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Article ; Online: Spatial Epidemiological Analysis of Keshan Disease in China.

Jia, Yuehui / Han, Shan / Hou, Jie / Wang, Ruixiang / Li, Guijin / Su, Shengqi / Qi, Lei / Wang, Yuanyuan / Du, Linlin / Sun, Huixin / Hao, Shuxiu / Feng, Chen / Wang, Yanan / Liu, Xu / Zou, Yuanjie / Zhang, Yiyi / Li, Dandan / Wang, Tong

Annals of global health

2022 Volume 88, Issue 1, Page(s) 79

Abstract: Objectives: Few researchers have studied the national prevalence of Keshan disease (KD) in China ... analysis showed that global clustering of latent Keshan disease (LKD) prevalence was noted (Moran's ... I = 0.22, Z = 7.06, and P < 0.0001), no global clustering of chronic Keshan disease (CKD ...

Abstract	Objectives: Few researchers have studied the national prevalence of Keshan disease (KD) in China using spatial epidemiological methods. This study aimed to provide geographically precise and visualized evidence for the strategies for KD prevention and control. Methods: We surveyed and analyzed 237,000 people in 280 out of 328 KD-endemic counties (85.4%) in mainland China using a design of key investigation based on case-searching in 2015-2016. ArcGIS version 9.0 was used for spatial autocorrelation analysis, spatial interpolation analysis and spatial regression analysis. Results: Global autocorrelation analysis showed that global clustering of latent Keshan disease (LKD) prevalence was noted (Moran's I = 0.22, Z = 7.06, and P < 0.0001), no global clustering of chronic Keshan disease (CKD) prevalence (Moran's I = 0.03, Z = 1.10, and P = 0.27) was observed. Spatial regression analysis showed that LKD prevalence was negatively correlated with per capita disposable income (t = -4.36, P < 0.0001). Local autocorrelation analysis at the county level effectively identified the cluster areas of LKD prevalence in the provinces of Shaanxi, Gansu, Shanxi, Inner Mongolia, and Jilin. The high-high cluster areas should be given priority for precision prevention and control of Keshan disease. Conclusions: This spatial epidemiological study revealed that LKD prevention and control should be strengthened in areas with high values of clustering. Our findings provided spatially, geographically precise and visualized evidence for prioritizing KD prevention and control.
MeSH term(s)	Cardiomyopathies/epidemiology ; China/epidemiology ; Enterovirus Infections/epidemiology ; Humans ; Spatial Analysis ; Spatio-Temporal Analysis
Language	English
Publishing date	2022-09-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2821756-1
ISSN	2214-9996 ; 2214-9996
ISSN (online)	2214-9996
ISSN	2214-9996
DOI	10.5334/aogh.3836
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Article: A County-Level Spatial Study of Serum Selenoprotein P and Keshan Disease.

Jia, Yuehui / Wang, Ruixiang / Su, Shengqi / Qi, Lei / Wang, Yuanyuan / Wang, Yanan / Zou, Yuanjie / Liu, Xu / Zhang, Yiyi / Hou, Jie / Feng, Hongqi / Li, Qi / Wang, Tong

Frontiers in nutrition

2022 Volume 9, Page(s) 827093

Abstract: Background: Keshan disease (KD) is strongly associated with selenium deficiency. Selenoprotein P ...

Abstract	Background: Keshan disease (KD) is strongly associated with selenium deficiency. Selenoprotein P (SELENOP) is a recognized molecular biomarker of selenoproteins and an important indicator of selenium nutrition. This study was aimed at providing geographically precisely visualized evidence of selenium nutrition at molecular level for assessing KD prevention, control, and elimination on the etiological perspective. Methods: We used spatial ecological design for this study. The serum SELENOP levels of the residents were measured by ELISA. ArcGIS version 9.0 was used for spatial description, spatial autocorrelation analysis of SELENOP levels and spatial regression with per capita disposable income. Results: The mean serum SELENOP levels of the 6,382 residents in 1,688 counties were 4.62 ± 1.82 μg/mL. The mean serum SELENOP levels of the residents living in the townships and rural areas of KD endemic counties were not statistically significantly lower than those of the KD non-endemic counties. The mean serum SELENOP levels were globally clustered (Moran's Conclusions: The results of this study were the geographically precisely visualized evidence of selenium nutrition at molecular level for assessing KD elimination on the etiological perspective. The cold spot counties found by Getis-Ord-Gi
Language	English
Publishing date	2022-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.827093
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Article: A county-level spatial epidemiological study of hair selenium and Keshan disease.

