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Article ; Online: Exploring the Fluconazole-Resistance Modifying Activity and Potential Mechanism of Action of Fixed Oil from Caryocar coriaceum Wittm. (Caryocaraceae) against Candida Species.

Almeida-Bezerra, José Weverton / Pereira da Cruz, Rafael / Bezerra da Silva, Viviane / Da Silva Neto, João Xavier / Alves Lopes de Souza, Larissa / de Oliveira Bezerra de Sousa, Daniele / Monteiro Salgueiro Araujo, Nadine / Guimarães Gomes Silva, Rafael / Quefi, Blasco / Rau, Martinho / Andrade Rebelo, Ricardo / Castro Dos Santos, Sarah / Everson da Silva, Luiz / Douglas Melo Coutinho, Henrique / Almeida Menezes, Saulo / Bezerra Morais-Braga, Maria Flaviana / Morais de Oliveira, Antonio Fernando

Chemistry & biodiversity

2024 Volume 21, Issue 3, Page(s) e202301960

Abstract: The fixed oil from the inner mesocarp of Caryocar coriaceum Wittm. is used in the Chapada do Araripe region of Brazil for the treatment of genitourinary candidiasis. This study aimed to evaluate the chemical composition, antifungal activity, reduction of ...

Abstract	The fixed oil from the inner mesocarp of Caryocar coriaceum Wittm. is used in the Chapada do Araripe region of Brazil for the treatment of genitourinary candidiasis. This study aimed to evaluate the chemical composition, antifungal activity, reduction of fungal virulence, and the preliminary toxicity of the fixed oil from the inner mesocarp of C. coriaceum tested against three Candida yeasts. The oil was characterized by gas chromatography (GC-MS and GC-FID). Antifungal activity was assessed using the serial microdilution method. Additionally, the potential of the oil as an enhancer of fluconazole action was tested at sub-inhibitory concentrations (MIC/8). The mechanism of action of C. coriaceum fixed oil was determined by evaluating the inhibition of morphological transition in Candida spp. The chemical composition of the fixed oil of C. coriaceum comprised both unsaturated and saturated fatty acids. Oleic (61 %) and palmitic (33 %) acids were the major constituents. Regarding its anti-Candida activity, the oil inhibited the growth of C. albicans (IC
MeSH term(s)	Animals ; Fluconazole/pharmacology ; Candida ; Antifungal Agents/pharmacology ; Antifungal Agents/chemistry ; Malpighiales ; Drosophila melanogaster ; Plant Oils/pharmacology ; Plant Oils/chemistry ; Candida albicans ; Microbial Sensitivity Tests
Chemical Substances	Fluconazole (8VZV102JFY) ; Antifungal Agents ; Plant Oils
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202301960
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Article: HPLC-DAD analysis and antimicrobial activities of

de Freitas, Maria Audilene / da Cruz, Rafael Pereira / Dos Santos, Antonia Thassya Lucas / Almeida-Bezerra, José Weverton / Machado, Antonio Júdson Targino / Dos Santos, Joycy Francely Sampaio / Rocha, Janaina Esmeraldo / Boligon, Aline Augusti / Bezerra, Camila Fonseca / de Freitas, Thiago Sampaio / do Nascimento Silva, Maria Karollyna / Mendonça, Ana Cleide Alcântara Morais / da Costa, José Galberto Martins / Coutinho, Henrique Douglas Melo / da Cunha, Francisco Assis Bezerra / Filho, Jaime Ribeiro / Morais-Braga, Maria Flaviana Bezerra

3 Biotech

2022 Volume 12, Issue 3, Page(s) 61

Abstract: ... Spondias ... ...

Abstract	Spondias mombin
Language	English
Publishing date	2022-02-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-022-03126-1
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Article: Persistent hypotension and other complications of celiac plexus neurolysis: A case report and literature review.

Dos Santos Silva, Rhuann Pontes / Lopes, Arthur José Maia / Bezerra, Roberto Borges / Andrade, Rafael Albanez / Andrade, Rebeca Gonelli / da Costa, Larissa Monteiro Ferreira / de Albuquerque da Cunha Andrade, Carolina Albanez

Clinical case reports

2023 Volume 11, Issue 6, Page(s) e7505

Abstract: Key clinical message: Persistent hypotension is a rare complication of celiac plexus neurolysis. It is important to know what are the main and rare complications and how to treat these in patients who undergo CPN.: Abstract: Celiac plexus neurolysis ... ...

