaired and consequently the HBV-specific cellular immune responses are downregulated. The present study aims to investigate whether monocyte-derived DC (MoDCs)-pulsed-HBV subviral particles (HBVsvp) can polarize Th1 cells to induce HBV-specific cytotoxic T-lymphocytes (CTL) responses in CHB patients. Methods and materials: To this end, the human hepatoma HepG2.2.15 cell line was used to produce HBVsvp as a culturing system, and HBVsvp were concentrated for highly virus titer using the polyethylene glycol protocol. Peripheral blood mononuclear cells (PBMCs), collected from CHB patients and healthy donors, were differentiated into MoDCs and T cells. PBMCs-derived MoDCs were first pulsed with HBVsvp and then cultured with PBMCs-derived T cells. MoDCs and/or T subsets cells were identified for phenotypic activation by FACS analysis. The cytokine secretion of IL-4, IL-12, and IFN-γ in the culture supernatants was detected. Results: The MoDCs were restored for their activation upon pulsing with HBVsvp in vitro, as identified by significantly overexpression of both CD86 and HLA-DR, and overproduction of IL-4 and IL-12. Furthermore, MoDCs-pulsed-HBVsvp induced Th1 frequencies and activated HBV-specific CTL to produce significantly highest amount of IFN-γ. Enhanced HBV-specific CTL led to strong cytolytic capacity against HepG2.2.15. Conclusion: Overall, our data suggest that in vitro activation of MoDCs with HBVsvp overcomes the functionally impaired DCs and T cells in CHB patients offering a promising tool for therapeutic or vaccine-based approaches against HBV.
Language	English
Publishing date	2020-08-05
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S265681
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Article: Apoptosis of T-cell subsets in colorectal cancer in vivo.

Youssef, Manal M S / Paish, Emma C / Murray, J Clifford / Farag, Naglaa M / Saleh, Khaled / Ellis, I O

The Egyptian journal of immunology

2014 Volume 21, Issue 2, Page(s) 61–74

Abstract: ... indicators. We used double immunohistochemistry to assess the apoptosis of T-cell subsets ... Monoclonal antibodies to T lymphocytes, T helper cells, cytotoxic T cells (CTLs), natural killer cells (NK), CD45 and ... CD45RO were used. Antibodies against cleaved caspase-3 as a marker of apoptosis were used. Apoptosis of T ...

Abstract	Dysfunction of the immune system in colorectal cancer (CRC) can be due to a number of reasons including apoptosis of tumour infiltrating lymphocytes (TILs). The aims of this study were to characterize, phenotypically, the apoptosis of TILs in CRC, and define the association of these findings with prognostic indicators. We used double immunohistochemistry to assess the apoptosis of T-cell subsets. Monoclonal antibodies to T lymphocytes, T helper cells, cytotoxic T cells (CTLs), natural killer cells (NK), CD45 and CD45RO were used. Antibodies against cleaved caspase-3 as a marker of apoptosis were used. Apoptosis of T-cell subsets was detected in the immune infiltrate in CRC. Apoptosis of T lymphocytes showed significant correlation with lymphatic metastasis (P = 0.01), Dukes' stage (P = 0.019). Apoptotic T helper cells showed significant correlation with metastasis (P = 0.04), lymphatic metastasis (P = 0.02), death (P = 0.04) and recurrence (P = 0.04). For apoptosis of CTLs, there was a significant correlation with histological classification (P = 0.02), lymphatic metastasis (P = 0.04), vascular metastasis (P = 0.03) and lymph node metastasis (P = 0.04). A significant association was found between the apoptosis of NK cells and the histological classification (P = 0.04). A significant association was found between the apoptosis of cd45RO cells and the histological classification (P = 0.04). In conclusion, apoptosis of lymphocytes provides theoretical foundation for metastasis and counterattack of colon cancer.
MeSH term(s)	Apoptosis/immunology ; Caspase 3/immunology ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Female ; Humans ; Leukocyte Common Antigens/immunology ; Male ; Neoplasm Metastasis ; Neoplasm Proteins/immunology ; Retrospective Studies ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/pathology
Chemical Substances	Neoplasm Proteins ; Leukocyte Common Antigens (EC 3.1.3.48) ; CASP3 protein, human (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
Language	English
Publishing date	2014
Publishing country	Egypt
Document type	Journal Article
ISSN	1110-4902
ISSN	1110-4902
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Article: Tumor Infiltrating T Lymphocytes and Apoptosis in Colorectal Cancer.