Jia, Yuehui / Li, Guijin / Wang, Ruixiang / Feng, Chen / Qi, Lei / Wang, Yuanyuan / Su, Shengqi / Zou, Yuanjie / Liu, Xu / Wang, Yanan / Zhang, Yiyi / Du, Linlin / Sun, Huixin / Hao, Shuxiu / Hou, Jie / Feng, Hongqi / Li, Qi / Wang, Tong

Frontiers in nutrition

2022 Volume 9, Page(s) 1011460

Abstract: Background: No spatial analysis of hair selenium and Keshan disease (KD) on a nationwide county ...

Abstract	Background: No spatial analysis of hair selenium and Keshan disease (KD) on a nationwide county-level has been performed. Selenium deficiency is a recognized environmental risk factor for KD. Hair selenium is one of the recognized biomarkers of selenium nutrition. This study aimed to perform a geographically precise and visualized assessment of the achievement of KD prevention and control at the level of selenium nutrition in terms of etiology. Methods: A spatial ecological study was conducted. The hair selenium content of the residents was assayed using an atomic fluorescence spectrometer. The spatial analysis was performed using ArcGIS. Results: The median of the hair selenium levels of the 3,028 participants in the 1,174 counties was 0.38 mg/kg, and the content of inhabitants in KD endemic counties was significantly lower than that in KD non-endemic counties (0.34 vs. 0.39 mg/kg, Conclusion: The median of the hair selenium levels of inhabitants living in KD endemic counties was significantly lower than that in KD non-endemic counties. All the 83 KD endemic counties with low-low clusters of hair selenium levels should be prioritized in KD precision prevention and control. These findings are geographically precise and visualized evidence of the assessment of the effectiveness of KD prevention and control at the level of selenium nutrition in terms of etiology.
Language	English
Publishing date	2022-11-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2022.1011460
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Article ; Online: Low Selenium and Low Protein Exacerbate Myocardial Damage in Keshan Disease by Affecting the PINK1/Parkin-mediated Mitochondrial Autophagy Pathway.

Zhang, Li-Wei / Feng, Hong-Qi / Fu, Song-Bo / Sun, Dian-Jun

Current medical science

2024 Volume 44, Issue 1, Page(s) 93–101

Abstract: Objective: Keshan disease (KD) is a myocardial mitochondrial disease closely related ...

Abstract	Objective: Keshan disease (KD) is a myocardial mitochondrial disease closely related to insufficient selenium (Se) and protein intake. PTEN induced putative kinase 1 (PINK1)/Parkin mediated mitochondrial autophagy regulates various physiological and pathological processes in the body. This study aimed to elucidate the relationship between PINK1/Parkin-regulated mitochondrial autophagy and KD-related myocardial injury. Methods: A low Se and low protein animal model was established. One hundred Wistar rats were randomly divided into 5 groups (control group, low Se group, low protein group, low Se + low protein group, and corn from KD area group). The JC-1 method was used to detect the mitochondrial membrane potential (MMP). ELISA was used to detect serum creatine kinase MB (CK-MB), cardiac troponin I (cTnI), and mitochondrial-glutamicoxalacetic transaminase (M-GOT) levels. RT-PCR and Western blot analysis were used to detect the expression of PINK1, Parkin, sequestome 1 (P62), and microtubule-associated proteins1A/1B light chain 3B (MAP1LC3B). Results: The MMP was significantly decreased and the activity of CK-MB, cTnI, and M-GOT significantly increased in each experimental group (low Se group, low protein group, low Se + low protein group and corn from KD area group) compared with the control group (P<0.05 for all). The mRNA and protein expression levels of PINK1, Parkin and MAP1LC3B were profoundly increased, and those of P62 markedly decreased in the experimental groups compared with the control group (P<0.05 for all). Conclusion: Low Se and low protein levels exacerbate myocardial damage in KD by affecting the PINK1/Parkin-mediated mitochondrial autophagy pathway.
MeSH term(s)	Animals ; Rats ; Autophagy/genetics ; Cardiomyopathies ; Enterovirus Infections ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Rats, Wistar ; Selenium ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Protein Kinases (EC 2.7.-) ; Selenium (H6241UJ22B) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; parkin protein (EC 2.3.2.27) ; PTEN-induced putative kinase (EC 2.7.11.1)
Language	English
Publishing date	2024-02-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-024-2834-x
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Article: Prevalence of hypertension in endemic and non-endemic areas of Keshan disease: A cross-sectional study in rural areas of China.

