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Article ; Online: Diagnostic accuracy of antineutrophil cytoplasmic antibodies (ANCA) in predicting relapses of ANCA-associated vasculitis: systematic review and meta-analysis.

Mehta, Pankti / Balakrishnan, Anu / Phatak, Sanat / Pathak, Mona / Ahmed, Sakir

2022 Volume 43, Issue 3, Page(s) 437–448

Abstract: Relapse in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is associated with significant morbidity and mortality. Utility of ANCA for prediction of relapses is still controversial. PubMed/MEDLINE, Scopus, and WebOfScience were ... ...

Abstract	Relapse in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is associated with significant morbidity and mortality. Utility of ANCA for prediction of relapses is still controversial. PubMed/MEDLINE, Scopus, and WebOfScience were searched, screened and confirmed for inclusion [PROSPERO No: CRD42020220308]. Studies measuring serial ANCA by ELISA or indirect immunofluorescence (IF), reporting relapses with sufficient data to calculate sensitivity and specificity were included. Diagnostic odds ratio (OR), sensitivity, specificity and likelihood ratios (LR) were synthesized using a bivariate mixed-effect regression model. Sub-group analysis included a comparison between ELISA and IIF, anti-myeloperoxidase (MPO) and -proteinase 3(PR3), and type of rise in ANCA. For meta-analysis of survival outcomes, hazard ratios were synthesized using a random-effect model. QUADAS-2 was used for assessing quality of studies, I
MeSH term(s)	Humans ; Antibodies, Antineutrophil Cytoplasmic ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis ; Myeloblastin ; Biomarkers ; Enzyme-Linked Immunosorbent Assay ; Recurrence ; Peroxidase
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic ; Myeloblastin (EC 3.4.21.76) ; Biomarkers ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	2022-08-30
Publishing country	Germany
Document type	Meta-Analysis ; Systematic Review
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-022-05192-3
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Zs.A 1639: Show issues

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Article ; Online: 5-year stroke rates in nonvalvular atrial fibrillation after watchman compared to direct oral anticoagulants.

Khalid, Syed I / Sathianathan, Shyama / Thomson, Kyle B / McGuire, Laura Stone / Soni, Mona C / Mehta, Ankit I

Journal of cardiology

2023 Volume 83, Issue 3, Page(s) 163–168

Abstract: Background: The WATCHMAN device (Boston Scientific; Marlborough, MA, USA) is noninferior to warfarin in preventing ischemic strokes while reducing bleeding risks associated with long term anticoagulation in nonvalvular atrial fibrillation (AFib). The ... ...

Abstract	Background: The WATCHMAN device (Boston Scientific; Marlborough, MA, USA) is noninferior to warfarin in preventing ischemic strokes while reducing bleeding risks associated with long term anticoagulation in nonvalvular atrial fibrillation (AFib). The device's performance compared to direct oral anticoagulants (DOAC) is less well known. Objective: To compare 5-year major bleeding and ischemic stroke rates in patients with nonvalvular AFib who received a WATCHMAN device or DOAC therapy after a major bleeding event. Methods: This retrospective, multicenter, 1:1 matched cohort study was derived from the PearlDiver Mariner database from 2010 to 2020. Patients with nonvalvular AFib on oral anticoagulation who had a major bleeding event were identified. Those who received either WATCHMAN or DOAC after resolution of the bleeding event were selected. The two groups were exactly matched 1:1 based on various comorbidities. Rates of ischemic stroke, transient ischemic attack (TIA), major bleeding, and hemorrhagic stroke were compared over 5 years. Results: Each cohort consisted of 2248 patients after 1:1 matching. The mean CHADS2-VASC score was 4.81 ± 1.25. At 5 years, the WATCHMAN cohort had significantly lower rates of major bleeding events [OR 0.24 (0.21, 0.27)], TIAs [OR 0.75 (0.58, 0.95)], and ischemic strokes [OR 0.72 (0.61, 0.86)]. There was no significant difference in hemorrhagic strokes [OR 1.14 (0.83, 1.58)]. Conclusion: Even in a high-risk population, the WATCHMAN is comparable to DOAC therapy in the primary prevention of hemorrhagic strokes and may provide benefit in the rates of bleeding events, TIAs, and ischemic strokes.
MeSH term(s)	Humans ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Anticoagulants/adverse effects ; Hemorrhagic Stroke ; Cohort Studies ; Retrospective Studies ; Treatment Outcome ; Stroke/epidemiology ; Stroke/etiology ; Stroke/prevention & control ; Hemorrhage/chemically induced ; Hemorrhage/epidemiology ; Hemorrhage/complications ; Ischemic Stroke/complications ; Ischemic Stroke/drug therapy ; Atrial Appendage ; Administration, Oral
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-08-03
Publishing country	Netherlands
Document type	Multicenter Study ; Journal Article
ZDB-ID	639364-0
ISSN	1876-4738 ; 0386-2887 ; 0914-5087
ISSN (online)	1876-4738
ISSN	0386-2887 ; 0914-5087
DOI	10.1016/j.jjcc.2023.07.015
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Zs.A 1794: Show issues

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Article ; Online: Expanding the access to kidney transplantation: Strategies for kidney transplant programs.