Abstract	Key clinical message: Persistent hypotension is a rare complication of celiac plexus neurolysis. It is important to know what are the main and rare complications and how to treat these in patients who undergo CPN. Abstract: Celiac plexus neurolysis is an effective treatment for visceral abdominal pain in oncological patients. Although it rarely has complications, some side effects may occur. A patient with visceral abdominal pain who developed long-lasting orthostatic hypotension and was treated with the use of corticosteroids after a neurolytic celiac plexus block for intractable pain. We describe a rare complication and its treatment and we emphasize the importance of having a guide for the management and treatment of rare complications. We also suggest that every patient be informed about complications, from the most common to the rarest.
Language	English
Publishing date	2023-06-08
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.7505
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Article ; Online: Patellofemoral pain syndrome in children and adolescents: A cross-sectional study.

Sanchis, Geronimo José Bouzas / Barbosa, Joubert Vitor de Souto / Cavalcanti, Rafael Limeira / Bezerra, Josiane Pereira / Santos, Maristela Linhares Dos / Guedes, Thais Sousa Rodrigues / Assis, Sanderson José Costa de / Santana, Rebeca de Castro / Lopes, Johnnatas Mikael / Oliveira, Angelo Giuseppe Roncalli da Costa / Guedes, Marcello Barbosa Otoni Gonçalves

PloS one

2024 Volume 19, Issue 4, Page(s) e0300683

Abstract: Objectives: To assess the prevalence and associated factors of Patellofemoral Pain Syndrome (PFPS) in children and adolescents.: Method: A population-based cross-sectional study was conducted with children and adolescents aged 10 to 18 years, who ... ...

Abstract	Objectives: To assess the prevalence and associated factors of Patellofemoral Pain Syndrome (PFPS) in children and adolescents. Method: A population-based cross-sectional study was conducted with children and adolescents aged 10 to 18 years, who presented a history of peripatellar and/or retropatellar pain, attending elementary or high school in urban public schools in Natal, Brazil. The sample size was calculated based on a minimum outcome prevalence of 22%. Results: A prevalence of 24.7% of PFPS was found. There was a positive association of PFPS with active students (p < 0.01; PR: 2.5; CI: 1.4-4.5), low functional capacity (p < 0.01; PR: 8.0; CI: 5.0-12.8), and those classified as pubertal (p < 0.03; PR: 1.8; CI: 1.0-3.2). Conclusion: There was a considerable prevalence of PFPS in children and adolescents, as well as an association between the level of sexual maturation and adjustable determinants, such as the level of physical activity and low functional capacity in this group.
MeSH term(s)	Child ; Humans ; Adolescent ; Cross-Sectional Studies ; Patellofemoral Pain Syndrome/epidemiology ; Exercise Therapy ; Exercise ; Prevalence
Language	English
Publishing date	2024-04-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0300683
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Article ; Online: ESPORTE, CIDADE E GEOGRAFIA

Lucas Nascimento de Mattos / João Paulo Rosalin / Fernando Chamone Franco / Rafael Freitas Bezerra / Leandro Luís Lino dos Santos / Jonathan Ferreira

Ensaios de Geografia, Vol 9, Iss 19, Pp 196-

2022 Volume 210

Abstract: Entrevista com Victor Andrade de Melo, professor da UFRJ e coordenador do Sport: Laboratório de História do Esporte e do Lazer. ...

Abstract	Entrevista com Victor Andrade de Melo, professor da UFRJ e coordenador do Sport: Laboratório de História do Esporte e do Lazer.
Keywords	história dos esportes ; história do lazer ; geografia histórica dos esportes ; Geography (General) ; G1-922
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Universidade Federal Fluminense (UFF)
Document type	Article ; Online
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Article ; Online: Assessment of antioxidant and antiparkinsonian potential of a new diterpene isolated from

Bastos, Rafael Carneiro / Vasconcelos, Carlos Franciney Moreira / Paiva, Marcela Bezerra / Reis, Thomas Dominik de Sousa Dos / Souza, Ricardo Basto / Dos Santos, Hélcio Silva / Bandeira, Paulo Nogueira / Aguiar, Lissiana Magna Vasconcelos / Cunha, Rodrigo Maranguape Silva da

Free radical research

2023 Volume 56, Issue 11-12, Page(s) 760–770

Abstract: Oxidative stress is related to health problems including neurological and neurodegenerativedisturbs, such as Parkinson's disease. Natural compounds are reported as source of antioxidant molecules. Therefore, this study aimed to analyze the antioxidant ... ...