Hou, Jie / Zhu, Lifang / Jin, Shuran / Li, Jinshu / Xing, Zhifeng / Wang, Yanling / Wan, Xiaoyan / Guo, Xianni / Wang, Anwei / Wang, Xiuhong / Liu, Jinming / Ma, Jing / Zhou, Shuang / Zhang, Xiangdong / Zheng, Heming / Wang, Jianhui / Feng, Hongqi / Sun, Shuqiu / Wang, Tong

Frontiers in nutrition

2023 Volume 10, Page(s) 1086507

Abstract: ... of life of people worldwide. Keshan disease (KD) is an endemic cardiomyopathy related to low selenium ...

Abstract	Background: Hypertension is a major public health concern that strongly influences the quality of life of people worldwide. Keshan disease (KD) is an endemic cardiomyopathy related to low selenium, threatening residents in rural areas of 16 provinces in China. Furthermore, the prevalence of hypertension in the KD-endemic areas has been increasing annually. However, hypertension research associated with KD has only focused on endemic regions, and no studies have compared hypertension prevalence between endemic and non-endemic areas. Therefore, this study investigated the prevalence of hypertension to provide a basis for preventing and controlling hypertension in the KD-endemic areas, even in rural areas. Methods: We extracted blood pressure information from cardiomyopathy investigation data from a cross-sectional study of the KD-endemic and non-endemic areas. The hypertension prevalence between the two groups was compared using the Chi-square test or Fisher s exact test. Additionally, Pearson's correlation coefficient was employed to evaluate the relationship between the per capita gross domestic product (GDP) and hypertension prevalence. Results: There was a statistically significant increase of hypertension prevalence in the KD-endemic areas (22.79%, 95% confidence interval [CI]: 22.30-23.27%) over the non-endemic areas (21.55%, 95% CI: 21.09-22.02%). In the KD-endemic areas, more men had hypertension than women (23.90% vs. 21.65%, Conclusions: The increasing hypertension prevalence is a public health problem in the KD-endemic areas. Healthy diets, such as high consumption of vegetables and seafoods, and foods that are rich in selenium, might help prevent and control hypertension in the KD-endemic areas and other rural areas in China.
Language	English
Publishing date	2023-02-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2023.1086507
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Article ; Online: Hair Selenium of Residents in Keshan Disease Endemic and Non-endemic Regions in China.

Jia, Yuehui / Wang, Ruixiang / Li, Guijin / Feng, Chen / Qi, Lei / Wang, Yuanyuan / Su, Shengqi / Zou, Yuanjie / Liu, Xu / Wang, Yanan / Zhang, Yiyi / Du, Linlin / Sun, Huixin / Hao, Shuxiu / Hou, Jie / Feng, Hongqi / Li, Qi / Wang, Tong

Biological trace element research

2022 Volume 201, Issue 7, Page(s) 3256–3267

Abstract: Few nationwide investigations on hair selenium (Se) and Keshan disease (KD) have been conducted. KD ...