Nishio Lucar, Angie G / Patel, Ankita / Mehta, Shikha / Yadav, Anju / Doshi, Mona / Urbanski, Megan A / Concepcion, Beatrice P / Singh, Neeraj / Sanders, M Lee / Basu, Arpita / Harding, Jessica L / Rossi, Ana / Adebiyi, Oluwafisayo O / Samaniego-Picota, Milagros / Woodside, Kenneth J / Parsons, Ronald F

Clinical transplantation

2024 Volume 38, Issue 5, Page(s) e15315

Abstract: Kidney transplantation is the most successful kidney replacement therapy available, resulting in improved recipient survival and societal cost savings. Yet, nearly 70 years after the first successful kidney transplant, there are still numerous barriers ... ...

Abstract	Kidney transplantation is the most successful kidney replacement therapy available, resulting in improved recipient survival and societal cost savings. Yet, nearly 70 years after the first successful kidney transplant, there are still numerous barriers and untapped opportunities that constrain the access to transplant. The literature describing these barriers is extensive, but the practices and processes to solve them are less clear. Solutions must be multidisciplinary and be the product of strong partnerships among patients, their networks, health care providers, and transplant programs. Transparency in the referral, evaluation, and listing process as well as organ selection are paramount to build such partnerships. Providing early culturally congruent and patient-centered education as well as maximizing the use of local resources to facilitate the transplant work up should be prioritized. Every opportunity to facilitate pre-emptive kidney transplantation and living donation must be taken. Promoting the use of telemedicine and kidney paired donation as standards of care can positively impact the work up completion and maximize the chances of a living donor kidney transplant.
MeSH term(s)	Kidney Transplantation ; Humans ; Health Services Accessibility ; Tissue and Organ Procurement/methods ; Kidney Failure, Chronic/surgery ; Living Donors/supply & distribution ; Waiting Lists
Language	English
Publishing date	2024-04-30
Publishing country	Denmark
Document type	Journal Article ; Review
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.15315
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Zs.A 2204: Show issues

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Article ; Online: Assessing Impact: Implementing an Opioid Prescription Protocol in Otolaryngology.

Thal, Arielle G / Ahmed, Sadia / Kim, Stanley / Yang, Christina J / Gao, Qi / Gangar, Mona / Mehta, Vikas

Journal of patient safety

2022 Volume 18, Issue 6, Page(s) e992–e998

Abstract: Objective: A lack of guidance for pain control after otolaryngology surgery can lead to overprescription of opioids. We implemented a postoperative site-specific opioid prescription protocol and analyzed the impact on opioid prescriptions.: Methods: ... ...

Abstract	Objective: A lack of guidance for pain control after otolaryngology surgery can lead to overprescription of opioids. We implemented a postoperative site-specific opioid prescription protocol and analyzed the impact on opioid prescriptions. Methods: This is a retrospective cohort study. A postoperative opioid prescription protocol was implemented within our otolaryngology department at a tertiary academic medical center on January 1, 2020. Retrospective chart review was completed for all patients undergoing otolaryngology surgery from November 1, 2019, to February 29, 2020 (2 months before and after initiation of intervention; n = 1070). The primary outcome was change in the amount of opioid prescribed for the preintervention and postintervention cohorts. Unplanned contact related to pain and opioid refills were tracked to assess pain control. Results: A total of 940 cases were included; adult and pediatric data were analyzed separately. There were 489 pediatric cases, 250 preintervention and 239 postintervention. There was a significant decrease in the amount of opioid prescribed per pediatric patient in the postintervention cohort (2.7 versus 0.32 morphine milligram equivalents, P = 0.02), and 99% of patients were not prescribed opioids at all. There was no significant change in unplanned contact, and no refills were required. There were 451 adult cases, 200 preintervention and 251 postintervention. There was no statistically significant decrease in the amount of opioid prescribed per adult patient (56.8 versus 51.7 morphine milligram equivalents, P = 0.23). There was no significant increase in unplanned contact or refills. Conclusions: A postoperative opioid prescribing protocol can reduce the amount of opioid prescribed without increasing unplanned contact or opioid refills.
MeSH term(s)	Adult ; Analgesics, Opioid/therapeutic use ; Child ; Drug Prescriptions ; Humans ; Morphine Derivatives/therapeutic use ; Otolaryngology ; Pain, Postoperative/drug therapy ; Pain, Postoperative/prevention & control ; Practice Patterns, Physicians' ; Retrospective Studies
Chemical Substances	Analgesics, Opioid ; Morphine Derivatives
Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2394324-5
ISSN	1549-8425 ; 1549-8417
ISSN (online)	1549-8425
ISSN	1549-8417
DOI	10.1097/PTS.0000000000000970
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Zs.A 6583: Show issues