Youssef, Manal M S / Paish, Emma C / Murray, J Clifford / Farag, Naglaa M / Saleh, Khaled / Ellis, I O

The Egyptian journal of immunology

2015 Volume 22, Issue 1, Page(s) 19–28

Abstract: ... mAbs) to T lymphocytes to detect TILs and double immunohistochemistry to assess apoptosis ... T lymphocytes were detected in the immune infiltrate in CRC. TUNEL staining disclosed a high level of cell death ... among TILs. Apoptosis of T lymphocytes showed significant correlation with Dukes' stage (P = 0.02 ...

Abstract	Dysfunction of the immune system in colorectal cancer (CRC) can be due to a number of reasons including apoptosis of tumour infiltrating lymphocytes (TILs). The aims of this study was to investigate TILs in colorectal cancer and characterize apoptosis of TILs using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay for detecting DNA fragments. We used monoclonal antibodies (mAbs) to T lymphocytes to detect TILs and double immunohistochemistry to assess apoptosis. T lymphocytes were detected in the immune infiltrate in CRC. TUNEL staining disclosed a high level of cell death among TILs. Apoptosis of T lymphocytes showed significant correlation with Dukes' stage (P = 0.02), lymphatic metastasis (P = 0.03), vascular metastasis (P = 0.01), lymph node metastasis (P = 0.02) and age of patient (P = 0.01). In conclusion, CRC may elude immunological surveillance by inducing apoptosis of TILs.
MeSH term(s)	Aged ; Apoptosis/immunology ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Female ; Humans ; Immunohistochemistry ; In Situ Nick-End Labeling ; Kaplan-Meier Estimate ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/pathology ; Male ; Middle Aged ; T-Lymphocytes/immunology ; T-Lymphocytes/pathology
Language	English
Publishing date	2015
Publishing country	Egypt
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1110-4902
ISSN	1110-4902
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Article ; Online: Characterization of clinical human prostate cancer lesions using 3.0-T sodium MRI registered to Gleason-graded whole-mount histopathology.

Broeke, Nolan C / Peterson, Justin / Lee, Joseph / Martin, Peter R / Farag, Adam / Gomez, Jose A / Moussa, Madeleine / Gaed, Mena / Chin, Joseph / Pautler, Stephen E / Ward, Aaron / Bauman, Glenn / Bartha, Robert / Scholl, Timothy J

Journal of magnetic resonance imaging : JMRI

2018 Volume 49, Issue 5, Page(s) 1409–1419

Abstract: ... Purpose: To measure the distribution of tissue sodium concentration (TSC), proton T: Study type: Cross ... sectional.: Subjects: Ten men with biopsy-proven PCa.: Sequences/field strength: Sodium, proton T ... as the standard for prostate cancer lesion characterization. Regional TSC and T: Statistics: Differences ...

Abstract	Background: Overtreatment of prostate cancer (PCa) is a healthcare issue. Development of noninvasive imaging tools for improved characterization of prostate lesions might reduce overtreatment. Purpose: To measure the distribution of tissue sodium concentration (TSC), proton T Study type: Cross-sectional. Subjects: Ten men with biopsy-proven PCa. Sequences/field strength: Sodium, proton T Assessment: All imaging data were coregistered to Gleason-graded postprostatectomy histology, as the standard for prostate cancer lesion characterization. Regional TSC and T Statistics: Differences in ΔTSC, ADC, and ΔT Results: Evaluation of the correlation of ΔTSC, ADC, and ΔT Data conclusion: The results of this preliminary study suggest that changes in TSC, assessed by sodium MRI, has utility as a noninvasive imaging assay to accurately characterize PCa lesions. Sodium MRI may provide useful complementary information on mpMRI, which may assist the decision-making of men choosing either active surveillance or treatment. Level of evidence: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:1409-1419.
MeSH term(s)	Cross-Sectional Studies ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neoplasm Grading ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Sodium
Chemical Substances	Sodium (9NEZ333N27)
Language	English
Publishing date	2018-11-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.26336
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