Abstract	Few nationwide investigations on hair selenium (Se) and Keshan disease (KD) have been conducted. KD is closely associated with Se deficiency. Hair Se is an important biomarker for selenium nutrition. This research aimed to provide evidence for assessment of KD prevention, control, and elimination at the molecular level from the etiological perspective of selenium nutrition. The hair Se of the residents living in the KD endemic and non-endemic areas were determined through atomic fluorescence spectrometer. The median of the hair Se levels of the inhabitants living in KD endemic counties was significantly lower than that in KD non-endemic counties (0.34 vs 0.39 mg/kg, U = -10.03, P < 0.0001). The proportion of Se-deficient or Se-marginal residents in KD endemic counties was significantly higher than that in KD non-endemic counties (56.9% vs 36.6%, U = -9.57, P < 0.0001). The medians of the hair Se levels in KD endemic provinces of Shannxi, Heilongjiang, and Gansu were the lowest (0.35mg/kg), and in the category of Se-marginal status. The hair Se level featured a positive Spearman correlation with per capita disposable income (r
MeSH term(s)	Humans ; Selenium ; China/epidemiology ; Cardiomyopathies/epidemiology ; Hair/chemistry
Chemical Substances	Selenium (H6241UJ22B)
Language	English
Publishing date	2022-10-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	445336-0
ISSN	1559-0720 ; 0163-4984
ISSN (online)	1559-0720
ISSN	0163-4984
DOI	10.1007/s12011-022-03444-8
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Article ; Online: Risk factors for Keshan disease: a prospective cohort study protocol of gut flora.

Li, Zhenzhen / Wei, Jin / Zhang, Yanping / Li, Gaopeng / Zhu, Huange / Lei, Na / He, Qian / Geng, Yan / Zhu, Jianhong

BMC cardiovascular disorders

2020 Volume 20, Issue 1, Page(s) 481

Abstract: Background: Keshan disease is an endemic cardiomyopathy of undefined causes. Being involved ... in the unclear pathogenesis of Keshan disease, a clear diagnosis, and effective treatment cannot be initiated ... to identify biomarkers for the early diagnosis and further explore new therapeutic targets for Keshan disease ...

Abstract	Background: Keshan disease is an endemic cardiomyopathy of undefined causes. Being involved in the unclear pathogenesis of Keshan disease, a clear diagnosis, and effective treatment cannot be initiated. However, the rapid development of gut flora in cardiovascular disease combined with omics and big data platforms may promote the discovery of new diagnostic markers and provide new therapeutic options. This study aims to identify biomarkers for the early diagnosis and further explore new therapeutic targets for Keshan disease. Methods: This cohort study consists of two parts. Though the first part includes 300 participants, however, recruiting will be continued for the eligible participants. After rigorous screening, the blood samples, stools, electrocardiograms, and ultrasonic cardiogram data would be collected from participants to elucidate the relationship between gut flora and host. The second part includes a prospective follow-up study for every 6 months within 2 years. Finally, deep mining of big data and rapid machine learning will be employed to analyze the baseline data, experimental data, and clinical data to seek out the new biomarkers to predict the pathogenesis of Keshan disease. Discussion: Our study will clarify the distribution of gut flora in patients with Keshan disease and the abundance and population changes of gut flora in different stages of the disease. Through the big data platform analyze the relationship between environmental factors, clinical factors, and gut flora, the main factors affecting the occurrence of Keshan disease were identified, and the changed molecular pathways of gut flora were predicted. Finally, the specific gut flora and molecular pathways affecting Keshan disease were identified by metagenomics combined with metabonomic analysis. Trial registration: ChiCTR1900026639. Registered on 16 October 2019.
MeSH term(s)	Adolescent ; Adult ; Aged ; Bacteria/classification ; Bacteria/genetics ; Bacteria/metabolism ; Big Data ; Biomarkers/metabolism ; Cardiomyopathies/diagnosis ; Cardiomyopathies/microbiology ; Cardiomyopathies/virology ; Case-Control Studies ; Enterovirus Infections/diagnosis ; Enterovirus Infections/microbiology ; Enterovirus Infections/virology ; Female ; Gastrointestinal Microbiome ; Humans ; Intestines/microbiology ; Male ; Metabolomics ; Metagenomics ; Middle Aged ; Prospective Studies ; Research Design ; Young Adult
Chemical Substances	Biomarkers
Language	English
Publishing date	2020-11-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2059859-2
ISSN	1471-2261 ; 1471-2261
ISSN (online)	1471-2261
ISSN	1471-2261
DOI	10.1186/s12872-020-01765-x
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Article ; Online: A spatial study on Keshan disease prevalence and selenoprotein P in the Heilongjiang Province, China.