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Article ; Online: The Efficacy of Human Papillomavirus Vaccination as an Adjuvant Therapy in Recurrent Respiratory Papillomatosis.

Ponduri, Anusha / Azmy, Monica C / Axler, Eden / Lin, Juan / Schwartz, Rachel / Chirilă, Magdalena / Dikkers, Frederik G / Yang, Christina J / Mehta, Vikas / Gangar, Mona

The Laryngoscope

2023 Volume 133, Issue 9, Page(s) 2046–2054

Abstract: Objective: To characterize the efficacy of human papillomavirus (HPV) vaccination as an adjuvant therapy in recurrent respiratory papillomatosis (RRP).: Data sources: PubMed, Embase, Cochrane, Google Scholar, ClinicalTrials.gov, and Web of Science ... ...

Abstract	Objective: To characterize the efficacy of human papillomavirus (HPV) vaccination as an adjuvant therapy in recurrent respiratory papillomatosis (RRP). Data sources: PubMed, Embase, Cochrane, Google Scholar, ClinicalTrials.gov, and Web of Science databases were queried for articles published before April 2021. Review methods: All retrieved studies (n = 870) were independently analyzed by two reviewers according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement using predefined inclusion and exclusion criteria. 13 studies met inclusion criteria. A random-effects meta-analysis was performed to study intersurgical interval (ISI) and number of surgical procedures per year before and after vaccination. Results: The systematic review included 13 studies, comprising 243 patients. All studies utilized the Gardasil® quadrivalent vaccine, and one study (Yiu et al. 2019) utilized both the quadrivalent and Gardasil® 9-valent vaccines. Our meta-analysis included 62 patients with ISI data across 4 studies, and 111 patients with data on the number of surgical procedures per month across 7 studies. The mean number of surgical procedures decreased by 4.43 per year after vaccination (95% CI, -7.48 to -1.37). Mean ISI increased after vaccination, with a mean difference of 15.73 months (95% CI, 1.46-29.99). Two studies reported on HPV sero-conversion, with HPV seropositivity of 100% prior to vaccination and 25.93% after vaccination. Conclusion: The addition of HPV vaccination was associated with an increase in time between surgeries and reduction in the number of surgical procedures required. HPV vaccination may be a beneficial adjuvant treatment for RRP. Level of evidence: NA Laryngoscope, 133:2046-2054, 2023.
MeSH term(s)	Humans ; Papillomavirus Vaccines/therapeutic use ; Papillomavirus Infections/prevention & control ; Papillomavirus Infections/surgery ; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 ; Human Papillomavirus Viruses ; Vaccination ; Respiratory Tract Infections/prevention & control ; Respiratory Tract Infections/surgery
Chemical Substances	Papillomavirus Vaccines ; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30560
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Ul II Zs.82: Show issues

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Article ; Online: Quantitative X-ray fluorescence analysis: Trace level detection of toxic elemental impurities in drug product by ED-XRF spectrometer.

Chowdhury, Anirban Roy / Maheshwari, Neelesh / Soni, Jigar / Kapil, Mona / Mehta, Tushar / Mukharya, Amit

Journal of pharmaceutical and biomedical analysis

2020 Volume 189, Page(s) 113292

Abstract: Inorganic impurity analysis of pharmaceutical drug products is of paramount importance at trace levels due to the availability of toxic metals. The existing techniques require extensive development and chemical treatment to evaluate the presence of class ...

