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  1. Article ; Online: Recognising primary aldosteronism as a disorder in its own right.

    Funder, John W

    The Medical journal of Australia

    2023  Volume 219, Issue 6, Page(s) 259–260

    MeSH term(s) Humans ; Hyperaldosteronism/complications ; Hyperaldosteronism/diagnosis
    Language English
    Publishing date 2023-08-18
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.52082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Who and How Should We Screen for Primary Aldosteronism?

    Funder, John W

    Hypertension (Dallas, Tex. : 1979)

    2023  Volume 80, Issue 12, Page(s) 2495–2500

    Abstract: There are mounting data that at least 30% of hypertensives who are appropriately screened have primary aldosteronism (PA), rather than the commonly reported figure of 5% to 10%. Second, there are similar data that undertreated patients with PA have a 3- ... ...

    Abstract There are mounting data that at least 30% of hypertensives who are appropriately screened have primary aldosteronism (PA), rather than the commonly reported figure of 5% to 10%. Second, there are similar data that undertreated patients with PA have a 3-fold higher risk profile than essential hypertensives with the same blood pressure levels. Third, clinicians managing hypertension measure success as sustainable lowering of blood pressure; untreated hypertensive patients with PA are thus in double jeopardy. Finally, and crucially, fewer than 1% of patients with hypertension are ever screened-let alone investigated-for PA. Accordingly, for "Who should we screen?" the answer is simple-all patients with hypertension. For "How they should be screened?" the answer is also simple-add spironolactone 25 mg/day for 4 weeks and measure the blood pressure response. In established hypertension, a fall of <10 mm Hg means PA is unlikely; above 12 mm Hg PA, it is probable. Newly presenting hypertension is much the same-hold off on first-order antihypertensive(s) and prescribe spironolactone 25 mg/day for 4 weeks. If blood pressure falls into the normal range, continue; if it does not, prescribe a standard antihypertensive. It is likely that the above protocols-a first start, amenable to refinement-will find additional hypertensives with unilateral PA; it is probable that the overwhelming majority will have bilateral disease. What this means is that we have a major public health issue on our hands: how can this be the case?
    MeSH term(s) Humans ; Spironolactone/therapeutic use ; Hyperaldosteronism/diagnosis ; Hyperaldosteronism/drug therapy ; Antihypertensive Agents/therapeutic use ; Hypertension/diagnosis ; Hypertension/drug therapy ; Blood Pressure ; Aldosterone ; Renin
    Chemical Substances Spironolactone (27O7W4T232) ; Antihypertensive Agents ; Aldosterone (4964P6T9RB) ; Renin (EC 3.4.23.15)
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.20536
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Primary Aldosteronism: Imaging vs. Lateralization.

    Funder, John W

    American journal of hypertension

    2022  Volume 35, Issue 6, Page(s) 512–513

    MeSH term(s) Adrenal Glands ; Aldosterone ; Humans ; Hyperaldosteronism/diagnostic imaging
    Chemical Substances Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpac012
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  4. Article ; Online: Primary Aldosteronism: Strike Two.

    Funder, John W

    American journal of hypertension

    2021  Volume 34, Issue 1, Page(s) 28–29

    MeSH term(s) Aldosterone ; Diagnostic Tests, Routine ; Humans ; Hyperaldosteronism/diagnosis ; Hypertension/diagnosis ; Hypertension/etiology
    Chemical Substances Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2021-02-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpaa171
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  5. Article ; Online: Primary Aldosteronism: Three Strikes and Out.

    Funder, John W

    Hypertension (Dallas, Tex. : 1979)

    2021  Volume 77, Issue 3, Page(s) 900–903

    MeSH term(s) Aldosterone ; Humans ; Hyperaldosteronism/diagnosis ; Hyperaldosteronism/epidemiology
    Chemical Substances Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.120.16585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Primary aldosteronism: a consensus statement.

    Funder, John W

    Journal of hypertension

    2020  Volume 38, Issue 10, Page(s) 1937–1939

    MeSH term(s) Adrenalectomy ; Consensus ; Humans ; Hyperaldosteronism/surgery ; Hyperaldosteronism/therapy ; Hypertension
    Language English
    Publishing date 2020-09-01
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000002568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 614: Show issues

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  7. Article ; Online: Primary Aldosteronism: At the Tipping Point.

    Funder, John W

    Annals of internal medicine

    2020  Volume 173, Issue 1, Page(s) 65–66

    MeSH term(s) Aldosterone ; Cross-Sectional Studies ; Humans ; Hyperaldosteronism/complications ; Hyperaldosteronism/diagnosis ; Prevalence
    Chemical Substances Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M20-1758
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    Ua VI Zs.178/2: Show issues Location:
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  8. Article ; Online: Primary Aldosteronism in Newly Diagnosed Hypertensive Patients: Lessons From China.

    Funder, John W

    Journal of the American College of Cardiology

    2020  Volume 75, Issue 16, Page(s) 1923–1925

    MeSH term(s) China/epidemiology ; Humans ; Hyperaldosteronism/complications ; Hyperaldosteronism/diagnosis ; Hyperaldosteronism/epidemiology ; Hypertension/diagnosis ; Hypertension/epidemiology
    Language English
    Publishing date 2020-04-24
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.02.055
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    Zs.A 1846: Show issues Location:
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    Zs.MO 196: Show issues

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  9. Article ; Online: Primary Aldosteronism: The Next Decade.

    Funder, John W

    Hypertension (Dallas, Tex. : 1979)

    2020  Volume 76, Issue 2, Page(s) 325–326

    MeSH term(s) Aldosterone ; Angiotensin II ; Humans ; Hyperaldosteronism/diagnosis ; Hyperaldosteronism/epidemiology ; Hypertension/diagnosis ; Hypertension/drug therapy ; Hypertension/epidemiology ; Ramipril ; Renin
    Chemical Substances Angiotensin II (11128-99-7) ; Aldosterone (4964P6T9RB) ; Renin (EC 3.4.23.15) ; Ramipril (L35JN3I7SJ)
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.120.15456
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  10. Article ; Online: Apparent Mineralocorticoid Excess: Research as an Art Form.

    Funder, John W

    Endocrine

    2020  Volume 70, Issue 3, Page(s) 439–440

    MeSH term(s) 11-beta-Hydroxysteroid Dehydrogenase Type 2 ; Humans ; Hypertension ; Hypokalemia ; Mineralocorticoid Excess Syndrome, Apparent ; Mutation ; Mineralocorticoid Excess Syndrome, Apparent
    Chemical Substances 11-beta-Hydroxysteroid Dehydrogenase Type 2 (EC 1.1.1.146) ; HSD11B2 protein, human (EC 1.1.1.146)
    Language English
    Publishing date 2020-09-29
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-020-02488-x
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