Wang, Yanan / Zhang, Xiao / Wang, Tong / Hou, Jie / Guo, Zhongying / Han, Xiaomin / Zhou, Huihui / Liang, Hong / Xing, Zhifeng

International journal of occupational medicine and environmental health

2021 Volume 34, Issue 5, Page(s) 659–666

Abstract: Objectives: Few spatial studies on Keshan disease (KD) prevalence and serum selenoprotein P ...

Abstract	Objectives: Few spatial studies on Keshan disease (KD) prevalence and serum selenoprotein P (SELENOP) levels have been reported in the Heilongjiang Province, China. This study aimed to investigate the spatial relationships between KD prevalence, SELENOP levels, and the socio-economic status for the precise prevention and control of KD. Material and methods: The study was carried out in all the 66 KD endemic counties in the Heilongjiang Province using a non-probability sampling method of a key village survey based on county-wide case-searching. The participants completed a questionnaire and had their serum SELENOP levels measured using enzyme-linked immunosorbent assay. Thematic maps were created, and spatial regression analysis was performed by ordinary least squares using ArcGIS 9.0. Results: Overall, 53 676 residents were surveyed based on case-searching, and blood samples were collected from 409 residents. In total, 50 chronic KD cases were identified with a total prevalence of 9.3/10 000 population. The prevalence in the Tangyuan County was the highest (250/10 000 population). The mean serum SELENOP level was 13.96 mg/l. The spatial regression analysis showed that KD prevalence positively correlated with SELENOP levels and negatively with Conclusions: The Tangyuan County should be considered for the precise prevention and control of KD. Further research is necessary to verify the reliability of SELENOP for estimating body selenium levels, and to better understand the relationship between selenium intake and KD in the investigated area. Int J Occup Med Environ Health. 2021;34(5):659-66.
MeSH term(s)	Cardiomyopathies ; China/epidemiology ; Enterovirus Infections ; Humans ; Prevalence ; Reproducibility of Results ; Selenoprotein P
Chemical Substances	Selenoprotein P
Language	English
Publishing date	2021-04-12
Publishing country	Poland
Document type	Journal Article
ZDB-ID	1199049-1
ISSN	1896-494X ; 0867-8383 ; 1232-1087
ISSN (online)	1896-494X
ISSN	0867-8383 ; 1232-1087
DOI	10.13075/ijomeh.1896.01749
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Article ; Online: A spatial study on serum selenoprotein P and Keshan disease in Heilongjiang Province, China.

Wang, Yanan / Zou, Yuanjie / Wang, Tong / Han, Shan / Liu, Xu / Zhang, Yiyi / Su, Shengqi / Zhou, Huihui / Zhang, Xiao / Liang, Hong

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

2021 Volume 65, Page(s) 126728

Abstract: Background: Few spatial studies on serum selenoprotein P (SELENOP) and Keshan disease (KD) have ...