Abstract	Inorganic impurity analysis of pharmaceutical drug products is of paramount importance at trace levels due to the availability of toxic metals. The existing techniques require extensive development and chemical treatment to evaluate the presence of class I (Pb, Cd, Hg and As) and class II (Co, V and Ni) heavy metal elements which are harmful to the environment. To overcome these issues, a cost and time effective wavelength dispersive X-ray fluorescence spectrometry (XRF) was introduced to determine the concentration of trace elements in one of the angiotensin receptor blocker (ARB) (tablet sample 300 mg) according to guidelines addressed in ICH Q3D and USP. The validation study focused on class I and class II elements are also in accordance with regulatory guidelines. Overall it includes the comprehensive characterization of analytical method which is compliant with the requirement of USP. The novelty of this work includes the application of EDXRF in routine analysis of trace elements (especially volatile Hg) present in the pharmaceutical product beyond the previously published studies for the limited number of the non-pharmaceutical regime. Apart from this it also requires minimal sample preparation and method development and is able to quantify toxic impurities which are present in the sample in less than 20 ppm concentration, with the lowest level of detection up to 0.1 ppm.
MeSH term(s)	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Pharmaceutical Preparations ; Spectrometry, X-Ray Emission ; Trace Elements ; X-Rays
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Pharmaceutical Preparations ; Trace Elements
Language	English
Publishing date	2020-06-23
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2020.113292
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Zs.A 1850: Show issues

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Article ; Online: Intra- and Interobserver Reliability of Bone Volume Estimation Using OsiriX Software in Patients with Cleft Lip and Palate Using Cone Beam Computed Tomography.

Kochhar, Anuraj Singh / Sidhu, Maninder Singh / Prabhakar, Mona / Bhasin, Ritasha / Kochhar, Gulsheen Kaur / Dadlani, Himanshu / Spagnuolo, Gianrico / Mehta, Viral Vijay

Dentistry journal

2021 Volume 9, Issue 2

Abstract: The objective of the current study was to evaluate intra- and interobserver bone volume measurements and effect of orientation on the reliability of bone volume evaluation in as-acquired vis-à-vis oriented cone beam computed tomography scans using Osirix ...

Abstract	The objective of the current study was to evaluate intra- and interobserver bone volume measurements and effect of orientation on the reliability of bone volume evaluation in as-acquired vis-à-vis oriented cone beam computed tomography scans using Osirix software and possible correlation between gender, age, and bone volume required. For this, 31 cone beam computed tomography (CBCT) scans of 14 girls and 17 boys (aged 9-13) with unilateral cleft lip and/or palate who met the inclusion criteria were analyzed. Efficacy and reliability of third party software Osirix for bone volume calculation was assessed using as acquired and oriented volumes by three specialists (a radiologist, an orthodontist, and an oral maxillofacial surgeon). The dataset and readings were anonymized to prevent any bias. Two-way mixed model analysis on as-acquired and oriented observations exhibited intra-class coefficient (ICC) values ≥ 0.90. Wilcoxon signed rank test (
Language	English
Publishing date	2021-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681351-8
ISSN	2304-6767 ; 2304-6767
ISSN (online)	2304-6767
ISSN	2304-6767
DOI	10.3390/dj9020014
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Article ; Online: Should Transplant Nephrology Pursue Recognition from the Accreditation Council for Graduate Medical Education (ACGME)?

Singh, Neeraj / Anand, Prince M / Gupta, Gaurav / Sawinski, Deirdre / Fix, Oren / Adey, Deborah / Akalin, Enver / Zayas, Carlos / Dadhania, Darshana / Doshi, Mona / Cibrik, Diane / Gupta, Mallika / Parsons, Ronald / Leca, Nicolae / Santos, Rowena Delos / Concepcion, Beatrice P / Nishio Lucar, Angie G / Ong, Song / Sridhar, Vikas Srinivasan /

Parajuli, Sandesh / Zachariah, Mareena / Mehta, Shikha / Soliman, Karim / Shawar, Saed / Husain, Syed Ali / Preczewski, Luke / Friedewald, John / Mohan, Sumit / Wiseman, Alexander / Samaniego, Millie / Kumar, Vineeta / Tanriover, Bekir / Bloom, Roy

Clinical journal of the American Society of Nephrology : CJASN

2024

Abstract: Kidney transplant is not only the best treatment for patients with advanced kidney disease but it also reduces health care expenditure. The management of transplant patients is complex as they require special care by transplant nephrologists who have ... ...