Abstract	Oxidative stress is related to health problems including neurological and neurodegenerativedisturbs, such as Parkinson's disease. Natural compounds are reported as source of antioxidant molecules. Therefore, this study aimed to analyze the antioxidant and neuroprotective potential of a new diterpene isolated from
MeSH term(s)	Rats ; Male ; Animals ; Antioxidants/pharmacology ; Parkinson Disease/drug therapy ; Rats, Wistar ; Croton ; Antiparkinson Agents/pharmacology ; Oxidative Stress ; Diterpenes/pharmacology ; Neuroprotective Agents/pharmacology ; Disease Models, Animal ; Oxidopamine/pharmacology
Chemical Substances	Antioxidants ; Antiparkinson Agents ; Diterpenes ; Neuroprotective Agents ; Oxidopamine (8HW4YBZ748)
Language	English
Publishing date	2023-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1194130-3
ISSN	1029-2470 ; 1071-5762
ISSN (online)	1029-2470
ISSN	1071-5762
DOI	10.1080/10715762.2023.2176763
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Article: LC-MS Analysis and Antifungal Activity of

Andrade-Pinheiro, Jacqueline Cosmo / Sobral de Souza, Celestina Elba / Ribeiro, Daiany Alves / Silva, Andressa de Alencar / da Silva, Viviane Bezerra / Dos Santos, Antonia Thassya Lucas / Juno Alencar Fonseca, Victor / de Macêdo, Delmacia Gonçalves / da Cruz, Rafael Pereira / Almeida-Bezerra, José Weverton / Machado, Antonio Júdson Targino / de Freitas, Thiago Sampaio / de Brito, Edy Sousa / Ribeiro, Paulo Riceli Vasconcelos / da Costa, José Galberto Martins / Coutinho, Henrique Douglas Melo / Kowalska, Grażyna / Rowiński, Rafał / Kowalski, Radosław /

Morais-Braga, Maria Flaviana Bezerra

Plants (Basel, Switzerland)

2023 Volume 12, Issue 2

Abstract: ... Fungi of ... ...

Abstract	Fungi of the
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12020415
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Article ; Online: Impact of COVID-19 pandemic on prostate cancer outcomes at an uro-oncology referral center.

Andrade, Guilherme Miranda / Sesconetto, Lucas / da Silva, Rafael Benjamim Rosa / Dos Santos, Gabriela Guimarães Rodrigues / Kayano, Paulo Priante / Baccaglini, Willy / Bezerra, Murilo Borges / Bianco, Bianca / Lemos, Gustavo Caserta / Carneiro, Arie

International braz j urol : official journal of the Brazilian Society of Urology

2023 Volume 49, Issue 2, Page(s) 233–242

Abstract: Introduction: To evaluate the possible effects of the coronavirus disease 2019 (COVID-19) pandemic on the oncologic results of patients with prostate cancer regarding clinical staging, presence of adverse pathological outcomes, and perioperative ... ...

Abstract	Introduction: To evaluate the possible effects of the coronavirus disease 2019 (COVID-19) pandemic on the oncologic results of patients with prostate cancer regarding clinical staging, presence of adverse pathological outcomes, and perioperative complications. Materials and methods: This retrospective study included patients who underwent radical prostatectomy. The time between biopsy and surgery, staging tests, final histopathological evaluation after surgery, lymphadenectomy rate, postoperative complications, and prostatic specific antigen (PSA) levels (initial and 30 days after surgery) were analyzed and compared in a group of patients before and during the pandemic period. Results: We included 226 patients: 88 in the pre-pandemic period and 138 during the pandemic period. There was no statistically significant difference in mean age, body mass index, ASA, pathological locally advanced disease, the proportion of patients who underwent lymphadenectomy, and ISUP grade in the biopsy between the groups. Positive surgical margins, prostatic extracapsular extension, and PSA levels at 30 days were also similar between the groups. The mean time between medical consultation and surgery was longer in the pandemic period than in the pre-pandemic (124 vs. 107 days, p<0.001), and the mean time between biopsy and medical consultation (69.5 days vs. 114 days, p<0.001) and between biopsy and surgery (198.5 days vs. 228 days, p=0.013) was shorter during the pandemic. The incidence of severe early and late perioperative complications was similar between the periods. Conclusions: There was no delay between diagnosis and treatment at our institution during the COVID-19 pandemic period. No worsening of the prostate cancer features was observed.
MeSH term(s)	Male ; Humans ; Prostate-Specific Antigen ; Pandemics ; Retrospective Studies ; COVID-19/pathology ; Prostatic Neoplasms/pathology ; Prostatectomy/methods ; Neoplasm Staging
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-05-16
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2206649-4
ISSN	1677-6119 ; 1677-5538
ISSN (online)	1677-6119
ISSN	1677-5538
DOI	10.1590/S1677-5538.IBJU.2022.0393
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Article ; Online: Biocultural correlates of gross motor coordination in prepubescent children: A cross-sectional study.

da Silva Lima, Braulio Patrick / Giudicelli, Bruno Barbosa / Dos Santos Pinheiro, Ingrid Kelly Alves / Santos, Douglas Henrique Bezerra / Magalhães, Kleberton Carlos Silva / Dos Santos Henrique, Rafael / da Silva, Danilo Rodrigues Pereira / Silva, Manuel João Coelho E / de Oliveira Luz, Leonardo Gomes

American journal of human biology : the official journal of the Human Biology Council

2023 Volume 36, Issue 4, Page(s) e24002

Abstract: Aim: This study aimed to explore the association of gross motor coordination (GMC) with a matrix of biocultural factors in prepubescent children, taking into account weight status, somatic maturation, sociodemographic variables, and type of school.: ... ...