Abstract	Background: Few spatial studies on serum selenoprotein P (SELENOP) and Keshan disease (KD) have been reported at the county-level in Heilongjiang province, China. This study aimed to provide visualized spatial epidemiological evidence of selenium molecular marker in residents living in endemic areas for the precise assessment of prevention, control, and elimination of KD. Methods: Using a spatial ecological study design, 587 subjects living in cities, townships, and rural areas of 50 KD endemic counties and 37 non-endemic counties in Heilongjiang province were investigated. The serum SELENOP levels of the participants were measured by enzyme-linked immunosorbent assay. Thematic maps were created, and spatial regression analysis was conducted using ordinary least squares. Results: The mean serum SELENOP level of the 587 subjects was 7.4 ± 3.0 μg/mL. The mean levels of serum SELENOP were higher in cities (7.4 ± 2.9 μg/mL) and townships (7.9 ± 3.2 μg/mL) than in rural areas (6.0 ± 3.0 μg/mL). The mean levels of serum SELENOP were trending towards high levels in non-endemic areas (7.4 ± 3.0 μg/mL) than in KD endemic areas (6.3 ± 3.3 μg/mL). Spatial regression analysis showed that the serum SELENOP level was positively correlated with the per capita gross domestic product. Conclusion: Selenium deficiency may still exist in some KD endemic counties in Heilongjiang province, including Lingdong, Nenjiang, and Baiquan; these counties should be considered as key areas for precision prevention, control, and elimination of KD. Inclusion of selenium in the national surveillance of KD will provide more evidence for the assessment of KD elimination from a selenium nutrition perspective.
MeSH term(s)	Adult ; Cardiomyopathies/blood ; Cardiomyopathies/epidemiology ; China/epidemiology ; Enterovirus Infections/blood ; Enterovirus Infections/epidemiology ; Female ; Humans ; Male ; Selenoprotein P/blood ; Young Adult
Chemical Substances	Selenoprotein P
Language	English
Publishing date	2021-02-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1236267-0
ISSN	1878-3252 ; 1611-602X ; 0946-672X
ISSN (online)	1878-3252 ; 1611-602X
ISSN	0946-672X
DOI	10.1016/j.jtemb.2021.126728
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Article ; Online: Relationship Between Myocardial Injury and Expression of PGC-1α and Its Coactivators in Chronic Keshan Disease.

Jiang, Shuai / Ye, Qian-Ru / Zhen, Rong-Xia / Zhang, Juan-Niu / Zhang, Yi-Yi / Liu, Xu / Hou, Jie

Current medical science

2021 Volume 42, Issue 1, Page(s) 85–92

Abstract: Objective: Keshan disease (KD) is a mitochondrial cardiomyopathy. The present study explored ...

Abstract	Objective: Keshan disease (KD) is a mitochondrial cardiomyopathy. The present study explored the roles of peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1α (PGC-1α), the key regulator of mitochondrial structure and function, and its coactivators in myocardial injury in chronic KD. Furthermore, the usefulness of these molecules in the diagnosis of chronic KD was assessed. Methods: In the present case-control study, 43 patients with chronic KD and 30 healthy individuals living in KD endemic areas were included. The myocardial injury indicators and mRNA expression levels of PGC-1α, nuclear respiratory factor 1 (NRF1), PPARα, and estrogen-related receptor alpha (ERRα) in peripheral blood were examined. Results: It was found that the levels of atrial natriuretic peptide, creatine kinase, and lactate dehydrogenase (LDH) were higher in patients with chronic KD, when compared to controls, while the level of bradykinin was lower. Furthermore, the PGC-1α, NRF1 and PPARα mRNA levels were higher in patients with KD. The area under the receiver operating characteristic curve and the optimal diagnostic threshold of LDH was 0.937 and 304.0 U/L, respectively. It is noteworthy that the area under the combined receiver operating characteristic curve was larger, when compared to that for LDH detection alone (Z=2.055, P=0.0399). The area under the curve for the "LDH+PPARα" combination was 0.984, with 96.7% sensitivity and 93.0% specificity. Conclusion: The combined detection of LDH and the expression of PPARα can be performed to diagnose the chronic KD.
MeSH term(s)	Adolescent ; Adult ; Cardiomyopathies/metabolism ; Case-Control Studies ; Chronic Disease ; Enterovirus Infections/metabolism ; Female ; Humans ; L-Lactate Dehydrogenase/metabolism ; Male ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Young Adult
Chemical Substances	PPARGC1A protein, human ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; L-Lactate Dehydrogenase (EC 1.1.1.27)
Language	English
Publishing date	2021-10-27
Publishing country	China
Document type	Journal Article
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-021-2454-7
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