Abstract	Kidney transplant is not only the best treatment for patients with advanced kidney disease but it also reduces health care expenditure. The management of transplant patients is complex as they require special care by transplant nephrologists who have expertise in assessing transplant candidates, understand immunology and organ rejection, have familiarity with perioperative complications, and have the ability to manage the long-term effects of chronic immunosuppression. This skill set at the intersection of multiple disciplines necessitates additional training in Transplant Nephrology. Currently, there are more than 250,000 patients with a functioning kidney allograft and over 100,000 waitlisted patients awaiting kidney transplant, with a burgeoning number added to the kidney transplant wait list every year. In 2022, more than 40,000 patients were added to the kidney wait list and more than 25,000 received a kidney transplant. The Advancing American Kidney Health Initiative, passed in 2019, is aiming to double the number of kidney transplants by 2030 creating a need for additional transplant nephrologists to help care for them. Over the past decade, there has been a decline in the Nephrology-as well Transplant Nephrology-workforce due to a multitude of reasons. The American Society of Transplantation Kidney Pancreas Community of Practice created a workgroup to discuss the Transplant Nephrology workforce shortage. In this article, we discuss the scope of the problem and how the Accreditation Council for Graduate Medical Education recognition of Transplant Nephrology Fellowship could at least partly mitigate the Transplant Nephrology work force crisis.
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.0000000000000441
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Article ; Online: Gas Sensing with Bare and Graphene-covered Optical Nano-Antenna Structures.

Mehta, Bhaven / Benkstein, Kurt D / Semancik, Steve / Zaghloul, Mona E

Scientific reports

2016 Volume 6, Page(s) 21287

Abstract: The motivation behind this work is to study the gas phase chemical sensing characteristics of optical (plasmonic) nano-antennas (ONA) and graphene/graphene oxide-covered versions of these structures. ONA are devices that have their resonating frequency ... ...

Abstract	The motivation behind this work is to study the gas phase chemical sensing characteristics of optical (plasmonic) nano-antennas (ONA) and graphene/graphene oxide-covered versions of these structures. ONA are devices that have their resonating frequency in the visible range. The basic principle governing the detection mechanism for ONA is refractive index sensing. The change in the concentration of the analyte results in a differing amount of adsorbate and correlated shifts in the resonance wavelength of the device. In this work, bare and graphene or graphene oxide covered ONA have been evaluated for gas sensing performance. Four different analytes (ethanol, acetone, nitrogen dioxide and toluene) were used in testing. ONA response behavior to different analytes was modified by adsorption within the graphene and graphene oxide overlayers. This work is a preliminary study to understand resonance wavelength shift caused by different analytes. Results imply that the combination of well-structured ONA functionalized by graphene-based adsorbers can give sensitive and selective sensors but baseline drift effects identified in this work must be addressed for applied measurements.
Language	English
Publishing date	2016-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep21287
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Article ; Online: High-throughput spatial sensitive quantitative phase microscopy using low spatial and high temporal coherent illumination.

Ahmad, Azeem / Dubey, Vishesh / Jayakumar, Nikhil / Habib, Anowarul / Butola, Ankit / Nystad, Mona / Acharya, Ganesh / Basnet, Purusotam / Mehta, Dalip Singh / Ahluwalia, Balpreet Singh

Scientific reports

2021 Volume 11, Issue 1, Page(s) 15850

Abstract: High space-bandwidth product with high spatial phase sensitivity is indispensable for a single-shot quantitative phase microscopy (QPM) system. It opens avenue for widespread applications of QPM in the field of biomedical imaging. Temporally low ... ...

Abstract	High space-bandwidth product with high spatial phase sensitivity is indispensable for a single-shot quantitative phase microscopy (QPM) system. It opens avenue for widespread applications of QPM in the field of biomedical imaging. Temporally low coherence light sources are implemented to achieve high spatial phase sensitivity in QPM at the cost of either reduced temporal resolution or smaller field of view (FOV). In addition, such light sources have low photon degeneracy. On the contrary, high temporal coherence light sources like lasers are capable of exploiting the full FOV of the QPM systems at the expense of less spatial phase sensitivity. In the present work, we demonstrated that use of narrowband partially spatially coherent light source also called pseudo-thermal light source (PTLS) in QPM overcomes the limitations of conventional light sources. The performance of PTLS is compared with conventional light sources in terms of space bandwidth product, phase sensitivity and optical imaging quality. The capabilities of PTLS are demonstrated on both amplitude (USAF resolution chart) and phase (thin optical waveguide, height ~ 8 nm) objects. The spatial phase sensitivity of QPM using PTLS is measured to be equivalent to that for white light source and supports the FOV (18 times more) equivalent to that of laser light source. The high-speed capabilities of PTLS based QPM is demonstrated by imaging live sperm cells that is limited by the camera speed and large FOV is demonstrated by imaging histopathology human placenta tissue samples. Minimal invasive, high-throughput, spatially sensitive and single-shot QPM based on PTLS will enable wider penetration of QPM in life sciences and clinical applications.
Language	English
Publishing date	2021-08-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-94915-w
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