Abstract	Aim: This study aimed to explore the association of gross motor coordination (GMC) with a matrix of biocultural factors in prepubescent children, taking into account weight status, somatic maturation, sociodemographic variables, and type of school. Methods: One hundred twenty-nine prepubescent children, of both sexes, aged between 8.00 and 8.99, were assessed for GMC (Körperkoordinationstest Für Kinder - KTK), weight status, biological maturation (predicted mature stature), sex, mother's education level and type of school. Binary logistic regression was used to examine the relationship between higher values of KTK and associated biocultural factors. Results: Normoponderal children are more likely to attain better total KTK scores than those with overweight or obesity (OR: 2.942; LC 95%: 1.189, 7.280). In addition, children who are more advanced in terms of biological maturation exhibited significantly lower odds of being in the high KTK category than their less advanced peers (OR: 0.670; LC 95%: 0.474,0.946). Sex, mother's education level and the type of school are not associated with higher performance on KTK. Conclusion: Weight status and biological maturation are associated with motor competence in prepubescent children. Future studies should consider additional correlates to better understand the complex interactions between biological, psychosocial and behavioral factors in the prediction of motor competence.
MeSH term(s)	Male ; Child ; Female ; Humans ; Cross-Sectional Studies ; Motor Skills ; Obesity ; Overweight ; Motor Activity
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025339-7
ISSN	1520-6300 ; 1042-0533
ISSN (online)	1520-6300
ISSN	1042-0533
DOI	10.1002/ajhb.24002
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Article ; Online: Maternal high-fat diet alters the neurobehavioral, biochemical and inflammatory parameters of their adult female rat offspring.

Vieira, Anne Caroline Alves / Pinheiro, Rafael Oliveira / Soares, Naís Lira / Bezerra, Maria Luiza Rolim / Nascimento, Davi Dos Santos / Alves, Adriano Francisco / Sousa, Maria Carolina de Paiva / Dutra, Maria Letícia da Veiga / Lima, Marcos Dos Santos / Donato, Nilcimelly Rodrigues / Aquino, Jailane de Souza

Physiology & behavior

2023 Volume 266, Page(s) 114180

Abstract: Background: Lipid metabolism dysregulations have been associated with depressive and anxious behaviors which can affect pregnant and lactating individuals, with indications that such changes extend to the offspring. Therefore, the aim of this study was ... ...

Abstract	Background: Lipid metabolism dysregulations have been associated with depressive and anxious behaviors which can affect pregnant and lactating individuals, with indications that such changes extend to the offspring. Therefore, the aim of this study was to evaluate the effect of a maternal high-fat diet on the neurobehavioral, biochemical and inflammatory parameters of their adult female offspring. Methods: Wistar rats ± 90 days old were mated. The dams were allocated to consume a control (CTL) or high-fat (HFD) diet during pregnancy and lactation. After weaning, the female offspring from the CTL (N = 10) and HFD (N = 10) groups received standard chow. The offspring behavioral tests were started at 120 days old. Then, the somatic measures were evaluated followed by euthanasia, histological and biochemical analyses. Results: The HFD group had less ambulation and longer immobility time in the open field test compared to the CTL. The HFD group had lower HDL (48.4%) and a higher adiposity (71.8%) and LDL (62.2%) than the CTL. The CTL had a higher organic acid concentration in the intestine, mainly acetic and butyric acids, however the HFD had a higher citric and acetic acid concentration in the brain and ischemic lesion in the hippocampus with a higher NF-κB concentration. Conclusion: The results demonstrate deleterious effects of a maternal HFD on the neurobehavioral and biochemical parameters of their offspring which may be associated with the role of organic acids and NF-κB in fetal programming.
MeSH term(s)	Pregnancy ; Humans ; Rats ; Animals ; Female ; Rats, Wistar ; Diet, High-Fat/adverse effects ; Lactation ; NF-kappa B ; Prenatal Exposure Delayed Effects/metabolism ; Maternal Nutritional Physiological Phenomena
Chemical Substances	NF-kappa B
Language	English
Publishing date	2023-04-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2023.114180
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